Thyroid Hormone-Induced Cytosol-to-Nuclear Translocation of Rat Liver Nrf2 Is Dependent on Kupffer Cell Functioning by Luis A. Videla, Pamela Cornejo, Pamela Romanque, Catherine Santibáñez, Iván Castillo, Romina Vargas

“…Under these conditions, T3-induced tumor necrosis factor-α (TNF-α) response was eliminated by previous GdCl3 administration. …”
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Nomograms Predicting Survival, Recurrence and Beneficiary Identification of Adjuvant Chemotherapy in Treatment-naïve Patients with Rectal Cancer who Underwent Upfront Curative Rese... by Yukihide Kanemitsu, MD, Tomofumi Uotani, MD, Shunsuke Tsukamoto, PhD, Hideki Ueno, PhD, Megumi Ishiguro, PhD, Soichiro Ishihara, PhD, Koji Komori, PhD, Kenichi Sugihara, PhD, Study Group for Nomogram of the Japanese Society for Cancer of the Colon and Rectum

“…In the training cohort, age predicted survival, venous invasion predicted recurrence, and sex, tumor location, histological type, preoperative carcinoembryonic antigen, invasion depth, lymphatic invasion, positive radial margin, and numbers of metastatic nodes and examined nodes predicted both. …”
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Systematic review and meta-analysis of the impact of abnormal expression of long non coding RNA on the prognosis of acute myeloid leukemia by Guihong Liu, Liangliang Sun, Peng Lv, Rong Qiao, Lihang Wang, Arong Jin

“…ObjectiveLong non-coding RNA (lncRNA) is aberrantly expressed in a variety of tumor diseases. To date, its specific role in acute myeloid leukemia (AML) has not been fully elucidated. …”
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Composition analysis and mechanism of Guizhi Fuling capsule in anti-cisplatin-resistant ovarian cancer by Lei Dou, Yan Yan, Enting Lu, Fangmei Li, Dongli Tian, Lei Deng, Xue Zhang, Rongjin Zhang, Yin Li, Yi Zhang, Ye Sun

“…Then, LC-MS/MS analysis of GFC chemical composition. qRT-PCR, scratch tests, transwell, pseudopodium formation, immunofluorescence, and western blotting were used to explore the mechanism by which GFC inhibited A2780/DDP cell migration and invasion. Finally, the anti-tumor efficacy of GFC was verified by in vivo experiments. …”
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Complicaciones en la cirugía ginecológica by Sara Amneris Urgellés Carreras, Maritza Álvarez Fiallo, Vilvia Ramos Zamora, Enrique Reyes Guerrero, Odalys Acosta León

“…Conclusiones: Las principales complicaciones de la cirugía ginecológica fueron el íleo paralítico y el absceso de la cúpula, las complicaciones se presentaron fundamentalmente en pacientes operadas por mioma uterino y tumor de ovario. De acuerdo con el tipo de operación, ocurrieron en pacientes operadas por histerectomía total abdominal con doble anexectomía y la histerectomía total abdominal sin anexectomía, y las comorbilidades más frecuentes fueron la obesidad y la asociación de comorbilidad.…”
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Low Systemic Inflammation Response Index Predicts Good Prognosis in Locally Advanced Pancreatic Carcinoma Patients Treated with Concurrent Chemoradiotherapy by Erkan Topkan, Huseyin Mertsoylu, Ahmet Kucuk, Ali Ayberk Besen, Ahmet Sezer, Duygu Sezen, Yasemin Bolukbasi, Ugur Selek, Berrin Pehlivan

“…Pretreatment SIRI is a novel independent prognosticator that may further enhance the conventional tumor-node-metastases staging system in a more precise prediction of the OS and PFS outcomes of LAPC patients after radical CRT.…”
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Preclinical evaluation of avutometinib and defactinib in high‐grade endometrioid endometrial cancer by Tobias Max Philipp Hartwich, Miranda Mansolf, Cem Demirkiran, Michelle Greenman, Stefania Bellone, Blair McNamara, Shuvro P. Nandi, Ludmil B. Alexandrov, Yang Yang‐Hartwich, Silvia Coma, Jonathan Pachter, Alessandro D. Santin

