Parishin B blocking TRIB3-AKT1 interaction inhibits breast cancer lung metastasis by Xiongtao Cheng, Xiongtao Cheng, Jianguo Sun, Shouhong Chen, Nan Wang, Weijing Tang, Zijian Xia, Yuhong Shu, Shouhong Gao, Zhipeng Wang, Xinxia Wang, Rongzi Shao, Jianxiong Cao, Jianxiong Cao

“…Besides, inhibiting TRIB3 to turn “cold tumor” hot has also been proved to be an effective therapeutic strategy for BC. …”
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Liver sinusoidal endothelial cells regulate the balance between hepatic immunosuppression and immunosurveillance by Kimberly N. Kremer, Hadeel A. Khammash, Anjelica M. Miranda, Lauren N. Rutt, Shannon M. Twardy, Paige E. Anton, Margaret L. Campbell, Christian Garza-Ortiz, David J. Orlicky, Roberta Pelanda, Rebecca L. McCullough, Raul M. Torres

“…Thus, LSEC critically regulate the balance between preventing/limiting liver injury and permitting sufficient tumor immunosurveillance with normal hepatic functions likely contributing to HCC development under conditions of chronic liver insult.…”
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The efficacy of open transanal drainage tube against anastomotic leakage in left-sided colorectal cancer surgery: a propensity score matching study by Gen Tsujio, Tatsunari Fukuoka, Atsushi Sugimoto, Ken Yonemitsu, Yuki Seki, Hiroaki Kasashima, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Masatsune Shibutani, Takahiro Toyokawa, Shigeru Lee, Kiyoshi Maeda

“…PSM was performed between the OPEN and CLOSED groups on the basis of the following 13 factors: age, sex, BMI, diabetes mellitus (DM), smoking history, modified Glasgow prognostic score (mGPS), ASA-PS, location of distal tumor edge, operative procedure, surgical approach, operative time, intraoperative blood loss, and pathological stage. …”
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Development and validation of a prognostic prediction model for elderly gastric cancer patients based on oxidative stress biochemical markers by Xing-Qi Zhang, Ze-Ning Huang, Ju Wu, Chang-Yue Zheng, Xiao-Dong Liu, Ying-Qi Huang, Qi-Yue Chen, Ping Li, Jian-Wei Xie, Chao-Hui Zheng, Jian-Xian Lin, Yan-Bing Zhou, Chang-Ming Huang

“…The SHAP results identified pN, pT, perineural invasion, tumor size, and GIOSS as key predictive features. …”
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Lerociclib plus fulvestrant in patients with HR+/HER2− locally advanced or metastatic breast cancer who have progressed on prior endocrine therapy: LEONARDA-1 a phase III randomize... by Binghe Xu, Qingyuan Zhang, Yang Luo, Zhongsheng Tong, Tao Sun, Changping Shan, Xinlan Liu, Yumin Yao, Bing Zhao, Shusen Wang, Xiaohua Zeng, Changlu Hu, Xi Yan, Xiaojia Wang, Hongyan Jia, Zhendong Chen, Fuming Qiu, Xinhong Wu, Deyong Zhang, Tong Li

“…Abstract Lerociclib (GB491), a highly selective oral CDK4/6 inhibitor, has displayed anti-tumor activity and differentiated safety and tolerability profile in previous ph1/2 clinical trials. …”
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Similar Clinical and Surgical Outcomes Achieved with Early Compared to Late Anti-TNF Induction in Mild-to-Moderate Ulcerative Colitis: A Retrospective Cohort Study by Christopher Ma, Candace L. Beilman, Vivian W. Huang, Darryl K. Fedorak, Karen Wong, Karen I. Kroeker, Levinus A. Dieleman, Brendan P. Halloran, Richard N. Fedorak

“…Biologic agents targeting tumor necrosis factor alpha are effective in the management of ulcerative colitis (UC), but their use is often postponed until after failure of other treatment modalities. …”
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Induced Inflammatory and Oxidative Markers in Cerebral Microvasculature by Mentally Depressive Stress by Yuequan Zhu, Yazeed Haddad, Ho Jun Yun, Xiaokun Geng, Yuchuan Ding

