Oncolytic alphavirus-induced extracellular vesicles counteract the immunosuppressive effect of melanoma-derived extracellular vesicles by Darshak K. Bhatt, Annemarie Boerma, Silvina Odete Bustos, Andréia Hanada Otake, Alexis Germán Murillo Carrasco, Patrícia Pintor Reis, Roger Chammas, Toos Daemen, Luciana Nogueira de Sousa Andrade

“…Abstract Extracellular vesicles (EVs)-mediated communication by cancer cells contributes towards the pro-tumoral reprogramming of the tumor microenvironment. …”
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BRCA1 is involved in sustaining rapid antler growth possibly via balancing of the p53/endoplasmic reticulum stress signaling pathway by Qianqian Guo, Zhen Wang, Jiping Li, Chao Ma, Junjun Zheng, Hengxing Ba, Guokun Zhang, Chunyi Li

“…Interestingly deer antlers, arguably the fastest regenerating mammalian tissue, have not been reported, thus far, to grow malignant tumors. They provide a mammalian model to understand the possible mechanism by which rapid regeneration is achieved while avoiding the development of malignancies. …”
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Assessment of Treatment Outcomes and Associated Factors Among Pediatric Patients With Burkitt Lymphoma at Kenyatta National Hospital by Divya Kumari Toor, Amsalu Degu, Peter N. Karimi

“…Most patients had reduced tumor size and stable disease during the follow‐up period. …”
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Case report: A case report and literature review on the efficacy of high-dose aumolertinib combined intrathecal pemetrexed by Ommaya reservoir for EGFR-mutated NSCLC with leptomeni... by Maoxi Zhong, Maoxi Zhong, Maoxi Zhong, Li Zhou, Li Zhou, Li Zhou, Jing Guo, Jing Guo, Jing Guo, Chuan Chen, Chuan Chen, Chuan Chen, Wei Wang, Wei Wang, Wei Wang, Xiaoping Huang, Xiaoping Huang, Xiaoping Huang, Yi Liu, Yi Liu, Yi Liu

“…This also indicates that the tumor is highly malignant and aggressive, which brings great challenges to treatment. …”
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Highlights of Thirty-Year Experience of CO2 Laser Use at the Florence (Italy) Department of Dermatology by Piero Campolmi, Paolo Bonan, Giovanni Cannarozzo, Andrea Bassi, Nicola Bruscino, Meena Arunachalam, Michela Troiano, Torello Lotti, Silvia Moretti

“…The recurrence of viral lesions (condylomas and warts) have been not more frequent than those due to other techniques. Tumor recurrence is minor compared with radiotherapy or surgery. …”
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MicroRNA-21 as a Regulator of Cancer Stem Cell Properties in Oral Cancer by Milica Jaksic Karisik, Milos Lazarevic, Dijana Mitic, Maja Milosevic Markovic, Nicole Riberti, Drago Jelovac, Jelena Milasin

“…Oral squamous cell carcinoma (OSCC) is a highly aggressive malignancy with poor prognosis, mainly due to the presence of cancer stem cells (CSCs), a small subpopulation of cells that contribute to therapy resistance and tumor progression. The principal objective of this study was to investigate the role of miRNA-21 in the maintenance of cancer cell stemness and the possibility of altering it. …”
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A New Prognostic Risk Model Based on PPAR Pathway-Related Genes in Kidney Renal Clear Cell Carcinoma by Yingkun Xu, Xiunan Li, Yuqing Han, Zilong Wang, Chenglin Han, Ningke Ruan, Jianyi Li, Xiao Yu, Qinghua Xia, Guangzhen Wu

“…There is a clear correlation between this model and metastasis, tumor, stage, grade, and fustat. Conclusions. To the best of our knowledge, this is the first study to analyze the entire PPAR pathway in KIRC in detail and successfully establish a risk model for patient prognosis. …”
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Iron improves the antiviral activity of NK cells by Simone Schimmer, Vaasudevan Sridhar, Zelal Satan, Anton Grebe, Mohamed Saad, Bernd Wagner, Nele Kahlert, Nele Kahlert, Tanja Werner, Dana Richter, Ulf Dittmer, Kathrin Sutter, Kathrin Sutter, Elisabeth Littwitz-Salomon, Elisabeth Littwitz-Salomon

