Molecular effects of clinically relevant chemotherapeutic agents on choline phospholipid metabolism in triple negative breast cancer cells by Caitlin M. Tressler, Kanchan Sonkar, Menglin Cheng, Vinay Ayyappan, Ruoqing Cai, Kristine Glunde

“…The magnetic resonance spectroscopy (MRS)-detected total choline (tCho) signal was shown to be a promising biomarker for assessing the response to chemotherapy treatment early on, as breast tumor tCho decreases after the first treatment cycle in patients who respond to chemotherapy cocktails. …”
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Lactate Dehydrogenase-A-Forming LDH5 Promotes Breast Cancer Progression by Fang T, Hu L, Chen T, Li F, Yang L, Liang B, Wang W, Zeng F

“…Tianxing Fang,1– 4 Liyu Hu,5 Tianshun Chen,4 Fei Li,6 Liu Yang,4 Bin Liang,7 Wenjun Wang,8 Fancai Zeng4 1Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 2Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, People’s Republic of China; 3Institute of Nuclear Medicine, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 4Laboratory of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 5Oral & Maxillofacial Reconstruction and Regeneration of Luzhou Key Laboratory, The Affiliated Stomatological Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 6Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 7Department of General Surgery (Breast Surgery), the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 8Institute for Cancer Medicine and School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, People’s Republic of ChinaCorrespondence: Fancai Zeng; Wenjun Wang, Email zfcai@swmu.edu.cn; wenjunwang1213@126.comBackground: Breast cancer (BC) has become the main malignant tumor threatening the health of women worldwide. …”
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Normal butanol fraction of Polygonum hydropiper L. flavonoids reduces inflammation caused by PCV2 infections in cell and mouse models by Yu-heng Wei, Shu-mian Zhou, Shu-mian Zhou, Shu-mian Zhou, Wen Zhao, Qi Chen, Qiu-hua Wang, Qiu-hua Wang, Mei-ling Yu, Ying-yi Wei, Ting-jun Hu, Ting-jun Hu, Ting-jun Hu

“…Inflammatory factors such as Monocyte Chemoattractant Protein-1 (MCP-1), interleukin-6 (IL-6), IL-8, IL-10, Tumor Necrosis Factor-alpha (TNF-α), Reactive Oxygen Species (ROS), and Nitric Oxide (NO) were quantified using ELISA, RT-qPCR and immunohistochemistry.ResultsResults showed that a PCV2 titer of 104.5 TCID50/0.1 mL when applied to RAW264.7 cells effectively established an in vitro inflammatory model at 12 and 24 h post-infection. …”
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NSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis by Kaifeng Niu, Zixiang Chen, Mengge Li, Guannan Ma, Yuchun Deng, Ji Zhang, Di Wei, Jiaqi Wang, Yongliang Zhao

“…However, how NSUN2 activity is response to acidic condition in tumor microenvironment and then regulates cancer cell survival remain to be clarified. …”
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Phase Ib study of pembrolizumab in combination with trastuzumab emtansine for metastatic HER2-positive breast cancer by Sara M Tolaney, Tianyu Li, Edward T Richardson, Judith Agudo, Elizabeth A Mittendorf, Beth Overmoyer, Eric P Winer, Adrienne G Waks, Tanya E Keenan, Nabihah Tayob, Gerburg M Wulf, Victoria Attaya, Leilani Anderson, Ian E Krop, Eliezer M Van Allen

“…Programmed cell death ligand-1 and tumor infiltrating lymphocytes did not correlate with response in this small cohort.Conclusions T-DM1 plus pembrolizumab was a safe and tolerable regimen. …”
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Anti-HER2 biparatopic antibody KJ015 has near-native structure, functional balanced high affinity, and synergistic efficacy with anti-PD-1 treatment in vivo by Zheng Wang, Yu Liu, Yunxia Xu, Lin Lu, Zhen Zhu, Baojie Lv, Xin Fang, Yao Tang, Jinhua Wang, Yu Cheng, Ying Hu, Junwen Lou, Peican Wu, Chendan Liu, Yanjun Liu, Xin Zeng, Qing Xu

“…It exhibited enhanced synergy when administered subcutaneously with hyaluronidase and anti-PD-1 mAb in a mouse tumor model, suggesting promising clinical prospects for this combination.…”
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AGD1/USP10/METTL13 complexes enhance cancer stem cells proliferation and diminish the therapeutic effect of docetaxel via CD44 m6A modification in castration resistant prostate can... by Hong Wang, Chunli Cui, Weiyi Li, Hui Wu, Jianjun Sha, Jiahua Pan, Wei Xue

