Diallyl Disulfide Suppresses Inflammatory and Oxidative Machineries following Carrageenan Injection-Induced Paw Edema in Mice by Hongxing Zhang, Chi Shang, Zhao Tian, Hatem K. Amin, Rami B. Kassab, Ahmed E. Abdel Moneim, Yingang Zhang

“…Carrageenan injection potentiated an inflammatory reaction as presented by the elevated serological C-reactive protein (CRP) levels and transcription of tumor necrosis factor-alpha (TNF-α, Tnfα), interleukin-1 beta (IL-1β, Il1b), interleukin-2 (IL-2, Il2), inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase-2 (COX-2, Ptgs2), prostaglandin E2 (PGE2), monocyte chemoattractant protein-1 (MCP-1, Ccl1), nuclear factor kappa B (NF-κB), and myeloperoxidase (MPO) activity, while interleukin-10 (IL-10) was declined in the injured paw tissue. …”
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Reduced Systemic Levels of IL-10 Are Associated with the Severity of Obstructive Sleep Apnea and Insulin Resistance in Morbidly Obese Humans by Sonia Leon-Cabrera, Yoaly Arana-Lechuga, Enrique Esqueda-León, Guadalupe Terán-Pérez, Antonio Gonzalez-Chavez, Galileo Escobedo, Javier Velázquez Moctezuma

“…Blood samples were obtained for estimation of total cholesterol and triglycerides, insulin, glucose, insulin resistance, tumor necrosis factor alpha (TNF-α), interleukin 12 (IL12), and interleukin 10 (IL-10). …”
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Prognostic significance of total choline on in-vivo proton MR spectroscopy for prediction of late recurrence in patients with hormone receptor-positive, HER2-negative early breast... by Hyunjik Kim, Heungkyu Park, Yongsoon Chun, Hagjun Kim, Hyeonman Baek, Yunyeong Kim

“…A strong choline peak may be a surrogate for aggressive tumor biology but its clinical relevance is unclear. …”
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Risk Factors for Contralateral Occult Papillary Thyroid Carcinoma in Patients with Clinical Unilateral Papillary Thyroid Carcinoma: A Case-Control Study by Liu Yihao, Li Shuo, Xi Pu, Wang Zipeng, Sun Hanlin, Chang Qungang, Wang Yongfei, Yin Detao

“…Furthermore, there was no statistical correlation between the diameter of the occult tumor and the four obtained variables. Conclusion. …”
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Identifying MTHFD1 and LGALS4 as Potential Therapeutic Targets in Prostate Cancer Through Multi-Omics Mendelian Randomization Analysis by Huan Han, Hanwen Su, Zhihua Lv, Chengliang Zhu, Jingtao Huang

“…In contrast, MTHFD1was expressed in both tumor and microenvironmental cells and was associated with poor survival. …”
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Immunohistochemical expression of parathyroid hormone-related protein and ezrin in invasive breast carcinoma of no special type: a retrospective analysis by Menna Allah Gamil Ali Shalaby, Marwa Mohammed Dawoud, Marwa Salah Gadallah, Asmaa Gaber Abdou

“…Ezrin expression was also significantly elevated in IBC-NST, with higher H score values correlating with high tumor grade (p = 0.002), high N stage (p = 0.045), advanced AJCC stage grouping (p = 0.0043) and metastasis (p = 0.001). …”
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A New Risk Score Based on Lipid Indicators for Patients with Advanced Hepatocellular Carcinoma by Wei X, Guo Z, Zhang T, Liang J

“…Using the COX proportional risk model analysis method, we then created a risk score and examined them using Kaplan-Meier, time-dependent receiver operating characteristics (ROC) curve, and nomogram analysis.Results: In predicting overall survival (OS), free fatty acid/high-density lipoprotein cholesterol (FFHL), tumor size, and BCLC stage were independent prognostic variables. …”
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Molecular Mechanisms and Therapeutic Prospects of Immunotherapy and Targeted Therapy in Primary Central Nervous System Lymphoma by Lin Zhong MM, Anqing Lu MB, Xiyue Lu MM, Xiaoyin Liu MD, Lujia Cao MM, Shihong Zhu MM, SiJun Diao MM, Xu Cheng MM, Hongwei Wu MB, Jing Chen MD

“…Investigating the mechanisms, specific targets, and signaling pathways, as well as interactions with the tumor microenvironment (TME), can provide a solid foundation for further exploration and potentially enhance the optimization of treatment approaches for PCNSL. …”
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Evaluation of Epstein-Barr Virus Latent Membrane Protein 2 Specific T-Cell Receptors Driven by T-Cell Specific Promoters Using Lentiviral Vector by Dongchang Yang, Qing Shao, Hua Sun, Xiaoxin Mu, Yun Gao, Runqiu Jiang, Jiajie Hou, Kun Yao, Yun Chen, Beicheng Sun

“…In conclusion, LMP2-specific CTLs by lentiviral transduction have the potential use for treatment of EBV-related tumors.…”
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Deapioplatycodin D inhibits glioblastoma cell proliferation by inducing BNIP3L-mediated incomplete mitophagy by Yu Sun, Guangze Zhu, Renshuang Zhao, Yaru Li, Hongyang Li, Yunyun Liu, Ningyi Jin, Xiao Li, Yiquan Li, Tiemei Liu

