Effects of Tp53 Gene Mutations on the Survival of Non-Small Cell Lung Cancer (NSCLC); A Short Review by Zhang C, Yang C, Shi Q

“…Mutated p53 protein may have some pro-oncogenic impact, and the variations may change tumor inhibitors into oncogenes. The diverse mutational spectrum of TP53 in NSCLC with different mutations is linked to varied treatment responses. …”
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PHYTOCHEMICAL PROFILE, ANTIOXIDANT AND CYTOTOXIC ACTIVITIES OF LEAF EXTRACT OF Dipteryx lacunifera DUCKE by Krislany A. L. Guedes Araujo, Herbert G. Sousa, João P. da Silva Gomes, Renato Pinto de Sousa, Éverton L. de França Ferreira, Monica T. Pupo, Pedro M. da Silva Costa, Claudia Pessoa, Mahendra Rai, Mariana H. Chaves, Gerardo Magela Vieira Junior

“…However, neither fraction exhibited inhibition of tumor cell lines tested. These findings enhance our understanding of the chemical and biological potential of the D. lacunifera species.…”
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POTENCY OF SOURSOP LEAF EXTRACT AND CURCUMIN WITH MAGNETIC AND MUCUS-PENETRATING NANOPARTICLE AS COLORECTAL CANCER ALTERNATIVE THERAPY by Faiza Rahma Ebnudesita, Ayik Rochyatul Jannah, Savira Butsainah Dienanta, Reny I'tishom

“…Review: Soursop leaf extract has acetogenin agent as an anti-tumor, anti-inflammatory, and cytotoxic agent that acts specifically on target organs. …”
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Konik ışınlı bilgisayarlı tomografi istek nedenlerinin incelenmesi by Eda Didem Yalçın, Aslıhan Artaş

“…En fazla isteğin implant planlaması (% 47.72) amacıyla olduğu belirlendi. Daha sonra sırasıyla tümör ve kist benzeri patolojiler  (% 23.07), gömülü dişlerin lokalizasyonu ve komşu anatomik yapılarla ilişkisinin incelenmesi (% 6.73), ortodontik amaçlı (% 3.76), travma (% 3.46), süpernümerer diş (% 2.87), paranazal sinüs patolojilerinin incelenmesi (%2.38), diş kökleri-mandibular kanal ilişkisinin değerlendirilmesi (% 2.18), dudak damak yarığı (%1.58), temporomandibular eklem patolojilerinin incelenmesi (% 1.29) ve diğer istek nedenleri (% 4.96) için yapıldığı saptandı. …”
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The Diagnostic Performance of 18F-FDG PET/CT in Recurrent Pancreatic Cancer: A Systematic Review and Meta-analysis by Gu A, Yuezhan Shan, Huasong Huo, Chao Ding, Caixia Sun

“…Conclusions. 18F-FDG PET-CT was found to be a reliable detection method in recurrent pancreatic tumor.…”
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Expanded Use of Vorasidenib in Non-Enhancing Recurrent CNS WHO Grade 3 Oligodendroglioma by Alexander S. Himstead, Jefferson W. Chen, Eleanor Chu, Mari A. Perez-Rosendahl, Michelle Zheng, Sherin Mathew, Carlen A. Yuen

“…<b>Results:</b> We present a case of a 71-year-old male with a grade 3 non-enhancing oligodendroglioma successfully treated with vorasidenib with an 11% reduction in residual tumor volume. Vorasidenib was well tolerated in our patient with a mild elevation in his liver transaminases that resolved following a brief interruption in treatment. …”
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Cell Differentiation Trajectory Predicts Prognosis and Immunotherapeutic Response in Clear Cell Renal Cell Carcinoma by Jin Xu, Xi Chen, Yinyu Chen, Qiushuang Wang, Yingliang Jin, Huashuo Zhao

“…Finally, we found the expression level of model DRGs was associated with a tumor-immune microenvironment (TIME) pattern and the response of 83 compounds or inhibitors was significantly different in the two risk groups. …”
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Pulmonary Hypertension due to a Pulmonary Artery Leiomyosarcoma: A Case Report by Seyyed Hassan Adeli, Bardia Nemati, Mahboubeh Jandaghi, Mohammad Mahdi Riahi, Fatemeh Hosseinzadeh, Fatemeh Salarvand

“…She was operated, a yellowish-shiny solid mass in pulmonary trunk was seen intraoperatively, and pulmonary endarterectomy was performed. Her tumor was pathologically diagnosed as pulmonary artery leiomyosarcoma. …”
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GNG2 inhibits brain metastases from colorectal cancer via PI3K/AKT/mTOR signaling pathway by Chenhua Luo, ZhiMing Xiao, WenLong Yang

“…Our study suggests that GNG2 contributes to tumor suppression in CRC, particularly in preventing brain metastasis, and could serve as a promising biomarker and treatment target for mCRC, offering fresh insights into the molecular processes driving cancer progression and metastasis.…”
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Induction of tyrosine aminotransferase in mice is inhibited by activated metabolites of ortho- aminoazotoluene by V. I. Kaledin, S. I. Ilnitskaya, N. A. Popova, O. A. Koval, I. A. Pyshnaya, L. F. Gulyaeva

