Unexpected acute appendicitis found at laparoscopic surgery for a right ovarian teratoma: A case report by Rie Okuya, Hiroshi Ishikawa, Nozomi Sakai, Eri Katayama, Kaori Kuroda, Kaori Koga

“…Acute appendicitis and adnexal torsion associated with ovarian tumors are possible causes of acute abdomen in women, yet differentiation remains challenging. …”
Get full text

Long noncoding RNAs predict the survival of patients with colorectal cancer as revealed by constructing an endogenous RNA network using bioinformation analysis by Hui Zhang, Zhuo Wang, Jianzhong Wu, Rong Ma, Jifeng Feng

“…Abstract Long noncoding RNAs (lncRNAs) are aberrantly expressed in various cancers types and can function as competing endogenous RNAs (ceRNAs), which promote and maintain tumor initiation and progression. In this study, we explored the functional roles and regulatory mechanisms of lncRNAs as ceRNAs in colorectal cancer and their clinical potential as biomarkers. …”
Get full text

Effect of cold atmospheric plasma on common oral pathogenic microorganisms: a narrative review by Jiajun Xin, Hao Zhang, Yushen Li, Yifei Dai, Xiantao Chen, Jiatong Zou, Rui Wang, Zhihui Liu, Bowei Wang

“…Cold atmospheric plasma (CAP), as the fourth state of matter, has gradually become a hot topic in the field of biomedicine due to its good antibacterial, anti-inflammatory, and anti-tumor capabilities. It is expected to become a major asset in the regulation of oral microbiota.Methods We conducted a search in PubMed, Medline, and Wiley databases, focusing on studies related to CAP and oral pathogenic microorganisms. …”
Get full text

Epigenetic Biomarkers and the Wnt/β-Catenin Pathway in Opisthorchis viverrini-associated Cholangiocarcinoma: A Scoping Review on Therapeutic Opportunities. by Alok Kafle, Sutas Suttiprapa, Mubarak Muhammad, Jan Clyden B Tenorio, Roshan Kumar Mahato, Norhidayu Sahimin, Shih Keng Loong

“…Emerging studies highlight a predominant hypermethylation phenotype in Opisthorchis viverrini (O. viverrini) tumor tissues, underscoring the significance of abnormal DNA methylation and histone modifications in genes and their promoters as reliable targets for Ov-CCA.…”
Get full text

Understanding Autoimmune Mechanisms in Multiple Sclerosis Using Gene Expression Microarrays: Treatment Effect and Cytokine-related Pathways by A. Achiron, M. Gurevich, D. Magalashvili, I. Kishner, M. Dolev, M. Mandel

“…These genes belong to a variety of families such as interleukins, small inducible cytokine subfamily and tumor necrosis factor ligand and receptor. Further analysis disclosed seven cytokine-associated genes within the immunomodulatory treatment signature, and two cytokine-associated genes SCYA4 (small inducible cytokine A4) and FCAR (Fc fragment of IgA, CD89) that were common to both the MS gene expression signature and the immunomodulatory treatment gene expression signature. …”
Get full text

Hyaluronidase-responsive hydrogel loaded with magnetic nanoparticles combined with external magnetic stimulation for spinal cord injury repair by Zhiyi Fan, Guofu Zhang, Wanda Zhan, Juehan Wang, Chaoyong Wang, QianYing Yue, Zhangheng Huang, Yongxiang Wang

“…Hyaluronidase is typically associated with tumor progression and bacterial infections. Analysis showed that hyaluronidase also persistently increased in a rat total excision model. …”
Get full text

Retrosigmoid endoscopic keyhole for vestibular schwannomas: Systematic review and meta-analysis by Ernesto Enrique Horta-Tamayo, Diana Rosa Ortega-Raez, Lary Benice Rodríguez Santillan, Luis César Acosta González, Martha Suárez Rodríguez, Arminda González González

