Structural and functional connectivity coupling as an imaging marker for bone metastasis pain in lung cancer patients by Jiahui Zheng, Chengfang Wang, Xiaoyu Zhou, Yu Tang, Lin Tang, Yong Tan, Jing Zhang, Hong Yu, Jiuquan Zhang, Daihong Liu

“…Background: Cancer pain is a common symptom in patients with malignant tumors and associated with poor prognosis and a high risk of death. …”
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Polymorphisms in immunosuppression-related genes are associated with AML by Mingying Li, Mingying Li, Jingjing Ye, Jingjing Ye, Mengyuan Chang, Mengyuan Chang, Lei Feng, Lei Feng, Tingting Liu, Tingting Liu, Di Zhang, Di Zhang, Yuyan Wu, Yuyan Wu, Yuechan Ma, Yuechan Ma, Guangqiang Meng, Guangqiang Meng, Chunyan Ji, Chunyan Ji, Tao Sun, Tao Sun

“…Despite new immunotherapeutic strategies entering standard clinical care for various tumors, progress in AML remains poor. Multi-omics analyses, such as single-cell transcriptomics, have revealed many potential new targets to improve AML prognosis from an immunological perspective.MethodsDNA from 307 AML patients and 316 healthy individuals were extracted. …”
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Chronic Inflammation May Enhance Leiomyoma Development by the Involvement of Progenitor Cells by Monia Orciani, Miriam Caffarini, Alessandra Biagini, Guendalina Lucarini, Giovanni Delli Carpini, Antonella Berretta, Roberto Di Primio, Andrea Ciavattini

“…Moreover, inflammation is involved in the development of several tumors. The aim of this work was to understand if progenitor cells sustain a chronic inflammatory microenvironment that enhances leiomyoma development. …”
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Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis by Ying Xu, Weiwei Meng, Yingqi Dai, Lin Xu, Ning Ding, Jinqing Zhang, Xuewei Zhuang

“…We utilized chromatin immunoprecipitation sequencing with H3K18la antibodies, transcriptomics of clinical BC samples, and proteomics and ATAC-seq analyses of in vivo tumors to identify the genes regulated by H3K18la and the transcription factor PPARD. qPCR and Western blot assays were used to detect expressions of molecules. …”
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Salivary metabolomics in oral cancer: A systematic review by Rita Antonelli, Giacomo Setti, Nathaniel S. Treister, Thelma A. Pertinhez, Elena Ferrari, Mariana Gallo, Ronell Bologna-Molina, Paolo Vescovi, Marco Meleti

“…Diagnosis of oral squamous cell carcinoma (OSCC) is frequently delayed, with most tumors being detected in advanced stages.Saliva may represent the ideal fluid for early detection of dysplastic and malignant oral lesions. …”
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Immunohistochemical Profile of p62/SQSTM1/Sequestosome-1 in Human Low- and High-Grade Intracranial Meningiomas by Antonio Ieni, Cristina Pizzimenti, Vincenzo Fiorentino, Mariausilia Franchina, Antonino Germanò, Giovanni Raffa, Maurizio Martini, Guido Fadda, Giovanni Tuccari

“…Although, recently, p62 expression has been analyzed in different neurodegenerative and glial neoplastic diseases, no available information have been reported in meningiomas, which have an high epidemiological relevance being the second most common category of intracranial tumors after gliomas. Generally meningiomas have a benign behavior, but their recurrence is not uncommon mainly when atypical or anaplastic varieties occur. …”
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Magnetic hybrid Pd/Fe-oxide nanoparticles meet the demands for ablative thermo-brachytherapy by Rogier van Oossanen, Alexandra Maier, Jérémy Godart, Jean-Philippe Pignol, Antonia G. Denkova, Gerard C. van Rhoon, Kristina Djanashvili

“…The heating ability of the best performing Pd/Fe-oxide-21 was calculated to be sufficient to ablate tumors with a radius ±4 and 12 mm using 10 and 1 mg/mL nanoparticle concentration, respectively.Conclusions Nanoparticles consisting of non-magnetic palladium-core and magnetic iron oxide shell are suitable for magnetic hyperthermia/thermal ablation under clinically safe conditions of 346 kHz and 19.1 mT, with minimal eddy current effects in combination with maximum SLP.…”
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Bullatine A suppresses glioma cell growth by targeting SIRT6 by Zhi Wang, Yushuai Zhu, Can Luo, Fan Zhang, Jiannong Zhao, Chuanyi Fu

“…Gliomas are the most common primary tumors of the nervous system, which is generally treated using adjuvant chemotherapy following surgical resection. …”
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An Explainable Artificial Intelligence Model for the Classification of Breast Cancer by Tarek Khater, Abir Hussain, Riyad Bendardaf, Iman M. Talaat, Hissam Tawfik, Sam Ansari, Soliman Mahmoud

“…This could improve the understanding of the diagnosis and treatment of breast cancer by identifying the most important features of breast cancer tumors and the way they affect the classification task. …”
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High‐Throughput Single‐Nucleus RNA Profiling of Minimal Puncture FFPE Samples Reveals Spatiotemporal Heterogeneity of Cancer by Weiqin Jiang, Xiang Zhang, Ziye Xu, Qing Cheng, Xiaohan Li, Yuyi Zhu, Fangru Lu, Ling Dong, Linghui Zeng, Weixiang Zhong, Yongcheng Wang, Longjiang Fan, Hongyu Chen