“…Abstract Background High‐grade endometrial cancers (EAC) are aggressive tumors with a high risk of progression after treatment. …”
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HGF-Modified Dental Pulp Stem Cells Mitigate the Inflammatory and Fibrotic Responses in Paraquat-Induced Acute Respiratory Distress Syndrome by Panpan Geng, Yuning Zhang, Huan Zhang, Xiwen Dong, Yuefeng Yang, XiaoNa Zhu, Chu-Tse Wu, Hua Wang

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Gingival Anaplastic Large-Cell Lymphoma Mimicking Hyperplastic Benignancy as the First Clinical Manifestation of AIDS: A Case Report and Review of the Literature by Rafaela Elvira Rozza-de-Menezes, Stefânia Jeronimo Ferreira, Diogo Lenzi Capella, Stephan Schwartz, Ana Helena Willrich, Lúcia de Noronha, Aline Cristina Batista Rodrigues Johann, Paulo Henrique Couto Souza

“…An excisional biopsy was performed, and large pleomorphic cells with an abundant cytoplasm, sometimes containing prominent nucleoli and “Hallmark” cells, were observed through hematoxylin and eosin staining. The tumor cells showed strong CD30 expression, EMA, Ki-67, and LCA, and negative stain for p80NPM/ALK, CKAE1/AE3, CD20, CD3, CD56, and CD15. …”
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Therapeutic drug monitoring and neutralizing anti-drug antibody detection to optimize TNF-alpha inhibitor treatment for uveitis by Howard C. Chen, Jenny Shunyakova, Amit K. Reddy, Srujay Pandiri, Lynn Hassman

“…Here, we investigated the use of therapeutic drug monitoring and neutralizing anti-drug antibody detection as a strategy to optimize tumor necrosis factor (TNF)-alpha inhibitor treatment in patients who have a suboptimal response to the initial dosing of adalimumab.MethodRetrospective cohort study performed in two tertiary referral uveitis services in the United States between 2015 to 2023. …”
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The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen proline hydroxylation and favoring T lymphocyte infiltration by Chiara Cencioni, Silvia Malatesta, Virginia Vigiano Benedetti, Valerio Licursi, Livia Perfetto, Federica Conte, Danilo Ranieri, Armando Bartolazzi, Martina Kunkl, Loretta Tuosto, Alberto Larghi, Geny Piro, Antonio Agostini, Giampaolo Tortora, Vincenzo Corbo, Carmine Carbone, Francesco Spallotta

“…Noteworthy, semaglutide, an incretin agonist, prevents the higher dysmetabolism-dependent PDAC stromal deposition and allows T lymphocyte infiltration, reducing tumor development. Conclusions These results shed light on novel therapeutic options for PDAC patients with metabolic syndrome aimed at PDAC stroma reshape.…”
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Dietary Nigella sativa nanoparticles enhance broiler growth performance, antioxidant capacity, immunity, gene expression modulation, and cecal microbiota during high ambient temper... by Ahmed M. Elbaz, Eman S. Ashmawy, M. A. A. Farahat, Ahmed Abdel‑Maksoud, Shimaa A. Amin, Zangabel S. Mohamed

“…Furthermore, Nano-NS supplementation significantly increased (P < 0.05) serum immunoglobulin (IgG and IgA), and superoxide dismutase (SOD) levels, while decreasing malondialdehyde (MDA), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) concentration. …”
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The Treatment Effect of Plantago Major on Lung Cancer Based on the Computed Tomography and Pathological Findings: A Case Report Study by Saade Abdalkareem Jasim, Bashar Mudhaffar Abdullah, Patricio Yánez-Moretta, Wesam R. Kadhum, Yasser Fakri Mustafa, Enas R. Alwaily, Munther Abosoda, Ali Alsalamy, Sada Ghalib Al-Musawi, Alaa A. Omran

“…Results: The volume of the tumor was reduced by about 62% (based on CT imaging findings) after the treatment with PM. …”
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The diagnostic value of cytology in the mammary intraductal lesions of patients with pathological nipple discharge by Yifei Zeng, Jifeng Li, Dongxiao Zhang, Na Fu, Yu Zhou, Yubo Guo, Min Liu, Hongkai Zhang, Jianchun Cui

