A Confusing Coincidence: Neonatal Hypoglycemic Seizures and Hyperekplexia by Nihat Demir, Murat Doğan, Sanem Yılmaz, Erdal Peker, Keziban Bulan, Oğuz Tuncer

“…Genetic defects in glycine receptors as well as encephalitis, tumors, inflammation, and disgenesis are among the etiologic causes of the disease. …”
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MELANOMAS, SARCOMAS, AND RENAL METASTASES IN THE LIVER: HOW TO TREAT? by Angelica Maria LUCCHESE, Antonio Nocchi KALIL, Alessandro L. DINIZ, Karl J. OLDHAFER, Timothy M. PAWLIK, René ADAM, Olivier SOUBRANE, Maria Ignez BRAGHIROLI, Ricardo Lemos COTTA-PEREIRA

“…ABSTRACT Liver metastases from melanomas, sarcomas, and renal tumors are less frequent. Treatment and prognosis will depend on whether they are isolated or multiple, size and location, the presence or absence of extrahepatic neoplastic disease, age, stage of the initial disease, initial treatments instituted, time of evolution, and clinical condition of the patient. …”
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Abiraterone Acetate and Castration Resistant Ductal Adenocarcinoma of the Prostate by Edgar Linden-Castro, Marcela Pelayo-Nieto, Alejandro Alias-Melgar, Daniel Espinosa-Perezgrovas, Ivan Ramirez-Galindo, Gabriel Catalan-Quinto

“…Ductal adenocarcinoma of the prostate is a rare histological variant that only represents <1% of prostate tumors. This histological variant has several important clinical implications with respect to their evolution, clinical prognosis, and treatment. …”
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Giant Lipoma of Posterior Cervical Region by Mahendra Singh, Ashish Saxena, Lovekesh Kumar, Snehal K. Karande, Yuvraj Kolhe

“…Lipomas are the slow growing soft tissue tumors of benign nature. They commonly grow on torso and extremities but may also develop in head and neck region. …”
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An Unusual Case of Gastrointestinal Bleeding from Isolated Gallbladder Varices in a Patient with Pancreatic Cancer Complicated by Portal Biliopathy by Mahir Gachabayov, Kubach Kubachev, Elbrus Abdullaev, Nonna Zarkua, Abakar Abdullaev, Artur Fokin

“…Portal biliopathy is the complex of abnormalities of extrahepatic and intrahepatic bile ducts, cystic duct, and gallbladder, arising as a result of extrahepatic portal vein obstruction and noncirrhotic portal fibrosis, which can be caused by coagulopathies, tumors, inflammation, postoperative complications, dehydration, and neonatal umbilical vein catheterization. …”
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Orbitotemporal Neurofibromatosis: Case Report by Mahalakshmi Balasubramanyam, Goutham Cugati, Bipasha Mukherjee

“…Plexiform neurofibromas occur in about 60% of neurofibromatosis type 1(NF-1) patients and can lead to severe morbidity by disfigurement or compression of vital structures. Moreover, these tumors can undergo malignant transformation. Both focal and localized bone abnormalities are part of the phenotypic expression of NF-1. …”
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Pathology and diagnostic approaches to well-differentiated hepatocellular lesions: a narrative review by Joon Hyuk Choi, Swan N. Thung

“…Well-differentiated hepatocellular lesions (WDHLs) are liver tumors or nonneoplastic lesions in which the cells closely resemble normal hepatocytes. …”
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Cowden syndrome: Familial presentation and genetic insights by K. C. Shashidhara, Keerthi Yenamala, Prajval Reddy Nachu, L. K. Prajwal, Sai Surya Chukkapalli

“…Beyond these, patients face elevated risks of breast, thyroid, and endometrial tumors. While PTEN mutations predominate, other genes such as KILLIN, SDH B/D, РІКСА, and AK1 contribute to a subset of cases. …”
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Editorial: Visceral surgery and education by Gabriel Sandblom, Magnus Kjellman, Magnus Kjellman, Lars Enochsson

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High Ano1 expression as key driver of resistance to radiation and cisplatin in HPV-negative head and neck squamous cell carcinoma by Solenne Bourdier, Anne-Sophie Fisch, Keziban Merve Alp, Ridhima Das, Philipp Mertins, Ingeborg Tinhofer

“…Copanlisib and afatinib were identified as promising candidates for combination therapy of 11q13-amplified HNSCC tumors. We demonstrated a predominant role for Ano1 in treatment resistance in Cyclin D1highAno1high HNSCC tumors and identified novel potential treatment combinations for this high-risk patient group.…”
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Preclinical Evaluation of Oncolytic Δγ134.5 Herpes Simplex Virus Expressing Interleukin-12 for Therapy of Breast Cancer Brain Metastases by James J. Cody, Pietro Scaturro, Alan B. Cantor, G. Yancey Gillespie, Jacqueline N. Parker, James M. Markert

