A hepatocellular carcinoma model with and without parenchymal liver damage that integrates technical and pathophysiological advantages for therapy testing by Karina Benderski, Paul Schneider, Panayiotis Kordeves, Michael Fichter, Jenny Schunke, Federica De Lorenzi, Feyza Durak, Barbara Schrörs, Özlem Akilli, Fabian Kiessling, Matthias Bros, Mustafa Diken, Stephan Grabbe, Jörn M. Schattenberg, Twan Lammers, Alexandros Marios Sofias, Leonard Kaps

“…C-HCC mice had a significantly higher tumor load than non-cirrhotic HCC mice. Both HCC and C-HCC models displayed extensive ECM formation, increased levels of vascularization, and immune cell infiltration compared to healthy and non-cancerous cirrhotic livers. …”
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Radiosensitizing capacity of fenofibrate in glioblastoma cells depends on lipid metabolism by Bayan Alkotub, Lisa Bauer, Ali Bashiri Dezfouli, Khouloud Hachani, Vasilis Ntziachristos, Gabriele Multhoff, Morteza Hasanzadeh Kafshgari

“…Since the stability of plasma and lysosomal membranes is maintained by the presence of the stress-inducible heat shock protein 70 (Hsp70) which has a strong affinity to tumor-specific glycosphingolipids, necrosis occurs predominantly in LN18 cells having a lower membrane Hsp70 expression density than U87 cells.In summary, our findings indicate that the lipid metabolism of tumor cells can affect the radiosensitizing capacity of FF when encountered either as a free drug or as a drug loaded in biomimetic lipid vesicles.…”
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Serum Levels and Placental Expression of NGAL in Gestational Diabetes Mellitus by Xiaoqian Yin, Yan Huo, Li Liu, Yixing Pan, Suxin Liu, Runfang Wang

“…We examined serum concentrations of NGAL and tumor necrosis factor-α (TNF-α) in maternal blood and cord blood and their expression levels in the term placentas and umbilical cord. …”
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LncRNA H19 Promotes Gastric Cancer Metastasis via miR-148-3p/SOX-12 Axis by Xin Zhang, Ge Wang, Xiaoru Li, Yanqing Liu, Xue Wu, Yazhe Zhou, Jie Liu, Haiying Wang, Rui Jiao, Ying Chen, Qiang Wang

“…Gastric cancer (GC) is the most common malignant tumor and ranks third in the world. LncRNA H19 (H19), one of the members of lncRNA, is overexpressed in various tumors. …”
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Inhibiting HnRNP L-mediated alternative splicing of EIF4G1 counteracts immune checkpoint blockade resistance in Castration-resistant prostate Cancer by Xumin Zhou, Shilong Cheng, Zhongjie Chen, Jinming Zhang, Jiaqi Wang, Qiang Li, Xumin Zhou

“…In vivo, inhibition of EIF4G1 by the inhibitor, SBI-0640756, attenuated HnRNP l-induced tumor progression and immunosuppressive activity. …”
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Neostigmine Attenuates Proinflammatory Cytokine Expression in Preoptic Area but Not Choroid Plexus during Lipopolysaccharide-Induced Systemic Inflammation by Andrzej P. Herman, Dorota Tomaszewska-Zaremba, Marta Kowalewska, Aleksandra Szczepkowska, Małgorzata Oleszkiewicz, Agata Krawczyńska, Maciej Wójcik, Hanna Antushevich, Janina Skipor

“…Neostigmine suppressed (p<0.05) LPS-stimulated synthesis of cytokines such as interleukin- (IL-) 1β, IL-6, and tumor necrosis factor (TNF) α in the POA, and this effect was similar to that induced by the treatment with systemic AChE inhibitor—donepezil (2.5 mg/animal). …”
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USO DA TERAPIA POR PRESSÃO NEGATIVA PARA CICATRIZAÇÃO DE FERIDAS ONCOLÓGICAS: RELATO DE EXPERIÊNCIA by Giovani Basso da Silva, Vinicius Souza dos Santos, Lucas Paulo de Souza, Ana Paula Dias da Silva, Fabiane Mendonça da Rosa, Eliane Goldberg Rabin, João Gabriel Toledo Medeiros

“…O paciente, homem de 66 anos, apresentava ferida complexa decorrente de laparotomia e retirada de tumor. O sistema RENASYS foi utilizado em oito trocas de curativo ao longo de oito semanas, com pressões ajustadas conforme o estágio do tratamento. …”
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GPX3-Mediated Oxidative Stress Affects Pyrimidine Metabolism Levels in Stomach Adenocarcinoma via the AMPK/mTOR Pathway by Yaowen Zhang, Yixin Yang, Shanshan Kuang, Yang Zhang, Hancheng Qin, Jisheng Xie

“…Amino acid metabolism, including ATP production, nucleotide synthesis, and redox homeostatic processes, are associated with proliferation and differentiation of tumor cells. This study aimed to identify novel prognostic biomarkers and potential therapeutic targets of amino acid metabolism-related genes for stomach adenocarcinoma (STAD). …”
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Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as possible anticancer agents by Çevik Ulviye Acar, Osmaniye Derya, Levent Serkan, Sağlik Begüm Nurpelin, Çavuşoğlu Betül Kaya, Karaduman Abdullah Burak, Özkay Yusuf, Kaplancikli Zafer Asim

