Mitochondrial KMT9 methylates DLAT to control pyruvate dehydrogenase activity and prostate cancer growth by Yanhan Jia, Sheng Wang, Sylvia Urban, Judith M. Müller, Manuela Sum, Qing Wang, Helena Bauer, Uwe Schulte, Heike Rampelt, Nikolaus Pfanner, Katrin M. Schüle, Axel Imhof, Ignasi Forné, Christopher Berlin, August Sigle, Christian Gratzke, Holger Greschik, Eric Metzger, Roland Schüle

“…KMT9 is localized in mitochondria of PCa cells, but not in mitochondria of other tumor cell types. Mitochondrial KMT9 regulates PDC activity by monomethylation of its subunit dihydrolipoamide transacetylase (DLAT) at lysine 596. …”
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Radical Scavenging Activity-Based and AP-1-Targeted Anti-Inflammatory Effects of Lutein in Macrophage-Like and Skin Keratinocytic Cells by Jueun Oh, Ji Hye Kim, Jae Gwang Park, Young-Su Yi, Kye Won Park, Ho Sik Rho, Min-Seuk Lee, Jae Won Yoo, Seung-Hyun Kang, Yong Deog Hong, Song Seok Shin, Jae Youl Cho

“…Lutein significantly reduced several skin inflammatory responses, including increased expression of interleukin-(IL-) 6 from LPS-treated macrophages, upregulation of cyclooxygenase-(COX-) 2 from interferon-γ/tumor necrosis-factor-(TNF-) α-treated HaCaT cells, and the enhancement of matrix-metallopeptidase-(MMP-) 9 level in UV-irradiated keratinocytes. …”
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Loading monocytes with magnetic nanoparticles enables their magnetic control without toxicity by Laura Mödl, Laura Mödl, Lucas R. Carnell, Rene Stein, Andrea Kerpes, Felix Pfister, Barbara Wirthl, Wolfgang A. Wall, Christoph Alexiou, Christina Janko

“…This principle can be used to make monocytes magnetically steerable in order to improve tumor accumulation, e.g., for immunotherapy with chimeric antigen receptor (CAR) monocytes. …”
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Systematic review and bayesian network meta-analysis: comparative efficacy and safety of six commonly used biologic therapies for moderate-to-severe Crohn’s disease by Haohang Su, Haohang Su, Shengwei Xiao, Zhiqing Liang, Zhiqing Liang, Tianrong Xun, Jinfang Zhang, Jinfang Zhang, Xixiao Yang, Xixiao Yang

“…Infliximab combined with azathioprine was most effective for inducing clinical response in TNF (tumor necrosis factor) antagonist-naïve patients. …”
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Aberrant Expression of JAM2 Inhibits Invasion and Migration in Lung Adenocarcinoma by Jun Chen, Yuan Cui, Zhimeng Chen, Hao Ding, Chang Li, Sheng Ju, Cheng Ding, Chun Xu, Jun Zhao, Xin Tong

“…JAM2, a member of the Junctional adhesion molecule (JAM) family, plays diverse roles in cell–cell contacts and tumor development. Although JAM2's expression and functions have been reported in various cancers, its clinical and biological significance in LUAD remains unclear. …”
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A Case of Solitary Necrotic Nodule Treated with Laparoscopic Hepatectomy: Spontaneous Regression of Hepatocellular Carcinoma? by Hirokazu Tomishige, Zenichi Morise, Yoshikazu Mizoguchi, Norihiko Kawabe, Hidetoshi Nagata, Hisanori Ohshima, Jin Kawase, Satoshi Arakawa, Rie Yoshida, Masashi Isetani

“…Since the possibility of malignant tumor with necrotic change could not be ruled out, she underwent laparoscopic anatomical segmentectomy of the liver. …”
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Targeting ATAD3A Phosphorylation Mediated by TBK1 Ameliorates Senescence‐Associated Pathologies by Yujiao He, Yanchen Liu, Mingyue Zheng, Yuxiu Zou, Mujie Huang, Linsheng Wang, Ge Gao, Zhongjun Zhou, Guoxiang Jin

