The Pathogenesis of Necroptosis-Dependent Signaling Pathway in Cerebral Ischemic Disease by Yang Xu, Ji Zhang, Lingsong Ma, Shoucai Zhao, Shizun Li, Tingting Huang, Zhaohu Chu

“…Necroptosis is downstream of the tumor necrosis factor (TNF) receptor family, and also interaction with NOD-like receptor pyrin 3 (NLRP3) induced inflammasome activation. …”
Get full text

Implicative Statistical Analysis to Identify Prognostic Factors for Mortality from Lymphomas in Children and Adolescents by Mayelyn Rodríguez Estenger, Nelsa María Sagaró del Campo, Larisa Zamora Matamoros, Evelyn Yolanda Fundichely Vázquez

“…The state of the deceased or alive patient at the time of the study was analyzed as the dependent variable and the following were taken as covariates: poor prognosis stage, presence of B symptoms, histological subtype, presence of three or more extranodal sites, metastasis, age and presence of tumor mass. Two statistical techniques were applied: binary logistic regression and implicative statistical analysis. …”
Get full text

Impact of Anterior Commissure Involvement and Frozen Guided Resections on Oncological Outcomes after Laser Cordectomy in Early Glottic Cancers – A 10-year Retrospective Analysis fr... by Elizabeth Mathew Iype, Ankit Vishwani, Bipin T Varghese, Shaji Thomas, Sahya S Lal

“…Conclusion: TLM is a safe and effective treatment of early glottic carcinoma. Apart from tumor (T) staging, ACI and frozen positivity were negative predictive factors. …”
Get full text

MoS₂–Plasmonic Hybrid Platforms: Next-Generation Tools for Biological Applications by Nayra A. M. Moussa, Seungah Lee, Seong Ho Kang

“…The primary focus areas include highly sensitive biosensors for detecting cancer and infectious disease biomarkers, high-resolution imaging of cellular dynamics, and the development of phototherapy methods that allow for accurate tumor ablation through light-induced thermal and reactive oxygen species generation. …”
Get full text

Genetic Risk Prediction for Normal-Karyotype Acute Myeloid Leukemia Using Whole-Exome Sequencing by Seong Gu Heo, Eun Pyo Hong, Ji Wan Park

“…We searched for somatic mutations from 10 pairs of tumor and normal cells by using a highly efficient and reliable analysis workflow for whole-exome sequencing data and performed association tests between the NK-AML and somatic mutations. …”
Get full text

Increased miRNA-375 causes oxidative damage but promotes apoptosis resistance and cell migration in the clam Ruditapes philippinarum by Ming Cong, Zhaoshun Li, Wenwen Tian, Yixian Yu, Yu Che, Jiasen Lv

“…Results showed that increased expression of miRNA-375 interfered with the expression levels of both its target genes and ammonia toxicity-related genes, which would probably lead to oxidative stress, migration of damaged cells, apoptosis resistance, and increased possibility of tumor formation. In addition, miRNA-375 increased MDA content but decreased glutamate content and caused serious structure damage to the clam gills. …”
Get full text

Effect of cyclosporin A on inflammatory cytokine production by U937 monocyte-like cells by Juan E. Losa Garcia, María Rosa Martín de Cabo, Fernando Mateos Rodríguez, Jesús Pérez Losada, Antonio Jiménez López, José Luis Pérez Arellano

“…Interleukin-1g (IL-1β), tumor necrosis factor-α (TNF-α), IL-6 and IL-8 levels were measured in supernatants using specific enzyme-linked immunosorbent assays. …”
Get full text

Nonfunctioning Pituitary Adenoma That Changed to a Functional Gonadotropinoma by Gerson Geovany Andino-Ríos, Lesly Portocarrero-Ortiz, Carlos Rojas-Guerrero, Alejandro Terrones-Lozano, Alma Ortiz-Plata, Alfredo Adolfo Reza-Albarrán

“…We considered that the patient had a functional gonadotropinoma due to the hyperestrogenemia in the context of secondary amenorrhea, resolving the hyperestrogenemia after almost complete resection of the tumor. Conclusion. It is necessary to point out from a clinical and/or biochemical point of view the change in functionality that a nonfunctional pituitary adenoma may have. …”
Get full text

Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1 by Huizhen Fan, Chunyan Jiang, Baoyuan Zhong, Jianwen Sheng, Ting Chen, Qingqing Chen, Jingtao Li, Hongchuan Zhao

“…Five targets, including interleukin 6 (IL-6), the 26S proteasome, tumor necrosis factor alpha (TNF-α), transforming growth factor beta 1 (TGF-β1) and p53, and corresponding high-mobility group box 1 (HMGB1) signaling and T helper cell differentiation were thought to be associated with matrine’s mechanism. …”
Get full text

Hybrid Carcinoma of the Larynx: A Case Report (Adenoid Cystic and Adenocarcinoma) and Review of the Literature by Ilias Karasmanis, John K. Goudakos, Iosif Vital, Thomas Zarampoukas, Victor Vital, Konstantinos Markou