“…We have previously described an oncolytic herpes simplex virus (HSV), designated M002, which lacks both copies of the γ134.5 neurovirulence gene and carries a murine interleukin 12 (IL-12) expression cassette, and have validated its antitumor efficacy in a variety of preclinical models of primary brain tumors. However, M002 has not been yet evaluated for use against metastatic brain tumors. …”
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Reliability of Endoscopic Ultrasound Using Miniprobes and Grayscale Histogram Analysis in Diagnosing Upper Gastrointestinal Subepithelial Lesions by Samiullah Khan, Rui Zhang, Weili Fang, Tao Wang, Shu Li, Danna Wang, Yixiang Chang, Lanping Zhu, Bang-mao Wang, Wentian Liu

“…The EUS images of SELs, particularly, leiomyoma and GIST, were further analyzed via a grayscale histogram to differentiate between the two tumors. Results. Of the 709 patients, 47 cases were pathologically undetermined. …”
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Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study by P. Pronzato, G. Mustacchi, A. De Matteis, F. Di Costanzo, E. Rulli, I. Floriani, M. E. Cazzaniga

“…Younger women more frequently had tumors with ER/PgR-negative(𝜒2=7.07; 𝑃=.008), HER2 amplification (𝜒2=5.76; 𝑃=.01), and high (≥10%) Ki67 labelling index (𝜒2=9.53; 𝑃=.002). …”
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Transcriptomic-Based Identification of miR-125a Novel Targets in Human Hepatocarcinoma Cells by Ilenia De Leo, Nicola Mosca, Mariaceleste Pezzullo, Danila Valletta, Francesco Manfrevola, Vincenza Grazia Mele, Rosanna Chianese, Aniello Russo, Nicoletta Potenza

“…Hepatocellular carcinoma (HCC) is among the most aggressive and lethal human tumors. Many functional studies have demonstrated the role of non-coding RNAs (ncRNA), particularly microRNAs (miRNA), in the regulation of hepatocarcinogenesis driving pathways. …”
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Interval Cancers in a Population-Based Screening Program for Colorectal Cancer in Catalonia, Spain by M. Garcia, X. Domènech, C. Vidal, E. Torné, N. Milà, G. Binefa, L. Benito, V. Moreno

“…Within the study period, 97 tumors were screen-detected and 74 tumors were diagnosed after a negative screening. …”
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Valproic acid targets IDH1 mutants through alteration of lipid metabolism by Lubayna S. Elahi, Michael C. Condro, Riki Kawaguchi, Yue Qin, Alvaro G. Alvarado, Brandon Gruender, Haocheng Qi, Tie Li, Albert Lai, Maria G. Castro, Pedro R. Lowenstein, Matthew C. Garrett, Harley I. Kornblum

“…In this study, we show that valproic acid (VPA), a brain penetrant anti-seizure medication and histone deacetylase inhibitor, inhibits the growth of IDH1 mutant tumors in vivo and in vitro, with at least some selectivity over IDH1 wild-type tumors. …”
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Characterization of the growth-inhibitory and apoptosis-inducing activities of a triterpene saponin, securioside B against BAC1.2F5 macrophages by Satoru Yui, Tomoya Kudo, Kazumi Hodono, Yoshihiro Mimaki, Minpei Kuroda, Yutaka Sashida, Masatoshi Yamazaki

“…Background: Since the growth state of macrophages in local pathological sites is considered a factor that regulates the processes of many disease, such as tumors, inflammation, and atherosclerosis, the substances that regulate macrophage growth or survival may be useful for disease control. …”
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Neurofibromatosis Type 1 with Bladder Involvement by Iyimser Üre, Serhat Gürocak, Ipek Isik Gönül, Sinan Sözen, Nuri Deniz

“…The malignant transformation of the disease is rare, and unlike malign tumors, the treatment option for benign disease is usually conservative. …”
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Round Ligament Leiomyoma Presenting as an Incarcerated Inguinal Hernia: Case Report and Review of the Literature by Marc Najjar, Marc Mandel

“…Leiomyomas are common benign gynecologic tumors occurring in up to 30% of women. Round ligament leiomyomas however are very rare and, if symptomatic, can present as an inguinal hernia. …”
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Endoscopically Assisted Resection of a Rare Mass: Intra-Articular Osteochondroma of Shoulder Originated from Scapula by Baran Sarikaya, Fatih Suluova, Baki Volkan Cetin, Zeynep Bekin Sarikaya

“…Osteochondromas are the most common benign bone tumors which are mostly seen in the metaphysis of distal femur, proximal tibia, and proximal humerus. …”
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