Long non-coding RNA OSTM1-AS1 promotes renal cell carcinoma progression by sponging miR-491-5p and upregulating MMP-9 by Jun-Feng Chen, Sha-Zhou Ye, Ke-Jie Wang, Xiang-yu Meng, Bin-bin Yang, Ke Rong Wu, Qi Ma

“…The in vivo trial demonstrated that OSTM1-AS1 suppression resulted in tumor growth inhibition among nude mice. In summary, our findings indicate, for the first time, at least to the best of our knowledge, that OSTM1-AS1 serves as an oncogene among RCC by promoting proliferation, invasion, and metastasis through its targeting of the miR-491-5p/MMP9 axis. …”
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Glioma Image-Level and Slide-Level Gene Predictor (GLISP) for Molecular Diagnosis and Predicting Genetic Events of Adult Diffuse Glioma by Minh-Khang Le, Masataka Kawai, Kenta Masui, Takashi Komori, Takakazu Kawamata, Yoshihiro Muragaki, Tomohiro Inoue, Ippei Tahara, Kazunari Kasai, Tetsuo Kondo

“…The latest World Health Organization (WHO) classification of central nervous system tumors (WHO2021/5th) has incorporated molecular information into the diagnosis of each brain tumor type including diffuse glioma. …”
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Ethnobotanical survey of medicinal plants used in management of breast cancers in Qatar by Rasha.S.Abo El Alaa, Hend Al-Jaber, Fatima Al Zahraa Chokor, Abdullah A. Shaito, Layla Al-Mansoori

“…The complexity of breast cancer requires diverse treatment approaches influenced by tumor characteristics and biology. Despite advancements, current treatments still fall short of providing definitive solutions, particularly for triple-negative breast cancer. …”
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Efficacy and Safety of Low-Dose Lenvatinib and Toripalimab in Patients With Recurrent Platinum-Resistant Ovarian Cancer: Study Protocol of a Multicenter, Open-Label, Single-Arm, Ph... by Su H, Shang X, Liu H, Wang Y, Yu Y, Xu Y, Jiang K, Feng F

“…Our previous pilot study indicated that a reduced starting dose of lenvatinib may maintain comparable anti-tumor activity with favorable safety in heavily pre-treated ovarian cancer. …”
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MAP17 is a Novel NASH Progression Biomarker Associated with Macrophage Infiltration, Immunotherapy Response, and Oxidative Stress by Huang Z, Chen J, Liu S, Xiang X, Long Y, Tan P, Fu W

“…The CIBERSORT algorithm assessed the correlation between MAP17 and immune cell infiltration within the tumor microenvironment (TME), while the TIDE algorithm predicted responses to immunotherapy. …”
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A clinical efficacy analysis of single-port thoracoscopic lung resection in the treatment of male patients with non-small cell lung cancer using surface localization and CT-guided... by Qinghua Wang, Yujie He, Xiaowei Xie, Qinghua Wu

“…The perioperative indicators, serum tumor markers, pulmonary function indicators and stress response indicators were compared between the two groups. …”
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Ethyl Acetate Extract of <i>Cichorium glandulosum</i> Activates the P21/Nrf2/HO-1 Pathway to Alleviate Oxidative Stress in a Mouse Model of Alcoholic Liver Disease by Shuwen Qi, Chunzi Zhang, Junlin Yan, Xiaoyan Ma, Yewei Zhong, Wenhui Hou, Juan Zhang, Tuxia Pang, Xiaoli Ma

“…Inflammation was mitigated through reduced levels of Tumor Necrosis Factor Alpha (TNF-α), Interleukin-1 Beta (IL-1β), and C-X-C Motif Chemokine Ligand 10 (CXCL-10). …”
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Overexpression of Parkin promotes the protective effect of mitochondrial autophagy on the lung of rats with exertional heatstroke by Ran Meng, Zhengzhong Sun, Ruxue Chi, Yan Gu, Yuxiang Zhang, Jiaxing Wang

“…Enzyme-linked immunosorbent assay were used to determine the levels of interleukin-6 (IL-6), IL-1β, and tumor necrosis factor-α, and reactive oxygen species. …”
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Lycium barbarum polysaccharide inhibits retinal neovascularization and inflammation in vitro and in vivo by Bin Wu, Xue Wang, Wei Zhang, Xin Wang, Qi-Miao Wang, Ya-Ju Pang, Yi-Chun Kong

