A deep multiple instance learning framework improves microsatellite instability detection from tumor next generation sequencing by John Ziegler, Jaclyn F. Hechtman, Satshil Rana, Ryan N. Ptashkin, Gowtham Jayakumaran, Sumit Middha, Shweta S. Chavan, Chad Vanderbilt, Deborah DeLair, Jacklyn Casanova, Jinru Shia, Nicole DeGroat, Ryma Benayed, Marc Ladanyi, Michael F. Berger, Thomas J. Fuchs, A. Rose Brannon, Ahmet Zehir

“…To overcome this critical issue, we developed MiMSI, an MSI classifier based on deep neural networks and trained using a dataset that included low tumor purity MSI cases in a multiple instance learning framework. …”
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Engineered GM-CSF polarizes protumorigenic tumor-associated macrophages to an antitumorigenic phenotype and potently synergizes with IL-12 immunotherapy by Yue Wang, Kevin Chang, Aslan Mansurov, Jun Ishihara, Seounghun Kang, Trevin Kurtanich, Hye Rin Chun, Anna J Slezak, Lisa R Volpatti, Thomas Wang, Aaron T Alpar, Kirsten C Refvik, O Isabella Hansen, Gustavo J Borjas, Brendan T K Berg, Ha-Na Shim, Kevin T Hultgren, Suzana Gomes, Ani Solanki, Melody A Swartz, Jeffrey A Hubbell

“…We evaluated tumor responses at the levels of outcome, cellular responses, and cytokine responses in both the tumors and the tumor-draining lymph nodes. …”
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Identification of SETD4 as an Onco‐Immunological Biomarker Encompassing the Tumor Microenvironment, Prognoses, and Therapeutic Responses in Various Human Cancers by Yuyun Zhong, Ruiqi Wang, Zijie Huang, Zhaoting Hu, Bin Peng, Bin Chen, Liyue Sun

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Bilateral Paget’s Disease of the Breast—Case Report of Long-Time Misdiagnosed Tumors with Underlying Ductal Carcinomas and Review of the Literature by Dietrich Barth

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Craniofacial Brown Tumor in Patients with Secondary Hyperparathyroidism to Chronic Renal Failure: Report of Two Cases in Cipto Mangunkusumo Hospital by Diani Kartini, Maria K. Siswiandari, Gunawan Wibisana, Erwin D. Yulian, Ahmad Kurnia, Sonar S. Panigoro, Azdi Z. Albar, Muchlis Ramli

“…Brown tumor is a bone lesion that arises in the setting of excess osteoclast activity in hyperparathyroidism. …”
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Sistema de retracción tubular "Neuroport-Hospital Hermanos Ameijeiras" con apoyo endoscópico para tumores cerebrales profundos by Peggys Oleydis Cruz Pérez, Omar López Arbolay, Marlon Manuel Ortiz Machín, Carlos Roberto Vargas Gálvez

“…Introducción: Los tumores cerebrales profundos son un desafío desde la perspectiva quirúrgica. …”
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Carbohydrate ligand engagement with CD11b enhances differentiation of tumor-associated myeloid cells for immunotherapy of solid cancers by Mei Zhang, Veronique Roche, Victor Sandoval, Claire Wolford, Zachary Senders, Julian Anthony Kim, Susan Pereira Ribeiro, Alex Yicheng Huang, Rafick-Pierre Sekaly, Joshua Lyons

“…Background Efforts to modulate the function of tumor-associated myeloid cell are underway to overcome the challenges in immunotherapy and find a cure. …”
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Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy by Laura Grunewald, Lena Andersch, Konstantin Helmsauer, Silke Schwiebert, Anika Klaus, Anton G. Henssen, Teresa Straka, Marco Lodrini, Sebastian G. Wicha, Steffen Fuchs, Falk Hertwig, Frank Westermann, Alice Vitali, Carlotta Caramel, Gabriele Büchel, Martin Eilers, Kathy Astrahantseff, Angelika Eggert, Uta E. Höpken, Johannes H. Schulte, Thomas Blankenstein, Kathleen Anders, Annette Künkele

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TYRO3 blockade enhances anti-PD-1 therapy response by modulating expression of CCN1 in tumor microenvironment by Miso Park, Da-Sol Kuen, Keon Wook Kang, Yeonseok Chung, Jaewoo Park, Munkyung Choi, Yeonji Kim, Eun Chae Roh, Yong June Choi, Yoon Gyoon Kim, Sung Yun Cho

