Involvement of Toll Like Receptor 2 Signaling in Secondary Injury during Experimental Diffuse Axonal Injury in Rats by Yonglin Zhao, Junjie Zhao, Ming Zhang, Yahui Zhao, Jiaxi Li, Xudong Ma, Tingqin Huang, Honggang Pang, Bo Wang, Jinning Song

“…Intracerebral knockdown of TLR2 significantly downregulated TLR2 expression, attenuated cortical apoptosis, lessened glial response, and reduced the secondary axonal and neuronal injury in the cortex by inhibiting phosphorylation of mitogen-activated protein kinases (MAPK) including Erk, JNK, and p38, translocation of NF-κB p65 from the cytoplasm to the nucleus, and decreasing levels of proinflammatory cytokines including interleukin-6, interleukin-1β, and tumor necrosis factor-α. On the contrary, administration of TLR2 agonist to DAI rats achieved an opposite effect. …”
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Improving dexamethasone drug loading and efficacy in treating rheumatoid arthritis via liposome: Focusing on inflammation and molecular mechanisms by Mohammad Yasin Zamanian, Hamidreza Zafari, Maria K. Osminina, Alla A. Skakodub, Raed Fanoukh Aboqader Al‐Aouadi, Maryam Golmohammadi, Nikta Nikbakht, Iman Fatemi

“…The anti‐inflammatory mechanism is associated with the downregulation of pro‐inflammatory cytokines like tumor necrosis factor‐α (TNF‐α) and B‐cell–activating factor (BAFF), which are key players in the pathogenesis of RA. …”
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Therapeutic effects of Pueraria lobata (Willd.) Ohwi root and Hovenia dulcis Thunb. extracts on alcoholic liver disease: Network pharmacology and experimental validation by Zhendong Chen, Yu Yue, Hongyan An, Haisu Yan, Hyeok-Joo Park, Pei Lin

“…Moreover. inflammatory responses were mitigated, as indicated by reductions in the expression of tumor necrosis factor-alpha and interleukin-6, and we detected reduction in the levels of alanine aminotransferase and aspartate aminotransferase, thereby indicating hepatoprotective effects. …”
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Case report: A rare case of a long-term survivor of glioblastoma who underwent two courses of hypofractionated radiotherapy as part of her care by Midhad Mrvoljak, Midhad Mrvoljak, Shubhendu Mishra, Liam Chen, Liam Chen, Elizabeth Neil, Elizabeth Neil, Eric Ehler, Stephanie Terezakis, Stephanie Terezakis, Lindsey Sloan, Lindsey Sloan

“…Glioblastoma (GB) is a primary brain tumor that is lethal and challenging to treat. The 3-year overall survival (OS) of patients with this diagnosis has stayed the same since 2005. …”
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The role of VANGL2 in glioma oncogenesis and progression: insights into expression profiles and prognostic relevance by Mingyu Zhao, Mingyu Zhao, Mingyu Zhao, Mingyu Zhao, Shanshuang Chen, Shanshuang Chen, Shanshuang Chen, Shanshuang Chen

“…In vitro experiments further confirmed that VANGL2 promotes glioma cell migration, invasion, proliferation, and tumor sphere formation. We identified a significant correlation between increased VANGL2 expression and IDH mutation in glioma patients. …”
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TNF Superfamily: A Growing Saga of Kidney Injury Modulators by Maria D. Sanchez-Niño, Alberto Benito-Martin, Sara Gonçalves, Ana B. Sanz, Alvaro C. Ucero, Maria C. Izquierdo, Adrian M. Ramos, Sergio Berzal, Rafael Selgas, Marta Ruiz-Ortega, Jesus Egido, Alberto Ortiz

“…Members of the TNF superfamily participate in kidney disease. Tumor necrosis factor (TNF) and Fas ligand regulate renal cell survival and inflammation, and therapeutic targeting improves the outcome of experimental renal injury. …”
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The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma by Shahid Banday, Alok K. Mishra, Romana Rashid, Tianyi Ye, Amjad Ali, Junhui Li, Jason T. Yustein, Michelle A. Kelliher, Lihua Julie Zhu, Sara K. Deibler, Sunil K. Malonia, Michael R. Green

