Mechanism of <italic>Hedyotis Diffusa</italic> in Treatment of Osteosarcoma based on Network Pharmacology and Molecular Docking by Qin LIU, Xinwei DUAN, Xihai LI

“…After topology analysis to PPI, the eight core genes that indicate a close interaction were estrogen receptor 1(ESR1), JUN, and RAC-alpha serine/threonine-protein kinase(AKT1), G1/S-specific cyclin-D1(CCND1), FOS, mitogen-activated protein kinase 1(MAPK1), cellular tumor antigen p53(TP53)and MYC. The 2, 037 results of biological process(BP), 39 results of cellular components(CC)and 129 results of molecular function(MF)together constituted 2, 205 results of GO enrichment analysis with <italic>P</italic>&lt;0.05. …”
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Enhancing growing rabbit heat stress resilience through dietary supplementation with natural antioxidants by Ibrahim Talat El-Ratel, Aml Mekawy, Sara H.M. Hassab, Sameh Abdelnour

“…The serum Immunoglobulin G (IgG) was significantly increased, while tumor necrosis factor alpha (TNF-α), interleukin-4 (IL-4), and interferon gamma (IFN-γ) were decreased by all feed additives (P < 0.05). …”
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Artificial neural network systems to predict the response to sintilimab in squamous-cell non-small-cell lung cancer based on data of ORIENT-3 study by Tongji Xie, Guangyu Fan, Le Tang, Puyuan Xing, Yuankai Shi

“…The mechanism exploration on the spatial level indicated that patients with better response to immunotherapy had fewer clusters of both tumor and cytotoxicity T cell spots. Interpretation The four ANN systems showed high accuracy, robustness and stability in predicting the response to sintilimab for patients with sqNSCLC.…”
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Prognosis conferred by molecular features of appendix-derived Pseudomyxoma Peritonei by Ruiqing Ma, Guojun Li, Yingjiang Ye, Lei Liang, Chong Wang, Haipeng Zhou, Pu Zhang, Lubiao An, Guanjun Shi, Qian Chen, Hongbin Xu, Zhidong Gao

“…MUC16-mutated patients had worse PFS (P = 0.016) and OS (P = 0.004) compared to wild-type patients. Patients with tumor mutational burden (TMB) > 1(P = 0.026) or alterations in TP53 (P = 0.006) or SMAD4 (P = 0.013) had significantly worse OS compared to those with a TMB < 1 or normal genes. …”
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Anti-Inflammatory, Antioxidant and Antibacterial Properties of Tomato Skin and Pomegranate Peel Extracts: A Sustainable Approach for Oral Health Care by Alessia Silla, Angela Punzo, Francesca Bonvicini, Matteo Perillo, Marco Malaguti, Antonello Lorenzini, Ismaela Foltran, Dario Mercatante, Mara Mandrioli, Maria Teresa Rodriguez-Estrada, Silvana Hrelia, Cristiana Caliceti

“…Additionally, the extracts significantly reduced the expression of tumor necrosis factor α (<i>p</i> < 0.05) and Monocyte Chemoattractant Protein 1 (<i>p</i> < 0.001), suggesting an anti-inflammatory role. …”
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Branched-chain fatty acids from goat milk alleviate ulcerative colitis via the TLR4/NF-κB/NLRP3 pathway by Jiaxin Zhang, Jinjing Zhong, Zhengying Cui, Yu Shen, Yaping Zheng, Yu Zhang, Chaoxin Man, Yanmei Hou, Qianyu Zhao, Yujun Jiang

“…These data also show that BCFAs can down-regulate the gene and protein expression of the toll-like receptor 4 (TLR4)/ nuclear factor κB p65 (NF-κB p65)/NOD-like receptor thermal protein domain associated protein 3 (NLRP3) signaling pathway, and at the same time significantly reduce the expression of pro-inflammatory factors tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and IL-18 in colon tissue, and significantly increase the expression of the anti-inflammatory factor IL-10. …”
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Molecular Programming Design of Glyconucleic Acid Aptamer with High Stability by Yongqi Han, Rongjun Zhang, Hong‐Liang Bao, Mei Yang, Yuan Gao, Xiaobo Gao, Ruowen Wang, Weihong Tan, Ding‐Kun Ji

“…Moreover, it is confirmed that this approach displays insignificant effects on the DNA aptamers’ tumor‐targeting ability and metabolism in vivo. This method offers a simple, economical, and efficient strategy for precise glycosylation modification of nucleic acids. …”
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FLOT Neoadjuvant Chemotherapy Followed by Laparoscopic D2 Gastrectomy in the Treatment of Locally Resectable Advanced Gastric Cancer by Shun Zhang, Dongyi Yan, Qi Sun, Tao Du, Dongliang Cao, Yao Yang, Biao Yuan, Haiqiang Li, Xiaohua Jiang, Chun Song

“…The type of surgical procedure was determined by the location and extent of the primary tumor. Results. 23 patients were reviewed in the study. 20 patients (81.2%) received four courses of FOLT therapy, while 3 patients (18.8%) received three courses of treatment. …”
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Food nutrition and toxicology targeting on specific organs in the era of single-cell sequencing by Xiaofei Wang, Xiaowen Cheng, Huiling Liu, Xiaohuan Mu, Hao Zheng

“…ScRNA-seq applications has been summarized on three typical organs (brain, liver, kidney), and two representative immune- and tumor related health problems. The ever-increasing role of scRNA-seq in dietary food research with further improvement can provide sub-cellular information and the coupling between other cellular modalities. …”
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A Nomogram Built on Clinical Factors and CT Attenuation Scores for Predicting Treatment Response of Acute Myeloid Leukemia Patients by Linna Liu, Wenzheng Lu, Li Xiong, Han Qi, Robert Peter Gale, Bin Yin