“…Co-cultures of macrophages and T cells were performed to verify the role of CCN1 in the tumors.Results TYRO3 blockade boosts antitumor immune responses in both the tumor-draining lymph nodes and tumors in MC38-syngeneic mice models. …”
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Assessment of the impact of surgical treatment of primary malignant bone tumors on the quality of life of patients in peacetime and in the realities of wartime in Ukraine by O. Drobotun, N. Ternovyy, S. Konovalenko, A. Khmel

Subjects: “…bone tumors…”
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Systematic Evaluation of Clinical Efficacy of Shiyiwei Shenqi (Ginseng and Astraglus, Eleven Ingredients) Preparation in Adjuvant Chemotherapy for Malignant Tumor by Bowei HUANG, Yuhui ZENG, Lisha LU, Huijuan GAN

Subjects: “…malignant tumor…”
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Flavonoids of Rosa rugosa Thunb. inhibit tumor proliferation and metastasis in human hepatocellular carcinoma HepG2 cells by Zhiguo Zhang, Meilin Wang, Shu Xing, Chen Zhang

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CGH, cDNA and Tissue Microarray Analyses Implicate FGFR2 Amplification in a Small Subset of Breast Tumors by Mervi Heiskanen, Juha Kononen, Maarit Bärlund, Joachim Torhorst, Guido Sauter, Anne Kallioniemi, Olli Kallioniemi

“…Finally, a tissue microarray based FISH analysis of 750 uncultured primary breast cancers demonstrated in vivo amplification of the FGFR2 gene in about 1% of the tumors. In conclusion, three consecutive microarray (CGH, cDNA and tissue) experiments revealed high‐level amplification and overexpression of the FGFR2 in a breast cancer cell line, but only a low frequency of involvement in primary breast tumors. …”
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Poorly Differentiated Neuroendocrine Tumor of the Rectum Coexistent with Giant Rectal Villous Adenoma Presenting as McKittrick-Wheelock Syndrome by Sammy G. Nakhla, Traci T. Murakami, Srinath Sundararajan

“…We report here the first reported case of a 55-year-old man with a large rectal villous adenoma coexistent with a poorly differentiated neuroendocrine tumor of rectum presenting with McKittrick-Wheelock Syndrome. …”
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Cytoplasmic SALL4-A isoform expression as a diagnostic marker of less aggressive tumor behavior in gastric cancer by Saeed Rahmani, Amirhesam Babajani, Maryam Abolhasani, Roya Ghods, Elham Kalantari, Zahra Madjd

“…Conclusion Cytoplasmic SALL4-A expression in GC is associated with less aggressive tumor phenotypes and shows promise as a diagnostic marker. …”
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Spinal schistosomiasis masquerading as spinal cord tumor in a 12-year-old male adolescent: A case report by Gashaw Arega, Leul Adane, Eden Mekonnen, Michael A. Negussie

“…Spinal schistosomiasis, a rare manifestation of schistosomal infection, can closely mimic the presentation of spinal cord tumors and pose significant diagnostic challenges. …”
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DAMPs prognostic signature predicts tumor immunotherapy, and identifies immunosuppressive mechanism of pannexin 1 channels in pancreatic ductal adenocarcinoma by Qianxue Wu, Qian Xiao, Qian Xiao, Xin Tang, Liuying Li, Daqiang Song, Yang Zhou, Benhua Li, Benhua Li, Guosheng Ren, Guosheng Ren, Fang Luo

“…Mechanically, through Bulk-RNA sequencing and experiments, we found that PANX1 promoted tumor progression and immune regulation via the ATP release to active NOD1/NFκB signaling pathway in PDAC.ConclusionOur in silico analyses established a classification system based on ICD-related DAMPs genes in PDAC, and constructed a DAMPs-related prognostic model to predict the efficacy of immunotherapy. …”
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lncRNA, miRNA, and mRNA of plasma and tumor-derived exosomes of cardiac myxoma-related ischaemic stroke by Lin Ma, Yu-Hua Liu, Chun Liu, Shu-Qi Wang, Jun Ma, Xiao-Qing Li, Min Ren, Ting-Ting Yang, Guang-Zhi Liu

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PRDX2 induces tumor immune evasion by modulating the HDAC3-Galectin-9 axis in lung adenocarcinoma cells by Yunjia Dong, Anqi Cheng, Jiawei Zhou, Jianqiang Guo, Yafeng Liu, Xuan Li, Maoqian Chen, Dong Hu, Jing Wu

“…Abstract Background PRDX2 is significantly expressed in various cancers and is associated with the proliferation of tumor cells. Nonetheless, the precise mechanism of PRDX2 in tumor immunity remains incompletely understood. …”
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Comparative study of single-port single-channel and single-port multi-channel adrenalectomy in various maximum tumor diameters by Pengcheng Zhang, Yuhan Pei, Yunlai Zhi, Fanghu Sun, Ninghong Song

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