Relationships of dermatologic symptoms and quality of life in patients with psoriatic arthritis: analysis of two tofacitinib phase III studies by Peter C. Taylor, Andrew G. Bushmakin, Joseph C. Cappelleri, Pamela Young, Rebecca Germino, Joseph F. Merola, Gil Yosipovitch

“…Objectives Evaluate relationships between changes in dermatologic assessments and quality of life (QoL) measures; quantify dermatologic symptom severity impacts on QoL in patients with psoriatic arthritis (PsA) treated with tofacitinib.Methods Data were from two phase III studies; patients received tofacitinib 5 or 10 mg twice daily (BID), adalimumab 40 mg every other week, or placebo advancing to tofacitinib 5 or 10 mg BID at Month 3. …”
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Photovoltaic Farms: Economic Efficiency of Investments in South-East Poland by Joanna Żurakowska-Sawa, Arkadiusz Gromada, Anna Trocewicz, Adrianna Wojciechowska, Marcin Wysokiński, Anetta Zielińska

“…The payback period (both simple and discounted) for investments with the subsidy was, on average, almost twice as fast as for investments without the subsidy, while the average unit cost of electricity generation with the subsidy was about 30% lower than without it.…”
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Levetiracetam Induced Behavioral Abnormalities in a Patient with Seizure Disorder: A Diagnostic Challenge by Oluwaseun Ogunsakin, Terence Tumenta, Scarlet Louis-Jean, Ayesha Mahbub, Peterson Rabel, Tolu Olupona, Shaheen Alam

“…This research describes the case of a 28-year-old woman with seizure disorder and a psychiatric history of schizoaffective disorder who developed aggressive behavior, paranoia, and severe hostility following administration of Levetiracetam 750 mg orally twice daily. She developed acute behavioral symptoms which were reversed with cessation of Levetiracetam. …”
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Patient Preference for Once-Weekly Dosing in Type 2 Diabetes Mellitus in Japan by Rohini Sen, Alan L. Shields, Koichiro Atsuda

“…Moreover, the value of a once-weekly (QW) administration of oral medications for T2DM compared to once, twice, or thrice daily (QD, BID, TID) regimens is unclear. …”
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Optimization of the DNA isolation procedure for assessing the genetic diversity of essential oil roses (<i>Rosa</i> L.) by S. B. Seitadzhieva, S. Z. Guchetl, S. V. Didovich, E. V. Gorodnyaya

“…DNA preparations extracted with the modified technique were well visualized on the electropherogram and demonstrated high spectrophotometric values. DNA content was twice as high in preparations isolated with an extraction buffer with PVP, compared to a PVP-free buffer. …”
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Magnetic and pH sensitive nanocomposite microspheres for controlled temozolomide delivery in glioblastoma cells by Meysam Ahmadi, Muhammad Hossein Ashoub, Kamran Heydaryan, Sanaz Abolghasemi, Elmuez A. Dawi, Ghazal khajouei, Mahnaz Amiri

“…This is approximately twice the amount of drug release in the absence of a magnetic field and more than that in the presence of a 50 Hz magnetic field. …”
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Descriptive Investigation of Strongyloidiasis Infection and Characterization of Strongyloides stercoralis Using Morphological and Molecular-Based Methods by Nayana Gunathilaka, Nilmini Chandrasena, Tharaka Wijerathna, Yoshito Fuji, Deepa Gunasekara, Ruwan Prasanna Gunatilaka, Ranjan Premaratna

“…The patient’s gastrointestinal symptoms improved with a six-day course of albendazole (400 mg twice daily). Negative posttreatment stool microscopy, culture, and PCR confirmed successful clearance of infection. …”
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Single-Path High-Resolution Digital PWM Architectures With Cascadability of Delay Lines by Marziyeh Hajiheidari, Joel Fushekati, Mohammad Emad, Bas J. D. Vermulst, Jeroen van Duivenbode, Henk Huisman

“…It is demonstrated that bothhldead time and duty cycle can be modified with high accuracy and resolution and updated twice per switching cycle.…”
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Repairing and Strengthening of Damaged RC Columns Using Thin Concrete Jacketing by Bassam A. Tayeh, Mohammed Abu Naja, Samir Shihada, Mohammed Arafa

“…The experimental program showed that the Group 1 specimens had ultimate load capacities more than twice those of the unjacketed reference columns and the same axial capacity as the monolithically cast reference columns. …”
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Research on the related between microstructures and impact toughness of Ti80 alloy by Bin Hu, Jinyang Ge, Junyang He, Bin Kong, Xiaoyong Zhang, Kechao Zhou

