Angesinenolide B, A Phthalide Dimeric Peroxide, Exerts Anti-Inflammatory Properties by Suppressing MAPK/STATs Signaling Pathways and ROS Production by Zhang L, Liu Y, Wang H, Guo S, Lv J

“…ELISA was employed to investigate the generation of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), while qRT-PCR was utilized to analyze the mRNA expressions of TNF-α, IL-6, inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). …”
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Reassessing the roles of oxidative DNA base lesion 8-oxoGua and repair enzyme OGG1 in tumorigenesis by Jing Wang, Chunshuang Li, Jinling Han, Yaoyao Xue, Xu Zheng, Ruoxi Wang, Zsolt Radak, Yusaku Nakabeppu, Istvan Boldogh, Xueqing Ba

“…Thus, in addition to the potential mutagenicity, 8-oxoGua may contribute to tumor development and progression through the altered gene expression stemming from its epigenetic effects.…”
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Stromal architecture and fibroblast subpopulations with opposing effects on outcomes in hepatocellular carcinoma by Yifei Cheng, Xiaofang Chen, Li Feng, Zhicheng Yang, Liyun Xiao, Bin Xiang, Xiaodong Wang, Dongbin Liu, Penghui Lin, Jieyi Shi, Guohe Song, Wulei Qian, Boan Zhang, Yanan Xu, Zheng Gao, Lv Chen, Yingcheng Wu, Jiaqiang Ma, Youpei Lin, Haichao Zhao, Lihua Peng, Xuebin Mao, Yang Liu, Hao Hou, Mingyu Yang, Yuan Ji, Xiaoying Wang, Jian Zhou, Xun Xu, Xiyang Liu, Wu Wei, Xiaoming Zhang, Qiang Gao, Hu Zhou, Yidi Sun, Kui Wu, Jia Fan

“…Abstract Dissecting the spatial heterogeneity of cancer-associated fibroblasts (CAFs) is vital for understanding tumor biology and therapeutic design. By combining pathological image analysis with spatial proteomics, we revealed two stromal archetypes in hepatocellular carcinoma (HCC) with different biological functions and extracellular matrix compositions. …”
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Intratumoral pan-ErbB targeted CAR-T for head and neck squamous cell carcinoma: interim analysis of the T4 immunotherapy study by Fiona Reid, Sophie Papa, John Maher, Jean-Pierre Jeannon, James Spicer, Victoria Gibson, Selvam Thavaraj, Michael Metoudi, Christopher Fisher, Nicholas Beckley-Hoelscher, Andrew Hope, Maria Elstad, Antonella Adami, Richard Beatson, Molly Sarah George, Daniela Achkova, Evangelia Williams, Sefina Arif, Abdel Douri, Marc Delord, Mike Lyne, Dharshene Shivapatham, Sakina Gooljar, Arindam Mitra, Linda Gomm, Cienne Morton, Rhonda Henley-Smith, Alice Santambrogio, Cynthia Andoniadou, Sarah Allen, Gary J R Cook, Ana C Parente-Pereira, David M Davies, Farzin Farzaneh, Anna Schurich, Teresa Guerrero-Urbano

“…Frequent treatment-related adverse events were tumor swelling, pain, pyrexias, chills, and fatigue. …”
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The development and maintenance of immunity against visceral leishmaniasis by Rahul Tiwari, Awnish Kumar, Vishal Kumar Singh, Rajneesh, Shashi Bhushan Chauhan, Shyam Sundar, Susanne Nylén, Christian Engwerda, Rajiv Kumar

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Postoperative Complications of Laparoscopic Total Gastrectomy versus Open Total Gastrectomy for Gastric Cancer in a Meta-Analysis of High-Quality Case-Controlled Studies by Mikito Inokuchi, Sho Otsuki, Norihito Ogawa, Toshiro Tanioka, Keisuke Okuno, Kentaro Gokita, Tatsuyuki Kawano, Kazuyuki Kojima

“…Studies matched for patients’ status, tumor stage, and the extents of lymph-node dissection were included. …”
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<i>CYP24A1</i> DNA Methylation in Colorectal Cancer as Potential Prognostic and Predictive Markers by Ru-Hua Zhou, Lei Li, Qing-Jian Ou, Yi-Fan Wang, Yu-Jing Fang, Cai-Xia Zhang

“…Taken together, our findings indicate that the methylation levels of specific CpG sites within the <i>CYP24A1</i> promoter region in blood leukocytes and tumors are potential prognostic and predictive markers for overall survival in CRC patients.…”
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Integrating machine learning with mendelian randomization for unveiling causal gene networks in glioblastoma multiforme by Lixin Du, Pan Wang, Xiaoting Qiu, Zhigang Li, Jianlan Ma, Pengfei Chen

“…Despite advances in understanding its molecular mechanisms, effective therapeutic strategies remain elusive due to the tumor’s genetic complexity and heterogeneity. Methods This study employed a comprehensive analysis approach integrating 113 machine learning algorithms with Mendelian Randomization (MR) analysis to investigate the molecular underpinnings of GBM. …”
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Pentraxin 3 Levels in Young Women with and without Polycystic Ovary Syndrome (PCOS) in relation to the Nutritional Status and Systemic Inflammation by Katarzyna Wyskida, Grzegorz Franik, Piotr Choręza, Natalia Pohl, Leszek Markuszewski, Aleksander Owczarek, Paweł Madej, Jerzy Chudek, Magdalena Olszanecka-Glinianowicz

