Modified Trochanteric Flip Osteotomy in Varus Intertrochanteric Osteotomy for Treatment of Legg–Calvé–Perthes Disease by Andrea Laufer, Carina Antfang, Georg Gosheger, Adrien Frommer, Gregor Toporowski, Henning Tretow, Robert Roedl, Bjoern Vogt

Get full text

WeiFu: A Novel Pan-Cancer Driver Gene Identification Method Using Incidence-Weighted Mutation Scores by Yanjie Ren, Azlan Mohd Zain, Yan Zhang, Rozita Abdul Jalil, Mahadi Bahari, Norfadzlan Bin Yusup, Mazlina Abdul Majid, Azurah A. Samah, Didik Dwi Prasetya, Nurhafizah Moziyana Mohd Yusop

“…Genetic and genomic variations are primary drivers of tumor development. Identifying driver genes from numerous passenger genes across pan-cancer poses a significant challenge due to varying mutation loads. …”
Get full text

Anti-allergic effect of 5,7-dihydroxy-4-methylcoumarin in IgE-mediated RBL-2H3 cells and PCA murine model by Sugeun Gwon, Seong-Ah Shin, Moonsu Kim, Sun Young Moon, Seyeon Choi, Minji Kim, Jun Hyuck Lee, Hyun Ho Park, Chang Sup Lee

“…Our findings demonstrated that 5,7-dihydroxy-4-methylcoumarin reduced the release of histamine and β-hexosaminidase and downregulated the mRNA expression of allergic-inflammatory cytokines, such as interleukin (IL)-4, IL-13, and tumor necrosis factor-alpha, as well as the inflammatory enzyme cyclooxygenase-2. …”
Get full text

Splenic B-Cell Lymphomas with Diffuse Cyclin D1 Protein Expression and Increased Prolymphocytic Cells: A Previously Unrecognized Diagnostic Pitfall by Khaled Algashaamy, Yaohong Tan, Nicolas Mackrides, Alvaro Alencar, Jing-Hong Peng, Joseph Rosenblatt, Juan P Alderuccio, Izidore S. Lossos, Francisco Vega, Jennifer Chapman

“…Both lymphomas were very unusual because the tumor cells diffusely and strongly expressed cyclin D1 despite lacking the t(11; 14)(q13; q32) as detected by several approaches including next-generation sequencing, fluorescence in situ hybridization using CCND1 break apart probe and fusion probes for t(11; 14)(q13; q32), and conventional karyotyping. …”
Get full text

Three-dimensional diffractive acoustic tomography by Luca Menozzi, Tri Vu, Aidan J. Canning, Harshal Rawtani, Carlos Taboada, Marie Elise Abi Antoun, Chenshuo Ma, Jesse Delia, Van Tu Nguyen, Soon-Woo Cho, Jianing Chen, Theresa Charity, Yirui Xu, Phuong Tran, Jun Xia, Gregory M. Palmer, Tuan Vo-Dinh, Liping Feng, Junjie Yao

“…Using 3D-DAT on small animal models, we mapped the distribution of the biliverdin-binding serpin complex in glassfrogs, tracked gold nanoparticle accumulation in a mouse tumor model, imaged genetically-encoded photoswitchable tumors, and investigated polyfluoroalkyl substances exposure on developing embryos. …”
Get full text

Quaternized Molecular Brush‐Grafted Injectable Microgel with Anti‐Inflammatory and Drainage Properties for Efficient Therapy of Anal Fistula by Runxian Wang, Pengwei Ma, Siqi He, Xiao Wang, Jinquan Zhang, Junwen Ye, Mingli Su, Xingxing Shi, Ruoxu Dou

“…Owing to the electrostatic interactions between the positively charged quaternized carbon nanotube molecular brush (CNT‐g‐PVBTMA) and the negatively charged inflammatory cytokines, GAA@CNT‐g‐PVBTMA microgel exhibits excellent anti‐inflammatory properties with scavenging rates of 92.6% for tumor necrosis factor‐α (TNF‐α) and 92.5% for interleukin‐1β (IL‐1β). …”
Get full text

