miR-129-5p Regulates the Immunomodulatory Functions of Adipose-Derived Stem Cells via Targeting Stat1 Signaling by He-Yang Zhang, Yu-Han Wang, Yan Wang, Yan-Nv Qu, Xiao-Hui Huang, Hui-Xin Yang, Chang-Ming Zhao, Youdi He, Si-Wei Li, Jin Zhou, Changyong Wang, Xiao-Xia Jiang

“…ASCs with miR-129-5p knockdown alleviated inflammatory bowel diseases and promoted tumor growth in vivo. Consistently, ASCs that overexpressed miR-129-5p exhibited reduced iNOS expression. …”
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Human head and neck cancer cell lines response to cold atmospheric plasma activated media is affected by the chemistry of culture media by Viviana di Giacomo, Marwa Balaha, Asia Pece, Ilaria Cela, Gianluca Fulgenzi, Giovanna Orsini, Tatiana Spadoni, Tirtha Raj Acharya, Nagendra Kumar Kaushik, Eun Ha Choi, Monica Rapino, Mariangela Mazzone, Gabriella Mincione, Gianluca Sala, Eloisa Sardella, Vittoria Perrotti

“…Cold atmospheric plasmas (CAPs) are partially ionized gases that have shown anti-tumor effectiveness over a wide range of cancer types with potential application into clinics. …”
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Cooling and Sterile Inflammation in an Oxygen-Glucose-Deprivation/Reperfusion Injury Model in BV-2 Microglia by Jana Lücht, Nele Rolfs, Sylvia J. Wowro, Felix Berger, Katharina R. L. Schmitt, Giang Tong

“…Furthermore, inducible nitric oxide synthase (iNOS), ionized calcium-binding adaptor molecule 1 (Iba1), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), interleukin-1α (IL-1α), monocyte chemotactic protein 1 (MCP-1), transforming growth factor β (TGFβ), CIRBP, and RBM3 gene expressions were assessed via reverse transcription polymerase chain reaction, and TNF-α, IL-6, and IL-1β releases into the cultured supernatants were assessed via enzyme-linked immunosorbent assays (ELISA). …”
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Real life outcome analysis of breast cancer brain metastases treated with Trastuzumab Deruxtecan by Alessandra Fabi, Alessandro Rossi, Roberta Caputo, Simona Pisegna, Simone Scagnoli, Francesco Pantano, Giuliana D’Auria, Palma Fedele, Agnese Fabbri, Claudio Vernieri, Michela Palleschi, Luisa Carbognin, Gianluigi Ferretti, Elena Di Monte, Ida Paris, Francesco Pavese, Ornella Garrone, Antonio Franco, Michelino De Laurentiis, Gianluca Franceschini, Giovanni Scambia, Diana Giannarelli, Riccardo Masetti, Andrea Botticelli

“…Abstract Tumor dissemination to the central nervous system (CNS) is almost a rule in the treatment journey of advanced HER2+ breast cancer (BC). …”
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PMAIP1 regulates the progression of follicular thyroid carcinoma through the Wnt3/FOSL1 pathway by Haobo Wang, Fangjian Shang, Yifang Wang, Bo Pang, Bo Pang, Longfei Kang, Longfei Kang, Chuanmin Zhou, Chuanmin Zhou, Dongyun Li, Dongyun Li, Zhongxin Li, Zhongxin Li, Xia Jiang, Xia Jiang, Bo Liu, Zengren Zhao

“…MethodsThis study examined the expression level of PMAIP1 in FTC through comprehensive analysis of databases, tumor tissues, and cell lines. Following the establishment of a stably transfected plasmid in cell lines, a series of functional assays and subcutaneous xenograft experiment were conducted to investigate the role of PMAIP1 in FTC. …”
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Ibuprofen reduces inflammation, necroptosis and protects photoreceptors from light-induced retinal degeneration by Ping-Wu Zhang, Zi-He Wan, Weifeng Li, Abhishek Vats, Kunal Mehta, Laura Fan, Lingli Zhou, Sean Li, Gloria Li, Casey J. Keuthan, Cynthia Berlinicke, Cheng Qian, Noriko Esumi, Elia J Duh, Donald J. Zack

“…Twenty-four hour after LD, retinal mRNA expression for the inflammatory-factors tumor necrosis factor (Tnf), interleukin-1 beta (Il1B), and C-C motif chemokine ligand 2 (Ccl2) increased by 10-, 17-, and 533-fold, respectively; in IBU-treated animals, the expression levels of these inflammatory factors were not significantly different from no-LD controls. …”
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AFP shields hepatocellular carcinoma from macrophage phagocytosis by regulating HuR-mediated CD47 translocation in cellular membrane by Yinglian Pan, Qiushi Yin, Zhaoliang Wang, Gang Wu, Kun Liu, Xiaowei Li, Jinchen Liu, Jiangzheng Zeng, Bo Lin, Wei Li, Mingyue Zhu, Mengsen Li