“…Cerebral microvasculature was isolated from the CRS and controls (n=10/group). mRNA and protein expressions of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), vascular cell adhesion molecule-1 (VCAM-1), and macrophage chemoattractant protein-1 (MCP-1) in the brain vessels were measured by real-time PCR and Western blot (n=10/group). …”
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An Optimized Liquid Chromatography–Mass Spectrometry Method for Ganglioside Analysis in Cell Lines by Akeem Sanni, Andrew I. Bennett, Yifan Huang, Isabella Gidi, Moyinoluwa Adeniyi, Judith Nwaiwu, Min H. Kang, Michelle E. Keyel, ChongFeng Gao, C. Patrick Reynolds, Brian Haab, Yehia Mechref

“…The optimized method was applied to profile gangliosides in neuroblastoma (COG-N-683), pancreatic cancer (PSN1), breast cancer (MDA-MB-231BR), and brain tumor (CRL-1620) cell lines. The ganglioside profile of the neuroblastoma cell line COG-N-683 showed an inverse relationship between GD1 and GD2. …”
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Additional Evidence for DDB2 T338M as a Genetic Risk Factor for Ocular Squamous Cell Carcinoma in Horses by Moriel H. Singer-Berk, Kelly E. Knickelbein, Zachary T. Lounsberry, Margo Crausaz, Savanna Vig, Nikhil Joshi, Monica Britton, Matthew L. Settles, Christopher M. Reilly, Ellison Bentley, Catherine Nunnery, Ann Dwyer, Mary E. Lassaline, Rebecca R. Bellone

“…Squamous cell carcinoma (SCC) is the most common periocular cancer in horses and the second most common tumor of the horse overall. A missense mutation in damage-specific DNA-binding protein 2 (DDB2, c.1012 C>T, p.Thr338Met) was previously found to be strongly associated with ocular SCC in Haflinger and Belgian horses, explaining 76% of cases across both breeds. …”
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Evaluating ChatGPT’s diagnostic potential for pathology images by Liya Ding, Lei Fan, Lei Fan, Miao Shen, Miao Shen, Yawen Wang, Kaiqin Sheng, Zijuan Zou, Huimin An, Zhinong Jiang

“…Both scanned and photographed images were tested to evaluate GPT-4’s generalization ability across different image types.ResultsGPT-4 achieved an overall accuracy of 0.64 in identifying tumor imaging and tissue origins. For colon polyp classification, accuracy varied from 0.57 to 0.75 in different subtypes. …”
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RETRACTED ARTICLE: Bone mesenchymal stem cell-derived exosomal microRNA-7-5p inhibits progression of acute myeloid leukemia by targeting OSBPL11 by Duanfeng Jiang, Xin Wu, Xiaoying Sun, Wei Tan, Xin Dai, Youbang Xie, Ashuai Du, Qiangqiang Zhao

“…Exo-miR-7-5p derived from BMSCs exhibited tumor homing effects in vitro and in vivo, and inhibited AML development. …”
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Neuroendocrine Neoplasms of the Gallbladder: A Clinicopathological Analysis of 13 Patients and a Review of the Literature by Pengyan Wang, Jingci Chen, Ying Jiang, Congwei Jia, Junyi Pang, Shan Wang, Xiaoyan Chang

“…Of these 9 patients with MiNENs, 8 had composite tumors and 1 had amphicrine carcinoma. Microscopically, the adenocarcinoma component was located in the surface mucosa, and the neuroendocrine component was in the area of deep invasion, liver infiltration, and lymph node metastasis. …”
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Clinical and molecular characteristics and long-term outcomes of pediatric intracranial meningiomas: a comprehensive analysis from a single neurosurgical center by Leihao Ren, Jiaojiao Deng, Hiroaki Wakimoto, Qing Xie, Ye Gong, Lingyang Hua

