Optimizing the dose-averaged linear energy transfer for the dominant intraprostatic lesions in high-risk localized prostate cancer patients by Bo Zhao, Nobuyuki Kanematsu, Shuri Aoki, Shinichiro Mori, Hideyuki Mizuno, Takamitsu Masuda, Hideyuki Takei, Hitoshi Ishikawa

“…This investigation demonstrated its superiority in delivering LETd boost without depending on tumor location and volume across different cases.…”
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Changes in Uterine Cancer Incidence Rates in Egypt by Saad Alshahrani, Amr S. Soliman, Ahmed Hablas, Mohamed Ramadan, Jane L. Meza, Steven Remmenga, Ibrahim A. Seifeldein, Robert M. Chamberlain

“…The data included age, marital status, number of children, residence, smoking, occupation, date and basis of diagnosis, tumor topography, morphology, stage and grade, and treatment. …”
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Multidisciplinary approach to the treatment of a patient with juxtarenal abdominal aortic aneurysm and renal cell cancer by A. V. Chupin, N. R. Masalimov, T. P. Baitman, A. A. Gritskevich, V. A. Kulbak, I. V. Miroshkina, E. V. Kondratyev, Ya. A. Stepanova, I. E. Timina

“…Currently, strategies for the management of tumor diseases of the urinary tract in combination with cardiovascular pathologies are controversial. …”
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Lonicera caerulea polyphenols inhibit fat absorption by regulating Nrf2-ARE pathway mediated epithelial barrier dysfunction and special microbiota by Yuehua Wang, Ningxuan Gao, Andrea Nieto-Veloza, Lingxi Zhou, Xiyun Sun, Xu Si, Jinlong Tian, Yang Lin, Xinyao Jiao, Bin Li

“…LCP also inhibited the dysfunction of the small intestine epithelial barrier, via alleviating the oxidative stress activated by Nrf2-ARE pathway, and by modulating the expressions of pro-inflammatory factors such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), cyclooxygenase-2 (COX-2), nuclear factor kappa-B p65 (NF-κB p65) and inducible nitric oxide synthase (iNOS) in the small intestine. …”
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Preoperative liquid biopsy transcriptomic panel for risk assessment of lymph node metastasis in T1 gastric cancer by Ping’an Ding, Jiaxiang Wu, Haotian Wu, Wenqian Ma, Tongkun Li, Peigang Yang, Honghai Guo, Yuan Tian, Jiaxuan Yang, Limian Er, Renjun Gu, Lilong Zhang, Ning Meng, Xiaolong Li, Zhenjiang Guo, Lingjiao Meng, Qun Zhao

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A novel approach to regulate glucose uptake in an anaplastic thyroid cancer cell line by Shabnam Heydarzadeh, Ali Asghar Moshtaghie, Maryam Daneshpour, Mehdi Hedayati

“…Altogether, these results suggest that the glucose pathway may be an essential target for therapeutic intervention to sensitize tumor cells to the cell death process by inhibition of glucose transporters. …”
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Protective Effects of Thalidomide on High-Glucose-Induced Podocyte Injury through In Vitro Modulation of Macrophage M1/M2 Differentiation by Hui Liao, Yuanping Li, Xilan Zhang, Xiaoyun Zhao, Dan Zheng, Dayue Shen, Rongshan Li

“…The present study explored the effects of Tha on mRNA and protein expressions of inducible nitric oxide synthase (iNOS), tumor necrosis factor- (TNF-) α, mannose receptor (CD206), and arginase- (Arg-) 1 in HG-activated macrophages. iNOS and TNF-α are established as markers of classically activated macrophage (M1). …”
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MicroRNA Regulation of Endothelial Junction Proteins and Clinical Consequence by Yugang Zhuang, Hu Peng, Victoria Mastej, Weiguo Chen

“…These regulations directly affect VE-cadherin-β-catenin complex stability and further affect embryo and tumor angiogenesis, vascular development, and so forth. miR-155 and miR-126 have been shown to regulate PECAM-1 and affect neutrophil rolling and EC junction integrity. …”
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Application of ATR-FTIR spectroscopy and multivariate statistical analysis in cancer diagnosis by Ao Song, Wanli Yang, Jun Wang, Yisa Cai, Lizheng Cai, Nan Pang, Ruihua Yu, Zhikun Liu, Chao Yang, Feng Jiang

“…Lung cancer is one of the most prevalent and lethal malignant tumors worldwide. Currently, clinical diagnosis primarily relies on chest X-ray examinations, histopathological analysis, and the detection of tumor markers in blood. …”
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Therapeutic Implications of PPARγ in Human Osteosarcoma by Eric R. Wagner, Bai-Cheng He, Liang Chen, Guo-Wei Zuo, Wenli Zhang, Qiong Shi, Qing Luo, Xiaoji Luo, Bo Liu, Jinyong Luo, Farbod Rastegar, Connie J. He, Yawen Hu, Barrett Boody, Hue H. Luu, Tong-Chuan He, Zhong-Liang Deng, Rex C. Haydon

“…Although dysregulation of tumor suppressor genes and oncogenes, such as Rb, p53, and the genes critical to cell cycle control, genetic stability, and apoptosis have been identified in OS, consensus genetic changes that lead to OS development are poorly understood. …”
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Thymus ad astra, or spaceflight-induced thymic involution by Wataru Muramatsu, Wataru Muramatsu, Maria Maryanovich, Maria Maryanovich, Maria Maryanovich, Taishin Akiyama, Taishin Akiyama, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis

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Morbilidad y mortalidad de la duodenopancreatectomía cefálica convencional en pacientes con enfermedad del confluente biliopancreático by José Alejandro Gutiérrez Aguller, Danilo Romaguera Barroso, Zenén Rodríguez Fernández, Oriol Valón Costa, Ana Lubín García, Lázaro Ibrahim Romero García

