Analysis of Progress and Challenges of EGFR-Targeted Molecular Imaging in Cancer With a Focus on Affibody Molecules by Weizhi Chen MD, Baozhong Shen MD, PhD, Xilin Sun PhD

“…Epidermal growth factor receptor (EGFR)-targeted cancer therapy requires an accurate estimation of EGFR expression in tumors to identify responsive patients, monitor therapeutic effect, and estimate prognosis. …”
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El estrés oxidativo: detonante fisiopatológico en la cardiomiopatía dilatada inducida por doxorrubicina by Yanet Hernández Matos, Liván Delgado Roche, Maité Ravelo González, Ronal Aroche Aportela

“…<p>La cardiomiopatía dilatada inducida por doxorrubicina constituye uno de los principales efectos indeseables del tratamiento de pacientes con tumores malignos. El estrés oxidativo constituye uno de los mecanismos fisiopatológicos que desempeñan un papel fundamental en la instauración de la enfermedad causada por este antibiótico del grupo de las antraciclinas. …”
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The tyrosine kinase inhibitor lenvatinib is oxidized by rat cytochromes P450 and affects their expression in rat liver by Indra Radek, Jelínková Sandra, Kollárová Katarína, Zahumenská Petra, Dvořák Josef, Dušková Šárka, Dračínská Helena

“…Lenvatinib is an orally effective tyrosine kinase inhibitor used to treat several types of tumors, including progressive, radioiodine-refractory differentiated thyroid cancer and advanced renal cell carcinoma. …”
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Progression of an Invasive ACTH Pituitary Macroadenoma with Cushing’s Disease to Pituitary Carcinoma by Clarissa Groberio Borba, Rafael Loch Batista, Nina Rosa de Castro Musolino, Vanielle Carvalho Machado, Ana Elisa Evangelista Alcantara, Gilberto Ochman da Silva, Valter Angelo Sperling Cescato, Malebranche Berardo Carneiro da Cunha Neto

“…Pituitary carcinomas are very rare tumors that in most cases produce prolactin and adrenocorticotropic hormone (ACTH). …”
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Synthesis and biological evaluation of new tri-heterocyclic derivatives as anti-colorectal cancer agents by Benjamin Victoir, Océane Pertegaz, Elfi Ducrocq, Marion Polomski, Maxime Guéguinou, William Raoul, Cécile Croix, Gildas Prié

“…Pharmacomodulations were strategically performed, and the in vitro activities of all tri-heterocyclic derivatives were assessed on HT29 and Lovo colorectal cancer cell lines, as well as on the non-tumoral NCM356 colonic epithelial cell line derived from normal mucosa. …”
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TRIZ Theory and the Method of Cancer Document Selection for Chemical Complexes and Innovation Schemes of Meta-Analysis with Lymphomas as an Example by Yan Huiquan, Lyu Penghui, Wang Ling, Yu Zhiming

“…In the face of the growing incidence of malignant tumors (about 3.929 million, data issued in January 2019) and the death rate (about 2.338 million, data issued in January 2019) and the limitation of the application of informatics in cancer treatment, this paper tried to use TRIZ theory to deduce new ideas about cancer treatments, perform literature analysis on schemes, and make retrieval strategy for meta-analyses on cancer therapy. …”
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Arterial Calcium Stimulation with Hepatic Venous Sampling in the Localization Diagnosis of Endogenous Hyperinsulinism by Paloma Moreno-Moreno, María Rosa Alhambra-Expósito, Aura Dulcinea Herrera-Martínez, Rafel Palomares-Ortega, Luis Zurera-Tendero, Juan José Espejo Herrero, María Angeles Gálvez-Moreno

“…This technique allows the localization of intrapancreatic insulinomas and represents useful tool for the diagnosis and surgical management of these tumors.…”
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Multilevel plasticity and altered glycosylation drive aggressiveness in hypoxic and glucose-deprived bladder cancer cells by Andreia Peixoto, Dylan Ferreira, Andreia Miranda, Marta Relvas-Santos, Rui Freitas, Tim S. Veth, Andreia Brandão, Eduardo Ferreira, Paula Paulo, Marta Cardoso, Cristiana Gaiteiro, Sofia Cotton, Janine Soares, Luís Lima, Filipe Teixeira, Rita Ferreira, Carlos Palmeira, Albert J.R. Heck, Maria José Oliveira, André M.N. Silva, Lúcio Lara Santos, José Alexandre Ferreira

“…Summary: Bladder tumors with aggressive characteristics often present microenvironmental niches marked by low oxygen levels (hypoxia) and limited glucose supply due to inadequate vascularization. …”
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Financial Toxicity and Kidney Disease in Children and Adults: A Scoping Review by Siligato R, Gembillo G, De Giorgi A, Di Maria A, Scichilone LM, Capone M, Vinci FM, Nicoletti S, Bondanelli M, Malaventura C, Storari A, Santoro D, Dionisi S, Fabbian F