“…The expression of epidermal growth factor receptor (EGFR), phosphatidylinositol 3-kinase (PI3K), mammalian target of rapamycin (mTOR), phosphorylated mammalian target of rapamycin (p-mTOR), protein kinase B (AKT), phosphorylated protein kinase B (p-AKT), interleukin-1β (IL-1β), inducible nitric oxide synthase (iNOS), and tumor necrosis factor-α (TNF-α) in each group were analyzed by Western blot. …”
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Novel Thiosemicarbazone Derivatives from Furan-2-Carbaldehyde: Synthesis, Characterization, Crystal Structures, and Antibacterial, Antifungal, Antioxidant, and Antitumor Activities by Wilfredo Hernández, Fernando Carrasco, Abraham Vaisberg, Evgenia Spodine, Maik Icker, Harald Krautscheid, Lothar Beyer, Carmen Tamariz-Angeles, Percy Olivera-Gonzales

“…All prepared thiosemicarbazone derivatives were evaluated for their in vitro antibacterial, antifungal, and antitumor activities against Staphylococcus aureus strains, Candida albicans/Candida tropicalis fungi, and seven human tumor cell lines (HuTu80, H460, DU145, M-14, HT-29, MCF-7, and LNCaP), respectively. …”
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Artificial Intelligence Models May Aid in Predicting Lymph Node Metastasis in Patients with T1 Colorectal Cancer by Ji Eun Baek, Hahn Yi, Seung Wook Hong, Subin Song, Ji Young Lee, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Seung-Jae Myung, Suk-Kyun Yang, Namkug Kim, Jeong-Sik Byeon

“…Conclusions: AI models trained on the basis of endoscopic findings and pathological features performed well in predicting LNM in patients with T1 CRC regardless of tumor location and initial treatment method.…”
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Predictors of Recurrence After Curative Surgery for Stage I Colon Cancer: Retrospective Cohort Analysis of the Italian Society of Surgical Oncology Colorectal Cancer Network Collab... by Giulia Turri, MD, Luigi Martinelli, MD, Daniela Rega, MD, Nicolò Tamini, MD, Lucia Paiano, MD, Simona Deidda, MD, QuocRiccardo Bao, MD, Laura Lorenzon, MD, PhD, Raffaele De Luca, MD, Caterina Foppa, MD, PhD, Valentina Mari, MD, Giovanni Taffurelli, MD, Arcangelo Picciariello, MD, PhD, Patrizia Marsanic, MD, Leandro Siragusa, MD, Francesco Bagolini, MD, Riccardo Nascimbeni, MD, Gianluca Rizzo, MD, PhD, Sara Vertaldi, MD, Michele Zuolo, MD, Giorgio Bianchi, MD, Lisa Marie Rorato, MD, Rossella Reddavid, MD, PhD, Gaetano Gallo, MD, PhD, Lorenzo Crepaz, MD, Alberto Di Leo, MD, Mario Trompetto, MD, Enrico Potenza, MD, Mauro Santarelli, MD, Nicola de’Angelis, MD, PhD, Francesco Ciarleglio, MD, Marco Milone, MD, PhD, Claudio Coco, MD, Guido Alberto Tiberio, MD, Gabriele Anania, MD, Giuseppe S. Sica, MD, PhD, Andrea Muratore, MD, Donato Francesco Altomare, MD, Isacco Montroni, MD, PhD, Maurizio De Luca, MD, Antonino Spinelli, MD, PhD, Michele Simone, MD, Roberto Persiani, MD, Gaya Spolverato, MD, Angelo Restivo, MD, Nicolò de Manzini, MD, Marco Braga, MD, Paolo Delrio, MD, Giuseppe Verlato, MD, PhD, Corrado Pedrazzani, MD, Adriana Gioia, Cristina Vacca, Dario Parini, Giovanni Tomasicchio, Marcello Calabrò, Bruno Sensi, Filomena Misuriello, Carlo Alberto Schena, Silvia Picotto

“…Also, preoperative carcinoembryonic antigen (P = 0.007) and tumor diameter (P < 0.001) were higher in the group who relapsed. …”
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Steroid hormone receptors, exome sequencing and treatment responsiveness of breast cancer patient-derived xenografts originated in a South American country by Gabriela Pataccini, Andrés Elia, Gonzalo Sequeira, Luisa Ambrosio, Marcela Coianis, Caroline A. Lamb, Paola A. Rojas, Paula Martínez Vázquez, Javier Burruchaga, Eunice Spengler, Silvia I. Vanzulli, Martin Abba, Claudia Lanari

“…Eight PDX were established: two ER + [BC-AR685 (PR +) and BC-AR707 (PR-)], one from a triple-negative (TN) recurrence whose primary tumor was ER + (BC-AR485), one HER2 + (BC-AR474) and four TN primary tumors (BC-AR553, BC-AR546, BC-AR631 and BC-AR687). …”
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Smart design in biopolymer-based hemostatic sponges: From hemostasis to multiple functions by Chen-Yu Zou, Chen Han, Fei Xing, Yan-Lin Jiang, Ming Xiong, Jesse Li-Ling, Hui-Qi Xie

