Proteomic Analysis of Hippocampus and Cortex in Streptozotocin-Induced Diabetic Model Mice Showing Dementia by Kenji Matsuura, Mieko Otani, Masaoki Takano, Keiichi Kadoyama, Shogo Matsuyama

“…Additionally, Western blotting validated the changes in translationally controlled tumor protein, ATP-specific succinyl-CoA synthetase beta subunit, and gamma-enolase isoform 1. …”
Get full text

A Case of Renal Pelvic Cancer Complicated by Horseshoe Kidney Treated with RoboSurgeon Gasless Single-Port Retroperitoneoscopic Nephroureterectomy by Hiroaki Suzuki, Kosuke Takemura, Kazumasa Sakamoto, Madoka Kataoka, Masaya Ito, Yasukazu Nakanishi, Ken-ichi Tobisu, Fumitaka Koga

“…CT and MRI revealed a right renal pelvic tumor of 28 mm in diameter. He underwent gasless single-port retroperitoneoscopic nephroureterectomy with division of the isthmus via the right pararectal small incision using the RoboSurgeon system. …”
Get full text

Role of p16INK4A in Replicative Senescence and DNA Damage-Induced Premature Senescence in p53-Deficient Human Cells by Razmik Mirzayans, Bonnie Andrais, Gavin Hansen, David Murray

“…The p16INK4A (hereafter p16) tumor suppressor is encoded by the INK4A/ARF locus which is among the most commonly dysregulated sequences in human cancer. …”
Get full text

Myxoid Chondrosarcoma of Maxilla in a Pediatric Patient: A Rare Case Report by Pranali Nimonkar, Nitin Bhola, Anendd Jadhav, Anuj Jain, Rajiv Borle, Rajul Ranka, Minal Chaudhary

“…Myxoid variant of chondrosarcoma is an uncommon potentially lethal malignant tumor which is even rare in pediatric age group. …”
Get full text

Intradural Extramedullary Capillary Hemangioma in the Upper Thoracic Spine: A Review of the Literature by Yoichiro Takata, Toshinori Sakai, Kosaku Higashino, Yuichiro Goda, Fumitake Tezuka, Koichi Sairyo

“…Capillary hemangiomas are benign tumors found in the skin and soft tissues in younger people. …”
Get full text

Late-onset and relapsed cytokine release syndrome after nivolumab treatment in a patient with head and neck squamous cell carcinoma: a case report by Tomoyuki Otsuka, Yoshiki Kojitani, Fumio Imamura, Junko Fukutake, Minako Nishio, Takashi Fujii, Toshihiro Kudo

“…CRS recurred during steroid tapering, coinciding with an increased tumor burden; however, it was successfully managed with increased steroid dosing. …”
Get full text

Proliferation and TH1/TH2 Cytokine Production in Human Peripheral Blood Mononuclear Cells after Treatment with Cypermethrin and Mancozeb In Vitro by Rajesh Mandarapu, Rajanna Ajumeera, Vijayalakshmi Venkatesan, Balakrishna Murthy Prakhya

“…In the study here, the possible effects of cypermethrin and mancozeb on lymphocyte proliferation and proinflammatory (tumor necrosis factor (TNF-) α) and immunoregulatory cytokine (interferon- (IFN-) γ, interleukins (IL) 2, 4, 6, and 10) formation in vitro were investigated. …”
Get full text

A Cost-effective Breath-hold Coaching Camera System for Patients Undergoing External Beam Radiotherapy by Akash Mehta, Emma Horgan, Prabhakar Ramachandran, Christopher Noble

“…Purpose: Organ motion can significantly affect the accurate delivery of radiation doses to the tumor, particularly for sites such as the breast, lung, abdomen, and pelvis. …”
Get full text

Regulator of G protein signaling-1 facilitates ovarian cancer development by modulating NF-kB signal pathway by Liu Shengnan, Xi Jiayan, Sun Meng, Li Li, Cai Shengyun, Xu Mingjuan

“…Abstract Regulator of G protein signaling 1 (RGS1) is known to be highly expressed in various tumors, but its specific effects and regulatory mechanism in ovarian cancer (OC) progression are not well understood. …”
Get full text

CHOLANGIOCARCINOMA: EPIDEMIOLOGY, HISTOPATHOLOGY, AND POTENTIAL PROGNOSTIC AND THERAPEUTIC IMPLICATIONS IN A COHORT FROM A REFERENCE CENTER IN SOUTHERN BRAZIL by João Pedro Pattussi BERTINATTI, Josenel Maria Barcelos MARÇAL, Eduardo CAMBRUZZI, Dido Eliphas LEÃO DE ALENCAR

“…The mean age of the patients was 63 years (26–89 years), with a mean tumor size of 5.5 cm. The median survival time was 7 months (0 to >50). …”
Get full text

