A Clinicopathological Profile of Prostate Cancer in Trinidad and Tobago by Ian Hosein, Rajendra Sukhraj, Lester Goetz, Nastassia Rambarran, Satyendra Persaud

“…Moderately differentiated tumors (Gleason 7) were the most common group. Using the D’Amico risk classification, most cases were found to be high risk (63.1%). …”
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Monoterapia con sildenafilo en pacientes con hipertensión pulmonar grave by Rodolfo Vega Candelario

“…Resultados: En el período entre diciembre de 2017 a diciembre de 2018 se operaron con hipertensión arterial pulmonar grave, 20 enfermos con trastornos valvulares cardíacos izquierdos, 8 congénitos y 3 tumores cardíacos primarios, con administración de sildenafilo en dosis de 100 a 150 miligramos diarios. …”
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Detection by Single-Cell RNA Sequencing of Virally Mediated Skin Diseases by Linda Zhou, Thomas H. Leung

“…We validate our pipeline with 100% sensitivity and specificity by (i) detecting Merkel cell polyomavirus in Merkel cell carcinoma samples, (ii) detecting specific human papillomavirus strains in known human papillomavirus–positive tumors, and (iii) detecting rubella virus transcripts in patients with known rubella-associated granulomas. …”
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Durvalumab Plus Chemotherapy for Advanced Biliary Tract Cancer Treatment: Insights from the TOPAZ-1 Trial by Ralph Fritsch

“…Biliary tract cancers (BTCs) are a difficult-to-treat group of tumors with an overall poor prognosis. Until 2022, combination chemotherapy was the first-line treatment standard for patients with advanced BTCs, achieving a moderate patient survival improvement. …”
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Heart Shaped Anterior Neck Lipoma Mimicking Thyroid Mass: A Case Report by Abdus Samad Ansari, Dhiraj Chaurasia, Bikash Yadav, Season Shrestha, Inku Shrestha Basnet

“…ABSTRACT Lipomas, one of the most common benign tumors, rarely occur in the anterior neck, often misdiagnosed as thyroid masses. …”
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5-Fluorouracil, Leucovorin, Oxaliplatin, and Irinotecan as a Potential Standard for Second-line Therapy in Extrapulmonary Neuroendocrine Carcinomas by I-Wei Ho, Nai-Jung Chiang, Jiun-I Lai, Peter Mu-Hsin Chang, San-Chi Chen, Yi-Ping Hung, Ming-Huang Chen

“…Background: Neuroendocrine carcinomas (NECs) are classified by the World Health Organization as poorly differentiated, aggressive Grade 3 tumors with high proliferative indices and frequent lung involvement. …”
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Potentially paraneoplastic glomerulopathies in a Brazilian cohort: a retrospective analysis by Marcella Soares Laferreira, Gianna Mastroianni Kirsztajn

“…Hematologic malignancies (35.8%) showed the highest prevalence, followed by colon, rectal, and gynecologic tumors. The glomerulopathy with the highest frequency was membranous glomerulopathy (MGN, 25 patients, 35.7%). …”
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Non-invasive Physiotherapeutic Approaches in Biliary Dyskinesia by Elena Costescu, Gabriela Calin, Vlad Țîrlea, Mihaiela Camelia Țabrean

“…Biliary dyskinesia seems to be an enigmatic, idiopathic but important pathology in terms of recurrent abdominal pain in the right upper quadrant, under the right costal border, in patients who feel the symptoms despite the non-detection of gallstones or tumors. The pathology can be the result of an improper response to hormonal stimulation, hypoactivity of the nerves that innervate the gallbladder or ineffective contraction of the sphincter of Oddi. …”
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AI-Based Screening Method for Early Identification of Invasive Ductal Carcinoma in Breast Cancer by Dominik Jánošík, Sila Yavuz

“…Next, by leveraging deep neural networks, we extracted effective features, and through a majority vote method, we performed data classification to establish a screening structure for the diagnosis of invasive ductal carcinoma of breast tumors. Our proposed system demonstrated superior performance by achieving 92.8% and 94.4% accuracy, 96% and 93% sensitivity, 91.5% and 92.0% precision, and 98.7% and 96.7% Area Under the Curve (AUC) in two distinct datasets, with minimal errors and high detection speed. …”
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Pediatric Patient with Omental Cyst: A Rare Case (CT scan is not Enough to Differentiate from Other Abdominal Cysts) by Donny Aditia, Andi Dwihantoro