“…The effect of AFP on regulating the level of CD47 in cellular membrane and growth of tumor in vivo was performed by animal experiment. …”
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A retrospective study of pembrolizumab combined with XELOX regimen in the treatment of advanced gastric cancer by FENG Huizhi, LIU Jingmei, BU Xiaoqian

“…Conclusion: The combination of pembrolizumab and XELOX regimen can regulate the expression levels of tumor markers in patients with advanced gastric cancer, prevent disease progression, improve patient quality of life, and help maintain intestinal microecology balance.…”
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Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3 by Ling Ye, Shengqi Shen, Qiankun Mao, Hui Lu, Haiying Liu, Pinggen Zhang, Zetan Jiang, Wenhao Ma, Yuchen Sun, Yiyang Chu, Zilong Zhou, Rui Liu, Jian Li, Shi-ting Li, Ping Gao, Huafeng Zhang

“…Notably, targeting HKDC1’s protein kinase activity, but not its HK activity, blocks RBBP5 phosphorylation and suppresses tumor growth. Clinical analysis further reveals that RBBP5 phosphorylation positively correlates with HKDC1 levels and poor HCC prognosis. …”
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Serum proteomic and metabolomic profiling of hepatocellular carcinoma patients co-infected with Clonorchis sinensis by Zeli Tang, Zeli Tang, Zeli Tang, Caibiao Wei, Xueling Deng, Qiumei Lin, Qiping Hu, Qiping Hu, Qiping Hu, Shitao Li, Jilong Wang, Yuhong Wu, Dengyu Liu, Dengyu Liu, Dengyu Liu, Min Fang, Min Fang, Tingzheng Zhan, Tingzheng Zhan, Tingzheng Zhan

“…Furthermore, C. sinensis triggered inflammation, insulin resistance, and pro-tumor immune escape, and exacerbated the complication of degenerative diseases.ConclusionThis study not only provides compelling evidence for elucidating the mechanisms underlying C. sinensis-mediated HCC development but also identifies potential therapeutic targets for HCC patients co-infected with C. sinensis.…”
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Nomogram for predicting early cancer-related death due to recurrence after liver resection in hepatocellular carcinoma patients with Barcelona Clinic Liver Cancer (BCLC) stage B/C:... by Zhan-Cheng Qiu, Hao-Zheng Cai, You-Wei Wu, Jun-Long Dai, Wei-Li Qi, Chu-Wen Chen, Yue-Qing Xu, Chuan Li, Tian-Fu Wen

“…Results In our LASSO-logistic regression model, three variables were independently associated with the ECRD due to recurrence: the alpha-fetoprotein-tumor burden score (ATS score, Odd Ratio [OR]: 1.12, p = 0.001), BCLC stage (OR: 4.39, p < 0.001) and the aspartate transaminase (AST) to alanine transaminase (ALT) ratio (AAR, OR: 1.49, p = 0.027) and we established the nomogram model based on these three variables. …”
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miR‐130a‐3p regulated TGF‐β1‐induced epithelial‐mesenchymal transition depends on SMAD4 in EC‐1 cells by Xiaokang Tian, Qian Fei, Mingyu Du, Hongming Zhu, Jinjun Ye, Luxi Qian, Zhiwei Lu, Wenjun Zhang, Yan Wang, Fanyu Peng, Jie Chen, Baoling Liu, Qian Li, Xia He, Li Yin

“…Epithelial‐mesenchymal transition (EMT) is crucial step of acquisition of "stemness" properties in tumor cells. However, the mechanism of esophageal cancer metastasis remains unclear. …”
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Deeper response predicts better outcomes in high-risk-smoldering-myeloma: results of the I-PRISM phase II clinical trial by Omar Nadeem, Michelle P. Aranha, Robert Redd, Michael Timonian, Sophie Magidson, Elizabeth D. Lightbody, Jean-Baptiste Alberge, Luca Bertamini, Ankit K. Dutta, Habib El-Khoury, Mark Bustoros, Jacob P. Laubach, Giada Bianchi, Elizabeth O’Donnell, Ting Wu, Junko Tsuji, Kenneth C. Anderson, Gad Getz, Lorenzo Trippa, Paul G. Richardson, Romanos Sklavenitis-Pistofidis, Irene M. Ghobrial