“…A blocking peptide, TAT‐PEP, specifically abrogating ATAD3A phosphorylation, results in elevated cell death by preventing doxorubicin‐induced senescence, thus leading to enhanced tumor sensitivity to chemotherapy. TAT‐PEP treatment also ameliorates various phenotypes associated with physiological aging. …”
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Validation of hyperthermia as an enhancer of chemotherapeutic efficacy: insights from a bladder cancer organoid model by Ying Xu, Guoliang Sun, Tiantian Yang, Huaibiao Li, Poyi Hu, Wanru Luo, Tingke Zhang, Haoran Liu, Guoyi Chen, Zhangqun Ye, Yuqing Wu, Jie Yu, Wanyi Chen, Kai Zhao, Chunyan Liu, Huiping Zhang

“…Objective This study aimed to evaluate the combined efficacy of hyperthermia and chemotherapy using a bladder cancer organoid model and to explore hyperthermia-related molecular pathways.Method Tumor organoids were generated by embedding RT4 bladder cancer cells into Matrigel. …”
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Aggregation control of anionic pentamethine cyanine enabling excitation wavelength selective NIR-II fluorescence imaging-guided photodynamic therapy by Yibin Li, Fei Qu, Fang Wan, Cheng Zhong, Jingyi Rao, Yijing Liu, Zhen Li, Jintao Zhu, Zhong’an Li

“…As a result, excitation wavelength selective NIR-II fluorescence imaging-guided PDT has been successfully demonstrated for tumor diagnosis and therapeutics of female mice.…”
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Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2 by Chrystian Junqueira Alves, Theodore Hannah, Sita Sadia, Christy Kolsteeg, Angela Dixon, Robert J. Wiener, Ha Nguyen, Murray J. Tipping, Júlia Silva Ladeira, Paula Fernandes da Costa Franklin, Nathália de Paula Dutra de Nigro, Rodrigo Alves Dias, Priscila V. Zabala Capriles, José P. Rodrigues Furtado de Mendonça, Paul A. Slesinger, Kevin D. Costa, Hongyan Zou, Roland H. Friedel

“…Abstract Glioblastoma (GBM) is a malignant brain tumor with diffuse infiltration. Here, we demonstrate how GBM cells usurp guidance receptor Plexin-B2 for confined migration through restricted space. …”
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Downregulated mRNA Expression of ZNF385B Is an Independent Predictor of Breast Cancer by Ning Yan, Cong Liu, Fang Tian, Ling Wang, Yimin Wang, Zhaoying Yang, Yan Jiao, Miao He

“…Although numerous studies have demonstrated the potential function of zinc finger proteins in tumor progression, the effects of ZNF385B in breast cancer (BC) are less studied. …”
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Treatment and Outcomes of Pancreatic Cancer in Armenia: A Retrospective Study From Resource-Limited Settings by Elen Baloyan, Davit Zohrabyan, Liana Safaryan, Armen Avagyan, Lilit Harutyunyan, Vardan Bardakhchyan, Jemma Arakelyan, Amalya Sargsyan, Martin Harutyunyan, Mariam Mailyan, Gevorg Tamamyan, Samvel Bardakhchyan

“…The main independent prognostic factor for overall survival (OS) was the TNM stage, whereas grade of the tumor was not significant. The median OS was 11 months (range, 2-169 months): In stages I-III, patients who had surgery (44.4%) lived significantly longer than those who did not (20 v 11 months; P = .008). …”
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Nicotinamide Mononucleotide Restores NAD⁺ Levels to Alleviate LPS-Induced Inflammation via the TLR4/NF-κB/MAPK Signaling Pathway in Mice Granulosa Cells by Mehboob Ahmed, Umair Riaz, Haimiao Lv, Muhammad Amjad, Sohail Ahmed, Shaokat Ali, Muhammad Usman Ghani, Guohua Hua, Liguo Yang

“…The results of this experiment demonstrated that LPS had negative effects on GCs in term of reduced viability and proliferation rates and upregulated the production of pro-inflammatory cytokines, including interleukin-1 beta (IL-1β), interleukin-6 (IL-6), cyclooxygenase-2 (Cox-2), and tumor necrosis factor-alpha (TNF-α). Notably, the levels of NAD⁺ and NAD⁺/NADH ratio in GCs were reduced in response to inflammation. …”
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Multidimension Analysis of the Prognostic Value, Immune Regulatory Function, and ceRNA Network of LY6E in Individuals with Colorectal Cancer by Ting Li, Weidong Liu, Chun Wang, Man Wang, Wenjia Hui, Jiajie Lu, Feng Gao

