HER2 Negative Mammary Paget’s Disease or In Situ Melanoma? A Case Report and Review of the Literature by Luana-Andreea Boșoteanu, Mariana Așchie, Cristian Ionuţ Orǎșanu, Mădălina Boșoteanu

“…The histopathological and immunohistochemical approach is derived from the exigency of excluding the possibility of synchronous tumors—a mammary invasive carcinoma, accompanied by another component with MPD phenotypic mimicry. …”
Get full text

Primary Gliosarcoma of the Cerebellum in a Young Pregnant Woman: Management Challenges and Immunohistochemical Features by Marco Meloni, Salvatore Serra, Giulia Bellisano, Nikolaos Syrmos, Sanjeeva Jeyaretna, Mario Ganau

“…GS should be considered in the differential diagnosis of posterior cranial fossa tumors with radiological features of meningioma or glioblastoma, even in young patients. …”
Get full text

Developing a risk score using liquid biopsy biomarkers for selecting Immunotherapy responders and stratifying disease progression risk in metastatic melanoma patients by Amalia Azzariti, Simona De Summa, Tommaso M. Marvulli, Ivana De Risi, Giuseppe De Palma, Roberta Di Fonte, Rossella Fasano, Simona Serratì, Sabino Strippoli, Letizia Porcelli, Michele Guida

Get full text

The impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applications by Jiangxia Du, Minhui Shen, Jiajia Chen, Hao Yan, Zhifei Xu, Xiaochun Yang, Bo Yang, Bo Yang, Peihua Luo, Peihua Luo, Kefeng Ding, Yuhuai Hu, Qiaojun He, Qiaojun He, Qiaojun He, Qiaojun He

Get full text

Problems of diagnosis and treatment of primary operable breast cancer by E. A. Troshenkov, A. A. Kostin

“…Phenotypic diversity of tumors is directly related to genotypic variations, which can be determined with analyzing gene expression in a comprehensive immunohistochemical study. …”
Get full text

Association between Neurofibromatosis Type 1 and Breast Cancer: A Report of Two Cases with a Review of the Literature by Yoon Nae Seo, Young Mi Park

“…Neurofibromatosis type 1 (NF1) is one of the most common genetic diseases in humans and is associated with various benign and malignant tumors, including breast cancer. However, an increased risk of breast cancer in NF1 patients has not been widely recognized or accepted. …”
Get full text

Usefulness of Whole-Body Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography in Patients with Neurofibromatosis Type 1: A Systematic Review by Giorgio Treglia, Silvia Taralli, Francesco Bertagna, Marco Salsano, Barbara Muoio, Pierluigi Novellis, Maria Letizia Vita, Fabio Maggi, Alessandro Giordano

“…FDG-PET and PET/CT are useful methods to identify malignant change in neurogenic tumors in NF1 and to discriminate malignant from benign neurogenic lesions.…”
Get full text

Is Occult Obscure Gastrointestinal Bleeding a Definite Indication for Capsule Endoscopy? A Retrospective Analysis of Diagnostic Yield in Patients with Occult versus Overt Bleeding by Ikue Watari, Shiro Oka, Shinji Tanaka, Makoto Nakano, Taiki Aoyama, Shigeto Yoshida, Kazuaki Chayama

“…The small-bowel lesions in cases of occult OGIB were diagnosed as ulcer/erosive lesions (n=18, 18%), vascular lesions (n=11, 11%), and tumors (n=4, 3%), and those in cases of overt OGIB were diagnosed as ulcer/erosive lesions (n=51, 16%), vascular lesions (n=31, 10%), and tumors (n=20, 6%). …”
Get full text

Melanoma Development and Progression Are Associated with Rad6 Upregulation and β-Catenin Relocation to the Cell Membrane by Karli Rosner, Darius R. Mehregan, Evangelia Kirou, Judith Abrams, Seongho Kim, Michelle Campbell, Jillian Frieder, Kelsey Lawrence, Brittany Haynes, Malathy P. V. Shekhar

“…Eighty-eight cutaneous tumors, 30 nevi, 29 primary melanoma, and 29 metastatic melanomas, were immunostained with anti-β-catenin and anti-Rad6 antibodies. …”
Get full text

Identification of p53 and Its Isoforms in Human Breast Carcinoma Cells by Zorka Milićević, Vladan Bajić, Lada Živković, Jelena Kasapović, Uroš Andjelković, Biljana Spremo-Potparević

“…The isoforms expressed also varied between individual tumors, indicating potential roles of these p53 variants in human breast cancer.…”
Get full text

Effect of “Time To Surgery” on the Endometrial Cancer Prognosis by Engin Celik, Harika Yumru Celiksoy, Hamdullah Sozen, Hale Goksever Celik, Semen Onder, Mehmet Yavuz Salihoglu, Samet Topuz