“…In a subgroup analysis, those series where the diameters of the tumor lesion were greater than 3 cm showed less preservation of facial function. …”
Get full text

Opposing Roles of Leptin and Ghrelin in the Equine Corpus Luteum Regulation: An In Vitro Study by António Galvão, Angela Tramontano, Maria Rosa Rebordão, Ana Amaral, Pedro Pinto Bravo, Anna Szóstek, Dariusz Skarzynski, Antonio Mollo, Graça Ferreira-Dias

“…Thus, the aim of this study was: (i) to characterize the immunolocalization, mRNA and protein levels of leptin (LEP), Ghrelin (GHR) and respective receptors LEPR and Ghr-R1A, throughout luteal phase; and (ii) to evaluate the role of LEP and GHR on progesterone (P4), prostaglandin (PG) E2 and PGF2α, nitric oxide (nitrite), tumor necrosis factor-α (TNF); macrophage migration inhibitory factor (MIF) secretion, and on angiogenic activity (BAEC proliferation), in equine corpus luteum (CL) from early and mid-luteal stages. …”
Get full text

Association between Serum Neopterin and Inflammatory Activation in Chronic Kidney Disease by Ashok Kumar Yadav, Vinod Sharma, Vivekanand Jha

“…We also estimated highly sensitive CRP (hsCRP) and interluekin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in the CKD subjects. …”
Get full text

Integrating MAPK pathway inhibition into standard-of-care therapy for pediatric low-grade glioma by Erin E. Crotty, Aimee A. Sato, Aimee A. Sato, Mohamed S. Abdelbaki

“…Pediatric low-grade gliomas (pLGG) are a group of tumors largely driven by alterations in a single genetic pathway, known as the RAS-RAF-mitogen-activated protein kinase (MAPK) pathway. …”
Get full text

Recurrence of a t(8;21)-Positive Acute Myeloid Leukemia in the Form of a Granulocytic Sarcoma Involving Cranial Bones: A Diagnostic and Therapeutic Challenge by Ambra Di Veroli, Alessandro Micarelli, Mariagiovanna Cefalo, Eleonora Ceresoli, Daniela Nasso, Laura Cicconi, Simone Mauramati, Fabrizio Ottaviani, Adriano Venditti, Sergio Amadori

“…Granulocytic sarcoma (GS) is a rare extramedullary solid tumor defined as an accumulation of myeloblasts or immature myeloid cells. …”
Get full text

Novel Chlorin with a HYNIC: Synthesis, ^99mTc-Radiolabeling, and Initial Preclinical Evaluation by Alexander Popov, Nikita Suvorov, Mariia Larkina, Evgenii Plotnikov, Ruslan Varvashenya, Vitalina Bodenko, Gleb Yanovich, Petr Ostroverkhov, Maxim Usachev, Elena Filonenko, Mikhail Belousov, Mikhail Grin

“…One of the most effective ^99mTc chelators is 6-hydrazinylnicotinic acid (HYNIC), which, when combined with various vector molecules, can be used for targeted delivery of radionuclides to tumor tissues. At the same time, it is known that tetrapyrrole macrocycles are capable of selective accumulation in tumors, and thus can be used to target radiopharmaceuticals with ^99mTc. …”
Get full text

Intra-uterine Growth Restriction Downregulates the Hepatic Toll Like Receptor-4 Expression and Function by Ozlem Equils, Sapna Singh, Semra Karaburun, Daning Lu, Manikkavasagar Thamotharan, Sherin U. Devaskar

“…In the liver, IUGR led to a 20% increase in baseline tumor necrosis factor (TNF)-α mRNA expression ( p < 0.03) and a 70% increase in interleukin-1β (IL-1β) mRNA expression ( p < 0.008) as compared to the control rats (CM/CP; n = 7). …”
Get full text

Fimasartan Ameliorates Nonalcoholic Fatty Liver Disease through PPARδ Regulation in Hyperlipidemic and Hypertensive Conditions by Yong-Jik Lee, Yoo-Na Jang, Yoon-Mi Han, Hyun-Min Kim, Jong-Min Jeong, Hong Seog Seo