“…There were 22 breast malignant tumors, 75 intraductal papillomas and 22 non-tumorous lesions among the 119 PND patients. …”
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Blood Cell Ratio Combinations for Diagnosing Periprosthetic Joint Infections: A Preliminary Study by Yu Y, Wen Y, Xia J, Dong G, Niu Y

“…Yali Yu,1 Yanan Wen,2 Jiaxuan Xia,3 Guixiang Dong,1 Yanli Niu4 1Department of Clinical Laboratory, Zhengzhou Orthopaedic Hospital, Zhengzhou, People’s Republic of China; 2Department of Blood Transfusion, Huaihe Hospital, Henan University, Kaifeng, People’s Republic of China; 3School of Mathematics and Statistic, Henan University, Kaifeng, People’s Republic of China; 4Laboratory of Cell Signal Transduction, Henan Provincial Engineering Centre for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng, People’s Republic of ChinaCorrespondence: Yanli Niu, School of Basic Medical Sciences, Henan University, Kaifeng, People’s Republic of China, Email nyl0925@henu.edu.cnBackground: Periprosthetic joint infection (PJI) is a serious complication following total joint arthroplasty (TJA), which requires prompt and accurate diagnosis for effective management. …”
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Anti-Inflammatory and Anti-Migratory Effects of Morin on Non-Small-Cell Lung Cancer Metastasis via Inhibition of NLRP3/MAPK Signaling Pathway by Punnida Arjsri, Kamonwan Srisawad, Sonthaya Umsumarng, Pilaiporn Thippraphan, Songyot Anuchapreeda, Pornngarm Dejkriengkraikul

“…High rates of metastasis contribute significantly to the poor prognosis of NSCLC, in which inflammation plays an important role by enhancing tumor growth, angiogenesis, and metastasis. Targeting inflammatory pathways within cancer cells may thus represent a promising strategy for inhibiting NSCLC metastasis. …”
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Human Leukocyte Antigen Class I and II Alleles and Overall Survival in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma by Yani Lu, Amr M. Abdou, James R. Cerhan, Lindsay M. Morton, Richard K. Severson, Scott Davis, Wendy Cozen, Nathaniel Rothman, Leslie Bernstein, Stephen Chanock, Patricia Hartge, Sophia S. Wang

“…Genetic variation in the 6p21 chromosomal region, including human leukocyte antigen (HLA) genes and tumor necrosis factor (TNF), has been linked to both etiology and clinical outcomes of lymphomas. …”
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Complement factor H targeting antibody GT103 in refractory non-small cell lung cancer: a phase 1b dose escalation trial by Jeffrey M. Clarke, George R. Simon, Hirva Mamdani, Lin Gu, James E. Herndon, Thomas E. Stinchcombe, Neal Ready, Jeffrey Crawford, Guru Sonpavde, Stephen Balevic, Andrew B. Nixon, Michael Campa, Elizabeth B. Gottlin, Huihua Li, Ruchi Saxena, You Wen He, Scott Antonia, Edward F. Patz

“…Abstract GT103 is a first-in-class, fully human, IgG3 monoclonal antibody targeting complement factor H that kills tumor cells and promotes anti-cancer immunity in preclinical models. …”
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Most oncological pancreas resections must consider the mesopancreas by S. A. Safi, S. David, L. Haeberle, S. Vaghiri, T. Luedde, C. Roderburg, I. Esposito, G. Fluegen, W. T. Knoefel

“…Conclusion These important findings clearly show underestimated tumor extensions into the mesopancreas even in localized, primary resectable PDAC patients who are currently amenable for upfront resection. …”
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Testicular Cancer Presenting as Gastric Variceal Hemorrhage by Carlos Eduardo Salazar-Mejía, David Hernández-Barajas, Edio Llerena-Hernández, José Luis González-Vela, María Inés Contreras-Salcido, Adriana González-Gutiérrez, Omar David Borjas-Almaguer, Luis Alberto Pérez-Arredondo, Blanca Otilia Wimer-Castillo

“…The symptomatology caused by this tumor varies according to the site of metastasis. …”
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