Lunasin protease inhibitor concentrate decreases pro-inflammatory cytokines and improves histopathological markers in dextran sodium sulfate-induced ulcerative colitis by Andrea Nieto-Veloza, Zhihong Wang, Qixin Zhong, Doris D’Souza, Hari B. Krishnan, Vermont P. Dia

“…First, an in vitro test was performed in lipopolysaccharide (LPS)-activated RAW264.7 murine macrophages by measuring the production of nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α) as inflammatory markers. …”
Get full text

miR-146a expression and the miR-146a gene variant rs2910164 as diagnostic and prognostic biomarkers of oral cancer by Vuković Miodrag, Stojković Goran, Zeljić Katarina

“…The rs2910164 variant was associated with tumor histological grade (P=0.037), stage (P=0.036), and lymph node status (P=0.025). …”
Get full text

Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells by Lei-qing Li, Fang Shen, Xiao-yan Xu, Hong Zhang, Xiao-feng Yang, Wei-guo Liu

“…Finally, a subcutaneously C6 xenograft tumor model was established in the nude mice to test the in vitro efficacy of TK/GCV gene therapy. …”
Get full text

Encapsulated LyeTx III Peptide: Cytotoxic Agent Isolated from <i>Lycosa erythrognatha</i> Spider Venom by Daniel Moreira dos Santos, Livia Ramos Santiago, Nayara Araújo dos Santos, Wanderson Romão, Jarbas Magalhães Resende, Maria Elena de Lima, Márcia Helena Borges, Rosy Iara Maciel de Azambuja Ribeiro

“…Its activity when encapsulated is promising, as it can increase its half-life in the body and can also be targeted to specific tumors.…”
Get full text

Next generation thiazolyl ketone inhibitors of cytosolic phospholipase A2 α for targeted cancer therapy by Felicity J. Ashcroft, Asimina Bourboula, Nur Mahammad, Efrosini Barbayianni, Astrid J. Feuerherm, Thanh Thuy Nguyen, Daiki Hayashi, Maroula G. Kokotou, Konstantinos Alevizopoulos, Edward A. Dennis, George Kokotos, Berit Johansen

“…Our findings imply cPLA2α may support cancer by mitigating oxidative stress and inhibiting tumor suppressor expression and suggest that AVX420 has potential for treating acute leukemias and other cancers that are susceptible to oxidative cell death.…”
Get full text

YAP1 as a Novel Negative Biomarker of Immune Checkpoint Inhibitors for EGFR-Mutant Non-Small-Cell Lung Cancer by Ling-Chen Li, Xie-Wan Chen, Ling Fang, Chun-Li Jian, Yong-Xin Yu, Xing-Yun Liao, Jian-Guo Sun

“…The infiltration of immune cells and the expression of the identified tumor-associated antigens were identified with TIMER. …”
Get full text

Integrated bioinformatics and experimental analysis of CHAF1B as a novel biomarker and immunotherapy target in LUAD by Wei Du, Xiao-Wei Wu, Qing-Feng Li, Bing-Yu Zhang, Jing Wu, Ya-Ping Xu, Xue Yi

“…Chromosomal assembly factor 1B (CHAF1B), a p60 component of the CAF-1 complex, is closely linked to tumor incidence and cell proliferation. However, CHAF1B's biological role and molecular mechanism in LUAD remain unclear. …”
Get full text

Follicular Helper CD4+ T Cells, Follicular Regulatory CD4+ T Cells, and Inducible Costimulator and Their Roles in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis by Xue Zhang, Ruli Ge, Hongliang Chen, Maxwell Ahiafor, Bin Liu, Jinbo Chen, Xueli Fan

“…TFR cells not only express markers of TFH cells but also express markers of regulatory T (Treg) cells containing FOXP3, glucocorticoid-induced tumor necrosis factor receptor (GITR), cytotoxic T lymphocyte antigen 4 (CTLA-4), and IL-10, hence owing to the dual characteristic of TFH cells and Treg cells. …”
Get full text

Abdominal Aortic Occlusion and the Inflammatory Effects in Heart and Brain by Jun Xu, Sijie Li, Alexandra Wehbe, Xunming Ji, Yong Yang, Yu Yang, Linhui Qin, Feng-Yong Liu, Yuchuan Ding, Changhong Ren

“…In the hippocampus, AAO increased the levels of tumor necrosis factor (TNF-α), interleukin 1β (IL-1β), interleukin 6 (IL-6), IL-4, and IL-6, and decreased the level of TGF-β1. …”
Get full text

Mesenchymal Stem Cell Transplantation for Liver Cell Failure: A New Direction and Option by Yantian Cao, Bangjie Zhang, Rong Lin, Qingzhi Wang, Jie Wang, Fangfang Shen

Get full text

Socioeconomic status correlates with clinical outcomes in patients with acral melanoma by Rong Huang, Jiayu Wang, Kelin Zheng, Mengke Zhao, Zhengyun Zou, Zhengyun Zou, Zhengyun Zou