“…Exploratory single-cell RNA sequencing linked tumor MHC class I expression to proteasome inhibitor response, and a lower proportion of GZMB+ T cells within clonally expanded CD8+ T cells associated with suboptimal outcomes.…”
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Cardiovascular Disease and Other Competing Causes of Death in Older Kidney Cancer Patients by Yinglan Liang, Liangjia Zeng, Ruoyun Zhou, Manting Feng, Linglong Liu, Kexin Chen, Jinqi Huang, Haowen Liang, Baixin He, Binghua Zhang, Yican Ying, Yuerong Chen, Tianwang Guan, Min Yi

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The novel manualized RELIEVE-group treatment for burdened relatives of cancer patients: a feasibility study by Jessica Neumann, Jessica Neumann, Jil Beckord, Jil Beckord, Helen Samira Hesse, Helen Samira Hesse, Carl Martin, Carl Martin, Carlotta Mons, Carlotta Mons, Diana Chur, Diana Chur, Jörg Hense, Jörg Hense, Mitra Tewes, Martin Teufel, Martin Teufel, Eva-Maria Skoda, Eva-Maria Skoda

“…A total of 33 relatives of cancer patients were recruited from the West German Tumor Center and participated in the five modules of the RELIEVE treatment which included an introduction, communication skills, stress and anxiety management and self-care. …”
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Self‐Boosting Programmable Release of Multiple Therapeutic Agents by Activatable Heterodimeric Prodrug‐Enzyme Assembly for Antitumor Therapy by Shanshan Jiang, Bhaskar Gurram, Junfei Zhu, Shan Lei, Yifan Zhang, Ting He, Oya Tagit, Hui Fang, Peng Huang, Jing Lin

“…However, reactive oxygen species (ROS) as classical endogenous stimuli in the tumor microenvironment (TME) are not enough to achieve the expected drug release. …”
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Development of a clinical prediction model for benign and malignant pulmonary nodules with a CTR ≥ 50% utilizing artificial intelligence-driven radiomics analysis by Wensong Shi, Yuzhui Hu, Guotao Chang, He Qian, Yulun Yang, Yinsen Song, Zhengpan Wei, Liang Gao, Hang Yi, Sikai Wu, Kun Wang, Huandong Huo, Shuaibo Wang, Yousheng Mao, Siyuan Ai, Liang Zhao, Xiangnan Li, Huiyu Zheng

“…Abstract Objective In clinical practice, diagnosing the benignity and malignancy of solid-component-predominant pulmonary nodules is challenging, especially when 3D consolidation-to-tumor ratio (CTR) ≥ 50%, as malignant ones are more invasive. …”
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Effect of Ginkgolide B on Non-Alcoholic Fatty Liver Disease based on Notch Signaling Pathway by Hong YU, Junzi WU, Bo SONG, Jun LI

“…After intervention for four weeks, some indexs such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were compared; the differences of transforming growth factor-β1(TGF-β1) and tumor necrosis factor-α(TNF-α) in liver and plasma were compared; HE staining method was used to observe liver histopathological changes; Real-time fluorescent quantitative PCR method and Western blot method were used to detect the protein and mRNA expression of Notch-3, Hes-1. …”
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Integration analysis of microRNAs as potential biomarkers in early-stage lung adenocarcinoma: the diagnostic and therapeutic significance of miR-183-3p by Guodong Huang, Yuxia Liu, Lisha Li, Bing Li, Ting Jiang, Yufeng Cao, Xiaoping Yang, Xinning Liu, Honglin Qu, Shitao Li, Xin Zheng

“…IntroductionLung adenocarcinoma (LUAD) poses a significant therapeutic challenge, primarily due to delayed diagnosis and the limited efficacy of existing treatments.MethodsTo understand the pathogenesis and identify diagnostic biomarkers for LUAD in the early stage, we investigated differential miRNA expression in 33 stage I LUAD patients between tumor and matched paracancerous tissues by Illumina Sequencing. …”
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Exploring the Role of Radiosurgery for Atypical Meningiomas: Addressing Suboptimal Local Control in High-Risk Patients by Sanjeev Sreenivasan, MD, MCh, Salem Najjar, BA, Daniel Ma, MD, Sabrina L. Begley, BS, Yen-Ruh Wuu, MD, Zaker Rana, MD, Emile Gogineni, DO, Michael Schulder, MD, Anuj Goenka, MD

“…Results: We identified 45 pathologically confirmed atypical meningiomas in 25 patients. Thirty-three tumors underwent single-fraction SRS, and 12 tumors received hf-SRS. …”
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