Alpelisib-Induced Diabetic Ketoacidosis and Insulin-Resistant Hyperglycemia by Michael Loke, DO, Vishal Sehgal, MD, Niraj Gupta, MD

“…For patients where cessation is not an option, insulin and insulin sensitizing agents can be used to achieve glycemic control at the potential detriment of tumor treatment.…”
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A network dynamic nomogram for predicting overall survival and cancer-specific survival in patients with breast cancer liver metastases: an analysis based on the SEER database by Mengxiang Tian, Kangtao Wang, Ming Li

“…Both univariable and multivariable analyses revealed significant associations between OS and CSS in BCLM patients and 14 variables, including age, race, and tumor stage, among others. Utilizing these pertinent variables, we formulated nomograms for OS and CSS prediction. …”
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Macroporous Composite Cryogels with Embedded Polystyrene Divinylbenzene Microparticles for the Adsorption of Toxic Metabolites from Blood by Tanja Eichhorn, Alexander E. Ivanov, Maria B. Dainiak, André Leistner, Ingrid Linsberger, Hans Jungvid, Sergey V. Mikhalovsky, Viktoria Weber

“…Plain PS-DVB microparticles showed efficient adsorption of albumin-bound toxins related to liver failure (bilirubin and cholic acid) and of cytokines (tumor necrosis factor-alpha and interleukin-6). The rates of adsorption and the amount of adsorbed factors were lower for the embedded microparticles as compared to the parent PS-DVB microparticles, indicating the importance of the accessibility of the adsorbent pores. …”
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Merging metabolic modeling and imaging for screening therapeutic targets in colorectal cancer by Niki Tavakoli, Emma J. Fong, Abigail Coleman, Yu-Kai Huang, Mathias Bigger, Michael E. Doche, Seungil Kim, Heinz-Josef Lenz, Nicholas A. Graham, Paul Macklin, Stacey D. Finley, Shannon M. Mumenthaler

“…Our results highlighted hexokinase (HK) as a crucial target, which subsequently became our focus for experimental validation using patient-derived tumor organoids (PDTOs). Through metabolic imaging and viability assays, we found that PDTOs cultured in CAF-conditioned media exhibited increased sensitivity to HK inhibition, confirming the model predictions. …”
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Multifunctional Nanoparticles as Radiosensitizers to Overcome Hypoxia-Associated Resistance in Cancer Radiotherapy by Ming-Hong Chen, Hon-Pan Yiu, Yu-Chi Wang, Tse-Ying Liu, Chuan Li

“…PFH-based oxygen carriers can augment oxygenation within tumor tissues, thereby mitigating radioresistance. …”
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Development and validation of a prognostic nomogram model in primary cutaneous and subcutaneous soft tissue angiosarcoma by Jinqian Mao, Jin Hu, Yunfei Chen, Yiqing Li, Xiaoqin Run

“…All data were randomly allocated into a training set and a testing set to develop and validate the nomogram model.Results The findings showed that age, sex, grade, tumor size, multiple primary malignant tumors, stage, primary site surgery (PSS), radiotherapy (RT), and chemotherapy (CT) were correlated with prognosis (p < .05). …”
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Pitfalls and Challenges in the Interpretation of Rectal Cancer Magnetic Resonance Imaging by Abdul Haseeb Wani, Naseer A. Choh, Humairah M. Syed, Waris A. Mir, Rauf A. Wani, Irfan Robbani, Tahleel A. Shera

“…Primary lesion characterization, its morphology and internal characteristics, proximity of tumor to the mesorectal fascia, presence of extramural venous invasion, presence of extra mesorectal pelvic lymph nodes, and involvement of peritoneum and distant metastases are critical findings that impact patient management for which MRI is the preoperative gold standard. …”
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Awardee Summary of 2023 Taiwan Oncology Society Clinical Research Award Recipient: Persistent Endeavors on Research of Digestive Cancers for Three Decades by Kun-Huei Yeh

“…Third, on behalf of the Taiwan Oncology Society, we participated in and published the Pan-Asian adapted European Society for Medical Oncology (ESMO) Clinical Practice Guidelines for locally advanced and metastatic CRC, gastric, and esophageal cancers, and the consensus meeting on tumor-agnostic indications of microsatellite instability-high (MSI-H) and NTRK. …”
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Cellular Mechanisms of Multiple Myeloma Bone Disease by Angela Oranger, Claudia Carbone, Maddalena Izzo, Maria Grano

“…Therefore, the understanding of MM pathogenesis could be useful to the discovery of novel agents that will be able to both restore bone remodelling and reduce tumor burden.…”
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Preclinical evaluation of DC-CIK cells as potentially effective immunotherapy model for the treatment of glioblastoma by Annika Simone Lück, Jingjing Pu, Ahmad Melhem, Matthias Schneider, Amit Sharma, Ingo G. H. Schmidt-Wolf, Jarek Maciaczyk

“…The direct interactions between tumor and effector cells were found to be highly effective in GBM organoids (GBOs). …”
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Predictors of infliximab efficacy in patients with severe attack of ulcerative colitis by A. O. Golovenko, I. L. Khalif, O. V. Golovenko, V. V. Veselov