“…ObjectivesThis study aimed to investigate the impact of socioeconomic status on survival in Chinese patients with acral melanoma.MethodsWe collected clinical and socioeconomic information of 298 primary acral melanoma patients and performed Kaplan–Meier curves, log-rank tests, Cox proportional hazards models, and Pearson’s chi-squared tests to evaluate the relationships between clinical characteristics, socioeconomic factors, and survival outcomes.ResultsAmong the clinical characteristics, age, gender, stage, Breslow thickness, and primary tumor site significantly impacted survival in acral melanoma patients (p = 0.01, p = 0.05, p &lt; 0.01, p &lt; 0.01, p &lt; 0.01, respectively). …”
Get full text

CD146 promotes resistance of NSCLC brain metastases to pemetrexed via the NF-κB signaling pathway by Hao Qu, Yan Fang, Feng Zhang, Wenwen Liu, Shengkai Xia, Wenzhe Duan, Kun Zou

“…CD146 was recently found to play important roles in chemoresistance and tumor progression. However, the underlying mechanisms of CD146’s effects in pemetrexed resistance remain undefined.Method and resultsSensitivity to pemetrexed was assessed with a preclinical brain metastasis (BM) model based on lung adenocarcinoma PC9 cells. …”
Get full text

Ovarian adenomyoma: a case report by Weilong Liu, Tongtong Yao, Haiyan Wang, Wenjing Yu, Hongtang Shi, Jiwei Guo, Zhiqiang Liu

“…Abstract Introduction Ovarian adenomyoma is a rare gynecological tumor with a high misdiagnosis rate, leading many patients to undergo unnecessary surgeries that may affect fertility. …”
Get full text

Role of Ultrasonography in Monitoring Chemotherapeutic Effects on Primary Thyroid Lymphoma: A Single-Center Retrospective Study by Shirong Liu, Ying Fu, Ligang Cui, Shumin Wang, Shi Tan

“…Following one to two cycles of chemotherapy, a US examination revealed varying tumor reduction degrees and diminished blood flow signals. …”
Get full text

Establishment and characterization of ovarian clear cell carcinoma patient-derived xenografts by Joseph J. Caumanns, Shang Li, Gert J. Meersma, Evelien W. Duiker, Ate G. J. van der Zee, G. Bea A. Wisman, Steven de Jong

“…Cyclophilin A staining depicted the replacement of human stroma by mouse stroma in PDX.F2, while PAS/PAS-D staining confirmed cellular glycogen accumulation in OCCC tumors and PDXs. SNP array and Infinium MethylationEPIC BeadChip array data analysis demonstrated the copy number alterations and DNA methylation signatures of genome-wide and tumor-driver genes in PDXs generally resembled their patients’ tumors. …”
Get full text

Healthy function and high valued utilization of edible fungi by Yanrong Zhang, Dawei Wang, Yuetong Chen, Tingting Liu, Shanshan Zhang, Hongxiu Fan, Hongcheng Liu, Yu Li

“…In addition, edible fungi contain a variety of bioactive substances, such as polysaccharides, dietary fiber, steroids, polyphenols, and most of these compounds have antioxidant, anti-tumor and other physiological functions. This review comprehensively discusses the bioactive components and functional characteristics of edible fungi (such as antioxidant, anti-aging, hypolipidemic activities, etc.). …”
Get full text

Characterization of Interleukin-15-Transpresenting Dendritic Cells for Clinical Use by J. M. J. Van den Bergh, E. L. J. M. Smits, M. Versteven, H. De Reu, Z. N. Berneman, V. F. I. Van Tendeloo, E. Lion

“…Functionally, we show that IL-15-transpresenting DC are equal if not better inducers of T-cell proliferation and are superior in tumor antigen-specific T-cell activation compared with DC without IL-15 conditioning. …”
Get full text

Characterizing the pan-cancer role of exosomal miRNAs in metastasis across cancers by Piyush Agrawal, Gulden Olgun, Arashdeep Singh, Vishaka Gopalan, Sridhar Hannenhalli

“…Here, we aimed to characterize the role of exomiRs, derived from seven cancer types (four cell lines and three tumors), in influencing the pre-metastatic niche (PMN). …”
Get full text

Crosstalk between non-coding RNAs and programmed cell death in colorectal cancer: implications for targeted therapy by Seyed Reza Taha, Mehdi Karimi, Bahar Mahdavi, Milad Yousefi Tehrani, Ali Bemani, Shahriar Kabirian, Javad Mohammadi, Sina Jabbari, Meysam Hushmand, Alireza Mokhtar, Mohammad Hossein Pourhanifeh

“…Results ncRNAs were found to significantly regulate PCD pathways, impacting tumor growth, metastasis, and treatment sensitivity in CRC. …”
Get full text

Radiotherapy Suppresses Bone Cancer Pain through Inhibiting Activation of cAMP Signaling in Rat Dorsal Root Ganglion and Spinal Cord by Guiqin Zhu, Yanbin Dong, Xueming He, Ping Zhao, Aixing Yang, Rubing Zhou, Jianhua Ma, Zhong Xie, Xue-Jun Song

“…Female Sprague-Dawley rats were used and received tumor cell implantation (TCI) in rat tibia (TCI cancer pain model). …”
Get full text