Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly Women by Kishiko Ogawa, Kiyoshi Sanada, Shuichi Machida, Mitsuharu Okutsu, Katsuhiko Suzuki

“…Muscle thickness and circulating levels of C-reactive protein (CRP), serum amyloid A (SAA), heat shock protein (HSP)70, tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, monocyte chemotactic protein (MCP-1), insulin, insulin-like growth factor (IGF)-I, and vascular endothelial growth factor (VEGF) were measured before and after the exercise training. …”
Get full text

Giant Cell Reparative Granuloma of the Orbit: Clinicopathological Characteristics and Treatment by Álvaro Bengoa-González, Enrique Mencía-Gutiérrez, Beatriz Alonso-Martín, Bianca-Maria Laslău, Elena Salvador, Ana-Belén Enguita-Valls, María-Dolores Lago-Llinás

“…An ultrasonic aspirator system was used to remove the tumor tissue and its extension into cranial fossa. …”
Get full text

Exploring the prognosis of calponin h1 in carcinogenesis: A novel target in biomedical research by Roshna Sankar, Sharon John, Priya Devi, Sameer Gupta, Shalini Gupta

“…Stromal myofibroblasts play a crucial role in tumor invasion and metastasis by their capacity to alter the extracellular matrix. …”
Get full text

Rabex-5 E3 and Rab5 GEF domains differ in their regulation of Ras, Notch, and PI3K signaling in Drosophila wing development. by Theresa A Reimels, Mia Steinberg, Hua Yan, Sivan Shahar, Ashley Rosenberg, Kristina Kalafsky, Max Luf, Lindsay Kelly, Stacia Octaviani, Cathie M Pfleger

“…We propose that Rabex-5 acts as a tumor suppressor via its E3 activity to inhibit Ras, Notch, and PI3K signaling and as an oncogene via its Rab5 GEF activity to enhance Ras and Notch signaling.…”
Get full text

The Efficacy of Processing Strategies on the Gastroprotective Potentiality of Chenopodium quinoa Seeds by Abdalbasit Adam Mariod, Suzy Munir Salama

“…Gene expression was performed for gastric tumor necrosis factor alpha (TNF-α) and nuclear factor kappa of B cells (NF-kB). …”
Get full text

Late-Onset Bilateral Choroidal Metastases from Clear Cell Renal Cell Carcinoma by Constantinos D. Georgakopoulos, Athina Pallikari, Panagiotis Plotas, Olga E. Makri

“…Choroidal metastases from the primary renal tumor are extremely rare. The time interval between primary malignancy and choroidal metastasis is reported to be 12-96 months. …”
Get full text

Case Report: Winkelmann hip rotationplasty as a last-resort solution by Robin Evrard, Othmane Miri, Valérie Lacroix, Pierre-Louis Docquier, Thomas Schubert

“…., infection, trauma, or malignant tumors). Winkelmann Type BII rotationplasty is a rare procedure with limited literature. …”
Get full text

Portuguese consensus on first line treatment of moderate-to-severe psoriasis with a non-TNF inhibitor therapy – a delphi methodology by Tiago Torres, Sofia Magina, Maria João Paiva Lopes

“…In 2023, a 4.4% prevalence of PsO was reported in Portugal. Currently, Tumor Necrosis Factor inhibitors (TNFi) are the recommended first-line (1 L) biologic agents in Portugal given their lower cost. …”
Get full text

Risk of Candida Infection and Serious Infections in Patients with Moderate-to-Severe Psoriasis Receiving Biologics: A Systematic Review and Meta-Analysis of Randomized Controlled T... by Yue Feng, Baosen Zhou, Zhen Wang, Guijuan Xu, Lili Wang, Tingting Zhang, Yanping Zhang

“…The anti-interleukin (IL)-17 agents (95% confidence interval (CI) = 1.54–3.45, P<0.0001) and anti-IL-12/23 agents (95% CI = 1.69–3.83, P<0.0001) were associated with an increased risk of Candida infection compared with placebos, but there was no difference in Candida infection risk between anti-IL-17 agents and tumor necrosis factor inhibitors (TNFi) (95% CI = 0.92–3.07, P=0.09). …”
Get full text

Desmosomal Molecules In and Out of Adhering Junctions: Normal and Diseased States of Epidermal, Cardiac and Mesenchymally Derived Cells by Sebastian Pieperhoff, Mareike Barth, Steffen Rickelt, Werner W. Franke

“…We also emphasize the various plakophilin-2-positive plaques in AJs (coniunctiones adhaerentes) connecting proliferatively active mesenchymally-derived cells, including interstitial cells of the heart and several soft tissue tumor cell types. Moreover, desmoplakin has also been recognized as a constituent of the plaques of the complexus adhaerentes connecting certain lymphatic endothelial cells. …”
Get full text