Cyto-histological correlation of salivary gland lesions according to the Milan reporting system by Shireen Hamid, Muhammad Mudassar, Nida Hamid, Muhammad Sarwar Zia, Tariq Mehmood, Sadia Hameed

“…The cytology cases were categorized based on the Milan Salivary Gland Cytology Reporting System (MSRSGC): nondiagnostic, non-neoplastic, benign, or, salivary gland tumor of unknown malignant potential (SUMP), suspicious for malignancy, or malignant. …”
Get full text

Age-related immune response disparities between adults and children with severe COVID-19: a case–control study in China by Hongliang Chen, Hongliang Chen, Yuan Li, Liping Yuan, Fen Liu, Qian Sun, Qian Sun, Qingkai Luo, Yefei Lei, Yinglan Hou, Jiayan Li, Liang Cai, Shixing Tang

“…A case–control study was conducted using propensity score matching (PSM) to mitigate possible confounding factors.ResultsThe significant differences observed included lymphocyte exhaustion, an increased neutrophil-to-lymphocyte (NEU/LYM) ratio, high levels of C-reactive protein (CRP), and a cytokine storm, characterized by high levels of Th1 proinflammatory cytokines, including interleukin 1β (IL-1β), IL-6, IL-8, interferon type I (IFN-γ), and tumor necrosis factor (TNF-α) in the lung among severe adult COVID-19 patients. …”
Get full text

Tailgut Cyst—Gynecologist’s Pitfall: Literature Review and Case Report by Andrei Mihai Malutan, Viorela-Elena Suciu, Florin Laurentiu Ignat, Doru Diculescu, Razvan Ciortea, Emil-Claudiu Boțan, Carmen Elena Bucuri, Maria Patricia Roman, Ionel Nati, Cristina Ormindean, Dan Mihu

“…A computed tomography (CT) scan showed a presacral tumor with a right pararectal development. A surgical resection of the lesion using an anterior approach was performed, with the final pathological diagnosis of a retrorectal cystic hamartoma (“tailgut cyst”). …”
Get full text

Higher Prostate Weight Is Inversely Associated with Gleason Score Upgrading in Radical Prostatectomy Specimens by Leonardo Oliveira Reis, Emerson Luis Zani, Leandro L. L. Freitas, Fernandes Denardi, Athanase Billis

“…Gleason upgrading showed increased clinical stage (P=0.019), higher tumor extent (P=0.009), extraprostatic extension (P=0.04), positive surgical margins (P<0.001), seminal vesicle invasion (P=0.003), less “insignificant” tumors (P<0.001), and also worse DFS, χ2=4.28, df=1, P=0.039. …”
Get full text

Clerodendrum volubile Ethanol Leaf Extract: A Potential Antidote to Doxorubicin-Induced Cardiotoxicity in Rats by Olufunke Esan Olorundare, Adejuwon Adewale Adeneye, Akinyele Olubiyi Akinsola, Daniel Ayodele Sanni, Mamoru Koketsu, Hasan Mukhtar

“…Doxorubicin is widely applied in hematological and solid tumor treatment but limited by its off-target cardiotoxicity. …”
Get full text

Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial by Hui Chen, Shuai Liu, Lu Ji, Tianfeng Wu, Yong Ji, Yuying Zhou, Miaoyan Zheng, Meilin Zhang, Weili Xu, Guowei Huang

“…We quantified serum folate, amyloid beta (Aβ), interleukin-6 (IL-6), tumor necrosis factor α (TNFα), plasma homocysteine (Hcy), S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), and the mRNA levels of presenilin (PS), IL-6, and TNFα in leukocytes. …”
Get full text

