Immunotherapy in the Treatment of Metastatic Melanoma: Current Knowledge and Future Directions by Massimo Ralli, Andrea Botticelli, Irene Claudia Visconti, Diletta Angeletti, Marco Fiore, Paolo Marchetti, Alessandro Lambiase, Marco de Vincentiis, Antonio Greco

“…Melanoma is one of the most immunologic malignancies based on its higher prevalence in immune-compromised patients, the evidence of brisk lymphocytic infiltrates in both primary tumors and metastases, the documented recognition of melanoma antigens by tumor-infiltrating T lymphocytes and, most important, evidence that melanoma responds to immunotherapy. …”
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A model of competing saturable kinetic processes with application to thepharmacokinetics of the anticancer drug paclitaxel by Rebeccah E. Marsh, Jack A. Tuszyński, Michael Sawyer, Kenneth J. E. Vos

“…The longer the infusion time the better the drug delivery to the tumor compartment is a clinical recommendation we propose.…”
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Prognosis of the Keratinizing Squamous Cell Carcinoma of the Tongue Based on Surveillance, Epidemiology, and End Results Database by Hai Yu, Shuping Xie, Xinkai Zheng, Qiqi Zhao, Xichun Xia, Wai-Kit Ming, Leong Nga Cheng, Xi Duan, WenHsien Ethan Huang, Fang Huang, Jun Lyu, Liehua Deng

“…The model indicated that age, radiotherapy sequence, SEER stage, marital status, tumor size, American Joint Committee on Cancer (AJCC) stage, radiotherapy status, race, lymph node dissection status, and sex were factors influencing the OS of patients with KTSCC. …”
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MLL-AF4 upregulates 5-lipoxygenase expression in t(4;11) leukemia cells via the ALOX5 core promoter by Marius Hyprath, Maximilian Molitor, Ilona Schweighöfer, Rolf Marschalek, Dieter Steinhilber

“…As key enzyme in leukotriene biosynthesis, 5-LO plays a central role in inflammatory diseases, but the 5-LO pathway has also been linked to development of certain hematological and solid tumor malignancies. Of note, previous studies have shown that the leukemogenic fusion protein MLL-AF4 strongly increases ALOX5 gene promoter activity. …”
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Suppression of Matrix Metalloproteinase Production in Nasal Fibroblasts by Tranilast, an Antiallergic Agent, In Vitro by Toshiyuki Shimizu, Kenichi Kanai, Kazuhito Asano, Tadashi Hisamitsu, Harumi Suzaki

“…We evaluated whether tranilast (TR) could inhibit MMP production from nasal fibroblasts in response to tumor necrosis factor-α (TNF-α) stimulation in vitro. …”
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Recent advances of lysine lactylation in prokaryotes and eukaryotes by Wenjuan Zhao, Wenjuan Zhao, Jiayi Xin, Jiayi Xin, Xin Yu, Zhifang Li, Nan Li

“…Lysine lactylation is a newly discovered protein post-translational modification that plays regulatory roles in cell metabolism, growth, reprogramming, and tumor progression. It utilizes lactate as the modification precursor, which is an end product of glycolysis while functioning as a signaling molecule in cells. …”
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Exploring Unique Extracellular Vesicles Associated Signatures: Prognostic Insights, Immune Microenvironment Dynamics, and Therapeutic Responses in Pancreatic Adenocarcinoma by Kai Nan, Ming Zhang, Zilong Geng, Yuankai Zhang, Lin Liu, Zhi Yang, Peng Xu

“…However, the intricate interplay between extracellular vesicles-related lncRNAs and the tumor microenvironment (TME) remains poorly elucidated. …”
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A clinical study of minimal blood flow clamping combined with 3D printing technology in laparoscopic nephron-sparing surgery by Lingbo Yang, Pengtao Wei, Xiaohui Li, Jiantao Sun

“…There was no statistical significance in the positive rate of resection margin between the two groups (p > 0.05).ConclusionsIn laparoscopic nephron-sparing surgery, minimum blood flow clamping technology not only can meet the requirements of accurate tumor resection but also can maximize the preservation of residual renal function, greatly shorten the operation time, reduce the amount of blood loss, and reduce the incidence of perioperative complications, making it worthy of promotion in clinical work. …”
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From Nonfunctioning Adrenocortical Cancer to Biochemically Silent Paraganglioma Associated with SDHB Mutation: An Uncommon Presentation of a Patient with a Retroperitoneal Mass by Izabella Freitas, Anna Albuquerque, Luiz de Marco, null Eduardo, José Renan Melo, Juliana Drummond, Beatriz Rocha

“…An immunohistology review of previous slides was consistent with the hypothesis of a neuroendocrine tumor. Forty percent of the patients with PHEO/PGL have an underlying germline mutation. …”
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Free Tensor Fascia Lata Flap and Synthetic Mesh Reconstruction for Full-Thickness Chest Wall Defect by Jumpei Ono, Akira Takeda, Minekatsu Akimoto, Akira Iyoda, Yoshio Matsui, Yukitoshi Satoh, Eiju Uchinuma

