Naltriben promotes tumor growth by activating the TRPM7-mediated development of the anti-inflammatory M2 phenotype by Viviane Nascimento Da Conceicao, Yuyang Sun, Manigandan Venkatesan, Jorge De La Chapa Chapa, Karthik Ramachandran, Rahul S. Jasrotia, Victor Drel, Xiufang Chai, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh

“…Abstract Macrophage plasticity is critical for maintaining immune function and developing solid tumors; however, the macrophage polarization mechanism remains incompletely understood. …”
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Computed tomography-based contrast features for distinguishing extra-gastrointestinal stromal tumors from intra-abdominal fibromatosis by Lijing Zhang, Yongbo Li, Xinxin Luo, Deqi Li, Linlin Yin, Jiayue Li, Li Zhang

“…PURPOSE: This study aims to define the computed tomography (CT) criteria that distinguish extra-gastrointestinal stromal tumors (eGISTs) from intra-abdominal fibromatosis (IAF). …”
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Increased Early‐Mortality in Children With Solid Tumors During the COVID‐19 Pandemic in a Middle‐Income Country by Oscar Ramirez, Vivian Piedrahita, Santiago Bolivar, Karina Grillo, Adriana Linares, Carlos Pardo, Martha Piña, Amaranto Suarez, Carlos A. Portilla, Jesus Ardila, Viviana Lotero, Luz A. Urcuqui, Angela Trujillo, Patricia Montenegro, Luis E. Bravo, Paula Aristizabal, VIGICANCER Working Group

“…Conclusions We observed increased early‐mortality for solid tumors, particularly bone tumors and retinoblastoma, likely attributed to more advanced‐stage presentation and loss of treatment effectiveness due to healthcare disruptions. …”
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Assessment of Tumor Response to Neoadjuvant Chemotherapy in Breast Cancer Using MRI and 18F FDG PET/CT by Reem Yusuf AlBuainain, Fatema Yusuf Bunajem, Hussain Adnan Abdulla

“…The aim of this study was to assess tumor response to NACT by MRI and PET/CT, to determine which imaging modality is more accurate in detecting tumor response post NACT in breast cancer. …”
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Impact of glioma metabolism-related gene ALPK1 on tumor immune heterogeneity and the regulation of the TGF-β pathway by YaoFeng Hu, Sen Qin, RuCui Deng

“…In-depth analyses were conducted on immune cell infiltration and tumor microenvironmental aspects. Single-cell sequencing data were employed for clustering and differential expression analysis of genes associated with glioma. …”
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Targeting OAS3 for reversing M2d infiltration and restoring anti-tumor immunity in pancreatic cancer by Shaopeng Zhang, Ximo Xu, Kundong Zhang, Changzheng Lei, Yitian Xu, Pengshan Zhang, Yuan Zhang, Haitao Gu, Chen Huang, Zhengjun Qiu

“…Abstract Abundant infiltration of tumor-associated macrophages (TAMs) within the tumor stroma plays a pivotal role in inducing immune escape in pancreatic cancer (PC). …”
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Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment by Yi Ouyang, Yan Chen, Ting Xu, Yihao Sun, Sheng Zhao, Chunmei Chen, Yixin Tan, Liang He, Hui Liu

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Spatial profiling of endoplasmic reticulum stress markers in tumor associated cells predicts patient outcomes in pancreatic cancer by Georgia Porter, Murray D. Norris, Minoti Apte, Angelica M. Merlot

“…CAFs and immune cells were more likely to express BiP or CHOP when located close (< 20 μm) to tumor cells. High expression of CHOP in CAFs close to tumor cells correlated with improved patient survival. …”
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Three‐Dimensional Printed Prosthesis Reconstructs Bilateral Type III Pelvic Defect After Malignant Tumors Resection by Xuanhong He, Yi Luo, Chang Zou, Minxun Lu, Yuqi Zhang, Zhuangzhuang Li, Guy Romeo Kenmegne, Yong Zhou, Li Min, Chongqi Tu

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Transcriptomic Profiling and Tumor Microenvironment Classification Reveal Unique and Dynamic Immune Biology in HIV-Associated Kaposi Sarcoma by Jihua Yang, Ayse Ece Cali Daylan, Aleksei Shevkoplias, Ekaterina Postovalova, Meng Wang, Andrey Tyshevich, Matthew Lee, Hiba Narvel, Ksenia Zornikova, Nara Shin, Nikita Kotlov, Luca Paoluzzi, Changcheng Zhu, Balazs Halmos, Xingxing Zang, Haiying Cheng

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Hypericum Perforatum-Derived Exosomes-Like Nanovesicles: A Novel Natural Photosensitizer for Effective Tumor Photodynamic Therapy by Ma X, Chen N, Zeng P, He Y, Zhang T, Lu Y, Li Z, Xu J, You J, Zheng Y, Wang L, Luo M, Wu J

