Clinical implications of DNA ploidy, stroma, and nucleotyping in predicting peritoneal metastasis risk for gastric cancer by Jingwen Yuan, Yue Jiang, Fangfang Chen, Tian Li, Zhi Zeng, Shasha Ruan, Junfeng Yan, Jiatong Lu, Qiang Li, Jingping Yuan, Qiang Tong

“…Methods A comprehensive analysis was conducted on specimens obtained from 80 gastric cancer patients who underwent gastric resection at the Department of Gastrointestinal Surgery of Wuhan University Renmin Hospital. Tumor tissues were sectioned and stained. DNA ploidy, stroma, and nucleotyping were quantified using microscopy and digital analysis software. …”
Get full text

Tetrandrine Inhibits Titanium Particle-Induced Inflammatory Osteolysis through the Nuclear Factor-κB Pathway by Zige Liu, Yan Li, Fengying Guo, Chen Zhang, Guorui Song, Jiahao Yang, Desheng Chen

“…In addition, relevant inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6) were also significantly reduced in the calvaria of the Tet-treated groups. …”
Get full text

Potential involvement of cuproptosis induced by m6A-modified autophagy gene ATG10 in KICH by Qingyun Zhu, Daiquan Fu, Zhaohui Zhu, Jian Wu, Chenxi Li, Jiajun Chen, Chuan Chen, Yanxiang Li, Yuehui Guo, Xiangqi Li

“…This downregulation correlated with patient survival, suggesting a potential tumor-regulatory role. ATG10’s involvement in the protein lipidation pathway, essential for cuproptosis, was identified. …”
Get full text

Efficacy and safety of neoadjuvant bevacizumab plus chemotherapy in locally advanced gastric cancer patients: a retrospective, comparative study by Bin Yin, Wei Luo

“…Results Objective response rate (52.2% vs. 35.4%), disease control rate (91.3% vs. 81.3%), surgical resection rate (95.7% vs. 85.4%), R0 resection rate (87.0% vs. 75.0%), and the proportion of patients with tumor regression grade 0–1 (31.8% vs. 17.1%) tended to increase in bevacizumab plus chemo group versus chemo group, although there was no statistical significance. …”
Get full text

A case report of anaplastic thyroid carcinoma transformed from small papillary carcinoma successfully detected by ultrasonography in its early stage with review of literature by Hiroshi Arimitsu, Yui Nishijima, Naoyuki Higaki, Hitoshi Noguchi, Shinya Uchino, Tsukasa Murakami

“…Anaplastic thyroid carcinoma is generally found as an aggressive large tumor, and the ultrasound appearance of small anaplastic thyroid carcinoma is poorly understood at present. …”
Get full text

A Theoretical Study on the Efficacy and Mechanism of Combined YAP-1 and PARP-1 Inhibitors in the Treatment of Glioblastoma Multiforme Using Peruvian Maca <i>Lepidium meyenii</i> by Albert Gabriel Turpo-Peqqueña, Sebastian Luna-Prado, Renato Javier Valencia-Arce, Fabio Leonardo Del-Carpio-Carrazco, Badhin Gómez

“…Current therapeutic strategies, including surgery, chemotherapy, and radiotherapy, often fail due to the tumor’s ability to develop resistance. The proteins YAP-1 (Yes-associated protein 1) and PARP-1 (Poly-(ADP-ribose)–polymerase-1) have been implicated in this resistance, playing crucial roles in cell proliferation and DNA repair mechanisms, respectively. …”
Get full text