“…LY6E is overexpressed in several tumor types, including CRC, and patients with high expression levels of LY6E have a poor prognosis. …”
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Case report: Selpercatinib in the treatment of RET fusion-positive advanced lung adenocarcinoma: a challenging clinical case by Raffaella Pagliaro, Raffaella Pagliaro, Paola Maria Medusa, Paola Maria Medusa, Fabiana Vitiello, Luigi Aronne, Luigi Aronne, Susan F. M. Campbell, Susan F. M. Campbell, Fabio Perrotta, Fabio Perrotta, Andrea Bianco, Andrea Bianco

“…The patient experienced a significant reduction in tumor burden and reported improved symptom control, with no significant adverse effects during the 21-month follow-up period.ConclusionsThis case highlights the efficacy and tolerability of selpercatinib in treating advanced lung adenocarcinoma with a RET fusion. …”
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Clinical outcomes and adverse events of Hedgehog pathway inhibitors for advanced basal cell carcinoma patients: A systematic review and meta-analysis by Suvijak Untaaveesup, Wichapol Dendumrongsup, Pornteera Srichana, Chanamon Pongphaew, Gynna Techataweewan, Kanmanee Viratkapan, Nichanant Nampipat, Ben Ponvilawan, Chayanis Kositamongkol, Walaiorn Pratchyapruit, Pochamana Phisalprapa

“…Treatment options include surgery, radiotherapy, and systemic therapies, but tumor location and prior interventions can limit these methods. …”
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Preoperative prediction of multiple biological characteristics in colorectal cancer using MRI and machine learning by Qiao-yi Huang, Hui-da Zheng, Bin Xiong, Qi-ming Huang, Kai Ye, Shu Lin, Jian-hua Xu

“…Alteration in molecular characteristic expression is closely related to tumor invasiveness and can serve a novel biomarker for predicting cancer prognosis. …”
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Mechanism of dexmedetomidine protection against cisplatin induced acute kidney injury in rats by Zeng-lu Zheng, Jun-wei Ma, Yi Luo, Gui-jin Liang, Shi-jie Lei, Ke-jin Yan, Hai-bing Meng, Xiu-juan Liu

“…In addition, four serum biochemical indices were measured: histopathological damage in rat kidneys was detected; levels of inflammatory factors, interleukin (IL)-1β, IL-18, IL-6, and tumor necrosis factor alpha, in kidney tissue homogenate of rats were assessed through enzyme-linked immunosorbent assay (ELISA); and levels of NLRP-3, caspase-1, cleaved caspase-1, gasdermin D (GSDMD), and GSDMD-N in kidney tissues of rats were determined via western blotting.Results Dex treatment reduced nephromegaly and serum clinical marker upregulation caused by CP-induced AKI. …”
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Short- and Long-term Outcomes of One-stage Radical Resection and Anastomosis without Preoperative Decompression and Diverting Stoma between Incomplete Obstructive and Non-obstructi... by Kentaro Sato, Yosuke Fukunaga, Manabu Takamatsu, Tatsuki Noguchi, Takashi Sakamoto, Shimpei Matsui, Toshiki Mukai, Tomohiro Yamaguchi, Takashi Akiyoshi

“…Incomplete obstruction was characterized by the inability of a small-caliber endoscope to pass through the tumor without necessitating emergency surgery or decompression due to bowel obstruction. …”
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Desmoid-type fibromatosis of the breast: a case report and literature review by Zijun Zhao, Qingyao Shang, Chenxuan Yang, Jiaxiang Liu, Shanqing Liu, Xiaoqian Li, Xiyu Kang, Jiaxian Yue, Xin Wang, Xiang Wang

“…Breast desmoid-type fibromatosis (BDF) is a rare tumor predominated by mesenchymal cells. It has a high recurrence rate, although distal metastasis is uncommon. …”
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