“…We present a case of a 74-year-old man with a soft tissue tumor involving the left lateral chest wall. We performed an en block resection and skeletal reconstruction using a mesh, free tensor fascia lata (TFL) flap for soft tissue coverage. …”
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ATP-Binding Pocket-Targeted Suppression of Src and Syk by Luteolin Contributes to Its Anti-Inflammatory Action by Jeong-Oog Lee, Deok Jeong, Mi-Yeon Kim, Jae Youl Cho

“…Luteolin dose-dependently inhibited the secretion of nitric oxide (NO) and prostaglandin E2 (PGE2) and diminished the levels of mRNA transcripts of inducible NO synthase (iNOS), tumor necrosis factor- (TNF-) α, and cyclooxygenase-2 (COX-2) in lipopolysaccharide- (LPS-) and pam3CSK-treated macrophage-like RAW264.7 cells without displaying cytotoxicity. …”
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Plasminogen Activator Inhibitor-1 Level Correlates with Lipoprotein Subfractions in Obese Nondiabetic Subjects by Sándor Somodi, Ildikó Seres, Hajnalka Lőrincz, Mariann Harangi, Péter Fülöp, György Paragh

“…Lipoprotein subfractions were detected with Lipoprint System. Plasma PAI-1, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and myeloperoxidase (MPO) concentrations were determined with enzyme-linked immunosorbent assay (ELISA), while serum paraoxonase-1 (PON1) activities were measured by spectrophotometry. …”
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Effects of Apatinib on the “Stemness” of Non-Small-Cell Lung Cancer Cells In Vivo and Its Related Mechanisms by Bin Yang, Yan Wang, Zhuoying Chen, Yi-Ming Feng, Liang-Liang Shi

“…A xenograft model of lung cancer cells A549 was established in nude mice and randomized into a control group (n = 4) and an Apatinib group (n = 4). Tumor tissues were harvested after 2 weeks, and mRNA was extracted to detect changes in stemness-related genes (CD133, EPCAM, CD13, CD90, ALDH1, CD44, CD45, SOX2, NANOG, and OCT4) and Wnt/β-catenin, Hedgehog, and Hippo signal pathways. …”
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Unusual Presentation of Large Retroperitoneal Lipoma in a 3-Year-Old Child: A Case Report by Mesfin Wubishet, Betre Shimelis, Workye Tigabie, Ashenafi Lemma

“…A CT scan showed a large abdominal mass likely from the retroperitoneum, potentially a lipogenic tumor, though liposarcoma could not be excluded. …”
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Mining Prognostic Biomarkers of Thyroid Cancer Patients Based on the Immune-Related Genes and Development of a Reliable Prognostic Risk Model by Hongjun Fei, Xu Han, Yanlin Wang, Shuyuan Li

“…Purpose. Tumor immunity serves an essential role in the occurrence and development of thyroid cancer (THCA). …”
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A Multi-ingredient Supplement Reduced Markers of Muscle Damage after a Rugby Match in Collegiate Male Players by Chang-Li Hsueh, Wang-Shiang Huang, Chen-Kang Chang

“…In either trials, the plasma tumor necrosis factor-α and malondialdehyde concentrations were not significantly different. …”
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Potential Biomarkers and Signaling Pathways Associated with the Pathogenesis of Primary Ameloblastoma: A Systems Biology Approach by Zeynab Bayat, Azin Mirzaeian, Amir Taherkhani

“…Ameloblastoma is a benign odontogenic tumor that may lead to ameloblastic carcinoma. This study aimed to determine potential signaling pathways and biological processes, critical genes and their regulating transcription factors (TFs), and miRNAs, as well as protein kinases involved in the etiology of primary ameloblastoma. …”
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Case report: Gastric langerhans cell histiocytosis with BRAF deletion mutation in a child that was misdiagnosed as lymphoma by Zhi Wan, Zhi Wan, Xue Tang, Xue Tang, Ju Gao, Ju Gao, Jing-jing Sun, Jing-jing Sun

“…Langerhans cell histiocytosis (LCH) is a myeloid neoplasm associated with the infiltration of most organs but rarely involves the stomach. Stomach tumors in children are very rare and can be easily misdiagnosed. …”
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Association of Bone Loss with the Upregulation of Survival-Related Genes and Concomitant Downregulation of Mammalian Target of Rapamycin and Osteoblast Differentiation-Related Gene... by Elena V. Tchetina, Karina A. Maslova, Mikhail Y. Krylov, Valery A. Myakotkin

“…OP registered by low BMD indices in late postmenopausal patients was associated with a significant upregulation of autophagy protein ULK1, cyclin-dependent kinase inhibitor p21, and metalloproteinase MMP-9 gene expression in the blood compared to the healthy controls and in a significant downregulation of mTOR (mammalian target of rapamycin), RUNX2, and ALPL gene expression, while expression of cathepsin K, caspase-3, transforming growth factor (TGF)β1, interleukin- (IL-) 1β, and tumor necrosis factor α (TNFα) was not significantly affected. …”
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Profiling Pro‐Inflammatory Proteases as Biomolecular Signatures of Material‐Induced Subcutaneous Host Response in Immuno‐Competent Mice by Nam M.P. Tran, Anh T.H. Truong, Dang T. Nguyen, Tram T. Dang

“…Protease activity exhibits positive correlations with protein expression of pro‐inflammatory cytokines tumor necrosis factor α and interleukin 6 but negative correlation with pro‐fibrotic cytokine transforming growth factor β1. …”
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