“…Conclusions AGD1 mediates the stemness and apoptosis of PCSCs and promotes docetaxel treatment resistance by enhancing tumor growth and metastasis through USP10/METTL13-mediated CD44 mRNA decay in CRPC.…”
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Single-Cell Transcriptome Analysis Reveals Different Immune Signatures in HPV- and HPV + Driven Human Head and Neck Squamous Cell Carcinoma by Simin Li, Yang Wang, Rui Sun, Debora Franceschi, Hongying Pan, Chenxuan Wei, Anthony Chukwunonso Ogbuehi, Bernd Lethaus, Vuk Savkovic, Sebastian Gaus, Rüdiger Zimmerer, Dirk Ziebolz, Gerhard Schmalz, Xiao Jiang

“…RNA-seq data were used from 522 HNSCC primary tumor samples. 1,137 differentially expressed genes between HPV+ and HPV- HNSCC patients were investigated. 96 differentially expressed genes were associated with overall survival and highly enriched in B cell associated biological process. …”
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Investigation of Novel Aronia Bioactive Fraction-Alginic Acid Nanocomplex on the Enhanced Modulation of Neuroinflammation and Inhibition of Aβ Aggregation by Bong-Keun Jang, Soo Jung Shin, Hyun Ha Park, Vijay Kumar, Yong Ho Park, Jeom-Yong Kim, Hye-Yeon Kang, Sunyoung Park, Youngsun Kwon, Sang-Eun Shin, Minho Moon, Beom-Jin Lee

“…In vitro studies on microglial cells treated with AANCPs revealed a suppression of inflammatory cytokines (tumor necrosis factor-alpha and interleukin-6) induced by LPS. …”
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Effect of differences in vascular anatomy on surgical outcomes of left pancreatectomy: a retrospective study by Masahiro Fukada, Noriki Mitsui, Takeshi Horaguchi, Yuji Hatanaka, Itaru Yasufuku, Yuta Sato, Jesse Yu Tajima, Shigeru Kiyama, Yoshihiro Tanaka, Katsutoshi Murase, Nobuhisa Matsuhashi

“…In open-LP cases, high body mass index (> 24 kg/m2; OR 7.24; 95% CI 1.89–36.34; p < 0.01), tumor location (pancreatic body; OR 6.89; 95% CI 1.79–33.79; p < 0.01), and the SpA type (type 2; OR 5.86; 95% CI 1.72–24.65; p < 0.01) showed significant association with prolonged operations. …”
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Lignans are the main active components of Schisandrae Chinensis Fructus for liver disease treatment: a review by Ke Fu, Shu Dai, Cheng Ma, Yafang Zhang, Shenglin Zhang, Cheng Wang, Lihong Gong, Honglin Zhou, Yunxia Li

“…The results showed that the lignans in SC could achieve hepatoprotective effects by regulating lipid metabolism, anti-fibrosis, anti-inflammation, anti-oxidation, anti-tumor and regulating bile acid metabolism. The mechanism mainly involved adenosine 5’-monophosphate-activated protein kinase, endoplasmic reticulum stress, sterol regulatory element binding protein 1c, autophagy, transforming growth factor-β, mitogen-activated protein kinase, microRNA, nuclear factor kappa-B, nuclear factor erythroid-2-related factor 2, heat shock proteins and pregnane X receptor signaling pathways. …”
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Okra juice used for rapid wound healing through its bioadhesive and antioxidant capabilities by Biao Zhang, Yuanqiang Li, Kaijie Wu, Liqi Wei, Yining Chen, Yuan Zhang, Yiping Ren, Tianshu Zou, Pengcheng Yu, Hongxia Ma, Rui Chen, Xin Liu, Yan Cheng

“…The levels of pro-inflammatory tumor necrosis factor alpha (33.17 %) and Interleukin-6 (46.73 %) were significantly reduced. …”
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Intervening Non-Small-Cell Lung Cancer Progression by Cell Membrane Coated Platycodin D via Regulating Hsa-miR-1246/FUT9/GSK3&beta; Pathway by Zheng S, Xie Z, Zhou Z, Wang S, Xin Y, Lin J, Cheng K, Lu T, Qi R, Guo Y

“…In vivo, PD encapsulated in homologous cell membranes mitigated tumor growth and migration in metastatic NSCLC mice with minimal side effects.Conclusion: The application of PD prompted an increase in the expression levels of hsa-miR-1246 and a concurrent decrease in FUT9. …”
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Exploring how attachment insecurities mediate the link between sexual and partnership satisfaction in adolescents and young adults with cancer by Svenja Heyne, Hannah Brock, Diana Richter, Annekathrin Sender, Jenny Rosendahl, Michael Friedrich, Kristina Geue, Anja Mehnert-Theuerkauf