“…The nonsquamous carcinomas of the larynx are considered rare with the majority of malignant tumors in this area, reaching the rate of 95%, to be squamous cell neoplasms. …”
Get full text

CCDC154 knockdown inhibits growth of liver cancer via suppressing expression of Snail by Rulan Ma, Hongmei Nie, Caijing Mo, Dawei Yuan, Kun Zhu, Kang Li

“…Results The results showed that CCDC154 was highly expressed in LC and related to tumor grade and stage. High CCDC154 expression was associated with to poor outcomes in LC patients. …”
Get full text

Effect of Football on Fatigue of Patients with Breast Cancer Treated with Nano-Chemotherapy by Yu Zhang, Haonan Niu, Zhiwei Peng

“…In this study, a quasi-experimental study method was used to conveniently select 60 breast cancer outpatients with tumor-related fatigue symptoms in a tertiary hospital in Liaoning Province. …”
Get full text

Functional and Biological Role of Endothelial Precursor Cells in Tumour Progression: A New Potential Therapeutic Target in Haematological Malignancies by Antonia Reale, Assunta Melaccio, Aurelia Lamanuzzi, Ilaria Saltarella, Franco Dammacco, Angelo Vacca, Roberto Ria

“…EPCs are recruited from the bone marrow under the stimulation of growth factors and cytokines and reach the sites of neovascularization in both physiological and pathological conditions such as malignancies where they contribute to the “angiogenic switch” and tumor progression. An implementation of circulating EPCs in the bloodstream of patients with haematological malignancies has been demonstrated. …”
Get full text

Skin Flaps and Graft In Eyelid Reconstruction by Khairiah Nevrianty, Hendriati Hendriati

“…Dilaporkan seorang pasien perempuan, usia 55 tahun dikonsulkan dari subbagian Tumor dengan diagnosa karsinoma sel skuamosa kelopak bawah mata kanan, terdapat massa pada palpebra inferior dengan ukuran  40mmx 25mmx15mm dengan bola mata dalam batas normal. …”
Get full text

MDM2 inhibition is associated with the emergence of TP53-altered clonal hematopoiesis by Vishesh Khanna, Gohar Eslami, Rochelle Reyes, Robert Diep, Sebastian Fernandez-Pol, Henning Stehr, Carlos Jose Suarez, Harlan Pinto, James M. Ford, Tian Yi Zhang, Christopher T. Chen

“…Abstract Murine double minute 2 (MDM2) inhibitors have shown promising activity in TP53-wild type tumors and are under active investigation across a spectrum of malignancies. …”
Get full text

The link between spreading depolarization and innate immunity in the central nervous system by Kadir Oguzhan Soylu, Muge Yemisci, Hulya Karatas

“…Research has established a clear link between SD and the activation of pro-inflammatory pathways, particularly through the release of cytokines like interleukin-1β and tumor necrosis factor-α, and the involvement of inflammatory mediators such as cyclooxygenase-2 and high mobility group box 1 (HMGB1). …”
Get full text

Clinical Use of Dostarlimab in Advanced Stage and Recurrent Endometrial Cancer: Patient Selection and Perspectives by Bujnak AC, File B, Tewari KS

“…Advances in molecular tumor profiling have highlighted that a portion of EC tumors release high levels of neoantigens, indicating an opportunity to harness the immune system in therapeutic strategies. …”
Get full text

Are Onconeural Antibodies a Clinical Phenomenology in Paraneoplastic Limbic Encephalitis? by Hongliang Zhang, Chunkui Zhou, Limin Wu, Fengming Ni, Jie Zhu, Tao Jin

“…Paraneoplastic neurological syndromes (PNSs) occur in patients with cancer and can cause clinical symptoms and signs of dysfunction of the nervous system that are not due to a local effect of the tumor or its metastases. Most of these clinical syndromes in adults are associated with lung cancer, especially small cell lung cancer (SCLC), lymphoma, and gynecological tumors. …”
Get full text

Evolving trends in the prevalence and treatment of ankylosing spondylitis in Korea from 2010 to 2023: a population-based study by Yu-Seon Jung, Soo-Kyung Cho, Se Rim Choi, Sun-Young Jung, Yoon-Kyoung Sung

“…Comorbidities such as metabolic syndrome and musculoskeletal complications became more prevalent. Tumor necrosis factor-alpha inhibitor prescriptions rose from 29.7 to 41.6%, while the use of conventional synthetic disease-modifying antirheumatic drugs declined. …”
Get full text

Posttranscriptional Suppression of Lipopolysaccharide-Stimulated Inflammatory Responses by Macrophages in Middle-Aged Mice: A Possible Role for Eukaryotic Initiation Factor 2α by Ken Shirato, Kazuhiko Imaizumi

“…Although LPS-stimulated secretion of tumor necrosis factor-α (TNF-α) by the macrophages from middle-aged mice was significantly lower than that from young mice, LPS caused marked increases in levels of TNF-α mRNA in macrophages from middle-aged as well as young mice. …”
Get full text