Case Report: Rare cardiovascular characteristics of tuberous sclerosis complex with novel TSC2 variant by Zhiqin Du, Xiao Ma, Xiao Ma, Xiao Ma, Jianhua Li, Fang Yang, Yangfan Guo, Yangfan Guo

“…BackgroundTuberous sclerosis complex (TSC) is a multisystem genetic disorder primarily characterized by the development of benign tumors in multiple organs. While cardiovascular involvement is less common than neurological or renal manifestations, it typically presents with cardiac rhabdomyomas (CRs). …”
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Hemoperitoneo secundario a rotura de carcinoma hepatocelular by Yeney Espinosa Rodríguez, Josué Fuentes Rojas, Rene Rafael Bonachea Peña, Julio Roberto Betancourt Cervantes

“…Alrededor del 90 % de estos tumores se desarrollan sobre una enfermedad hepática previa. …”
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Risk factors for postoperative acute kidney injury after cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy: a meta-analysis and systematic review by Dengzhuo Chen, Yongli Ma, Jinghui Li, Liang Wen, Linfeng Liu, Guosheng Zhang, Hongkai Hu, Chengzhi Huang, Xueqing Yao

“…In addition, the risk of postoperative AKI varied by primary tumor site, with Appendix being less prone to AKI, while mesothelioma and ovarian, two sites with a greatly elevated risk of postoperative AKI. …”
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Uncovering the Beneficial Role of <i>Limosilactobacillus fermentum</i> E7 Exhibiting Antioxidant Activity in Ameliorating DSS-Induced Ulcerative Colitis in a Murine Model by Hongyan Zhang, Hailing Wang, Yue Li, Yue Leng, Ke Lin, Dayong Ren

“…Furthermore, E7 effectively regulated UC mouse intestinal microbiota composition, increased short-chain fatty acid concentration, and promoted the expression of anti-inflammatory factors, such as interleukin 10 (IL-10), while suppressing that of pro-inflammatory factors, such as interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α). Meanwhile, D1 and Q13 only exhibited partial alleviating effects. …”
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Elotuzumab Enhances CD16-Independent NK Cell-Mediated Cytotoxicity against Myeloma Cells by Upregulating Several NK Cell-Enhancing Genes by Yan-Hua Wang, Shotaro Hagiwara, Hiroshi Kazama, Yuki Iizuka, Norina Tanaka, Junji Tanaka

“…In this study, we demonstrated that Elo pretreatment significantly enhanced CD16-independent NK cell-mediated cytotoxicity in both SLAMF7-positive MM.1S and SLAMF7-negative K562, U266, and RPMI 8226 tumor cells. Upon direct simulation of CD16-independent NK cells with Elo, increased levels of CD107a degranulation and IFN-γ secretion were observed along with the upregulation of granzyme B, TNF-α, and IL-1α gene expression. …”
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Highly Expressing SCARA5 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma by Kawuli Jumai, Tangjuan Zhang, Bingzhang Qiao, Julaiti Ainiwaer, Haiping Zhang, Zhichao Hou, Idris Awut, Madinyat Niyaz, Liwei Zhang, Ilyar Sheyhidin

“…The K-M survival analysis indicated that SCARA5 expression quantity was not related to prognosis, but tumor volume and T classification were both the independent prognostic factors. …”
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Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Clinicopathologic Analysis with Evaluation of the E-Cadherin/β-Catenin Complex and Associated Genetic Alterations by Maria Del Valle Estopinal, Lavinia P. Middleton, Bita Esmaeli, Keyur P. Patel, Sara Nowroozizadeh, Michelle D. Williams

“…Next generation sequencing for the detection of somatic mutations was performed on each tumor with matched normal tissue, examining 50 cancer-related genes. …”
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Lung and Gut Microbiota as Potential Hidden Driver of Immunotherapy Efficacy in Lung Cancer by Carmine Carbone, Geny Piro, Vincenzo Di Noia, Ettore D’Argento, Emanuele Vita, Miriam Grazia Ferrara, Sara Pilotto, Michele Milella, Giovanni Cammarota, Antonio Gasbarrini, Giampaolo Tortora, Emilio Bria

“…In this review, we discuss some of the major findings depicting bacteria as crucial gatekeeper for the immune response against tumor and their role as driver of immunotherapy efficacy in lung cancer with a special focus on the distinctive role of gut and lung microbiota in the efficacy of immunotherapy treatment.…”
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Case report: Rituximab combined with plasma exchange treatment for systemic lupus erythematosus complicated with thrombotic microangiopathy and non-cirrhotic portal hypertension by Jinmei Huang, Wei Fan, Xuyan Chen, Shufan Wu, Zhigao Dong, Yi Zhang, Yiwan Lin, Pingping Xiao

“…The patient was negative for hepatitis virus, autoimmune liver disease antibodies, ceruloplasmin, and tumor markers. Therefore, SLE complicated by TMA and NCPH was considered. …”
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Matrix Metalloproteinases: Inflammatory Regulators of Cell Behaviors in Vascular Formation and Remodeling by Qishan Chen, Min Jin, Feng Yang, Jianhua Zhu, Qingzhong Xiao, Li Zhang