“…Our study examines partnership satisfaction, sexual satisfaction, and attachment insecurities, exploring how attachment-related anxiety and avoidance influence the relationship between sexual and partnership satisfaction across major tumor entities in this population. Patients and methods: We utilized data from two measurement time points (t1 and t6) of the AYA-LE study, a prospective longitudinal investigation examining the temporal course and associated factors of life satisfaction and psychological distress among AYA cancer survivors. …”
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Oxidative Stress, Antioxidant Capacity, and Inflammatory Markers in Patients with Idiopathic Complete Heart Block by Shobhit Shah, Monika Bhandari, Pravesh Vishwakarma, Wahid Ali, Mohammad Kaleem Ahmad, Abhishek Singh, Ayush Shukla, Akhil Kumar Sharma, Gaurav Chaudhary, Akshyaya Pradhan, Sharad Chandra, Rishi Sethi, S. K. Dwivedi

“…Serum total antioxidant capacity levels (TAOC) were used to calculate antioxidant activity. Tumor necrosis factor-alpha (TNF-alpha) and serum interleukin-5 (IL-5) levels were used to gauge the degree of inflammation. …”
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Tofacitinib Efficacy/Safety in Patients with Ankylosing Spondylitis by Baseline Body Mass Index: A Post Hoc Analysis of Phase 2/3 Trials by Hillary Norton, Paula Sliwinska-Stanczyk, Tomas Hala, Bassel El-Zorkany, Lori Stockert, Rajiv Mundayat, Lisy Wang, Christopher T. Ritchlin

“…At baseline, patients with BMI < 25 kg/m2 were younger and more likely to be current smokers/Asian, and patients with BMI ≥ 30 kg/m2 had higher mean waist circumference/swollen joint count (SJC) and were more likely to have enthesitis, high-sensitivity C-reactive protein (hsCRP) > 5 mg/L, an inadequate response to tumor necrosis factor inhibitors (TNFi), and prior biologic disease-modifying anti-rheumatic drug (bDMARD) use versus other categories. …”
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Improved Efficacy of a Predictive Model for Swallowing-Induced Breakthrough Pain Based on a Redefined Delineation Method in Locally Advanced Nasopharyngeal Carcinoma by Jian-Da Sun, MD, Ze-Kai Chen, MM, Shu-Peng Liu, PhD, Feng Ye, MD, Ting-Xi Tang, MD, Zhen-Hua Zhou, MD, Han-Bin Zhang, MM, Long-Shan Zhang, MD, Ting Xiao, BS, Lin-Lin Xiao, MM, Xiao-Qing Wang, MD, Jian Guan, MD

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The miR-146a SNP Rs2910164 and miR-155 SNP rs767649 Are Risk Factors for Non-Small Cell Lung Cancer in the Iranian Population by Neda K. Dezfuli, Ian M. Adcock, Shamila D. Alipoor, Sharareh Seyfi, Babak Salimi, Maryam Mafi Golchin, Neda Dalil Roofchayee, Mohammad Varhram, Esmaeil Mortaz

“…MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression and may act as both tumor suppressors and as oncogenes. The presence of single nucleotide polymorphisms (SNPs) inside the miRNA genomic region could affect target miRNA maturation, expression, and binding to its target mRNA and contribute to cancer development. …”
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Intranasal Administration of the Combination of Dextro-Ketamine and Dexmedetomidine for Treatment of Diabetic Neuropathic Pain in Rats by Sudo SZ, Montagnoli TL, Dematté BE, Santos AD, Trachez MM, Gubert F, Mendez-Otero R, Zapata-Sudo G

“…DM induced increased expression of glial fibrillary acid protein (GFAP) and tumor necrosis factor-alpha (TNF-alpha) detected by immunohistochemistry, indicating greater astrocyte activity and intense inflammatory response. …”
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Regulation and therapy: the role of ferroptosis in DLBCL by Yifan Wang, Yifan Wang, Zhengmei He, Zhengmei He, Xinyu Dong, Xinyu Dong, Yiming Yao, Yiming Yao, Qiuni Chen, Qiuni Chen, Yuye Shi, Yuye Shi, Yuan Deng, Yuan Deng, Quane Zhang, Quane Zhang, Liang Yu, Liang Yu, Liang Yu, Chunling Wang, Chunling Wang, Chunling Wang

“…Its occurrence pathway plays an essential impact on the therapeutic effect of tumors. Numerous studies have shown that modulating critical factors in the ferroptosis pathway can influence the growth of tumor cells in hematological malignancies including DLBCL. …”
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