“…In HepG2 cells and liver tissues, fimasartan was shown to increase the protein levels of peroxisome proliferator-activated receptor delta (PPARδ), phosphorylated 5′ adenosine monophosphate-activated protein kinase (p-AMPK), phosphorylated acetyl-CoA carboxylase (p-ACC), malonyl-CoA decarboxylase (MCD), medium chain acyl-CoA dehydrogenase (MCAD), and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), and it led to a decrease in the protein levels of 11 beta-hydroxysteroid dehydrogenase 1 (11β-HSDH1), fatty acid synthase (FAS), and tumor necrosis factor-alpha (TNF-α). Fimasartan decreased lipid contents in HepG2 and differentiated 3T3-L1 cells and liver tissues. …”
Get full text

Effect of Antifungal-Treated Host Macrophages on Candida glabrata by Hong-Bin Li, Na Li, Shu-Ran Wen, Ming-Yue Qiang, Zheng-Hui Yang, Tian-Xiang Dong, Yu-Ye Li, Yi-Qun Kuang

“…Neither ICZ nor AmB affected the secretion of interleukin-6 (IL-6), interleukin-8 (IL-8), or tumor necrosis factor-α (TNF-α) by C. glabrata-infected macrophages. …”
Get full text

Multiomic quantification of the KRAS mutation dosage improves the preoperative prediction of survival and recurrence in patients with pancreatic ductal adenocarcinoma by Won-Gun Yun, Daeun Kim, Youngmin Han, Wooil Kwon, Seong-Geun Lee, Jin-Young Jang, Daechan Park

“…Our prognostic scoring system included the mutation dosage from targeted sequencing ( > 0.195, 1 point), maximal tumor diameter at preoperative imaging ( > 20 mm, 1 point), and carbohydrate antigen 19-9 levels ( > 150 U/mL, 1 point). …”
Get full text

miR-7-5p Promotes Hepatic Stellate Cell Activation by Targeting Fibroblast Growth Factor Receptor 4 by Shuxia Tian, Min Chen, Bing Wang, Yonglong Han, Haonan Shang, Junming Chen

“…MicroRNA-7 (miR-7) is a tumor suppressor and associated with lipid homeostasis in the liver. …”
Get full text

Perivascular Invasion: A Promising Prognostic Parameter for Breast Cancer by Begüm Çalım GÜRBÜZ, Tuçe Söylemez AKKURT, Handan EREN, Hazal İzol ÖZMEN, Ebru ŞEN, Burçin PEHLİVANOĞLU

“…Lymphovascular invasion (LVI) and perineural invasion (PNI) were also significantly more frequent in tumors with PVI (p=0.001 and 0.02, respectively). …”
Get full text

Prognosis of invasive encapsulated follicular variant and classical papillary thyroid carcinoma: a propensity score-matched study using the SEER database by Shuai Jin, Lang Xie, Gongyou Zhang, Lei Liu, Kaide Xia, Hongzhou Liu, Haiwang Zhang, Peng Li

“…Abstract The latest World Health Organization Classification of Tumors, Fifth Edition, recognizes the invasive encapsulated follicular variant of papillary thyroid carcinoma (IEFVPTC) as a distinct malignant entity rather than a subtype of papillary thyroid carcinoma (PTC). …”
Get full text

Bioadhesive Chitosan Films Loading Curcumin for Safe and Effective Skin Cancer Topical Treatment by Seila Tolentino, Mylene M. Monteiro, Felipe Saldanha-Araújo, Marcilio Cunha-Filho, Tais Gratieri, Eliete N. Silva Guerra, Guilherme M. Gelfuso

“…<b>Conclusion</b>: The developed chitosan-based bioadhesive films represent a promising alternative for the topical treatment of skin tumors using curcumin.…”
Get full text