“…In particular, the FE and ECL exhibited superior impact toughness (132.5 J/cm2 and 110.0 J/cm2 respectively), nearly twice that of EDL (65.0 J/cm2). By investigating the microstructure deformation mechanisms and crack deflection behaviors, we found that equiaxed αp and colony αl in FE or ECL possess superior abilities of plastic deformation and crack deflection, promoting severe deformation of them, tortuous crack paths as well as high energy dissipation. …”
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Tocilizumab, an Exploratory Treatment for Severe COVID-19 Patients by Yong Wang, Yongfeng Chen, Xiangdong Zhou

“…Eleven patients received TCZ administration once, while the other 2 patients received it twice. The median level of IL-6 before TCZ administration was 27.91 (7.42–210.90) pg/mL. …”
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Non-acid reflux and sleep apnea: the importance of drug induced sleep endoscopy by Carlos O’Connor-Reina, Jose Maria Ignacio Garcia, Peter Baptista, Maria Teresa Garcia-Iriarte, Carlos Casado Alba, Monica Perona, Paz Francisca Borrmann, Laura Rodriguez Alcala, Guillermo Plaza

“…Case presentation A 54-year-old man without significant anatomical findings with obstructive sleep apnea syndrome and non-acid gastroesophageal reflux disease (GERD) disease whose Apnea- hypopnea index (AHI) was significantly reduced with the intake of 500 mg of sodium alginate twice a day for 6 months. Conventional digestive tests such as esophagoscopy and simple- and double-channel 24-h pH-metry suggested mild GERD. …”
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Impact of Postpartum Dexamethasone on Postpartum Disease Stabilization in Women with HELLP Syndrome by Ayla Sargın Oruç, Figen Türkçapar, Serdar Oğuz, Necati Hançerlioğulları, Ümit Bilge, Nuri Danışman

“…Patients in the treatment group were administered dexamethasone 8 mg, 4 mg and 2 mg IV twice daily, on the postoperative days 1, 2 and 3 consecutively. …”
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Examining the Validity and Reliability of Iranian Women's Sexual Self-Efficacy Questionnaire by Fatemeh Shabani, Rasol Roshan Chesli, Soheila Ghomian

“…A separate sample of 60 participants completed the women's sexual self-efficacy questionnaire twice, with an interval of one month between the assessments. …”
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Cross-cultural Adaptation, Translation, and Validation of Gujarati Version of Neck Disability Index in Patients with Chronic Neck Pain by Shlesha Vaidya, Shreya Vaid

“…Test–retest reliability for the NDI-G was examined in 50 patients, twice with an interval of 48 h. Results: In phase I, the cross-cultural adaptation process of the NDI-G was successful, and less difficulty was experienced in achieving an acceptable translation. …”
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Antithrombin III deficiency and idiopathic intracranial hypertension: a case report by Mansoureh Togha, Yousef Mokary, Elham Jafari

“…The patient was started on acetazolamide (1 g/day, increased to 2 g/day) and furosemide (20 mg/twice a day) and was encouraged to lose weight. These treatments led to some improvement for about 1 year, but her symptoms then worsened without an obvious cause. …”
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Experimental study and field application of hydraulic flushing technology in soft coal seam by Xun Zhao, Bei Hu, Baisheng Nie, Xianfeng Liu, Dan Zhao, Hongsheng Li, Chuan Deng, Zhengpeng Duan

“…Notably, the permeability of coal seam in hydraulic flushing area is close to twice that of ordinary drilling area.…”
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Color Assessment of Screw-Retained Implant Prostheses Access Hole Fillings: An In-Vitro Study by Arash Sarrafzadeh, Afrooz Nakhostin, Soheila Jadidi, Malihe Safari

“…The samples were subjected to thermocycling twice (T1 and T3), undergoing 1000 cycles in coffee, orange juice, and distilled water, followed by washing performed after each thermocycling (T2 and T4). …”
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Detailed Histologic Evaluation of Eosinophilic Esophagitis in Pediatric Patients Presenting with Dysphagia or Abdominal Pain and Comparison of the Histology between the Two Groups by Thirumazhisai S. Gunasekaran, Christopher Chu, Nemencio Ronquillo, Rohini Chennuri, Brian Adley, Kristina Borgen, Alan Schwartz, Robert Newberry, James Berman

“…Eosinophilic microabscesses, superficial layering of eosinophils, and epithelial desquamation were twice as common and significant in EoE-D group than EoE-AP. …”
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An Investigation of Presumptive Synergism of Oil Palm Bunch Ash and Sawdust Amendments in Remediation of crude oil Spiked Soil by Ejikeme Albert, Di Anyanwu

“…The setups were replicated five times and watered twice weekly. Results showed that soil pH increased from 8.7±0.04 to 10.5±0.06, 5.3±0.01 to 8.5±0.04 and 5.6±0.18 to 11.5±0.15 for TC, TD and TE respectively. …”
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