“…Body composition was assessed by bioimpedance, and plasma levels of pentraxin 3 (PTX3), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and monocyte chemoattractant protein 1 (MCP-1) were measured. …”
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c-FLIP and microRNA 708-5p gene expression in newly diagnosed and chemotherapy in acute myeloid leukemia of Iraqi patient by Jaafar Sadiq Jaafar, Hiba Muneer Abdual Hassan Al-Kafagi, Israa Hussein Hamzah

“…The researches emphasize the role of miRNA 708-5p as a tumor suppressor, which negatively regulates the antiapoptotic protein c-FLIP, indicating its potential as a therapeutic target in AML treatment. …”
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Cancer-associated fibroblasts induce almonertinib resistance in non-small cell lung cancer by Guohao Wei, Yu Nie, Min Sun, Wenzheng Zhou, Huihui Zhao, Fangfang Chen, Chuandong Zhu

“…Cancer-associated fibroblasts (CAFs) are essential matrix components in the tumor microenvironment, but their impact on almonertinib resistance is unknown. …”
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Effect of a Hemodialysis Session on Markers of Inflammation and Endotoxin by Shyam Dheda, David A Vesey, Carmel Hawley, David W Johnson, Magid Fahim

“…In this study, serum concentrations of endotoxin and inflammatory biomarkers, including high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), interleukin-1β (IL1β), ferritin and tumor necrosis factor (TNF), were measured in 30 adults receiving HD and 10 healthy individuals without kidney disease. …”
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Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper by Alexandra Rucavado, Teresa Escalante, Catarina F. P. Teixeira, Cristina María Fernándes, Cecilia Díaz, José María Gutiérrez

“…In contrast, no increments in tumor necrosis factor-α (TNF-α) and interferon-γ were detected. …”
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Transcriptome analysis reveals the anticancer effects of fenbendazole on ovarian cancer: an in vitro and in vivo study by Xin Wang, Wenda Tian, Ning Wang, Xiangqun Yang, Zhenyan Liu, Lvzhou Li, Taoyu Zhao, Chuanlin Wang, Hongping Zhang, Hongying Yang, Yue Jia

“…Finally, oral administration of FBZ inhibited tumor growth in a mouse model of xenograft ovarian cancer. …”
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Exploration of the Immune-Related Signatures and Immune Infiltration Analysis in Melanoma by Ai-lan Li, Yong-mei Zhu, Lai-qiang Gao, Shu-yue Wei, Ming-tao Wang, Qiang Ma, You-you Zheng, Jian-hua Li, Qing-feng Wang

“…Furthermore, the association between hub immune signatures and immune cell distribution was evaluated in specific tumor samples. The Wilcoxon rank-sum test was used to estimate immune infiltration density in the two groups, and results showed that the high-risk group exhibited a lower infiltration density, and the dominant immune cells included M0 macrophages (P=0.023) and activated mast cells (P=0.005).…”
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Manejo del cáncer de vejiga invasor de músculo con enfoque preservador de órgano: terapia trimodal by Carlos H. Abonía-Velasco, Herney A. García-Perdomo

“…Introducci&oacute;n: El c&aacute;ncer de vejiga es una patolog&iacute;a frecuente del tracto genitourinario, cuyo tratamiento acarrea morbilidad y alteraci&oacute;n de la calidad de vida y en particular en el subgrupo de pacientes con tumores vesicales clasificados como invasores de m&uacute;sculo. …”
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Correlation analysis of Hashimoto’s thyroiditis with papillary thyroid carcinoma occurrence and its central lymph node metastasis: a single center experience by Kang Sun, Kang Sun, Xiaoming Wang, Dexuan Chen, Chaoqun Ma

“…Through univariate and multivariate logistic regression, we proved that tumor position, Capsule + Extrathyroidal extension (ETE), multifocal tumors, and the total number of CLN dissected were independent risk factors for CLNM. …”
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Using partially shared radiomics features to simultaneously identify isocitrate dehydrogenase mutation status and epilepsy in glioma patients from MRI images by Yida Wang, Ankang Gao, Hongxi Yang, Jie Bai, Guohua Zhao, Huiting Zhang, Yang Song, Chenglong Wang, Yong Zhang, Jingliang Cheng, Guang Yang

“…Region of interests comprising the entire tumor and peritumoral edema were automatically segmented using a pre-trained deep learning model. …”
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Comprehensive multi-omics analysis showed that CDC6 is a potential prognostic and immunotherapy biomarker for multiple cancer types including HCC by Chenxuan Li, En-di Zhang, Rui Yu, Bo Yuan, Yunxin Yang, Zhong Zeng, Hanfei Huang

“…CDC6 was significantly positively associated with CD4+ Th2 cells and MDSC in a variety of tumors. Furthermore, immunomodulatory genes are strongly associated with CDC6 expression in most tumor types. …”
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The application of hepatopancreatoduodenectomy in advanced gallbladder carcinoma: Patient selection, surgical outcomes and influence on survival compared to radical cholecystectomy by Manar Mikhail Atyah, Yingjixing Luo, Ruyi Liu, Zhiying Yang, Li Xu

“…Comparisons included basic characteristics, liver function, tumor biomarkers, surgical complications, outcome, and survival. …”
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