“…Natural killer (NK) cells are innate immune cells that play a crucial role as a first line of defense against viral infections and tumor development. Iron is an essential nutrient for immune cells, but it can also pose biochemical risks such as the production of reactive oxygen species. …”
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Exploring the influence of pre-analytical variables on gene expression measurements and relative expression orderings in cancer research by Tian Tian, Guie Lai, Ming He, Xiaofang Liu, Yun Luo, You Guo, Guini Hong, Hongdong Li, Kai Song, Hao Cai

“…These paired samples were utilized to assess the impact of pre-analytical variables on gene expression measurements and REOs, including sampling methods, tumor sample heterogeneity, fixed time delays, preservation conditions, degradation levels, library preparation kits, amplification kits, RNA quantity, measuring platforms, and laboratory sites at single and multi-variable level. …”
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Comparison of Immunomodulation Properties of Porcine Mesenchymal Stromal/Stem Cells Derived from the Bone Marrow, Adipose Tissue, and Dermal Skin Tissue by Sun-A Ock, Raghavendra Baregundi Subbarao, Yeon-Mi Lee, Jeong-Hyeon Lee, Ryoung-Hoon Jeon, Sung-Lim Lee, Ji Kwon Park, Sun-Chul Hwang, Gyu-Jin Rho

“…Accordingly, we herein investigated the capacity of MSCs derived from several tissue sources to modulate both proinflammatory (interferon [IFN] γ and tumor necrosis factor [TNF] α) and immunosuppressive cytokines (transforming growth factor [TGF] β and interleukin [IL] 10) employing xenogeneic human MSC-mixed lymphocyte reaction (MLR) test. …”
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Methyltransferase-like 7B participates in bladder cancer via ACSL3 m6A modification in a ferroptosis manner by Jiani He, Changming Dong, Xiandong Song, Zhongkai Qiu, Hao Zhang, Yuanjun Jiang, Tao Liu, Xiaojun Man

“…Abstract Background Bladder cancer (BC) is a malignant tumor. Methyltransferase-like 7B (MEETL7B) is a methyltransferase and its role in BC has not yet been revealed. …”
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Kindlin-1 promotes gastric cancer cell motility through the Wnt/β-catenin signaling pathway by Jun-Ho Jang, Jiyoon Jung, Hyeon-Gu Kang, Woong Kim, Won-Jin Kim, Hana Lee, Ju Yeon Cho, Ran Hong, Jeong Won Kim, Joon-Yong Chung, Kyung-Hee Chun, Seok-Jun Kim

“…Abstract Despite advances in gastric cancer diagnosis and treatment, its prognosis remains poor owing to aggressive tumor progression and metastasis. As understanding the relevant molecular mechanisms is essential to effectively improve patient outcomes, we elucidated the role of Kindlin-1 in gastric cancer progression and metastasis. …”
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Analysis of the predictive value of the prostate-specific antigen-to-neutrophil ratio for the diagnosis of prostate cancer by Yuxuan Chen, Haisheng Yan, Yaoqin Xu, Kexin Chen, Runqin Yang, Jiali Yang, Ruian Zhu, Rui Lin, Jiang Wang, Jie Liu, Pingsheng Gao, Lei Pang, Lexin Wang

“…Neutrophils have been found to be associated with tumor development and inflammation. Based on this, we combined PSA and absolute neutrophil counts to calculate the total PSA to absolute neutrophil ratio (PNR), which is higher in patients with prostate cancer and lower in those with benign conditions. …”
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Evaluating pre-processing and deep learning methods in medical imaging: Combined effectiveness across multiple modalities by Thien B. Nguyen-Tat, Tran Quang Hung, Pham Tien Nam, Vuong M. Ngo