“…Abnormal angiogenesis and vascular remodeling contribute to pathogenesis of a number of disorders such as tumor, arthritis, atherosclerosis, restenosis, hypertension, and neurodegeneration. …”
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High Grade Myofibroblastic Sarcoma of Paratesticular Soft Tissues by Ioannis Anastasiou, Panagiotis K. Levis, Ioannis Katafigiotis, Georgios Karaolanis, Viktoria-Varvara Palla, Evangelos Felekouras, Antonios Athanasiou, Marina Perdiki, Dionysios Mitropoulos, Constantinos A. Constantinides

“…Tumors of the paratesticular region most often arise from the soft tissue surrounding the spermatic cord and the epididymis or from the soft tissue (dartos muscle) of the scrotal wall. …”
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Neutrophil to Lymphocyte Ratio as a Predictive Factor in Iraqi Patients with Thyroid Cancer by Fatima Falah Hassan, Wafaa Fadhil Hamed, Luma Yousif Mehdi

“…The results showed that the highest number and percentage of malignant thyroid tumors 21 (35%) was among the age group (50-≥ 60) years, while the lowest number and percentage of malignant tumors 10 (16.7%) was among the age groups (20-29) and (30-39) years. …”
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MicroRNA-155 Participates in the Expression of LSD1 and Proinflammatory Cytokines in Rheumatoid Synovial Cells by Ziliang Yu, Hao Liu, Jianbo Fan, Feihu Chen, Wei Liu

“…Lysine-specific demethylase 1 (LSD1) has been found that it can ameliorate the severity of RA. Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 are key proinflammatory cytokines implicated in the pathogenesis of RA. …”
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TNF-α and Microalbuminuria in Patients with Type 2 Diabetes Mellitus by I.-Th. Lampropoulou, M. Stangou, A. Papagianni, T. Didangelos, F. Iliadis, G. Efstratiadis

“…Albumin-creatinine ratio (ACR) was calculated in first-morning urine samples. Serum and urinary tumor necrosis factor-α (TNF-α) levels were determined by ELISA. …”
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Insights into the Multidisciplinary Approach for Metastatic Acinic Cell Lung Carcinoma: The Pathologist’s Role in Romania Today by Dorela-Codruta Lazureanu, Amelia Burlea, Robert Barna, Daniela Cipu, Mihaela Pasca Fenesan, Ioan Icma, Marioara Cornianu

“…It is histologically similar to this kind of tumor described in salivary glands, but with a different immunophenotype. …”
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Spore-Derived Isolates from a Single Basidiocarp of Bioluminescent <i>Omphalotus olivascens</i> Reveal Multifaceted Phenotypic and Physiological Variations by Rudy Diaz, David Bermudes

“…This same subset produced an anticancer agent that was highly potent against MDA-MB-468 breast cancer tumor cells. We interpret these variations in haploids as significant in altering <i>Omphalotus</i> physiology and its production of secondary metabolites, which may in turn alter their ecology and life cycle, and could be further applied to studying fungal physiologies and facilitate linking them to their genetic underpinnings.…”
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New Method To Prevent Contamination In Minimal Invasive Surgery: Usage Of Endoprotector by Betül Güzelyüz, Server Sezgin Uludağ, Engin Hatipoğlu, Egemen Özdemir, Sefa Ergün, Kemal Selçuk Şengün

“…It reduces peritonitis and intra-abdominal infections, the need for irrigation, and the use of drains, thus shortening postoperative ileus and hospital stay; and predicted to reduce outcomes such as tumor implantation.…”
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MicroRNA-29b Suppresses Inflammation and Protects Blood-Brain Barrier Integrity in Ischemic Stroke by Xiaoqing Ma, Ho Jun Yun, Kenneth Elkin, Yunliang Guo, Yuchuan Ding, Guangwen Li

“…Methods. miR-29b from stroke patients and rats with middle cerebral artery occlusion (MCAO) were assessed using real-time polymerase chain reaction (PCR). miR-29b agomir was used to increase miR-29b expression in leukocytes via intravenous injection. C1q and tumor necrosis factor (C1QTNF) 6, interleukin- (IL-) 1β, zonula occludens- (ZO-) 1, occludin, and ischemic outcomes were assessed in MCAO rats. …”
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Antilipotoxicity Activity of Osmanthus fragrans and Chrysanthemum morifolium Flower Extracts in Hepatocytes and Renal Glomerular Mesangial Cells by Po-Jung Tsai, Mei-Ling Chang, Ching-Mei Hsin, Chung-Chieh Chuang, Lu-Te Chuang, Wen-Huey Wu

“…OF and CM also suppressed the mRNA expression of interleukin- (IL-) 1β, IL-6, IL-8, tumor necrosis factor- (TNF-) α, and transforming growth factor- (TGF-) β by HepG2 cells treated with conditioned medium derived from lipopolysaccharide-treated THP-1 monocytes. …”
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NOP2/Sun RNA Methyltransferase 4 Regulates the Mammalian Target of Rapamycin Signaling Pathway to Promote Hepatocellular Carcinoma Progression by Congren Wang, Shaoying Ke, Shaoze Lin, Conglin Lin, Zhibing Cai, Lingju Hong, Qunxiong Pan

“…The western blot was utilized to determine the protein expression level of NSUN4 and mammalian target of rapamycin (mTOR) pathway-related proteins in cells and mouse tumor tissues. Cell counting kit-8 and colony formation assays were employed to measure cell proliferation ability. …”
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