Effect of pimobendan on cytokine levels in doxorubicin-induced cardiotoxicity by Burak Dik, Orhan Çorum, Ayşe Er

“…The purpose of this study was to determine the effects of PIMO on tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6 and IL-10 in the DOX-induced cardiotoxicity.…”
Get full text

Prognostic and Predictive Values of Metabolic Parameters of F-FDG PET/CT in Patients With Non-Small Cell Lung Cancer Treated With Chemotherapy by Xueyan Li MD, Dawei Wang BM, Lijuan Yu MD

“…Results: Survival ROC showed that maximum standardized uptake value (SUVmax), metabolic tumor volume 50% (MTV50), and total lesion glycolysis 50% (TLG50) had larger area under the curve, and the optimal cutoff values were 11.72, 4.04, and 34.55, respectively. …”
Get full text

Decreased Rivaroxaban Levels in a Patient with Cerebral Vein Thrombosis Receiving Phenytoin by Ana F. Becerra, Tomas Amuchastegui, Aldo H. Tabares

“…An abdominal mass was diagnosed and removed by laparoscopy (gastrointestinal stromal tumor). On day 5, she was switched to rivaroxaban 15 mg b.i.d. …”
Get full text

Obesity Related Alterations in Plasma Cytokines and Metabolic Hormones in Chimpanzees by Pramod Nehete, Elizabeth R. Magden, Bharti Nehete, Patrick W. Hanley, Christian R. Abee

“…We observed increased plasma circulating levels of proinflammatory TH-1 cytokines, Interferon gamma, interleukin-6, interleukin-12p40, tumor necrosis factor, soluble CD40 ligand, and Interleukin-1β and anti-inflammatory TH-2 cytokines, Interleukin-4, Interleukin-RA, Interleukin-10, and Interleukin-13 in overweight and obese chimpanzees. …”
Get full text

Organotin Compound Derived from 3-Hydroxy-2-formylpyridine Semicarbazone: Synthesis, Crystal Structure, and Antiproliferative Activity by Joanna Wiecek, Dimitra Kovala-Demertzi, Zbigniew Ciunik, Joanna Wietrzyk, Maria Zervou, Mavroudis A. Demertzis

“…Compounds 1 and 2 have been evaluated for antiproliferative activity in vitro against the cells of three human tumor cell lines: MCF-7 (human breast cancer cell line), T24 (bladder cancer cell line), A549 (nonsmall cell lung carcinoma), and a mouse fibroblast L-929 cancer cell line.…”
Get full text

RASGRF2 as a potential pathogenic gene mediating the progression of alcoholic hepatitis to alcohol-related cirrhosis and hepatocellular carcinoma by Zhengyuan Chen, Danfeng Fan, Tianyi Hang, Xiaoqing Yue

“…Spatial transcriptome data indicated that RASGRF2 was highly expressed in HCC tumor tissues. Compared with the paracancerous tissues, the RASGRF2 gene was significantly overexpressed in HCC tissues. …”
Get full text

Competing Risks Analysis of Cancer-associated Recurrent Thrombosis, Major Bleeds, and Death in a Geriatric Cohort by Joshua D. Brown, Kelley L. Ratermann, Kelley L. Ratermann, Jeffery C. Talbert, Jeffery C. Talbert, Val R. Adams, Val R. Adams

“…**Results:** Treatment groups differed on baseline variables including age, comorbidities, and tumor sites. After balancing the treatment groups on baseline characteristics, those receiving LMWHs had no difference in recurrent VTE compared to warfarin but had less than half the risk of major bleeding (HR=0.48 [0.27-0.85]). …”
Get full text

Protective Effect of Shenfu Injection against Sepsis-induced Acute Lung Injury by Suppressing Inflammation and Apoptosis Through the Regulation of the Janus Kinase 2/Signal Transdu... by Li-Juan Cao, Hai-Tang Xie, Zhong-Xia Chu, Yue Ma, Ming-Ming Wang, Shi Zhuang

“…SFI could significantly reduce the levels of tumor necrosis factor-α, interleukin-6 (IL-6), and IL-1β in plasma and BALF. …”
Get full text

TMEM100 Modulates TGF-β Signaling Pathway to Inhibit Colorectal Cancer Progression by Huixia Li, Chuan Cheng, Weibo You, Jiujian Zheng, Jie Xu, Peng Gao, Jianping Wang

“…This study investigated the functional mechanism of transmembrane protein 100 (TMEM100) as a tumor inhibitor gene in CRC cells and offered a reference for the treatment of CRC. …”
Get full text

Obesity, dietary interventions and microbiome alterations in the development and progression of prostate cancer by Shaun Trecarten, Michael A. Liss, Jill Hamilton-Reeves, John DiGiovanni

“…The microbiome also plays a pivotal role in the prostate tumor microenvironment (TME), contributing to inflammation, local tissue hypoxia, and epithelial-mesenchymal transition. …”
Get full text