“…Three studies reported the impact of FT on nephrolithiasis, and 3 studies analyzed the link between FT and renal tumors. The methods used for detecting FT differed and were based on consultations, questionnaires, expenditures and database records analysis. …”
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Describing quality of life trajectories in young Hispanic women with breast cancer: 5-year results from a large prospective cohort by Bryan F. Vaca-Cartagena, Ana S. Ferrigno Guajardo, Hatem A. Azim Jr, Federico Rotolo, Antonio Olivas-Martinez, Alejandra Platas, Alan Fonseca, Fernanda Mesa-Chavez, Marlid Cruz-Ramos, Ana Rodriguez, Alejandro Mohar, Cynthia Villarreal-Garza

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RET inhibition overcomes resistance to combined CDK4/6 inhibitor and endocrine therapy in ER+ breast cancer by Charlotte K. Kindt, Sidse Ehmsen, Sidse Ehmsen, Sidse Ehmsen, Sofie Traynor, Benedetta Policastro, Nikoline Nissen, Mie K. Jakobsen, Monique F. Hundebøl, Lene E. Johansen, Martin Bak, Elsa Arbajian, Johan Staaf, Henrik J. Ditzel, Henrik J. Ditzel, Henrik J. Ditzel, Carla L. Alves

“…We further observed a shorter median survival to combined CDK4/6i and endocrine therapy in patients with RET-positive compared to RET-negative tumors, but this difference did not reach statistical significance.ConclusionsOur findings show that RET is overexpressed in ER+ metastatic breast cancer resistant to combined CDK4/6i and endocrine therapy, rendering RET inhibition a promising therapeutic approach for patients who experience disease progression on combined CDK4/6i and endocrine therapy.…”
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Stably Integrated for Assessment of Invasion Kinetics by Kelly N. Flentie, Min Qi, Seth T. Gammon, Yasmin Razia, Felix Lui, Luciano Marpegan, Aashish Manglik, David Piwnica-Worms, Jeffrey S. McKinney

“…Salmonella Typhimurium is a common cause of gastroenteritis in humans and also localizes to neoplastic tumors in animals. Invasion of specific eukaryotic cells is a key mechanism of Salmonella interactions with host tissues. …”
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Iodine-131 Metaiodobenzylguanidine Therapy for Neuroblastoma: Reports So Far and Future Perspective by Daiki Kayano, Seigo Kinuya

“…Neuroblastoma, which derives from neural crest, is the most common extracranial solid cancer in childhood. The tumors express the norepinephrine (NE) transporters on their cell membrane and take in metaiodobenzylguanidine (MIBG) via a NE transporter. …”
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Spatial stochastic models of cancer: Fitness, migration, invasion by Natalia L. Komarova

“…Cancer progression is driven by genetic and epigenetic events giving rise to heterogeneity of cellphenotypes, and by selection forces that shape the changingcomposition of tumors. The selection forces are dynamic and depend onmany factors. …”
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Premalignant Lesions in the Kidney by Ziva Kirkali, Kutsal Yorukoglu

“…Progression to invasive carcinoma is described in experimental cancer models, and in some human renal tumors. Similar molecular alterations are found in some putative premalignant changes. …”
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Chemokines in Renal Diseases by Stephan Segerer, Peter J. Nelson

“…Therefore, it is not surprising that chemokines play important roles in a wide range of human diseases, including genetic immunodeficiencies, infections, autoimmune diseases, and malignant tumors. In this report, we have reviewed recent developments (since mid 2003) in chemokines in renal diseases. …”
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ChatGPT-4.0 in oral and maxillofacial radiology: prediction of anatomical and pathological conditions from radiographic images by Shila Kahalian, Marieh Rajabzadeh, Melisa Öçbe, Mahmut Sabri Medisoglu

“…There was not a significant difference in accurate diagnosis of anatomical landmarks, cysts, and tumors (p&amp;gt;0.05). However, including internal structure information improved the diagnostic accuracy (p&amp;lt;0.05) Conclusion: GPT-4.0 showed a tendency to misdiagnose closely located anatomical structures and by adding additional clues its performance showed improvement, while its ability to recognize diverse differential diagnoses remains limited.…”
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Clinicopathological analysis of sclerosing angiomatoid nodular transformation in the spleen by Shufei Wei, Yongliang Han, Yingyong Hou, Liangliang Wang

“…Results: Fourteen cases were complicated with benign tumors of the liver, pancreas, kidney, uterus, and prostate. …”
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The Role of mTOR Inhibitors in Liver Transplantation: Reviewing the Evidence by Goran B. Klintmalm, Björn Nashan

“…In this review we surveyed the literature for reports of the use of mTOR inhibitors in adult liver transplantation with respect to renal function, efficacy, safety, neurological symptoms, de novo tumors, and the recurrence of HCC and HCV. The results of our review indicate that mTOR inhibitors are associated with efficacy comparable to CNIs while having benefits on renal function in liver transplantation. …”
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Extramedullary Plasmacytoma of the Oral Cavity: A Rare Case in the Buccal Mucosa by Armin Khaleghi, Nafise Shamloo

“…ABSTRACT Extramedullary plasmacytomas (EMP) are uncommon solitary tumors composed of neoplastic plasma cells occurring outside the bone. …”
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