重组人内皮抑素对胃肠间质瘤血管形成及生长的抑制作用

“…【目的】 研究重组人内皮抑素(recombinant human endostatin,rhES)能否抑制胃肠间质瘤(gastrointestinal stromal tumor,GIST)裸鼠移植肿瘤血管生成及生长,探讨抑制血管形成作为GIST治疗方法的可行性65377;【方法】 随机将20只荷瘤裸鼠分为实验组与对照组65377;对照组瘤周注射生理盐水,实验组瘤周注射rhES,连用10 d65377;自用药开始,每5 d测量肿瘤体积,直至用药结束后5 d65377;计算抑瘤率和肿瘤缩小率65377;比较实验组与对照组肿瘤体积65380;微血管密度(microvascular density,MVD)65380;bcl-2阳性表达率65380;凋亡指数(AI)及实验组治疗前后肿瘤体积差异是否具有显著性65377;【结果】 用药前实验组与对照组肿瘤体积无差别(P = 0.628)65377;用药后实验组肿瘤体积逐渐减小65377;用药结束后5 d,实验组肿瘤体积与用药前及对照组相比均明显缩小(P = 0.000),抑瘤率86.5%,肿瘤缩小率为55.5%65377;所有瘤株CD117均为阳性表达65377;实验组MVD低于对照组(P = 0.020)65377;实验组bcl-2阳性表达率均低于对照组(P = 0.023)65377;实验组AI高于对照组(P = 0.020)65377; 【结论】 rhES抑制GIST血管生成65380;促进肿瘤细胞凋亡及遏制肿瘤生长,有可能成为治疗GIST的有效方法之一65377;…”
Get full text

Targeting autophagy to enhance chemotherapy and immunotherapy in oral cancer by Xiaoli Zeng, Xiaoli Zeng, Xiaoli Zeng, Yue Chen, Yue Chen, Jing Wang, Jing Wang, Miao He, Miao He, Junyao Qiu, Yun Huang

“…Furthermore, autophagy induction can modulate the tumor immune microenvironment and enhance antitumor immunity. …”
Get full text

[18F]PARPi Imaging Is Not Affected by HPV Status In Vitro by Navjot Guru, Paula Demétrio De Souza França, Giacomo Pirovano, Cien Huang, Snehal G. Patel, Thomas Reiner

“…Human papillomavirus- (HPV-) associated oropharyngeal squamous cell carcinomas (OPSCCs) are clinically and pathologically distinct from HPV-negative tumors. Here, we explore whether HPV affects functional biomarkers, including γH2AX, RAD51, and PARP1. …”
Get full text

Ghrelin Protects Lipopolysaccharide-Induced Acute Lung Injury Rats against Pulmonary Vascular Dysfunction by Inhibiting Inflammation by Guang Li, Chen-Liang Zhou, Wen-Fang Xia, Di Zhang, Hui-Qing Lin

“…Four hours after establishing the ALI rat model, the mean pulmonary arterial pressure (mPAP), mean right ventricular systolic pressure (RVSP), levels of proinflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the bronchoalveolar lavage fluid (BALF), BALF cell count, wet-to-dry (W/D) lung weight ratios, and myeloperoxidase (MPO) activity in lung tissue for all four groups (ghrelin, ghrelin + ALI, saline, and saline + ALI) were measured. …”
Get full text

Inhibitory Effect of Flavonoid Extract of Lotus Leaf on Alcohol-Induced Gastric Injury by Antioxidant Capacity in Mice by Yi Chen, Qin Li, Zhiping Kuang, Xin Zhao, Ruokun Yi, Xiaowei He, Guangjing Feng

“…Besides, FELL significantly reduced the levels of interleukin 6 (IL-6), interleukin 12 (IL-12), tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ). …”
Get full text

Enhanced targeted treatment of cervical cancer using nanoparticle-based doxycycline delivery system by Sadia Anjum, Ayesha Akhtar, Saleh M. Aldaqal, Maisa S. Abduh, Hammad Ahmad, Riaz Mustafa, Faiza Naseer, Maryam Sadia, Tahir Ahmad

“…These results underscore the potential of HA-Chitosan-based DOX nanoparticles in improving cervical cancer treatment through enhanced targeted delivery and inhibition of tumor-promoting mechanisms.…”
Get full text

Clinical value of serum biomarkers, squamous cell carcinoma antigen and apolipoprotein C-II in follow-up of patients with locally advanced cervical squamous cell carcinoma treated... by Yoko Harima, Takuro Ariga, Yuko Kaneyasu, Hitoshi Ikushima, Sunao Tokumaru, Shigetoshi Shimamoto, Takeo Takahashi, Noriko Ii, Kayoko Tsujino, Anneyuko I Saito, Hiroki Ushijima, Takafumi Toita, Tatsuya Ohno

