Breast Cancer Treatment Practices in Elderly Women in a Community Hospital by Hua Wang, Awinder P. Singh, Serena A. St. Luce, Alan R. Go

“…A total of 393 female breast cancer patients aged 70 years and older, diagnosed within the years 1989–1999, were identified from the tumor registry of The Brooklyn Hospital Center. Comparisons between the 3 different subgroups 70–74, 75–79, and 80 years and older were made using the Pearson Chi Square test. …”
Get full text

Efficacy of Next-Generation Sequencing in Identifying Genetic Markers for Prostate Cancer Risk by Fahad H. Alaithan, Raghad H. Alaithan, Tauheed Ahmed

“…DNA samples were extracted from blood and tumor tissues, followed by library preparation and sequencing using an Illumina platform. …”
Get full text

Immune Microenvironment in Colorectal Cancer: A New Hallmark to Change Old Paradigms by Luis de la Cruz-Merino, Fernando Henao Carrasco, David Vicente Baz, Esteban Nogales Fernández, Juan José Reina Zoilo, Manuel Codes Manuel de Villena, Enrique Grande Pulido

“…Impact of immune microenvironment in prognosis of solid tumors has been extensively studied in the last few years. …”
Get full text

Synthesis and Characterization of Iodinated Chitosan Nanoparticles and Their Effects on Cancer Cells by Germán Alvarado Tenorio, Roberto Espinosa Neira, Carlos Alberto Ávila Orta, Gabriela Yolotzín Romero Zúñiga, Hortensia Ortega Ortiz

“…The cytotoxic effects on human tumor cells of chitosan and iodine-modified chitosan nanoparticles (CSNPs-I and CSNPs-IO3) were evaluated for 24 h in a range from 0.15 mg/mL to 0.95 mg/mL concentrations, where CSNPs-IO3 presented the lower viability for lung cancer A549, followed by cervical cancer HeLa cell and finally breast cancer MDA-MB-231, with a weight content of iodate ion in a range of 8.7 to 15 μg. …”
Get full text

Conventional and High-Speed Intravital Multiphoton Laser Scanning Microscopy of Microvasculature, Lymphatics, and Leukocyte-Endothelial Interactions by Timothy P. Padera, Brian R. Stoll, Peter T.C. So, Rakesh K. Jain

“…Finally, high-speed MPLSM, applied for the first time in vivo, is used to compare L-E interactions in normal tissue and a rhabdomyosarcoma tumor. Our work demonstrates the potential of MPLSM to noninvasively monitor physiology and pathophysiology both at the tissue and cellular level. …”
Get full text

Case Report of Successful Childbearing after Conservative Surgery for Cervical Mullerian Adenosarcoma by Seiji Kanayama, Masako Nakamura, Hidekazu Oi, Sumire Sugimoto, Yoshikazu Sasaki, Tomoko Uchiyama, Chiho Ohbayashi, Hiroshi Kobayashi

“…Mullerian adenosarcoma (MA) is a rare tumor variant with low malignancy potential and is reported to account for 8% of all uterine sarcomas. …”
Get full text

The Immunotherapeutic Effect of SIRPα-Silenced DCs against Cervical Cancer by Xiaojie Li, Wenying Zhou, Yanlan Liang, Changzhi Xu, Zhizhi Xie, Jiayin Liang, Bo Hu

“…Signal regulatory protein α (SIRPα), a transmembrane protein that is predominantly expressed in dendritic cells (DCs) or macrophages, interacts with CD47 that is overexpressed in almost all types of tumor cells. The interaction between SIRPα and CD47 leads to a negative signal that prevents the phenotypic and functional maturation of DC and inhibits phagocytosis. …”
Get full text

Chidamide Suppresses the Growth of Cholangiocarcinoma by Inhibiting HDAC3 and Promoting FOXO1 Acetylation by Yongpan Li, Jujia Zheng, Qiang Huo, Zhongchao Chen, Jun Chen, Xiangwei Xu

“…Additionally, CDM inhibited tumor growth in vivo via HDAC3 downregulation and FOXO1 acetylation induction. …”
Get full text

Glucosamine Inhibits the Proliferation of Hepatocellular Carcinoma Cells by Eliciting Apoptosis, Autophagy, and the Anti-Warburg Effect by Misako Samizu, Kaoruko Iida

“…GlcN also increased the expression of FoxO1 and FoxO3, known tumor suppressors in various cancers. Furthermore, GlcN treatment elevated the levels of LC3II (an autophagy marker) and AMP-activated protein kinase activity, suggesting intracellular energy shortage. …”
Get full text

In-depth inference of transcriptional regulatory networks reveals NPM1 as a therapeutic ribosomal regulator in MYC-amplified medulloblastoma by Tong Chen, Huiyao Chen, Mingyang Xia, Yunfei Liao, Hao Li, Xinran Dong, Yifeng Lin, Wenhao Zhou

