Sex and outcomes of patients with microsatellite instability-high and BRAF V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors by Michael Hoffmeister, Hermann Brenner, Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Julien Taieb, David Tougeron, Robyn L Ward, Marco Vitellaro, Thierry André, Pierre Laurent-Puig, Jitendra Jonnagaddala, Francesca Bergamo, Raghav Sundar, Claire Gallois, Michael J Overman, Jakob Nikolas Kather, Lisa Salvatore, Romain Cohen, Rossana Intini, Priya Jayachandran, Miriam Koopman, Javier Ros, Marwan Fakih, Vincenzo Nasca, Giacomo Mazzoli, Jeanine M L Roodhart, Filippo Ghelardi, Elena Elez, Durgesh Wankhede, Marta Ligero, Joseph Zhao, Koen Zwart, Jeroen Derksen, Nicholas Hawkins, Javier Carmona

“…Exploratory transcriptomic analyses suggest that tumors of males with BRAF mutated MSI-H metastatic CRC are characterized by an enrichment of androgen receptor signature and an immune-depleted microenvironment, with a reduction in memory B cells, activated natural killer cells, and activated myeloid dendritic cells.Conclusions Overall, our findings suggest a complex interplay between sex and BRAF mutational status that may modulate the activity of ICIs in patients with MSI-H mCRC and pave the way to novel tailored strategies.…”
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Anesthesia for pregnant patients with symptomatic neurological disease: 13 years’ experience from a tertiary care center by Stefano Catarci, Bruno Antonio Zanfini, Marco Scorzoni, Salvatore De Martino, Pietro Paolo Giuri, Luciano Frassanito, Gian Luigi Gonnella, Emanuele Capone, Francesco Vitale Di Maio, Giovanni Maddaloni, Antonio Lanzone, Gaetano Draisci

“…The main neurological disorders that affected pregnant women included vascular abnormalities and intracranial bleeding (N = 42, 17.6%), central nervous system tumors (N = 35, 14.6%), epilepsy and episodic and paroxysmal disorders of the central nervous system (N = 34, 14.2%), diseases of the neuromuscular junction and muscles (N = 26, 10.9%), demyelinating central nervous system diseases (N = 24, 10%). …”
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Early changes of peripheral circulating immune subsets induced by PD-1 inhibitors in patients with advanced malignant melanoma and non-small cell lung cancer by Simona Borilova, Peter Grell, Iveta Selingerova, Lenka Gescheidtova, Marie Mlnarikova, Ondrej Bilek, Radek Lakomy, Alexandr Poprach, Jan Podhorec, Igor Kiss, Rostislav Vyzula, Barbora Vavrusakova, Jiri Nevrlka, Lenka Zdrazilova-Dubska

“…Abstract Background Immune checkpoint inhibitors (ICIs), including those targeting PD-1, are currently used in a wide range of tumors, but only 20–40% of patients achieve clinical benefit. …”
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Molecular testing for cytologically suspicious and malignant (Bethesda V and VI) thyroid nodules to optimize the extent of surgical intervention: a retrospective chart review by Jessica Hier, Galit Avior, Marc Pusztaszeri, Joshua R. Krasner, Noura Alyouha, Veronique-Isabelle Forest, Michael P. Hier, Alex Mlynarek, Keith Richardson, Nader Sadeghi, Michael Tamilia, Richard J. Payne

“…Conclusions In this study, molecular testing in Bethesda V and VI thyroid tumors significantly improved the likelihood of optimal surgery. …”
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Research Status and Direction of Chronic Obstructive Pulmonary Disease Complicated with Coronary Heart Disease: A Bibliometric Analysis from 2005 to 2024 by Bian H, Zhu S, Xing W, Qi L, Xue J, Peng X, Jin Z, Zhao H