“…In analyzing 20 samples from various solid tumors, optimized snRandom‐seq still detected ≈17 000 genes and 12 000 long non‐coding RNAs (lncRNAs), achieving precise clustering based on tissue origin. …”
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Intravenous Contrast Agent in Abdominal CT: Is It Really Needed to Identify the Cause of Bowel Obstruction? Proof of Concept by Federica Vernuccio, Dario Picone, Gregorio Scerrino, Massimo Midiri, Giuseppe Lo Re, Roberto Lagalla, Giuseppe Salvaggio

“…Adhesions were identified on unenhanced CT as the etiology of small bowel obstruction in 80% (4/5) of patients. Tumors were identified on unenhanced CT as the etiology of large bowel obstruction in 67% (4/6) of patients. …”
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Hepatocellular carcinoma: signaling pathways and therapeutic advances by Jiaojiao Zheng, Siying Wang, Lei Xia, Zhen Sun, Kui Ming Chan, René Bernards, Wenxin Qin, Jinhong Chen, Qiang Xia, Haojie Jin

“…Therefore, HCC patients usually present with tumors in advanced and incurable stages. Several signaling pathways are dis-regulated in HCC and cause uncontrolled cell propagation, metastasis, and recurrence of HCC. …”
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Risk Factors of Hemophagocytic Lymphohistiocytosis in Adults with Fever of Unknown Origin: A Retrospective Study by Tian F, Xie N, Sun W, Zhang W, Zhang W, Chen J, Ruan Q, Song J

“…The incidence of HLH in adults with FUO was 6.4%, with hematological tumors being the primary cause. Multivariate analysis indicated that skin rash and elevated alanine aminotransferase, total bilirubin, triglycerides, lactate dehydrogenase, and ferritin levels were independent risk factors for HLH in adults with FUO.Conclusion: This study revealed the incidence rate, etiology distribution, and risk factors for HLH in adults with FUO. …”
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Boosting skin cancer diagnosis accuracy with ensemble approach by Priya Natha, Sivarama Prasad Tera, Ravikumar Chinthaginjala, Safia Obaidur Rab, C. Venkata Narasimhulu, Tae Hoon Kim

“…It’s still difficult to analyze the images to differentiate benign from malignant tumors, though. Better predictive modeling methods are needed since the diagnostic procedures used now frequently produce inaccurate and inconsistent results. …”
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Augmented immunogenicity of the HPV16 DNA vaccine via dual adjuvant approach: integration of CpG ODN into plasmid backbone and co-administration with IL-28B gene adjuvant by Yan Zhou, Ting Zhang, Zhirong Wang, Xuemei Xu

“…Furthermore, vaccination with CpG-modified mE7/HSP70 and mE6/HSP70 plasmids, alongside the Interleukin-28B (IL-28B) gene adjuvant, generated substantial preventive and therapeutic antitumor effects against HPV E6- and E7-expressing tumors in C57BL/6 mice. These results suggested that integrating these multiple strategies into an HPV DNA vaccine holds promise for effectively controlling HPV infection and related diseases.…”
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NTRK amplification occurs frequently in pan-TRK immunopositive dedifferentiated liposarcomas by Zoltán Lippai, Gergő Papp, Károly Szuhai, Johanna Sápi, Katalin Dezső, Zoltán Sápi

“…Pan-TRK antibody, which shows the overexpression of the NTRK1-2-3 genes, is a useful tool to detect tumors with or without NTRK gene alterations, due to high negative predictive value. …”
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The prognostic and immunomodulatory role of the MMR system in patients with stomach adenocarcinoma by Zhihui Tian, Lili Yang, Rong Yang, Wenhui Yang

“…The clinical value of the MMR molecular marker as an immunotherapy for advanced solid tumors has been documented. However, this therapy is not effective in some patients. …”
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Deferiprone ameliorates cisplatin induced peripheral neurotoxicity via ferritinophagy adjustment by Hanan Seddiek, Mira Hanna, Amany Elsayed Mohamed Hamoud, Marawan Abd Elbaset, Ahmed M. A. Akabawy, Mohamed Zakaria Kotb, Mohamed Mansour Khalifa

“…Abstract Cisplatin-induced neurotoxicity is one of the limiting factors to its use especially in tumors that demand high drug dosage. One of the Cisplatin pathways is ferritinophagy which may end up in ferroptosis. …”
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Examining the etiology and pregnancy outcomes of 152 critically ill pregnant patients in the Intensive Care Unit by Weiman Liu, Junyou Su, Sumei Wang

“…Results The results showed that the main obstetric factors leading to ICU admission were pregnancy-related hypertensive disease, postpartum hemorrhage, and acute fatty liver of pregnancy; the non-obstetric factors included either pregnancy complicated by heart disease, sepsis, or malignant tumors. The maternal mortality rate was higher in the non-obstetric direct factor group than in the obstetric direct factor group (22.12% vs. 6.25%, p = 0.016). …”
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The Development of Methods of BLOTCHIP^®-MS for Peptidome: Small Samples in Tuberous Sclerosis by Kunio Yui, George Imataka, Kotaro Yuge, Hitomi Sasaki, Tadashi Shiohama, Kyoichi Asada, Hidehisa Tachiki

“…Mutations in the TSC1 and TSC2 genes result in the constitutive hyperactivation of the mammalian target of the rapamycin (mTOR) pathway, contributing to the growth of benign tumors or hamartomas in various organs. TSC2 mutations were associated with a more severe phenotypic spectrum than TSC1 mutations because of the inhibition of the mTOR cascade. …”
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