“…In multivariate analysis, larger tumor size was independently associated with shorter PFS, OS, PPFS, and DMFS, while longer overall treatment time was independently associated with shorter PPFS. …”
Get full text

miR-504 Promoted Gastric Cancer Cell Proliferation and Inhibited Cell Apoptosis by Targeting RBM4 by Yi Zhang, Hongmei Yong, Jing Fu, Guangyi Gao, Huichang Shi, Xueyi Zhou, Mingsheng Fu

“…The relative expression of miR-504 was significantly upregulated in the gastric cancer group (n=25) than in the paired normal group (n=25), but the relative RBM4 expression was remarkably downregulated in the gastric tumor group, compared with the normal group. Additionally, miR-504 overexpression increased the viability of gastric cancer cells. …”
Get full text

Assessment of Anti-Inflammatory and Antioxidant Activities of a Proprietary Preparation of Quercetin–Rutin Blend (SophorOx™) in Exercised Rats by Devanand Shanmugasundaram, James Martin Roza

“…In addition, serum collected on days 8, 15, 22, and 29 were measured for the liver function test (LFT), random blood sugar (RBS), inflammatory markers C-reactive protein (CRP), oxidative stress markers (8-isoprostane (8-iso-PGF2α), malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), and cytokine levels interleukin-1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α)) by the ELISA method. …”
Get full text

Assessment of Cytokine Release against Oral Mucosal Cell Line Culture (TR146) Stimulated by Neutrophil Elastase Associated with Behcet’s Disease by Azeem Hussain Soomro, Erum Khan, Shafaq Noori, Mohid Abrar Lone, Zahid Syal, Sabir Sheikh

“…We used sandwich ELISA technique to isolate IL-1β (interleukin 1β), IL-8, and TNF-α (tumor necrosis factor). Results. We found no significant level of IL-8 and TNF-α when treated with different concentrations of neutrophil elastase after 4- and 24-hour incubation. …”
Get full text

Ningxiang pig-derived Lactobacillus reuteri improves the gut health of weaned piglets by regulating intestinal barrier function and cytokine profiles by Qian Xie, Mei Yang, Qing Duanmu, Meng Kang, Jing Wang, Bi E Tan

“…Furthermore, L. reuteri reduced mRNA expression of pro-inflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) (P < 0.05) in the jejunum and colon while enhancing the expression of the anti-inflammatory cytokine interleukin-10 (IL-10) (P < 0.05) in both the ileum and colon. …”
Get full text

6-Gingerol Normalizes the Expression of Biomarkers Related to Hypertension via PPARδ in HUVECs, HEK293, and Differentiated 3T3-L1 Cells by Yong-Jik Lee, Yoo-Na Jang, Yoon-Mi Han, Hyun-Min Kim, Hong Seog Seo

“…The lipid accumulation in differentiated 3T3-L1 cells was evaluated by using Oil Red O staining. 6- Gingerol increased the level of phosphorylated endothelial nitric oxide synthase (eNOS) protein but decreased that of vascular cell adhesion protein 1 (VCAM1) and tumor necrosis factor alpha (TNFα) in HUVECs. In HEK293 cells, the expression of the epithelial sodium channel (ENaC) protein was reduced by 6-gingerol. …”
Get full text

SOX7 is involved in polyphyllin D-induced G0/G1 cell cycle arrest through down-regulation of cyclin D1 by Zheng Bin, Wang Gang, Gao Wenbo, Wu Qiquan, Zhu Weizhi, Weng Guobin

“…Our results showed low expression of SOX7 in PCa tissues/cells compared to their non-tumorous counterparts/RWPE-1 cells. Moreover, PD inhibited the proliferation of PC-3 cells in a dose- and time-dependent manner. …”
Get full text

DAB2IP Downregulation Enhances the Proliferation and Metastasis of Human Gastric Cancer Cells by Derepressing the ERK1/2 Pathway by Liang Sun, Yizhou Yao, Ting Lu, Zengfu Shang, Shenghua Zhan, Weiqiang Shi, Guofeng Pan, Xinguo Zhu, Songbing He

“…DAB2IP (DOC2/DAB2 interactive protein) is downregulated in several cancer types, and its downregulation is involved in tumor cell proliferation, apoptosis, metastasis, and epithelial-mesenchymal transition (EMT). …”
Get full text