“…Abstract Background Meningioma represents the most common intracranial tumor in adults. However, it is rare in pediatric patients. …”
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Anti-arthritic potential of crude sulfated polysaccharide from marine macroalgae Sargassum ilicifolium (Turner) C. Agardh: Regulation of cytokine cascade by Ramamoorthi Lavanya, Jeyabalan Srikanth, Sankar Seethalakshmi, Begum M. Yasmin, Duraipandian Chamundeeswari, Sekar Mahendran, Wong Ling Shing, Subramaniyan Vetriselvan

“…Immunohistochemical studies revealed that CSP (5 mg/kg) significantly inhibited pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-2, and CD4 cells. …”
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Systematic identification of pathological mechanisms, prognostic biomarkers and therapeutic targets by integrating lncRNA expression variation in salivary gland mucoepidermoid carc... by Yan-ping Zou, Xiao-feng Shan, Jia-xuan Qiu, Yan Geng, Shang Xie, Ruo-lan Xiang, Zhi-gang Cai

“…Single-sample gene set enrichment analysis unveiled the tumors’ immune infiltration signature, suggesting active antigen presentation and a positive immune response for immunotherapy. …”
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Nerve Growth Factor Regulation by TNF-α and IL-1β in Synovial Macrophages and Fibroblasts in Osteoarthritic Mice by Shotaro Takano, Kentaro Uchida, Masayuki Miyagi, Gen Inoue, Hisako Fujimaki, Jun Aikawa, Dai Iwase, Atsushi Minatani, Kazuya Iwabuchi, Masashi Takaso

“…Specifically, real-time polymerase chain reaction analysis was used to evaluate the expression of tumor necrosis factor- (TNF-) α, interleukin- (IL-) 1β, IL-6, and NGF in CD11b+ and CD11b– cells isolated from the ST of a murine OA model. …”
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EPIGENETICS TODAY AND TOMORROW by B. F. Vanyushin

“…Various regulators of enzymatic modifications of histones are efficient in the treatment of different tumors as well. Use of specific small RNAs in the therapy of cancer and other diseases appears to be particularly promising, especially in connection with directed inhibition of transcription of genes responsible for cell malignization and metastasis. …”
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Elocalcitol, a fluorinated vitamin D derivative, prevents high-fat diet-induced obesity via SCAP downregulation and miR-146a-associated mechanisms by Monika Jürgenson, Keerthana Chithanathan, Aivar Orav, Külli Jaako, Janeli Viil, Mithu Guha, Kalev Kask, Alexander Zharkovsky

“…We also demonstrated that elocalcitol prevents an increase in the expression of proinflammatory cytokines such as interleukin-1 beta (Il1b), tumor necrosis factor-alpha (Tnf), and interleukin-18 (Il18), and this effect was associated with upregulation of microRNA-146a (miR-146a). …”
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Long-term neuropsychologic outcome of pre-emptive mTOR inhibitor treatment in children with tuberous sclerosis complex (TSC) under 4 months of age (PROTECT), a two-arm, randomized,... by Jan H. Driedger, Julian Schröter, PROTECT-Study Group, Steffen Syrbe, Afshin Saffari

“…Secondary endpoints include neuropsychologic outcomes at 12 months of age, seizure frequency, cardiac and cerebral tumor load, and safety assessments. Inclusion criteria are a definite TSC diagnosis and an age below four months at enrolment. …”
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Epigenetic «probes» for lung cancer monitoring: LINE-1 methylation pattern in blood- circulating DNA by A. A. Ponomaryova, Е. Y. Rykova, N. V. Cherdyntseva, A. A. Bondar, A. Y. Dobrodeev, A. A. Zavyalov, S. A. Tuzikov, L. O. Bryzgalov, T. I. Merkulova, V. V. Vlassov, P. P. Laktionov

“…The composition of circulating DNA (cirDNA) from plasma and cell-surface-bound circulating DNA (csb- cirDNA) was shown earlier to be altered in the blood of cancer patients due to accumulation of tumor- specific aberrantly methylated DNA fragments, which are currently considered valuable cancer markers. …”
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