PYR-41 and Thalidomide Impair Dendritic Cell Cross-Presentation by Inhibiting Myddosome Formation and Attenuating the Endosomal Recruitments of p97 and Sec61 via NF-κB Inactivation... by Xiang You, Dan Dan Xu, Di Zhang, Jie Chen, Feng Guang Gao

“…Cross-presentation allows dendritic cells (DC) to present endogenous antigen and induce protective immunity against microbe infection and tumors. But, up to now, the effects of PYR-41 and thalidomide on cross-presentation are still uncertain. …”
Get full text

Dysregulated Expression and Methylation Analysis Identified TLX1NB as a Novel Recurrence Marker in Low-Grade Gliomas by Hongzhou Duan, Zuozhen Yang, Chen Li, Jiayong Zhang, Shengli Shen, Changwei Yuan, Yingjin Wang

“…Low-grade gliomas (LGGs) are the most common CNS tumors, and the main therapy for LGGs is complete surgical resection, due to its curative effect. …”
Get full text

Thyroid Carcinoma on the Side of the Absent Lobe in a Patient with Thyroid Hemiagenesis by Hiroki Sato, Kiyoaki Tsukahara, Ray Motohashi, Midori Wakiya, Hiromi Serizawa, Atsushi Kurata

“…We report the case of a 64-year-old woman in whom left thyroid hemiagenesis was discovered incidentally during investigations of abnormal sensation during swallowing. A tumorous 1.4 cm lesion was also found on the side of the absent lobe, left of the isthmus. …”
Get full text

The Association Between Human Cytomegalovirus and Salivary Gland Cancer: An Analytical Study and Literature Review by Hagir Abd Rahman Mahmoud, Ahmed Mohamed Suleiman, Elwaleed Mohamed Elamin, Sawsan Abdel Rahim Mohammed

“…This study aimed to identify the presence of HCMV in different kinds of malignant salivary gland tumors in Sudanese patients. Methods: Eighty-four formalin-fixed paraffin-embedded tissues (FFPE) from Sudanese patients previously diagnosed with salivary gland cancer (SGC) between 2014 and 2022 were selected. …”
Get full text

Advance in identified targets of berberine by Penghai Sun, Ziyuan Wang, Yinchao Ma, Yuan Liu, Yintong Xue, Yan Li, Xiang Gao, Yuedan Wang, Ming Chu, Ming Chu, Ming Chu, Ming Chu

“…Berberine is an isoquinoline alkaloid, which has demonstrated significant therapeutic potential in the treatment of various diseases, including tumors, acute and chronic infections, autoimmune disorders, and diabetes. …”
Get full text

Age-related immunosenescence and Epstein–Barr virus-positive mucocutaneous ulcer presenting as oral cancer: a case report by Jiayuan Ye, Shengqiang Ji, Zhouxiao Wu, Genhua Ma, Jing Chen, Shimin Wu, Yilian Xie

“…It represents a benign lymphoproliferative disorder that clinically may mimic malignant tumors. However, EBVMCU typically progresses slowly and often resolves spontaneously without specific treatment, emphasizing the critical need for differential diagnosis from malignancies. …”
Get full text

Cyanoacrylate Associated Foreign Body Granulomatous Gastritis: A Report of Three Cases by Gunes Guner, Olcay Kurtulan, Taylan Kav, Cenk Sokmensuer, Gokhan Gedikoglu, Aytekin Akyol

“…Then the patient underwent distal pancreatectomy for pancreatic adenocarcinoma and during the operation a gastric mass was resected with a suspicion of tumoral infiltration. These three cases demonstrated that glue exposure causes active chronic inflammation with foreign body type granulomas, mucosal ulceration, and bleeding in the gastric mucosa. …”
Get full text

Sociobiology meets oncology: unraveling altruistic cooperation in cancer cells and its implications by Muhammad Sufyan bin Masroni, Evelyn Siew-Chuan Koay, Victor Kwan Min Lee, Siok Bian Ng, Soo Yong Tan, Karen Meiling Tan, Marco Archetti, Sai Mun Leong

“…Against the backdrop of existing knowledge on various social organisms found in nature, we explore the mechanisms underlying the manifestation of altruism within breast tumors, revealing a complex interplay of seemingly counteracting cancer signaling pathways and processes that orchestrate the delicate balance between cost and benefit underlying altruistic cooperation. …”
Get full text