“…Finally, activation of incomplete mitophagy in GBM cells by DPD through BNIP3L in vivo was demonstrated by establishing a mouse subcutaneous xenograft tumor model. In this study, in vitro and in vivo experiments established that DPD inhibited GBM cell growth by inducing BNIP3L-mediated incomplete mitophagy, which provides an experimental basis for studying new treatments of GBM. …”
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Phytochemical profile, therapeutic potentials, nutritional composition, and food applications of ginger: a comprehensive review by Great Iruoghene Edo, Ufuoma Augustina Igbuku, Raghda S. Makia, Endurance Fegor Isoje, Tayser Sumer Gaaz, Emad Yousif, Agatha Ngukuran Jikah, Khalid Zainulabdeen, Patrick Othuke Akpoghelie, Rapheal Ajiri Opiti, Arthur Efeoghene Athan Essaghah, Dina S. Ahmed, Huzaifa Umar

“…Ginger exerts its bioactivities via a number of mechanisms such as inhibiting the activation of tumor necrosis factor α and cyclooxygenase-2 in human synoviocytes and limiting the body’s leukotrienes and prostaglandins to elicit anti-inflammatory activity, activating the descendent inhibitory pathways of pain and suppressing the transmission of nociceptive signals thus exhibiting anti-nociceptive effects amongst others. …”
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Caracterización de pacientes con cáncer oral y su relación con la invasión en profundidad by José Daniel Gil Milá, Johannes René Maestre Cabello, Karen Martínez Gómez

“…<strong>Fundamento:</strong> el cáncer oral supone un reto para cualquier sistema de salud, integrar la invasión en profundidad como factor, a la par del tamaño tumoral, permite un estadiamiento y tratamiento efectivos. …”
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A Nonfunctioning Pituitary Macroadenoma Presenting as Cyclical Vomiting and Severe Hyponatremia in a Young Female by Dinuka S. Warapitiya, Dimuthu Muthukuda, W. A. H. P. Sanjeewa, Kushalee Poornima Jayawickreme, Shyama Subasinghe

“…Hydrocortisone and levothyroxine were started, and she underwent transsphenoidal resection of the pituitary tumor. She recovered from cyclical vomiting. Conclusion. …”
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Effects of bronchoscopic alveolar lavage–assisted mechanical ventilation on postoperative pulmonary infection and inflammatory factors in patients undergoing lung cancer surgery by Hui Zhu, Haiyang Lu

“…The levels of inflammatory markers (high-sensitivity C-reactive protein, procalcitonin, tumor necrosis factor α, high-mobility group box 1, interleukin 6, and macrophage inflammatory protein 1α) in peripheral blood were decreased regardless of the treatment method (all P <⁠0.05). …”
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Different Dietary Proportions of Fish Oil Regulate Inflammatory Factors but Do Not Change Intestinal Tight Junction ZO-1 Expression in Ethanol-Fed Rats by Yi-Wen Chien, Hsiang-Chi Peng, Ya-Ling Chen, Man-Hui Pai, Hsiao-Yun Wang, Hsiao-Li Chuang, Suh-Ching Yang

“…Hepatic thiobarbituric acid-reactive substance (TBARS) levels, cytochrome P450 2E1 protein expression, and tumor necrosis factor- (TNF-) α, interleukin- (IL-) 1β, IL-6, and IL-10 levels, as well as intracellular adhesion molecule (ICAM)-1 levels were significantly elevated, whereas plasma adiponectin level was significantly reduced in group E (p<0.05). …”
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Tanshinlactone triggers methuosis in breast cancer cells via NRF2 activation by Wanjun Lin, Zifeng Huang, Xuening Zhang, Dayuan Zheng, Yanchao Yang, Meina Shi, Dongfang Yang, Tong Chu, Wenzhe Ma

“…Human breast cancer cell lines-derived xenograft tumor explants assay was used to evaluate the compound’s efficacy and to assess the induction of methuosis via NRF2 activation by tanshinlactone.ResultsTanshinlactone selectively inhibits the growth of ER+ and HER2+/EGFR + breast cancer cells while showing limited cytotoxicity against other cancer types and normal cells. …”
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The knowledge mapping of traditional Chinese medicine for hepatocellular carcinoma: A bibliometric study by Wenya Pei, Boyu Jiao, Zexiong Chen, Jingchun Zeng, Yancheng Fu, Zhanmou Liang, Baoguo Sun, Jingwen Ruan, Shijun Zhang

“…The analysis indicated that traditional Chinese medicine may enhance immunity and regulate the local tumor microenvironment through mechanisms involving DNA damage, cell cycle arrest, and apoptosis by signaling pathways. …”
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LINC01355 Contributes to Malignant Phenotype of Oral Squamous Cell Carcinoma and Cytotoxic T Cell Infiltration via Activating Notch Signaling Pathway by Chen Zou, Siyuan Wu, Haigang Wei, Hailing Luo, Zhe Tang, Xia Li, Xiaozhi Lv, Yilong Ai

“…As shown, the silence of LINC01355 could repress OSCC tumor growth via inducing CD8+ T cell immune responses. …”
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HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the Breast by Katsumi Kito, Toshiharu Maeda, Keiko Ninomiya, Atsuro Sugita, Teiri Sagawa, Kinya Matsuoka, Kousei Kinoshita, Naoki Hyodo, Nagisa Morita, Keizo Furuya

“…Apocrine carcinoma, which is strictly defined as over 90% of tumor cells showing apocrine differentiation, is a rare variant of breast cancer. …”
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Correlation of Gleason Scores with Diffusion-Weighted Imaging Findings of Prostate Cancer by Rajakumar Nagarajan, Daniel Margolis, Steven Raman, Ke Sheng, Christopher King, Robert Reiter, M. Albert Thomas

“…In patients with a high-grade Gleason score (4+3), the ADC values were lower in the peripheral gland tissue, pathologically determined as tumor compared to low grade (3+3 and 3+4). The mean and standard deviation of the ADC values for patients with GS 3+3, GS 3+4, and GS 4+3 were 1.135±0.119, 0.976±0.103 and 0.831±0.087 mm2/sec. …”
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