“…These datasets include two X-ray collections: the COVID-19 Pneumonia Normal Chest PA Dataset and the Osteoporosis Knee X-ray Dataset; two CT scan datasets: the Chest CT-Scan Images Dataset and the Brain Stroke CT Image Dataset; two MRI datasets: the Breast Cancer Patients MRI and the Brain Tumor MRI Dataset; and two ultrasound datasets: the Ultrasound Breast Images for Breast Cancer and the MT Small Dataset. …”
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Pathogenicity of germline VHL variants is associated with renal cell carcinoma size in von Hippel-Lindau disease by Gustavo H. Mori, Gustavo F. C. Fagundes, Lucas S. Santana, Felipe Freitas-Castro, Ana Caroline F. Afonso, Delmar M. Lourenço Jr., Maria Adelaide A. Pereira, Fabio Y. Tanno, Victor Srougi, Jose L. Chambo, Mauricio D. Cordeiro, William C. Nahas, Ana O. Hoff, Maria Candida B. V. Fragoso, Berenice B. Mendonca, Ana Claudia Latronico, Madson Q. Almeida

“…Moreover, adrenal paraganglioma (PGL) (82.35% vs. 17.65%; p = 0.0001) and pancreatic neuroendocrine tumor (PNET) (81.81% vs. 18.18%; p = 0.007) were associated with missense VHL pathogenic or likely pathogenic variants compared with non-missense defects. …”
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CD56-Negative Aggressive NK Cell Leukemia Relapsing as Multiple Cranial Nerve Palsies: Case Report and Literature Review by M. Guerreiro, F. Príncipe, M. J. Teles, S. Fonseca, A. H. Santos, E. Fonseca, P. Gomes, C. Marques, M. Lima

“…The neoplastic natural killer (NK) cells usually harbor the Epstein-Barr virus (EBV) with a latent viral infection pattern type II; they often have a cytoplasmic CD3ε+ and surface CD3−, CD2+, and CD56+ immunophenotype, and they show complex genetic abnormalities affecting multiple tumor suppressor genes and oncogenes. We present a rare case of CD56-negative ANKL and review the clinical and laboratorial criteria for the diagnosis, as well as the available therapies. …”
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A comparative study of the developability of full-length antibodies, fragments, and bispecific formats reveals higher stability risks for engineered constructs by Itzel Condado-Morales, Fabian Dingfelder, Isabel Waibel, Oliver M. Turnbull, Bhargav Patel, Zheng Cao, Jais Rose Bjelke, Susanne Nedergaard Grell, Anja Bennet, Alissa M. Hummer, Matthew I. J. Raybould, Charlotte M. Deane, Thomas Egebjerg, Nikolai Lorenzen, Paolo Arosio

“…Here, we systematically analyzed 64 different antibody constructs targeting Tumor Necrosis Factor (TNF) which cover 8 distinct molecular format families, encompassing full-length antibodies, various types of single chain variable fragments, and bispecifics. …”
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7,12-Dimethylbenz(a)anthracene as a Model for Ovarian Cancer Induction in Rats by Ana Carolina Ciseski Gonçalves, Katia Candido Carvalho, José Antônio Orellana Turri, Ricardo dos Santos Simões, Jesus Paula Carvalho, Luiz Fernando Ferraz da Silva, José Maria Soares Júnior, Edmund Chada Baracat

“…We conclude that ovarian carcinogenesis can be studied using DMBA as an inducer in rat and mouse models with a long time range for tumor establishment (at least 110 days) and a high rate of mortality. …”
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Clinical Presentation, Risk Factors, and Treatment Modalities of Hepatocellular Carcinoma: A Single Tertiary Care Center Experience by Abdulrahman A. Aljumah, Hadi Kuriry, Mohammed AlZunaitan, Mohammed Al Ghobain, Mohamed Al Muaikeel, Ashwaq Al Olayan, Fahad Azzumeea, Bader Almutairi, Abduljaleel AlAlwan, Hamdan AlGhamdi

“…A total of 235 patients were included. Males had higher tumor size and incidence of portal vein thrombosis. …”
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miR-34a Regulates Multidrug Resistance via Positively Modulating OAZ2 Signaling in Colon Cancer Cells by Yong Li, Ping Gong, Ji-xue Hou, Wei Huang, Xiao-ping Ma, Yu-li Wang, Jing Li, Xiao-bin Cui, Na Li

“…Although aberrant expression of miR-34a, an essential tumor suppressor miRNA, has been frequently observed in colon cancer (CCa), whether miR-34a can regulate CCa progression by modulating other facets of this malignancy (such as multidrug resistance, MDR) remains unknown. …”
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