“…Se investigaron las variables: estadificación según clasificación tumor, linfonódulo, metástasis (TNM), diagnóstico anatomopatológico, complicaciones, tiempo quirúrgico y estado al egreso. …”
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SURGICAL TREATMENT OF PATIENTS WITH RESECTABLE NON SMALL CELL LUNG CANCER by K. I. Kolbanov, A. Kh. Trakhtenberg, O. V. Pikin, V. A. Glushko, A. B. Ryabov

“…Additional adverse prognostic factor in patients with N0 is adenogenous and macrocellular morphological type of cancer, at N1 - T4 tumors and macrocellular carcinoma, and N2 - Metastasis in some or all areas of the mediastinum and the volume of surgery - bilobectomy.…”
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A High-Salt Diet Disturbs the Development and Function of Natural Killer Cells in Mice by Xiaokang Zeng, Yan Li, Weibiao Lv, Xinhuai Dong, Chong Zeng, Liming Zeng, Zibo Wei, Xu Lin, Yanning Ma, Qiang Xiao

“…Moreover, it was also found that the ability of NK cells to secrete CD107a and IFN-γ in HSD-fed mice was decreased following stimulation with RMA-S and YAC-1 tumor cells. Finally, the underlying molecular mechanism was evaluated, and it was found that HSD increased the production of reactive oxygen species (ROS) by NK cells, while the expression of CD122 was decreased, suggesting that HSD downregulates CD122 expression in NK cells via ROS signaling, thereby reducing the responsiveness to IL-15 and ultimately inhibiting NK cell function. …”
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Tousled-like kinase loss confers PARP inhibitor resistance in BRCA1-mutated cancers by impeding non-homologous end joining repair by Min-ah Kim, Banseok Kim, Jihyeon Jeon, Jonghyun Lee, Hyeji Jang, Minjae Baek, Sang-Uk Seo, Dongkwan Shin, Anindya Dutta, Kyung Yong Lee

“…However, many tumor cells acquire resistance to PARPi, often by restoring HR in HRD cells through the inactivation of NHEJ. …”
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Selectively expressed RNA molecules as a versatile tool for functionalized cell targeting by Frederik Rastfeld, Marco Hoffmann, Sylvie Krüger, Patrick Bohn, Anne-Sophie Gribling-Burrer, Laura Wagner, Nils Hersch, Carina Stegmayr, Lukas Lövenich, Sven Gerlach, Daniel Köninger, Christina Hoffmann, Helene L. Walter, Dirk Wiedermann, Hajaani Manoharan, Gereon R. Fink, Rudolf Merkel, Heribert Bohlen, Redmond P. Smyth, Maria A. Rueger, Bernd Hoffmann

“…We effectively treat breast tumor cell clusters in mixed cell systems and shrink early U87 glioblastoma cell clusters in the brain of male mice without detectable side effects. …”
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Serum levels of oxidative stress, IL-8, and pepsinogen I/II ratio in Helicobacter pylori and gastric cancer patients: potential diagnostic biomarkers by Marwa Nasier-Hussain, Jaleel Najah Samanje, Khatere Mokhtari, Mohsen Nabi-Afjadi, Zeinab Fathi, Asieh Hoseini, Elham Bahreini

“…The findings were substantiated using various data analysis platforms such as Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN (The University of ALabama at Birmingham CANcer data analysis), cBioPortal, and TIMER (Tumor IMmune Estimation Resource). These parameters could serve as potential diagnostic biomarkers for screening and therapeutic interventions based on the cut-off values derived from ROC (receiver operating characteristic) curves for IL-8, PGI, PGII, and PGI/PGII across the three groups. …”
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Precise Detection of Gene Mutations in Fine-Needle Aspiration Specimens of the Papillary Thyroid Microcarcinoma Using Next-Generation Sequencing by Feng-xia Yu, Min-xia Hu, Han-xue Zhao, Li-juan Niu, Xue-yu Rong, Wei-hua Li, Qiang Zhu, Jian-ming Ying, Ning Lyu

“…There were no mutations found in TERT promoter or TP53. The tumor with a maximum diameter (Dmax) larger than 5 mm was shown to be significantly correlated with the BRAF mutation in a multivariate analysis (OR 5.52, 95% CI 1.51-26.42, P=0.033). …”
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Prognosis of patients with breast cancer who underwent breast-conserving surgery using a 3D-printed surgical guide after neoadjuvant chemotherapy by Ah Yoon Kim, Sae Byul Lee, Tae Kyung Yoo, Ji Sun Kim, Il Yong Chung, Hee Joung Kim, Jong Won Lee, Byung Ho Son, Jae Ho Jeong, Hee Jin Lee, Nam kug Kim, BeomSeok Ko

“…Personalized 3DP-BSG targeted tumors by tracking changes in breast and tumor anatomy on MRI before and after NACT. 203 patients with invasive breast cancer were enrolled in the study. …”
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Decreased Expression of Thyroglobulin and Sodium Iodide Symporter Genes in Hashimoto’s Thyroiditis by Anna Popławska-Kita, Beata Telejko, Katarzyna Siewko, Maria Kościuszko-Zdrodowska, Natalia Wawrusewicz-Kurylonek, Adam Krętowski, Justyna Hryniewicka, Janusz Dzięcioł, Witold Bauer, Robert Milewski, Małgorzata Szelachowska, Maria Górska

“…The aim of the study was to compare the expression of sodium iodide symporter (NIS), thyroglobulin (Tg), tumor necrosis factor-α (TNFα), and interleukin-1β genes in patients with Hashimoto’s thyroiditis (HT) and healthy individuals. …”
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