“…Anticancer activity studies of the compounds were evaluated against MCF-7 and A549 tumor cell lines. In addition, with the purpose of determining the selectivity of cytotoxic activities, the most active compound was screened against a noncancer NIH3T3 cell line (mouse embryonic fibroblast cells). …”
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Research progress of Traditional Chinese Medicine characteristic nursing techniques for patients with pancreatic cancer (中医特色护理技术在胰腺癌中的应用研究进展)... by GAO Donghua (高冬华), WANG Guiting (王贵婷), ZHANG Xinhui (张鑫辉), TIAN Wanqin (田婉琴), Tang Ling (唐玲)

“…Pancreatic cancer is a kind of digestive tract tumor, with a high degree of malignancy. Its clinical manifestations are mainly abdominal discomfort and dull pain, often accompanied by loss of appetite, loss of body shape and obstructive jaundice. …”
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Effect of extracellular vesicle ZNF280B derived from lung cancer stem cells on lung cancer progression by Qixia Guo, Jiayan Lu, Hui Zhao, Ding Zhou, Hua Liu

“…Additionally, subcutaneous tumor-bearing experiments in nude mice were performed to evaluate the roles of lung CSCs-EVs in lung cancer progression in vivo.Results The results indicated that lung CSCs-EVs accelerated the progression of lung cancer. …”
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Lipoic acid-boronophenylalanine-derived multifunctional vesicles for cancer chemoradiotherapy by Liqun Dai, Jie Liu, Tingyu Yang, Xiaorui Yu, Yi Lu, Lili Pan, Siming Zhou, Diyun Shu, Yuanhao Liu, Wuyu Mao, Zhiyong Qian

“…The vesicles demonstrate high efficiency in encapsulating doxorubicin, featuring a glutathione-responsive release mechanism, which present a promising option for tumor therapy. Additionally, the derivatives of the B-10 isotope, containing up to 1.6% boron, are engineered for incorporation into L P B-3-based vesicles. …”
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Proteomic Analysis of Lung Tissue in a Rat Acute Lung Injury Model: Identification of PRDX1 as a Promoter of Inflammation by Dongdong Liu, Pu Mao, Yongbo Huang, Yiting Liu, Xiaoqing Liu, Xiaoqing Pang, Yimin Li

“…Furthermore, overexpression of PRDX1 increased the expression of proinflammatory cytokines interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α), whereas knockdown of PRDX1 led to downregulated expression of cytokines induced by LPS. …”
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Systemic brain dissemination of glioblastoma requires transdifferentiation into endothelial-like cells via TGF-β-ALK1-Smad1/5 signaling by Thomas M.B. Ware, Adilson Fonseca Teixeira, Josephine Iaria, Rodney B. Luwor, Hong-Jian Zhu

“…This relies on the transdifferentiation of glioblastoma tumor cells into endothelial-like cells in a process we termed endothelialisation. …”
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Portrait of WWP1: the current state in human cancer by Jiaming Lei, Jun Chen, Wenwen Yu, Qing Wu, Shuang Jing, Yuanguang Tang, Li Lin, Meichun Hu

“…WWP1 demonstrates a dual function, acting predominantly as an oncogene in tumors but occasionally as a tumor suppressor. This review summarizes WWP1’s biological roles, therapeutic potential in oncology, upstream regulatory factors, and downstream substrates. …”
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İntraoral Lipom: Bir Olgu Sunumu by Ahmet Aktı, Abdullah Kalaycı, Hasan Küçükkolbaşı, Şeyma Koyuncu

“…Sonuç Lipom benign bir tümör olup tüm vücutta yaygın görülmekle beraber ağız içi lipomlar, rutin diş muayeneleri sırasında fark edilebilen nadir bir antitedir. …”
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Open Partial Horizontal Laryngectomy as a Conservative Salvage Treatment for Laser-Recurrent Laryngeal Cancer: A Multi-Institutional Series by Erika Crosetti, Andrea Borello, Andy Bertolin, Izabela Costa Santos, Marco Fantini, Giulia Arrigoni, Ilaria Bertotto, Andrea Elio Sprio, Fernando Luiz Dias, Giuseppe Rizzotto, Giovanni Succo

“…OPHL emerged as an effective organ-preserving alternative to total laryngectomy (TL) in select patients, especially those with limited tumor spread and preserved laryngeal function. The study highlights the importance of careful patient selection and thorough preoperative assessment to improve outcomes, positioning OPHL as a key option in treating recurrent laryngeal cancer and offering oncological control while preserving laryngeal functions.…”
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Targeting SLC4A4: A Novel Approach in Colorectal Cancer Drug Repurposing by Krunal Pawar, Pramodkumar P. Gupta, Pooran Singh Solanki, Ravi Ranjan Kumar Niraj, Shanker L. Kothari

“…This study aims to explore the role of the SLC4A4 transporter as a biomarker in CRC progression and its potential as a therapeutic target, particularly in relation to tumor acidity and immune response. Methods: The study utilized computational approaches, including receptor-based virtual screening and high-throughput docking, to identify potential SLC4A4 inhibitors. …”
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Pregnancy-Associated Plasma Protein A Induces Inflammatory Cytokine Expression by Activating IGF-I/PI3K/Akt Pathways by Weiping Li, Hongwei Li, Li Zhou, Zijian Wang, Bing Hua

“…The concentration of monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in culture supernatants was determined by ELISA. …”
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Melittin ameliorates schistosomiasis-induced liver fibrosis by suppressing signal transducer and activator of transcription 3 and nuclear factor kappa B by Ola I. Rozik, Manal M. Hussein, Ahmed S. El-elebiarie, Soad Nady

“…Hepatic granuloma index (GI) was measured in each experimental mouse, and serum tumor necrosis factor-α (TNF-α), interleukin-17 (IL-17), interleukin-10 (IL-10), and immunoglobulin E were measured by ELISA techniques. …”
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