A novel uORF regulates folliculin to promote cell growth and lysosomal biogenesis during cardiac stress by Maja Bencun, Laura Spreyer, Etienne Boileau, Jessica Eschenbach, Norbert Frey, Christoph Dieterich, Mirko Völkers

“…As a critical regulator of cell growth, protein synthesis and autophagy mechanistic target of rapamycin complex 1 (mTORC1) is an important mediator of pathological cardiac remodeling. The tumor suppressor folliculin (FLCN) is part of the network regulating non-canonical mTORC1 activity. …”
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Metastasis to the Bladder: A Rare Site of Recurrence of Renal Cell Carcinoma by Amanda Smart, Michael Wynne, Ezra Baraban, Yasser Ged, Armine Smith

“…In patients with RCC who develop solitary bladder metastasis amenable to resection following nephrectomy, there is a lack of evidence to guide therapy and a multidisciplinary discussion is warranted. However, if the tumor is amenable to resection, metastasectomy is a reasonable therapeutic approach and offers the patient an improved quality of life and an opportunity for remission.…”
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Exploration of treatment strategies for cerebral cavernous malformations: two case reports on non-resection treatment and literature review by Yibo Han, Yibo Han, Dong Liang, Dong Liang, Jing Guo, Yibao Wang, Yong Wang

“…Prior to surgery, patients underwent comprehensive imaging evaluations and received endoscopic third ventriculostomy rather than tumor resection. Both patients had favorable recoveries. …”
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Integrated Bioinformatics and Experimental Approaches Identified the Role of NPPA in the Proliferation and the Malignant Behavior of Breast Cancer by Aijun Sun, Xiaonan Sheng, Jinhai Tang, Zhenfeng Yu, Jian Zhang

“…Breast cancer is the 3rd most common type of malignant tumor worldwide with high heterogeneity, frequent recurrence, and high metastasis tendency. …”
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FROM ONCOLOGIST TO SURGEON - GENETICS IN COLORECTAL METASTASIS FOR SURGEONS by Marília Polo Mingueti e SILVA, Jorge SABBAGA, Henry Luiz NAJMAN, Carlos David Carvalho NASCIMENTO, Ricardo Lemos COTTA-PEREIRA, João Eduardo Leal NICOLUZZI, Maria Ignez BRAGHIROLI

“…With the development of treatments in metastatic disease and the use of targeted therapies and their biomarkers, it was possible to evaluate them within clinical studies both in the primary tumor and in the correspondence of metastases.…”
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The Relationship between a New Biomarker of Vagal Neuroimmunomodulation and Survival in Two Fatal Cancers by Y. Gidron, M. De Couck, D. Schallier, J. De Greve, J. L. Van Laethem, R. Maréchal

“…The vagus nerve may slow tumor progression because it inhibits inflammation. …”
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Calcific Tendinitis of the Supraspinatus Tendon in an Infant by Masanori Wako, Jiro Ichikawa, Kensuke Koyama, Yoshihiro Takayama, Hirotaka Haro

“…Although these images were suggestive of calcific tendinitis of the supraspinatus tendon, we performed an open biopsy and resection in order to differentiate between a suspected diagnosis of calcific tendinitis, which is incredibly rare within pediatric patients, and infection or a soft tissue tumor. Finally, calcific tendinitis of the supraspinatus tendon was diagnosed by pathologic experiment and successfully treated, with complete resolution of pain and movement. …”
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Relaparotomy Two Years after Incisional Hernia Repair Using a Free Fascia Lata Graft by Yuuki Sekine, Hiroyuki Sugo, Naoki Iwanaga, Shigefumi Neshime, Ikuo Watanobe

“…Two years later, the patient was readmitted because of recurrent tumors in the liver, and repeat hepatectomy was performed. …”
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Cutaneous Adnexal Cylindroma of Breast: Epithelial Immunoreactivities for GATA-3, Mammaglobin, and E-Cadherin Do Not Equate to a Mammary Ductal Neoplasm by A. Halima, A. M. Pannunzio, E. M. Erstine, J. S. Ko, W. F. Bergfeld, R. M. Malaya, M. B. Frankel, B. C. Calhoun, C. D. Sturgis

“…Cylindromas are benign epithelial neoplasms derived from cutaneous eccrine adnexal structures. These tumors are most commonly encountered on the head, neck, and scalp of older women. …”
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NMD Microarray Analysis for Rapid Genome-Wide Screen of Mutated Genes in Cancer by Maija Wolf, Henrik Edgren, Aslaug Muggerud, Sami Kilpinen, Pia Huusko, Therese Sørlie, Spyro Mousses, Olli Kallioniemi