“…Biological therapy by monoclonal antibodies against tumor necrosis factor (infliximab) allows to avoid colectomy at steroid-resistant severe attack of ulcerative colitis. …”
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Primary Malignant Melanoma of the Rectum: Report of Two Cases by Kodai Tomioka, Hitoshi Ojima, Makoto Sohda, Akiko Tanabe, Yasuyuki Fukai, Akihiko Sano, Takahiro Fukuda, Masahiko Murakami

“…The clinical diagnosis for each was rectal carcinoma at stage IIIc according to the tumor-node-metastasis classification (6th edition), and the patients underwent abdominoperineal resection with dissection of lymph nodes. …”
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A Rare Case of Severe Facial Disfiguration Due to Extranodal NK/T-Cell Lymphoma by Deng H, Yang Q, Shi Z

“…Huiyi Deng,1,2 Qintai Yang,1,2 Zhaohui Shi1,2 1Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2Department of Allergy, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaCorrespondence: Zhaohui Shi, Department of Otolaryngology-Head and Neck Surgery, Department of Allergy, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China, Email shizhh35@mail.sysu.edu.cnBackground: Extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT) is a rare, highly invasive Epstein-Barr virus associated hematological malignant tumor with an unfavorable prognosis. Although ENKTCL-NT has been previously reported, no relevant article has provided an intuitive, progressive series of schematic illustrations of the rapid progression of facial ulcers.Objective: This article reports a serious case of ENKTCL-NT that involved the entire process from onset to death.Case Summary: A 67-year-old man suffered a facial lesion started at the right ala nasi. …”
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A Case of Visceral Leishmaniasis in a 4-Year-Old Child Living in Nonendemic Area Located in Suburbs of Dakar, Senegal by Magatte Ndiaye, Dienaba Fafa Cissé, Aicha Djigal, Aminata Sow, Souléye Lélo, Fatoumata Ly, Isaac A. Manga, Mame Ami Diouf, Doudou Sow, Oumar Gaye, Boubacar Camara, Babacar Faye

“…The patient was admitted to the Pikine National Teaching Hospital for haemorrhagic, tumoral, and infectious syndromes. At admission, the patient presented with epistaxis and gingivorrhagia, a severe anaemic syndrome poorly tolerated, a systemic inflammatory response syndrome with fever at 39.5°C, a tumoral syndrome with 11 cm of hepatomegaly and 12 cm of type IV splenomegaly, and noninflammatory macropoly adenopathies. …”
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The Potential Role of Korean Mistletoe Extract as an Anti-Inflammatory Supplementation by Soo-Min Ha, Ji-Hyeon Kim, Jong-Won Kim, Do-Yeon Kim, Min-Seong Ha

“…Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP) were used as markers for inflammation. …”
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Umbilical Cord Mesenchymal Stem Cells Ameliorate Inflammation-Related Tumorigenesis via Modulating Macrophages by Yanxia Fu, Jun Li, Mengdi Li, Junfeng Xu, Zheng Rong, Fangli Ren, Yinyin Wang, Jianqiu Sheng, Zhijie Chang

“…HUC-MSCs were unable to form any tumor in immunodeficiency or normal mice with or without inflammatory stimulation. …”
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Heterozygous mutation in BRCA2 induces accelerated age-dependent decline in sperm quality with male subfertility in rats by Yashiro Motooka, Hideaki Tanaka, Yuki Maeda, Misako Katabuchi, Tomoji Mashimo, Shinya Toyokuni

“…Abstract Tumor suppressor BRCA2 executes homologous recombination to repair DNA double-strand breaks in collaboration with RAD51, involving exon 11 and 27. …”
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Super paramagnetic iron oxide contrast-enhanced magnetic resonance imaging was useful in differentiating an insulinoma from an accessory spleen: a case report with review of litera... by Ema Toyokuni, Hiroshi Okada, Goji Hasegawa, Mayuko Kadono, Sayaka Kato, Mari Yoneda, Michiaki Fukui

“…When a neuroendocrine tumor with abundant blood flow is located in the pancreatic tail, it is difficult to distinguish it from accessory spleen. …”
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Analysis of Publications on Psoriasis and Tuberculosis by Sevil Alkan, İrem Şahinoğlu, Mustafa Serhat Şahinoğlu

“…However, current treatments, especially anti tumor necrosis factor (TNF) treatments, can lead to tuberculosis. …”
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Cellular and Molecular Mediators of Neuroinflammation in the Pathogenesis of Parkinson’s Disease by Sandeep Vasant More, Hemant Kumar, In Su Kim, Soo-Yeol Song, Dong-Kug Choi

“…Although microglia forms the first line of defense for the neural parenchyma, uncontrolled activation of microglia may directly affect neurons by releasing various molecular mediators such as inflammatory cytokines (tumor necrosis factor-α, interleukin [IL]-6, and IL-1β), nitric oxide, prostaglandin E2, and reactive oxygen and nitrogen species. …”
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