“…Hupo Bian,1,* Shaoqi Zhu,2,* Wenjian Xing,3 Luying Qi,1 Jingnan Xue,1 Xiuhua Peng,1 Zanhui Jin,1 Hongxing Zhao1,4 1Department of Radiology, The First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, People’s Republic of China; 2Department of Endocrinology, The First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang, People’s Republic of China; 3Department of Radiology, The Linghu People’s Hospital, Huzhou, Zhejiang, People’s Republic of China; 4Huzhou Key Laboratory of Precise Diagnosis and Treatment of Urinary Tumors, Huzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongxing Zhao, Department of Radiology, Huzhou First People’s Hospital, The First Affiliated Hospital of Huzhou University, No. 158, Plaza Back Road, Wuxing District, Huzhou City, Zhejiang Province, People’s Republic of China, Email 50073@zjhu.edu.cnObjective: There is increasing evidence that chronic obstructive pulmonary disease (COPD) is associated with coronary heart disease (CHD). …”
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Finite element investigation for improving chest wall reconstruction process using ceramic and polymeric implants by Yomna H. Shash

“…Abstract Car accidents, infections caused by bacteria or viruses, metastatic lesions, tumors, and malignancies are the most frequent causes of chest wall damage, leading to the removal of the affected area. …”
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The role of FTO in m6A RNA methylation and immune regulation in Staphylococcus aureus infection-related osteomyelitis by Sijing Liu, Sijing Liu, Sijing Liu, Kai Li, Changhai Long, Mingwu Lao, Biao Ma, Changquan Liu, Haoyuan He, Chunjiang Wang, Wangzhu Chen, Bin Yu

“…Enrichment analyses suggested that these genes were involved in pathways related to the proliferation and oxidation of various immune cells, cellular senescence, and various tumors and immune cells, as well as cell cycle-related functions. …”
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The impact of different gastrointestinal reconstruction techniques on gut microbiota after gastric cancer surgery by Yu Yang, Yu Yang, Hang-Yu Zhou, Guo-Min Zhou, Guo-Min Zhou, Jin Chen, Rui Ming, Dong Zhang, Huai-Wu Jiang, Huai-Wu Jiang

“…IntroductionGastric cancer is one of the common malignant tumors in the digestive tract, characterized by high incidence and mortality rates. …”
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The Benefits of Using a Small Caliber Ureteroscope in Evaluation and Management of Urethral Stricture by Walid Shahrour, Pankaj Joshi, Craig B. Hunter, Vikram S. Batra, Hazem Elmansy, Sandesh Surana, Sanjay Kulkarni

“…Stricture length, tissue quality, presence of other proximal strictures, false passages, and bladder tumors or stones would be assessed visually. If the penile stricture was near obliterative (smaller than 4.5 Fr caliber), a two-staged procedure is elected to be performed. …”
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Transurethral Water Vapor Ablation: Potential for a Novel Prostate Cancer Management Strategy by Warlick CA, Spilseth BD, Dixon CM

“…Warlick et al used this new technology to treat tumors that were visible under magnetic resonance imaging (MRI) and confirmed to be cancerous via biopsy. …”
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Higher levels of oxidative balance score linked to lower risk of gallstones: findings from the 2017–2020 National Health and Nutrition Examination Survey by Ting Xiong, Ting Xiong, Ting Xiong, Zhonghuo Chen, Zhonghuo Chen, Zhonghuo Chen, Jianwei Yi, Jianwei Yi, Jianwei Yi, Taozhi Yu, Taozhi Yu, Taozhi Yu, Kai Wang, Kai Wang, Kai Wang, Kai Wang

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Comprehensive analysis of endoscopic ultrasound (EUS) in mediastinal lesions: patient characteristics, diagnostic outcomes, safety, and efficacy: a multi-country study by Hussein Okasha, Eyad Gadour, Ghias Un Nabi Tayyab, Andrada Seicean, Elbacha Hicham, Emad Emad, Turki Alamri, Nadeem Tehami, Heero Ismael Faraj, Ahmed Alzamzamy, Hiwa Hussein, Mohammed Tag-Adeen, Mohamed Elbasiony, Abed Al-Lehibi, Shereen Saleh, Zaher Houmani, Mohamed Abdelghani, Khaled Ragab, Zahi Ismaili, Othmane Drir, Elsayed Ghoneem, Omar Abdallah, Souad Rebiai, Nonthalee Pausawasdi, Fedoua Rouibaa, Mohamed Borahma, Hassan Atalla, Mahmoud Farouk, Ahmed Altonbary

“…Abstract Background Mediastinal lesions are tumors that develop mainly from structures commonly located in the three compartments of the mediastinum and the paravertebral areas. …”
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