“…Omental cysts are rare intra-abdominal tumors in children. It is challenging to diagnose since other big abdominal cysts are difficult to distinguish from in clinical and CT imaging. …”
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ErbB4 as a Potential Molecular Target in the Treatment of Esophageal Squamous Cell Cancers by Ke Zhao, Bao-Jun Chen, Zhi-Guo Chen

“…ErbB4 is an important member of ErbB subfamily of tyrosine kinases receptor with overexpression in several tumors; however its biological role in esophageal cancer is poorly understood till date. …”
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The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells by Katarína Smolková, Petr Ježek

“…When the reverse aconitase reaction and citrate efflux are added, this overall “anoxic” glutaminolysis mode may help highly malignant tumors survive aglycemia during hypoxia. Intermittent glycolysis would hypothetically be required to provide ATP. …”
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Mortality evolution in Cienfuegos province, 2010-2019 by Yenisvel Yut Vidal, Yadira Sarría Zerquera, Evangelina Dávila Cabo de Villa

“…The top three causes of death were heart disease, malignant tumors, and cerebrovascular disease. Of 13 maternal deaths, seven were from direct causes and six were indirect.…”
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Spinal ischemia: the rehabilitation potential. А clinical case by Svetlana I. Tolstaya, Vladimir V. Belopasov, Evgeny V. Chechukhin

“…The reasons for its development can include vascular malfomations, spinal stroke, extra- and intramedullary tumors, compression of the spinal cord in cases of vertebral fractures, intervertebral disc herniations, stenosis of the spinal canal at the cervical segment, medical manipulations and impaired segmental circulation during the anesthesia, lumbar puncture and surgical interventions. …”
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A computational and structural approach to identify malignant non-synonymous FOXM1 single nucleotide polymorphisms in triple-negative breast cancer by Prarthana Chatterjee, Satarupa Banerjee

“…Abstract The proliferation-specific oncogenic transcription factor, FOXM1 is overexpressed in primary and recurrent breast tumors across all breast cancer (BC) subtypes. Intriguingly, FOXM1 overexpression was found to be highest in Triple-negative breast cancer (TNBC), the most aggressive BC with the worst prognosis. …”
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Identification of ferroptosis-related signature predicting prognosis and therapeutic responses in pancreatic cancer by Ting Ting Chung, Zanyue Piao, Seung Jin Lee

“…Differentially expressed FRGs between tumors from TCGA-PAAD and normal pancreatic tissues from Genotype-Tissue Expression were analyzed to construct a prognostic risk model using univariate and multivariate Cox regression and LASSO analyses. …”
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Adrenocorticotropic Hormone Secreting Pheochromocytoma Underlying Glucocorticoid Induced Pheochromocytoma Crisis by Gil A. Geva, David J. Gross, Haggi Mazeh, Karine Atlan, Iddo Z. Ben-Dov, Matan Fischer

“…Pheochromocytomas are hormone secreting tumors of the medulla of the adrenal glands found in 0.1–0.5% of patients with hypertension. …”
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Inhibitory effect of terfenadine on Kir2.1 and Kir2.3 channels by Delgado-Ramírez Mayra, Rodriguez-Leal Fanny Junue, Rodríguez-Menchaca Aldo Azmar, Moreno-Galindo Eloy Gerardo, Sanchez-Chapula José Antonio, Ferrer Tania

“…Lately, the subfamily 2 of inward rectifier potassium channels (Kir2) has been implicated in the progression of some tumoral processes. Hence, we characterized the effects of terfenadine on Kir2.x channels expressed in HEK-293 cells. …”
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The Nrf-2/HO-1 Signaling Axis: A Ray of Hope in Cardiovascular Diseases by Xueyan Zhang, Yihan Yu, Hanyu Lei, Yufeng Cai, Jie Shen, Ping Zhu, Qingnan He, Mingyi Zhao

“…Rheumatic heart disease, cardiac tumors, arteriosclerosis, arrhythmia, hypertensive heart disease, and myocardial infarction have also been treated during experiments. …”
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The hype around ctDNA guiding an informed perioperative therapeutic strategy in early-stage non-small cell lung cancer by Gaia Passarella, Stefania Canova, Maria Ida Abbate, Giulia Caspani, Luca Sala, Alessandro Russo, Paola Muscolino, Francesca Colonese, Diego Luigi Cortinovis

“…At present, the clinical staging TNM system guides the clinical choice, however it is not entirely sufficient. Circulant tumoral DNA (ctDNA) emerged as a promising prognostic and predictive biomarker that may guide the future perioperative strategy and pave the way to personalized medicine also in this exciting field. …”
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