“…Our study reveals a therapeutically targetable mechanism that promotes EWSR1::FLI1 expression and ES tumor growth.…”
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Decoding oral cancer: insights from miRNA expression profiles and their regulatory targets by Xin Wang, Xin Wang, Shuang Zhang, Shuang Zhang, Shuyi Wang, Tao Cao, Tao Cao, Hong Fan, Hong Fan

“…Notably, most of these hub genes such as NEK2, NDC80, NUF2, PLK1, SMAD2, TP53, TPX2, TTK, UBE2C, WDHD1, WTAP, YWHAZ are directly or indirectly associated with cell cycle progression, underscoring the role of DEmiRs in driving tumor proliferation and survival in OC via dysregulating cell cycle. …”
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Frequency of IL-1B Gene Polymorphisms in Patients with Gastroesophageal Cancer in the Hakkari Region by Derya Yaman, Selin Akad-Dinçer, Yusuf Karakaş, Gözde Ünsoy, Yunus Kasım Terzi, Feride İffet Şahin

“…Objective: Gastric cancer is a complex malignant tumor associated with chronic inflammation. In the present study, we aimed to investigate the frequency of interleukin 1B (IL-1B) gene polymorphisms affecting gene expression in patients with gastroesophageal cancer (GC) diagnosed in the Hakkari region. …”
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Efectividad de Cucurbita pepo en el tratamiento de la hiperplasia prostática. Revisión sistemática y meta-análisis by José Alejandro Ávila Cabreja, Felicia María García Méndez, Elia de la Caridad Rodríguez Venegas, Adolfo Peña Velázquez

“…<strong></strong><p><strong>Fundamento</strong>: La hiperplasia prostática benigna es el tumor benigno más frecuente en hombres. El aceite extraído de la semilla de calabaza (<em>Curcubita pepo</em>) se emplea en el tratamiento de los síntomas asociados a dicha enfermedad. …”
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Fiber Bragg Grating Thermometry and Post-Treatment Ablation Size Analysis of Radiofrequency Thermal Ablation on Ex Vivo Liver, Kidney and Lung by Sanzhar Korganbayev, Leonardo Bianchi, Clara Girgi, Elva Vergantino, Domiziana Santucci, Eliodoro Faiella, Paola Saccomandi

“…Radiofrequency ablation (RFA) is a minimally invasive procedure that utilizes localized heat to treat tumors by inducing localized tissue thermal damage. …”
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Synchronous Occurrence of Splenic Pleomorphic Mantle Cell Lymphoma and Esophageal Adenocarcinoma with Overexpression of BCL1 Protein by Dominik Dabrowski, Roberto F. Silva, Michael Constantinescu, Rodney E. Shackelford, Nestor Dela Cruz, Eric X. Wei

“…We report a case of synchronic MCL and an esophageal tumor in an elderly male patient. Morphologically, the tumors were classified as splenic pleomorphic MCL and adenocarcinoma of the esophagus occurring concurrently. …”
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Scutellarin Attenuates Hypertension-Induced Expression of Brain Toll-Like Receptor 4/Nuclear Factor Kappa B by Xingyong Chen, Xiaogeng Shi, Xu Zhang, Huixin Lei, Simei Long, Huanxing Su, Zhong Pei, Ruxun Huang

“…Immunofluorescence and western immunoblot analyses revealed that hypertension contributed to the activation of TLR4 and NF-κB, accompanied by significantly enhanced expression of proinflammatory mediators, such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-18 (IL-18). …”
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Exploring seasonal dynamics of sea spray aerosol bioactivity: Insights into molecular effects on human bronchial epithelial cells by Zixia Liu, Emmanuel Van Acker, Maarten De Rijcke, Filip Van Nieuwerburgh, Colin Janssen, Jana Asselman