The zinc finger protein560(ZNF560) functions as a novel oncogenic gene in osteosarcoma by Xiong Dong, Guanhua Xu, Hongxiang Hong, Jinlong Zhang, Zhiming Cui, ZiLiang Yu

“…Abstract Background: Abnormal expression of Zinc finger (ZNF) genes is commonly observed in osteosarcoma (OS), the most prevalent malignant bone tumor in children and teenagers. This project focused on the role of ZNF560 in the progress of OS. …”
Get full text

Immunotherapy of osteosarcoma based on immune microenvironment modulation by Heping Lian, Heping Lian, Jiakui Zhang, Shuna Hou, Shuang Ma, Jiachen Yu, Wei Zhao, Duoyi Zhao, Zhiyu Zhang

“…Osteosarcoma is a highly malignant tumor with unsatisfactory therapeutic outcomes achieved by chemotherapy, radiotherapy, and surgery. …”
Get full text

Analysis of Salivary Cytokines in Retinopathy of Prematurity by Hwa-Shiu Wu, Hsin-Chun Huang, I-Lun Chen

“…The salivary levels of interleukin (IL)-6, IL-8, vascular endothelial growth factor (VEGF), and tumor necrosis factor (TNF)-α on D1 and D7 were significantly higher in the Moderate to Severe ROP group compared to the None to Mild ROP group (<i>p</i> = 0.005, 0.004, 0.026, 0.018, 0.001, 0.007, 0.025, and 0.002, respectively). …”
Get full text

Retrospective study of post-treatment 131I SPECT/CT imaging for personalizing therapy of patients with differentiated thyroid cancer by Sonya Sergieva, Teodor Sofiyanski, Bozhil Robev, Milena Dimcheva, Albena Fakirova

“…SPECT/CT showed thyroid remnant in 237 (42%) patients, tumor persistence – in 15 (2.7%), and local recurrence in the thyroid bad in 17 (3%) cases. …”
Get full text

DCE-MRI and DWI Integration for Breast Lesions Assessment and Heterogeneity Quantification by C. Andrés Méndez, Francesca Pizzorni Ferrarese, Paul Summers, Giuseppe Petralia, Gloria Menegaz

“…In order to better predict and follow treatment responses in cancer patients, there is growing interest in noninvasively characterizing tumor heterogeneity based on MR images possessing different contrast and quantitative information. …”
Get full text

Prognostic impact of primary versus secondary resistance to sorafenib in patients with HCC by Jin Lei, Hongyuan Dai, Ya Zhang, Guangling Ou, Zhi Peng Liang, Yinying Lu, Haiyang Li

“…They were divided into primary and secondary resistance groups according to tumor progression within 3 months. Resistance was the primary outcome of this study. …”
Get full text

A Case of an Incidentally Removed Lingual Osseous Choristoma by Tomotaka Hemmi, Jun Suzuki, Satoko Sato, Masumi Tabata, Kojiro Watanabe, Mitsuru Sugawara, Yukio Katori

“…Lingual osseous choristoma is a rare benign tumor consisting of normal matured bone tissue. It was first reported in 1913, and less than 100 cases of lingual osseous choristomas, mainly in their twenties and thirties, have been reported in the English literature until now. …”
Get full text

Prostate-Specific Membrane Antigen-Based Therapeutics by Naveed H. Akhtar, Orrin Pail, Ankeeta Saran, Lauren Tyrell, Scott T. Tagawa

“…Radiolabeled J591 has demonstrated accurate and selective tumor targeting, safety, and efficacy. Ongoing studies using anti-PSMA radioimmunotherapy with 177Lu-J591 seek to improve the therapeutic profile, select optimal candidates with biomarkers, combine with chemotherapy, and prevent or delay the onset of metastatic disease for men with biochemical relapse. …”
Get full text

Activated Platelets Induce an Anti-Inflammatory Response of Monocytes/Macrophages through Cross-Regulation of PGE2 and Cytokines by Bona Linke, Yannick Schreiber, Bettina Picard-Willems, Patrick Slattery, Rolf M. Nüsing, Sebastian Harder, Gerd Geisslinger, Klaus Scholich

“…Analyzing cocultures of platelets and murine bone marrow-derived macrophages or human monocytes, we found that collagen-activated platelets release high amounts of prostaglandin E2 (PGE2) that leads to an increased interleukin- (IL-) 10 release and a decreased tumor necrosis factor (TNF) α secretion out of the monocytes or macrophages. …”
Get full text

Diagnosis, Surgical Treatment, Recovery, and Eventual Necropsy of a Leopard (Panthera pardus) with Thyroid Carcinoma by Ashley Malmlov, Terry Campbell, Eric Monnet, Craig Miller, Becca Miceli, Colleen Duncan

“…On postmortem examination the tumor was found to involve the lung, liver, thyroid, parietal pleura, bronchial lymph nodes, and the internal intercostal muscles. …”
Get full text