“…In vivo, HPDEN-mediated PDT significantly suppressed tumor growth and induced extensive tumor necrosis, with no observable toxicity to major organs.Conclusion: HPDENs represent a novel plant-derived photosensitizer with dual ROS generation pathways and significant therapeutic efficacy, providing a promising platform for enhancing photodynamic therapy.Keywords: Hypericum perforatum-derived exosomes-like nanovesicles, photosensitizer, photodynamic therapy, reactive oxygen species, apoptosis…”
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Prognosis Analysis and Validation of Fatty Acid Metabolism-Related lncRNAs and Tumor Immune Microenvironment in Cervical Cancer by Xiaolin Lang, Changchang Huang, Hongyin Cui

“…The deregulation of fatty acid metabolism plays a crucial role in the progression of various tumors. This study is aimed at exploring the prognostic values of fatty acid metabolism- (FAM-) related long noncoding RNAs (lncRNAs) in CC. …”
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The up-regulation of SPTAN1 expression in Pancreatic adenocarcinoma is associated with tumor immune invasion and poor clinical prognosis by Wei Guo, LingYu Hu, ZhaoFeng Gao, XiaoRong Liu, XiaoDan Yang, XiaoGuang Wang

“…More and more studies have shown that SPTAN1 may be involved in the development and progression of a variety of tumors, including rectal cancer, Pancreatic adenocarcinoma, etc., and may affect their prognosis. …”
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Exploring the optimal reconstruction strategy for Enneking III defects in pelvis bone tumors: a finite element analysis by Jiazhuang Zhu, Jianping Hu, Kunpeng Zhu, Xiaolong Ma, Zhen Huang, Chunlin Zhang

Subjects: “…Pelvis bone tumors…”
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Sentinel lymph nodes biopsy for malignant tumors using Technefit radioactive colloid Technetium 99mTc by Irina Onofriychuk, Aziz Zikiryahodzhaev, Anatoliy Ermakov, Nataliya Ablitsova, Eric Saribekyan, Elena Rasskazova, Gadgimurad Zapirov, Stanislav Mikhailov, Andrey Kaprin, Anna Sukhotko, Serghei Covantsev

“…The first trial included Technefit intradermal-hypodermal injection into one point above the tumor node, RPP activity of 75 to 200 mBq at a room temperature of 21°C, without preliminary anesthesia with Novocain solution. …”
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DET induces apoptosis and suppresses tumor invasion in glioma cells via PI3K/AKT pathway by Rui Zhao, Mengran Wang, Zeyu Wu, Panpan Zhao, Huiling Dong, Yue Su, Chenghui Zhao, Min Qi, Shizhang Ling, Shizhang Ling, Xiaochun Jiang, Xiaochun Jiang

“…Currently, deoxyelephantopin (DET) has shown promising anti-inflammatory and anti-tumor effects. Using clinical prognostic analysis, molecular docking, and network pharmacology, this study aims to explore the primary targets and signaling pathways to identify novel GBM treatment approaches.MethodsUsing PharmMapper, the chemical structure of DET was examined for possible targets after being acquired from PubChem. …”
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Malignant Glandular Triton Tumor Arising in the Radial Nerve with Prolonged Survival: A Case Report and Review of the Literature by Batool M. AlAli, Samir S. Amr

“…Divergent differentiation is a well-known phenomenon in malignant peripheral nerve sheath tumors (MPNST) which occurs approximately in 15% of these tumors, usually towards mesenchymal elements. …”
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Human GM-CSF/IL-3 enhance tumor immune infiltration in humanized HCC patient-derived xenografts by Kelley Weinfurtner, David Tischfield, George McClung, Jennifer Crainic, John Gordan, Jing Jiao, Emma E. Furth, Wuyan Li, Erena Tuzneen Supan, Gregory J. Nadolski, Stephen J. Hunt, David E. Kaplan, Terence P.F. Gade

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The Utility of Circulating Tumor DNA (ctDNA) Monitoring in Cancer Patients Who Are Pregnant or Planning to Become Pregnant by Stacey A. Cohen, Anup Kasi, Nicole Hook, Michael Krainock, Griffin Budde, Allyson Koyen Malashevich, Jeffrey Meltzer, Russ Jelsema, Perry Olshan, Paul R. Billings, Alexey Aleshin, Andrew S. Poklepovic

“…Conversely, insufficient monitoring and treatment can lead to cancer progression, compromising the health of the patient. Personalized and tumor-informed circulating tumor DNA (ctDNA) testing (Signatera™, bespoke mPCR NGS assay) is a validated, noninvasive blood test that can accurately assess cancer progression and tumor response to treatment ahead of radiological imaging, across solid tumors. …”
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Distribution and clinicopathological characteristics of G-CSF expression in tumor cells and stromal cells in upper tract urothelial carcinoma by Go Kobayashi, Yohei Sekino, Hikaru Nakahara, Kohei Kobatake, Keisuke Goto, Tetsutaro Hayashi, Kazuhiro Sentani, Nobuyuki Hinata

“…Results In normal urothelium, G-CSF expression was weak or absent, whereas high expression of G-CSF was observed in UTUC tissues, both in tumor cells (TCs) and stromal cells (SCs). G-CSF expression in the TCs and SCs was associated with nodular/flat morphology, high grade, advanced T stage, and lymphovascular invasion in UTUC. …”
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