The prognostic value of boost dose in residual cervical lymph nodes in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy: a retrospective study by Mengting Xu, Liuling Wang, Jianming Ding, Yiying Xu, Zhaodong Fei

“…Conclusion For NPC patients with RCLN, adding a boost dosage following radical IMRT results in desirable tumor control and a positive clinical outcome. Individuals with detectable EBV DNA and N2-3 category may benefit from the boost radiation.…”
Get full text

Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation by Daniel Czyzyk, Wupeng Yan, Simon Messing, William Gillette, Takashi Tsuji, Mitsuhiro Yamaguchi, Shinji Furuzono, David M. Turner, Dominic Esposito, Dwight V. Nissley, Frank McCormick, Dhirendra K. Simanshu

“…Disrupting RAS-PI3Kα interaction enhances survival in lung and skin cancer models and reduces tumor growth and angiogenesis, although the structural details of this interaction remain unclear. …”
Get full text

655Val and 1170Pro ERBB2 SNPs in Familial Breast Cancer Risk and BRCA1 Alterations by Stefania Tommasi, Vita Fedele, Rosanna Lacalamita, Michele Bruno, Francesco Schittulli, David Ginzinger, Gery Scott, Serenella Eppenberger-Castori, Daniele Calistri, Silvia Casadei, Ian Seymour, Salvatore Longo, Gianluigi Giannelli, Brunella Pilato, Giovanni Simone, Christopher C. Benz, Angelo Paradiso

“…In conclusion, these findings point to the existence of an association of ERBB2 allelic variants at both loci with specific breast tumor phenotypes and to the need of deeply investigate different gene SNPs association for risk defining.…”
Get full text

Risk prediction models for dysphagia after radiotherapy among patients with head and neck cancer: a systematic review and meta-analysis by You Pu, Jin Yang, Lian Shui, Qianlong Tang, Xianqin Zhang, Guangguo Liu

“…Common predictors include mean dose to pharyngeal constrictor muscles, treatment setting, and tumor site. Of these models, most were constructed based on logistic regression, while only two studies used machine learning methods. …”
Get full text

Assessing the clinical support capabilities of ChatGPT 4o and ChatGPT 4o mini in managing lumbar disc herniation by Suning Wang, Ying Wang, Linlin Jiang, Yong Chang, Shiji zhang, Kun Zhao, Lu Chen, Chunzheng Gao

“…However, the difficulty in reading AI-generated content and occasional use of misleading terms, such as “tumor,” indicate a need for further improvements to reduce patient anxiety.…”
Get full text

Radiomics Features Based on MRI-ADC Maps of Patients with Breast Cancer: Relationship with Lesion Size, Features Stability, and Model Accuracy by Begumhan BAYSAL, Hakan BAYSAL, Mehmet Bilgin ESER, Mahmut Bilal DOGAN, Orhan ALIMOGLU

“…Three sample size configurations were identified based on tumor size (experiment 1: all cases, experiment 2: &gt;1 cm3, and experiment 3: &gt;2 cm3). …”
Get full text

Apelin/APJ system: a novel promising target for anti-oxidative stress in stroke by Weilin Xu, Weilin Xu, Jun Yan, Zachary D. Travis, Cameron Lenahan, Liansheng Gao, Liansheng Gao, Haijian Wu, Haijian Wu, Jingwei Zheng, Jingwei Zheng, Jianmin Zhang, Jianmin Zhang, Anwen Shao, Anwen Shao, Jun Yu, Jun Yu

Get full text

Exploratory Investigation of Intestinal Structure and Function after Stroke in Mice by Diya Ye, Yuting Hu, Ning Zhu, Weizhong Gu, Gao Long, Enfu Tao, Marong Fang, Mizu Jiang

“…Glial fibrillary acidic protein (GFAP) and the apoptosis-associated proteins (tumor necrosis factor (TNF-α), caspase-3, and cleaved caspase-3) were notably upregulated as well. …”
Get full text