“…There is a specific relationship between the effect of a carcinogen on TAT induction and its liver carcinogenicity in animals. Presuming tumor development being initiated not directly by the chemicals employed but their metabolically activated derivatives, the question arises whether TAT induction is inhibited by carcinogen metabolites or by their parent compounds. …”
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A New Prognostic Indicator of Immune Microenvironment and Therapeutic Response in Lung Adenocarcinoma Based on Peroxisome-Related Genes by Zhen Xiong, Liwen Zhang, Wei Fan

“…Lung adenocarcinoma (LUAD) has been the major cause of tumor-associated mortality in recent years and exhibits a poor outcome. …”
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LncRNA HOXA10-AS as a novel biomarker and therapeutic target in human cancers by Xin Hu, Yong Wang, Sijia Zhang, Xiaosi Gu, Xiaoyu Zhang, Lianlian Li, Lianlian Li

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The Role of Targeted Focal Therapy in the Management of Low-Risk Prostate Cancer: Update on Current Challenges by Daniel W. Smith, Diliana Stoimenova, Khadijah Eid, Al Barqawi

“…Furthermore, patient selection criteria for TFT, costs, side effects, and brachytherapy template-guided three-dimensional mapping biopsies (3DMB) for tumor localization will also be explored.…”
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Fenofibrate Exerts Antitumor Effects in Colon Cancer via Regulation of DNMT1 and CDKN2A by Rui Kong, Nan Wang, Wei Han, Wen Bao, Jie Lu

“…Finally, we demonstrated that fenofibrate administration inhibited tumor growth and DNMT1 activity in vivo. The PPARA agonist, fenofibrate, might serve as an applicable agent for epigenetic therapy of colon cancer patients.…”
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Urothelial Superior Vena Cava Syndrome with Limited Response to Radiation Therapy by Nishan Bingham, H. James Wallace III, Joanne Monterroso, Claire Verschraegen, Brenda L. Waters, Christopher J. Anker

“…Consequently, optimal management remains challenging, particularly in cases of high tumor burden. Here we present a case of highly advanced metastatic urothelial cancer with SVC syndrome and tracheal compression. …”
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Interaction of AURKA with TRIM28 revives dormant LSCC cells via Akt signaling pathway to promote LSCC metastasis by Liyun Yang, Liang Geng, Xinxin Zhang, Jing Lu, Hao Zhang, Geping Wu, Shuixian Huang

“…Akt signaling pathway played an essential role in promoting the tumor-promoting effects induced by TRIM28. Conclusion AURKA mediated TRIM28 to revive dormant LSCC cells via Akt signaling pathway to promote LSCC metastasis, targeting TRIM28 might provide a potential treatment strategy for LSCC.…”
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Effect of Lipopolysaccharide and TNFα on Neuronal Ascorbic Acid Uptake by Veedamali S. Subramanian, Trevor Teafatiller, Anshu Agrawal, Masashi Kitazawa, Jonathan S. Marchant

“…During chronic neuroinflammation or infection, CNS levels of lipopolysaccharide (LPS) and LPS-induced tumor necrosis factor-α (TNFα) are increased. Elevated levels of LPS and TNFα have been associated with neurodegenerative diseases together with reduced levels of AA. …”
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PSMA2 promotes chemo- and radioresistance of oral squamous cell carcinoma by modulating mitophagy pathway by Chun-I Wang, Cheng-Yi Chen, Ting-Wen Chen, Chun-Chia Cheng, Shu-Wen Hong, Tsung-You Tsai, Kai-Ping Chang

“…However, locoregional failure remains a critical issue affecting the prognosis of OSCC patients, largely due to tumor resistance against radiation or chemotherapy. …”
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Synergism of d-limonene and temozolomide on migratory and apoptotic behaviors of human glioblastoma cell lines by Megha Gautam, Reema Gabrani

“…Introduction: Glioblastoma (GBM), which is a heterogeneous and aggressive type of brain tumor, is known for its poor survival outcomes. The treatment of GBM remains challenging primarily due to the drug resistance to the current standard therapeutic option, temozolomide (TMZ). …”
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«SAVING» A TWO-STAGE LIVER RESECTION BY THE ALPPS TYPE by D. V. Sidorov, M. V. Lozhkin, L. O. Petrov, A. G. Isaeva

“…Despite the improvement of antitumor drugs, the main condition for the successful treatment of patients with metastatic colorectal cancer is the operation in a radical volume, implying a macroscopic and microscopic absence of a residual tumor. The main contraindications to anatomic resections of the liver include a marked decrease in liver function, insufficient volume of the remaining parenchyma of the liver, and for a long time, bilobar liver damage was considered, which excludes the possibility of simultaneous removal of all foci.The traditional variant of the surgical solution of the problem of bilobar metastatic liver injury is the implementation of two-stage anatomical resections. …”
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