“…Notably, as development frontier, the multi-functions of hemostatic materials is summarized, mainly including enhanced coagulation, antibacterial, avoiding tumor recurrence, promoting tissue repair, and hemorrhage monitoring. …”
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Association between resolution of MRI-detected inflammation and improved clinical outcomes in axial spondyloarthritis under long-term anti-TNF therapy by Joachim Sieper, Denis Poddubnyy, Fabian Proft, Mikhail Protopopov, Valeria Rios Rodriguez, Murat Torgutalp, Judith Rademacher, H Haibel, Kay-Geert Hermann, Christian Althoff

“…Objectives In this post-hoc analysis of ESTHER trial, we aimed to investigate the longitudinal relationship between inflammation on MRI and the achievement of inactive disease/low disease activity in patients with axial spondyloarthritis (axSpA) treated with long-term tumor necrosis factor (TNF) inhibitor etanercept.Methods Of the 76 patients with active axSpA in the ESTHER trial, we included all patients treated with etanercept for at least 6 months for main analysis. …”
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Ginseng exhibits adaptogenic-like activity in mice exposed to hypoxic-anoxic stress through activation of antioxidant/BDNF protective mechanisms and inhibition of pro-inflammatory... by James Olukayode Oni, Divine Oluwaferanmi Oyenekan, Yetunde Olamide Olayemi, Osarugue Christabel Irabor, Precious Ogbuji, McCarthy Oritseweyinmi Tova, Paul Ademola Adeleke, Gbemisayo Adetomiwa Abbas, Solomon Umukoro

“…Blood glucose and corticosterone levels alongside brain contents of malondialdehyde, nitrites, antioxidant profiles, pro-inflammatory cytokines (tumor necrosis factor–alpha and interleukin-6), glutamate, brain derived neurotrophic factor (BDNF), and nuclear factor kappa B (NF-κB) were determined. …”
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Postoperative Outcomes After Robotic Liver Resection of Caudate Lobe: A Systematic Review by Gabriela Del Angel Millan, Gianluca Cassese, Fabio Giannone, Celeste Del Basso, Mariantonietta Alagia, Marco Lodin, Igor Monsellato, Marco Palucci, Federico Sangiuolo, Fabrizio Panaro

“…Of these surgeries, 56.3% were performed for malignant tumors. Tumor size varied significantly between 0.9 and 7.7 cm in the largest diameter. …”
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Efficacy and safety of surufatinib plus toripalimab in treatment-naive, PD-L1-positive, advanced or metastatic non-small-cell lung cancer and previously treated small-cell lung can... by Ying Cheng, Panpan Zhang, Ming Lu, Zhendong Chen, Lijie Song, Si Shi, Feng Ye, Xing Zhang, Baorui Liu, Dongmei Ji, Yanqiao Zhang, Weiguo Su, Michael Shi, Songhua Fan, Panfeng Tan, Chen Zhong

“…Abstract Background Combining the programmed death-1 inhibitor toripalimab and the angio-immuno kinase inhibitor surufatinib showed preliminary antitumor activity in patients with advanced solid tumors in a phase I study. Here, we report the efficacy and safety of this combination regimen in treatment-naive advanced or metastatic non-small-cell lung cancer (NSCLC) patients with a programmed death-ligand 1 (PD-L1) tumor proportion score (TPS) of 1% or greater (PD-L1-positive) and patients with previously treated small-cell lung cancer (SCLC). …”
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Betulinic acid protects against ovarian impairment by decreasing F-2 toxin-induced oxidative stress and inflammation associated with the downregulation of p38 expression in mice by Li Kong, Xinyu Gao, Lijuan Zhu, Xing Lin, You Huang, Chunlin Huang, Wenjiang Yang, Yazhi Chen, Haoqiang Zhao, Jing Wu, Zhihang Yuan, Jin’e Yi

“…Subsequently, we found that 0.25 mg/kg BA played an anti-inflammatory role in the F-2 toxin-induced ovarian impairment by decreasing interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) mRNA expression, as well as inhibiting p38 protein expression.These data demonstrated that BA exerts its protective effect on F-2 toxin-induced ovarian oxidative impairment and inflammation by inhibiting p38 expression, which implies a natural product-based medicine to ameliorate F-2 toxin-caused female reproductive toxicity and provides a detoxifying method for food contaminated by mycotoxin.…”
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Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor by Junying Wang, Mengping Chen, Jinxing Jiang, Yike Wan, Xin Li, Minyue Zhang, Fei Xiao, Lu Zhong, Hua Zhong, Zhaoyu Qin, Jian Hou

“…SEL has been reported to promote the degradation of XPO1 protein in tumor cells. Nevertheless, in myeloma, the precise mechanisms underlying SEL-induced XPO1 degradation and its impact on drug responsiveness remain largely undefined. …”
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