“…Clinical biomarkers of tumor burden were also collected. Patients were classified into two groups based on treatment response: complete remission (CR; <i>n</i> = 24) and non-complete remission (NCR; <i>n</i> = 50). …”
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CircCCT2/miR-146a-5p/IRAK1 axis promotes the development of head and neck squamous cell carcinoma by Long He, Lanruo Li, Liting Zhao, Xiaoya Guan, Yujia Guo, Qi Han, Huina Guo, Hongliang Liu, Chunming Zhang

“…CCK-8 and colony formation assays were performed to determine cell proliferation, and Transwell assays were used to determine migration and invasion. A xenograft tumor model was used to study the influence of circCCT2 on HNSCC in vivo. …”
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A Mitochondria‐Related Signature in Diffuse Large B‐Cell Lymphoma: Prognosis, Immune and Therapeutic Features by Zhen‐Zhong Zhou, Jia‐Chen Lu, Song‐Bin Guo, Xiao‐Peng Tian, Hai‐Long Li, Hui Zhou, Wei‐Juan Huang

“…Conclusions We established a novel prognostic mitochondria‐related signature by machine learning algorithm, which also demonstrated outstanding predictive value in tumor microenvironment and responses to therapies.…”
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Synthesis and Evaluation of Cytotoxic Activity of RuCp(II) Complexes Bearing (Iso)nicotinic Acid Based Ligands by Bárbara Marques, Diogo M. Engrácia, João Franco Machado, Jaime A. S. Coelho, Filipa Mendes, Tânia S. Morais

“…Stability studies confirmed the robustness of both complexes in biological media, with compound 1 maintaining good stability in buffer solutions mimicking physiological (pH 7.4) and tumor-like (pH 6.8) environments. The cytotoxicity of the complexes was evaluated in vitro in several human cancer cell lines, namely melanoma (A375), alveolar adenocarcinoma (A549), epidermoid carcinoma (A431), and breast cancer (MDA-MB 231). …”
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Optimized chelator and nanoparticle strategies for high-activity 103Pd-loaded biodegradable brachytherapy seeds by Emanuel Sporer, Claire Deville, Natan J. W. Straathof, Linda M. Bruun, Ulli Köster, Mikael Jensen, Thomas L. Andresen, Paul J. Kempen, Jonas R. Henriksen, Andreas I. Jensen

“…Current BT relies on the placement of large sources of radioactivity at the tumor site, requiring applicators that may cause local traumas and lesions. …”
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Metastatic Uterine Leiomyosarcoma in the Upper Buccal Gingiva Misdiagnosed as an Epulis by Andrea Cassoni, Valentina Terenzi, Davina Bartoli, Oriana Rajabtork Zadeh, Andrea Battisti, Mario Pagnoni, Davide Conte, Alessandro Lembo, Sandro Bosco, Francesco Alesini, Valentino Valentini

“…Uterine leiomyosarcoma (LMS) is a rare tumor constituting 1% of all uterine malignancies. …”
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Urine proteomics defines an immune checkpoint-associated nephritis signature by Cassian Yee, Jamie S Lin, James P Long, Shailbala Singh, Yanlan Dong

“…Pathway analyses highlighted the involvement of JAK-STAT and tumor necrosis factor (TNF) signaling in ICI-AIN pathogenesis. …”
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Janus kinase inhibitor treatment for inflammatory diseases: excess or no excess risk of venous thromboembolism? by Yachar Dawudi, Samuel Benarroch, Hélène Helfer, David M. Smadja, Isabelle Mahé

“…An increased risk of VTEs was also observed in the ORAL Surveillance study, a randomized, noninferiority, postmarketing phase IV safety study comparing tofacitinib with anti-tumor necrosis factor in patients with rheumatoid arthritis. …”
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MiR-125b-5p ameliorates ox-LDL-induced vascular endothelial cell dysfunction by negatively regulating TNFSF4/TLR4/NF-κB signaling by Wenshuai He, Limin Zhao, Pengfei Wang, Maojia Ren, Yunfei Han

“…Results Our investigation revealed that exposure to ox-LDL led to a downregulation in miR-125b-5p, while upregulating the expression of tumor necrosis factor (ligand) superfamily, member 4 (TNFSF4), TLR4, p-p65 and p-IkBa in HUVECs in a dose-dependent manner. …”
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ATF3 Knockdown Exacerbates Astrocyte Activation by Inhibiting Phosphorylation of Drp1 in Ischemic Stroke by Huang R, Huang X, Yang H, Wu H, Liu F, Saw PE, Cao M

“…Rong Huang,1 Xiaoyan Huang,1 Hongmei Yang,1 Haixuan Wu,1 Fan Liu,1 Phei Er Saw,2,3 Minghui Cao1,4 1Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 2Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 3Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 4Department of Anesthesiology, Shenshan Medical Center, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Shanwei, 516600, People’s Republic of ChinaCorrespondence: Phei Er Saw; Minghui Cao, Email caipeie@mail.sysu.edu.cn; caomh@mail.sysu.edu.cnIntroduction: ATF3, a stress-induced transcription factor, has been implicated in the injury processes of various cell types, including neurons. …”
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Expression of angiotensin converting enzyme 2 in patients with oral squamous cell carcinoma by Shivani Sivasakthivel, Pratibha Ramani, Selvaraj Jayaraman

“…Fresh tissue samples were collected from the primary tumor areas of OSCC patients and healthy tissue samples from patients who had tooth extraction, and both tissues were stored at −80 °C. …”
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