“…There was no significant difference between the groups in terms of progression-free survival and disease-specific survival for cases with endometrioid type grade 1-2 tumors. There was also no significant difference between the groups regarding progression-free survival and disease-specific survival in the patients with tumors of endometrioid type grade 3 and non-endometrioid histology. …”
Get full text

High Prevalence of Human Papillomavirus in Colorectal Cancer in Hispanics: A Case-Control Study by Raul D. Bernabe-Dones, Maria Gonzalez-Pons, Alejandro Villar-Prados, Mercedes Lacourt-Ventura, Heriberto Rodríguez-Arroyo, Sharon Fonseca-Williams, Francisco E. Velazquez, Yaritza Diaz-Algorri, Sofia M. Lopez-Diaz, Nayra Rodríguez, Yasuhiro Yamamura, Marcia Cruz-Correa

“…HPV-16 was detected in 63.2% of the HPV-positive colorectal tumors; genome integration was observed in all HPV-16 positive cases. …”
Get full text

Nanostructured lipid carriers co-encapsulating Apigenin and Melatonin: An innovative strategy against cancer by Lorena Bonilla-Vidal, Marta Świtalska, Marta Espina, Joanna Wietrzyk, María Luisa García, Eliana B Souto, Anna Gliszczyńska, Elena Sánchez-López

“…Therefore, the combination of the pharmaceutical properties of the natural flavone Apigenin (APG) and the neurohormone Melatonin (MEL), could represent a key finding for tumoral processes. However, both possess low aqueous solubility and photosensitivity. …”
Get full text

Real-world clinical multi-omics analyses reveal bifurcation of ER-independent and ER-dependent drug resistance to CDK4/6 inhibitors by Zhengyan Kan, Ji Wen, Vinicius Bonato, Jennifer Webster, Wenjing Yang, Vladimir Ivanov, Kimberly Hyunjung Kim, Whijae Roh, Chaoting Liu, Xinmeng Jasmine Mu, Jennifer Lapira-Miller, Jon Oyer, Todd VanArsdale, Paul A. Rejto, Jadwiga Bienkowska

“…Machine learning models predict therapeutic dependency on ESR1 and CDK4 among ER-dependent tumors and CDK2 dependency among ER-independent tumors, confirmed by experimental validation.…”
Get full text

Case report: Bevacizumab-induced cerebrovascular events: a case series report and literature review by Ke Chen, Boyang Jiang, Boyang Jiang, Huiping Yan, Huiping Yan, Liu Yang, Liu Yang, Zheling Chen, Zheling Chen

“…In clinical use, bevacizumab has improved the overall survival (OS) and progression-free survival (PFS) of malignant solid tumors, and the safe use of bevacizumab has gradually become the mainstream direction of clinical, nursing and pharmaceutical research. …”
Get full text

Angiolipofibroma of the Cecum: A Rare Type of Submucosal Polyp by Gabriel M. Groisman

“…Mesenchymal type tumors originated in the submucosa represent a small percentage of colorectal polyps. …”
Get full text

Successful Treatment of Early Endometrial Carcinoma by Local Delivery of Levonorgestrel: A Case Report by D. Wildemeersch, E. Anderson, K. Lambein, P. Pauwels, M. Dhont

“…A full D&C, following removal of the device, was performed after 9 months, confirming absence of tumoral tissue. Examination after 24 months showed a very thin endometrium, indicating complete remission.…”
Get full text

Novel Thiazole Derivatives of Medicinal Potential: Synthesis and Modeling by Nour E. A. Abdel-Sattar, Abeer M. El-Naggar, M. S. A. Abdel-Mottaleb

“…This paper reports on the synthesis of new thiazole derivatives that could be profitably exploited in medical treatment of tumors. Molecular electronic structures have been modeled within density function theory (DFT) framework. …”
Get full text

Eruption of Odontomas into the Oral Cavity: A Report of 2 Cases by Sreenivasan Bhargavan Sarojini, Ektah Khosla, Thomas Varghese, Leena Johnson Arakkal

“…Odontomas are the commonest odontogenic tumors of the oral cavity and are by nature asymptomatic. …”
Get full text

An Unusual Cause of Intestinal Obstruction in a Young Adult Patient: Inflammatory Fibroid Polyp by Meryem Rais, Hafsa Chahdi, Mohammed Elfahssi, Abderrahmane Albouzidi, Mohamed Oukabli

“…Although inflammatory fibroid polyp is one of the rare conditions leading to intestinal obstruction in adults, it should be considered as a possible diagnosis in obstructive tumors of the small bowel causing intussusceptions. …”
Get full text