“…Downregulation of mTOR, PI3K, Akt, and NF-κB potentially indicates a protective response against tumor-promoting and inflammatory signals, whereas upregulation of AMPK may confer a beneficial effect on metabolic regulation. …”
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Development of a model for measuring sagittal plane parameters in 10–18-year old adolescents with idiopathic scoliosis based on RTMpose deep learning technology by Zhijie Kang, Guopeng Shi, Yong Zhu, Feng Li, Xiaohe Li, Haiyan Wang

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Functional Comparison between Healthy and Multiple Myeloma Adipose Stromal Cells by Nicolas Espagnolle, Benjamin Hebraud, Jean-Gérard Descamps, Mélanie Gadelorge, Marie-Véronique Joubert, Laura Do Souto Ferreira, Murielle Roussel, Anne Huynh, Luc Sensébé, Louis Casteilla, Michel Attal, Hervé Avet-Loiseau, Frederic Deschaseaux, Philippe Bourin, Jill Corre

“…Multiple myeloma (MM) is an incurable B cell neoplasia characterized by the accumulation of tumor plasma cells within the bone marrow (BM). As a consequence, bone osteolytic lesions develop in 80% of patients and remain even after complete disease remission. …”
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Mild hyperthermia with magnetic resonance- guided high intensity focused ultrasound combined with salvage chemoradiation for recurrent rectal cancer by Jonathan Peng, Ari Partanen, Samuel Pichardo, Robert Staruch, Kaitlyn Perry, Merrylee McGuffin, Yuexi Huang, Kelvin KW. Chan, Shun Wong, Greg Czarnota, Kullervo Hynynen, William Chu

“…Our primary objective was feasibility and toxicity.Results Six patients (total 11 screened) were treated with concurrent chemoradiation and mild hyperthermia with MR-HIFU. Tumor size varied between 3.1-16.6 cm. Patients spent an average of 228 min in the MRI suite and sonication with the external transducer lasted an average of 35 min. …”
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The m6A Methylation-Regulated AFF4 Promotes Self-Renewal of Bladder Cancer Stem Cells by Qian Gao, Jin Zheng, Zegui Ni, Pengli Sun, Congcong Yang, Maosheng Cheng, Mingqing Wu, Xiuhong Zhang, Lin Yuan, Yingyin Zhang, Yang Li

“…Mechanistically, METTL3 regulates the m6A modification and thereby the expression of AF4/FMR2 family member 4 (AFF4), knockdown of which phenocopies the METTL3 ablation and diminishes the tumor-initiating capability of BCSCs in vivo. AFF4 binds to the promoter regions and sustains the transcription of SOX2 and MYC which have critical biological functions in BCSCs. …”
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Radiomics-based Machine Learning Approach to Predict Chemotherapy Responses in Colorectal Liver Metastases by Yuji Miyamoto, Takeshi Nakaura, Mayuko Ohuchi, Katsuhiro Ogawa, Rikako Kato, Yuto Maeda, Kojiro Eto, Masaaki Iwatsuki, Yoshifumi Baba, Toshinori Hirai, Hideo Baba

“…We manually delineated three-dimensional tumor volumes, selecting the largest liver metastasis for measurement, using pretreatment portal-phase CT images and extracted 107 radiomics features. …”
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Knockdown of hexokinase 2 results in a decreased expression level of the glycolytic enzymes PFKP, BPGM, and GPI in RKO cell line by M. S. Fedorova, I. Y. Karpova, A. V. Lipatova, E. A. Pudova, Z. G. Guvatova, D. V. Kochetkov, A. V. Chaika, B. Y. Alekseev, M. V. Kiseleva, A. D. Kaprin, A. V. Kudryavtseva, A. V.  Snezhkina

“…There is often an increase in hexokinase 2 (HK2) exogenous expression in tumor cells, which makes it a promising target for anticancer therapy. …”
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