“…We combined NMD microarrays with array-based CGH (comparative genomic hybridization) in order to identify inactivation of tumor suppressor genes in cancer. Such a “mutatomics” screening of prostate cancer cell lines led to the identification of inactivating mutations in the EPHB2 gene. …”
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Machine learning identifies the association between second primary malignancies and postoperative radiotherapy in young-onset breast cancer patients. by Yulin Lai, Peiyuan Huang

“…<h4>Background</h4>A second primary malignant tumor is one of the most important factors affecting the long-term survival of young women with breast cancer (YWBC). …”
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Inhibitory Effect on Cerebral Inflammatory Response following Traumatic Brain Injury in Rats: A Potential Neuroprotective Mechanism of N-Acetylcysteine by Gang Chen, Jixin Shi, Zhigang Hu, Chunhua Hang

“…In this work, we investigated the effect of NAC administration on cortical expressions of nuclear factor kappa B (NF-κB) and inflammatory proteins such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and intercellular adhesion molecule-1 (ICAM-1) after TBI. …”
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Clinical Outcomes of Drug-Eluting Bead Transarterial Chemoembolization Loaded with Raltitrexed for the Treatment of Unresectable or Recurrent Hepatocellular Carcinoma by Yonghua Bi, Dechao Jiao, Jianzhuang Ren, Xinwei Han

“…The response evaluation criteria in solid tumors (RECIST) criteria and modified RECIST criteria (mRECIST) were used to assess the tumor response after the DEB-TACE procedure. …”
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E2F1 activates breast stromal fibroblasts and promotes their paracrine pro-carcinogenic effects by Layla A. Al-Kharashi, Falah H. Al-Mohanna, Abdelilah Aboussekhra, Abdelilah Abousekhra

“…We have shown that CAFs express higher levels of E2F1 compared to their adjacent tumor counterpart fibroblasts (TCFs). Importantly, E2F1 upregulation by ectopic expression transactivated quiescent breast stromal fibroblasts and promoted their paracrine pro-carcinogenic effects. …”
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Substernocleidomastoid Muscle Neck Lipoma: An Isolated Case Report by Ferdinand Rico, Dustin Hoang, John Lung, Olivia Puccio, Michelle Brito, M. Haris Nazim, Alan Sbar

“…Substernocleidomastoid neck lipoma in our case is a rare benign tumor that was challenging to excise.…”
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The Histopathological Spectrum of Pyogenic Granuloma: A Case Series by Vinay Marla, Ashish Shrestha, Khushboo Goel, Sajeev Shrestha

“…Pyogenic granuloma is a reactive tumor-like lesion commonly affecting the oral cavity. …”
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Differential expression of “A Disintegrin and Metalloproteinase 10” in hepatocellular carcinoma and the noncancerous hepatic tissues: Contribution to HCV-promoted hepatocarcinogene... by Amal Abd El Hafez, Basem H. Elesawy, Heba S. E. I. Hany

“…HCCs were statistically compared in relation with gender, age, cirrhosis, hepatitis C virus (HCV) status, alpha-fetoprotein (AFP) serum level, tumor size, multiplicity, encapsulation/invasion, grade, histological pattern and variant, mitosis, necrosis, vascular emboli, portal thrombosis, stage, recurrence, and mortality. …”
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Scutellarin combined with lidocaine exerts antineoplastic effect in human glioma associated with repression of epidermal growth factor receptor signaling. by Xiu-Ying He, Yui-Si Yang, Yue-Xiang Zheng, Qing-Jie Xia, Hong-Zhou Yu, Xiao-Ming Zhao, Ting-Hua Wang

“…<h4>Purpose</h4>Glioma is the most common primary intracranial tumors. Although great achievements have been made in the treatment, the efficacy is still unsatisfactory, which imposes a hefty burden on patients and society. …”
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Analysis of single nucleotide polymorphism of p16 gene in cytological samples of patients with oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) by Neetu Oommen, Vasanthi V, Ramya Ramadoss, Rajkumar Krishnan

“…Frequent homozygous deletions of the pl6 gene have been reported in many tumor cell lines including the brain, breast, osteosarcomas, melanomas, kidney, bladder, and ovary. …”
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Ultrasonic Analysis of Peptide- and Antibody-Targeted Microbubble Contrast Agents for Molecular Imaging of αβ-Expressing Cells by Paul A. Dayton, David Pearson, Jarrod Clark, Scott Simon, Patricia A. Schumann, Reena Zutshi, Terry O. Matsunaga, Katherine W. Ferrara

“…The α v β 3 integrin has been shown to be highly expressed on metastatic tumors and endothelial cells during neovascularization, and its expression has been shown to correlate with tumor grade. …”
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