“…Abstract Medulloblastoma (MB) is an aggressive pediatric brain tumor with distinct molecular heterogeneity. Identifying subtype-specific signatures within Group 3 and Group 4 remains challenging due to shared cytogenetic alterations and limitations of conventional differential gene expression analysis. …”
Get full text

Epithelioid Angiosarcoma Arising from a Huge Leiomyoma: A Case Report and a Literature Review by Takeya Hara, Ai Miyoshi, Yuji Kamei, Nao Wakui, Akiko Fujishiro, Serika Kanao, Hirokazu Naoi, Hirofumi Otsuka, Takeshi Yokoi

“…Uterine mesenchymal tumors other than leiomyosarcoma, carcinosarcoma, and endometrial stromal sarcomas are extremely uncommon. …”
Get full text

Application of Nano-drug Delivery Technology in Overcoming Drug Resistance 
in Lung Cancer by Yingchun LU, Chunyu WANG, Bin LIU

“…Lung cancer is one of the most malignant tumor, representing a significant threat to human health. …”
Get full text

Axillary Metastasis from an Occult Tubal Serous Carcinoma in a Patient with Ipsilateral Breast Carcinoma: A Potential Diagnostic Pitfall by Chantal Atallah, Gulbeyaz Altinel, Lili Fu, Jocelyne Arseneau, Atilla Omeroglu

“…In this context, the poorly differentiated appearance of the metastatic tumor and positive staining for estrogen receptor, might lead to a misdiagnosis of metastatic breast carcinoma. …”
Get full text

Head and Neck Schwannomas: A Surgical Challenge—A Series of 5 Cases by Ishtyaque Ansari, Ashfaque Ansari, Arjun Antony Graison, Anuradha J. Patil, Hitendra Joshi

“…Schwannomas, also known as neurilemmomas, are benign peripheral nerve sheath tumors. They originate from any nerve covered with schwann cell sheath. …”
Get full text

Technique of sacrectomy at the combined operations for locally advanced rectal cancer by P. V. Tsarkov, S. K. Efetov, I. A. Tulina, L. V. Sidorova

“…Lateral spread of the rectal tumor requires ligation of the internal iliac arteries from abdominal approach, dissection and underrunning of the fastened veins both from abdominal and crotch access after removal of neoplastic speciemen. …”
Get full text

Childhood-onset enthesitis-related arthritis leading to nephrotic syndrome due to secondary amyloidosis complicated by acute pulmonary embolism - The domino effect by Vishal Mangal, Bhaskar Datt, Arun Hegde, A W Kashif, Ankit Kumar, Jaspreet Kaur, Nidhi Goel, Anil Shankar Menon

“…He was managed with anti-tumor necrosis factor inhibitor therapy with a favorable outcome. …”
Get full text

LC-MS/MS-based proteomics and metabolomics of HCT-116 colorectal cancer cells: A potential anticancer activity of atorvastatin by Refat M. Nimer, Hiba A. Nazazleh, Belal A. Al-Husein, Salah Abdelrazig, Lina Elsalem, Lina A. Dahabiyeh

“…Colorectal cancer (CRC) is the third most prevalent tumor in men, the second most common in women, and the fourth leading cause of mortality worldwide. …”
Get full text

Roles of core fucosylation modification in immune system and diseases by Qiu Pan, Xiao-Lian Zhang

“…Research over the past three decades has revealed the critical role of FUT8-mediated core fucosylation modification in various physiological and pathological processes, including cell growth, adhesion, receptor activation, antibody-dependent cellular cytotoxicity (ADCC), tumor metastasis and infections. This review discusses the immune system function involving FUT8 and the mechanisms by which core fucosylation regulates immunity and contributes to disease. …”
Get full text

Unveiling the immunomodulatory dance: endothelial cells’ function and their role in non-small cell lung cancer by Sophia Daum, Lilith Decristoforo, Mira Mousa, Stefan Salcher, Christina Plattner, Baharak Hosseinkhani, Zlatko Trajanoski, Dominik Wolf, Peter Carmeliet, Andreas Pircher

“…Abstract The dynamic interactions between tumor endothelial cells (TECs) and the immune microenvironment play a critical role in the progression of non-small cell lung cancer (NSCLC). …”
Get full text

A Single Bout of Fasting (24 h) Reduces Basal Cytokine Expression and Minimally Impacts the Sterile Inflammatory Response in the White Adipose Tissue of Normal Weight F344 Rats by Kristin J. Speaker, Madeline M. Paton, Stewart S. Cox, Monika Fleshner

“…Glucose, nonesterified free fatty acids (NEFAs), insulin, leptin, and corticosterone were measured in plasma and tumor necrosis factor- (TNF-) α, interleukin- (IL-) 1β, IL-6, and IL-10 in plasma, and subcutaneous, intraperitoneal, and visceral compartments of white adipose tissue (WAT). …”
Get full text