A pivotal decade for bispecific antibodies? by Marlena Surowka, Christian Klein

“…In the 2020s, the approval of additional bsAbs can be expected in hematological malignancies, solid tumors and non-oncology indications, establishing bsAbs as essential part of the therapeutic armamentarium.…”
Get full text

The Principal of Dynamic Contrast Enhanced MRI, the Method of Pharmacokinetic Analysis, and Its Application in the Head and Neck Region by Toru Chikui, Makoto Obara, Arjan W. Simonetti, Masahiro Ohga, Shoichi Koga, Shintaro Kawano, Yoshio Matsuo, Takeshi Kamintani, Tomoko Shiraishi, Erina Kitamoto, Katsumasa Nakamura, Kazunori Yoshiura

“…Many researchers have established the utility of the dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) in the differential diagnosis in the head and neck region, especially in the salivary gland tumors. The subjective assessment of the pattern of the time-intensity curve (TIC) or the simple quantification of the TIC, such as the time to peak enhancement () and the wash-out ratio (WR), is commonly used. …”
Get full text

Shikonin Inhibits Non-Small-Cell Lung Cancer H1299 Cell Growth through Survivin Signaling Pathway by Haini Wang, Junli Zuo

“…Overexpressed survivin is associated with worse survival of several types of human tumors. In this study, the antitumor activity of shikonin in non-small-cell lung cancer (NSCLC) by regulating survivin pathway was investigated. …”
Get full text

Aquaporins in oral health and disease: A narrative review by Shailja Chatterjee

“…Its expression has been shown to have a significant correlation with the aggressiveness of tumors as well as prognosis. Aim: The current narrative review aimed to highlight the role of AQPs in maintaining homeostasis in cellular functioning and their expressions in diseased states and other conditions. …”
Get full text

Metastatic Breast Carcinoma to the Prostate Gland by Meghan E. Kapp, Giovanna A. Giannico, Mohamed Mokhtar Desouki

“…This case demonstrates the importance of considering a broad differential diagnosis and comparing histology and IHC to prior known malignancies in the setting of atypical presentation or rare tumors.…”
Get full text

The Role of TGFβ Signaling in Squamous Cell Cancer: Lessons from Mouse Models by Adam B. Glick

“…TGFβ signaling is tightly regulated in normal tissues and becomes deregulated during cancer development in cutaneous SCC and many other solid tumors. Because of these diverse biological processes regulated by TGFβ1, this cytokine and its signaling pathway appear to function at multiple points during carcinogenesis with distinct effects. …”
Get full text

Recent Advances in the Surgical Treatment of Differentiated Thyroid Cancer: A Comprehensive Review by Raghunandan Venkat, Marlon A. Guerrero

“…While surgery has remained the cornerstone of management of these tumors, the surgical approach has seen numerous innovations over the past few decades. …”
Get full text

Identification of O-glycosylation related genes and subtypes in ulcerative colitis based on machine learning. by Yue Lu, Yi Su, Nan Wang, Dongyue Li, Huichao Zhang, Hongyu Xu

“…O-GlcNAcylation plays a critical role in regulating immunity progression and the occurrence of inflammatory diseases and tumors. Yet, the mechanism of O-GlcNAc-associated colitis remains to be elucidated. …”
Get full text

Mammal tumours in men. A ten years study. by Lidia Torres Ajá

“…<strong>Results:</strong> The mayority of cases was registered in the 61-70 age group (44.4%); and respecting benign tumors, it was found in the 31-40 age group with 9 cases (31.3%). …”
Get full text

Regional blockade in endoscopic surgical removal of pituitary adenoma by N Akhmadov, E Nasibova

“…In transnasal transsphenoidal resection of pituitary tumors, bilateral regional anesthesia of the pterygopalatine fossa, performed through subzygomatic access, has been found to be the most optimal technique. …”
Get full text

Cardiac computed tomography for cardiac masses: a necessity or a luxury? by Imane Joudar, Siham Nasri, Imane Kamaoui, Imane Skiker

“…Specific imaging features of benign and malignant tumors, as well as non-neoplastic masses, are discussed, highlighting the role of CT in overall cardiac assessment. …”
Get full text

Belzutifan for the treatment of renal cell carcinoma by Xiancheng Wu, David Lazris, Risa Wong, Scott S. Tykodi

“…Most clear cell renal cell carcinoma (ccRCC) tumors are associated with VHL deletion or inactivation resulting in HIF-2α overexpression that represents a key contributor to tumorigenesis, thereby making belzutifan a uniquely optimal drug for targeting ccRCC. …”
Get full text