Left Kidney Undifferentiated Spindle Cell Sarcoma with Myeloid Cell Leukemia-1 Amplification: Therapeutic Response to Bortezomib, Venetoclax, and Dexamethasone Therapy by Cheng-Yu Tang, Chueh-Chuan Yen

“…The overexpression of myeloid cell leukemia-1 (MCL-1) has been identified in numerous hematologic malignancies and solid tumors. Currently, there are no selective MCL-1 inhibitors. …”
Get full text

Beta-adrenergic blocking agents in cutaneous and oral melanoma by Sivakamavalli Jeyachandran

“…In melanoma, beta-blockers may alter the tumor microenvironment, affecting cancer progression and treatment outcomes. …”
Get full text

Evolution of uncontrolled proliferation and the angiogenic switch in cancer by John D. Nagy, Dieter Armbruster

“…The former case yields a tumor-on-a-tumor, or hypertumor, as predicted in other studies, and the latter case may explain vascular hyperplasia evident in certain tumor types.…”
Get full text

Intra-Abdominal Testicular Seminoma in a Woman with Testicular Feminization Syndrome by Darshana D. Rasalkar, Bhawan K. Paunipagar, Alex Ng, Fernand M. Lai, Shalini Jain Bagaria

“…We report a case of intra-abdominal testicular tumor in a 36-year-old married lady presenting with chief complaints of primary amenorrhea. …”
Get full text

Endometrial Carcinoma Presenting as Vasculitic Sensorimotor Polyneuropathy by Marketa Vasku, Thomas Papathemelis, Nicolai Maass, Ivo Meinhold-Heerlein, Dirk Bauerschlag

“…Recommended therapy is stage-adjusted treatment of the primary tumor.…”
Get full text

Advanced Alveolar Soft Part Sarcoma Treated with Pazopanib over Three Years by Yoji Shido, Yukihiro Matsuyama

“…Alveolar soft part sarcoma (ASPS) is a rare malignant tumor that generally occurs in adolescents and young adults. …”
Get full text

Plexiform Schwannoma of the Tongue in a Pediatric Patient with Neurofibromatosis Type 2: A Case Report and Review of Literature by Samir M. Amer, Aijan Ukudeyeva, Harold S. Pine, Gerald A. Campbell, Cecilia G. Clement

“…Tumor cells were strongly positive for S-100 protein and negative for smooth muscle actin (SMA), and EMA highlighted perineural fibroblasts surrounding tumor nodules. …”
Get full text

From Benign Beginning to Malignant Giant: The Journey of Recurrent Cystosarcoma Phyllodes by Dinesh Kumar, Md Sahil Reza, Sushovon Das, Utpal De

“…A 42-year-old lady presented with a recurrent left breast mass, initially diagnosed as a benign phyllodes tumor. Despite wide local excision, the tumor recurred thrice over three years, each recurrence demonstrating increasing stromal cellularity and atypia. …”
Get full text

The onset of Type 3C diabetes mellitus in a young female due to distal pancreatectomy for solid pseudopapillary neoplasm by Ayaka Harada, Takatoshi Anno, Kohei Kaku, Hideaki Kaneto

“…Solid pseudopapillary neoplasm (SPN) is classified as an epithelial tumor identified from benign to low-grade malignant tumor. …”
Get full text

In-Trastuzumab Scintigraphy in HER2-Positive Metastatic Breast Cancer Patients Remains Feasible during Trastuzumab Treatment by Sietske B.M. Gaykema, Johan R. de Jong, Patrick J. Perik, Adrienne H. Brouwers, Carolien P. Schröder, Thijs H. Oude Munnink, Alphons H.H. Bongaerts, Elisabeth G.E. de Vries, Marjolijn N. Lub-de Hooge

“…Twenty-five tumor lesions in 12 patients were visualized on both scintigraphy series. …”
Get full text

Aortic Valve Papillary Fibroelastoma Associated with Acute Cerebral Infarction: A Case Report by Nobuhiro Takeuchi, Masanori Takada, Koichi Fujita, Yoshiharu Nishibori, Takao Maruyama, Kazuyoshi Naba

“…Pathological examination of the resected tumor suggested papillary fibroelastoma (PFE). Although no guidelines exist for PFE management, a mobile, cardiac tumor necessitates surgical resection to prevent thromboembolic events, even when small in size.…”
Get full text

PTEN Gene: A Model for Genetic Diseases in Dermatology by Corrado Romano, Carmelo Schepis

“…PTEN gene is considered one of the most mutated tumor suppressor genes in human cancer, and it’s likely to become the first one in the near future. …”
Get full text

Two rare localizations of chondrosarcoma: cervical and thoracic spine by Sameh Sayhi, Maha Rebai, Ahmed Harbaoui, Sameh Achoura, Arij Ezzouhour Yahyaoui, Nadia Ben Abdelhafidh

“…Chondrosarcoma is a primary malignant bone tumor, with spinal involvement being rare. Diagnosing this condition can be challenging and typically requires histological verification. …”
Get full text

Antitumor immunostimulatory effect via cell-killing action of a novel extracorporeal blood circulating photodynamic therapy system using 5-aminolevulinic acid by Hidetaka Maegawa, Masayuki Kohashi, Yasuo Harada, Akira Tanaka, Shimpei Kajiwara, Takashi Fujimoto, Hidehiro Atagi, Kenta Kaneda

“…Abstract This study investigated whether intravenous administration of tumor cells killed by photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA) had antitumor effects on distal tumors. …”
Get full text

Identification of Differentially Expressed Genes in Pituitary Adenomas by Integrating Analysis of Microarray Data by Peng Zhao, Wei Hu, Hongyun Wang, Shengyuan Yu, Chuzhong Li, Jiwei Bai, Songbai Gui, Yazhuo Zhang

“…The purpose of this study was to detect differentially expressed genes (DEGs) and biological processes during tumor formation of pituitary adenomas. We performed an integrated analysis of publicly available GEO datasets of pituitary adenomas to identify DEGs between pituitary adenomas and normal control (NC) tissues. …”
Get full text

Enavatuzumab, a Humanized Anti-TWEAK Receptor Monoclonal Antibody, Exerts Antitumor Activity through Attracting and Activating Innate Immune Effector Cells by Shiming Ye, Melvin I. Fox, Nicole A. Belmar, Mien Sho, Debra T. Chao, Donghee Choi, Yuni Fang, Vivian Zhao, Stephen F. Keller, Gary C. Starling, Patricia A. Culp

“…The initial evidence for a role of effector cells was obtained in a subset of tumor xenograft mouse models whose response to enavatuzumab relied on the binding of Fc of the antibody to Fcγ receptor. …”
Get full text

Lipoma intrapectoral gigante by William Omar Fernández Concepción, Amilkar Suárez Pupo, Mónica Patricia Acosta Gaibor, Lázaro Francisco Ramos Fuentes

“…Introducción: Los lipomas constituyen los tumores mesenquimatosos más comunes que se localizan generalmente en el tejido subcutáneo y están formados por tejido graso. …”
Get full text

Can Gastric Cancer Patients with High Mandard Score Benefit from Neoadjuvant Chemotherapy? by Wen-Zhe Kang, Bing-Zhi Wang, Deng-Feng Li, Zhi-Chao Jiang, Jian-Ping Xiong, Yang Li, Peng Jin, Xin-Xin Shao, Hai-Tao Hu, Yan-Tao Tian

“…A high Mandard score may indicate the tumor is insensitive to chemotherapy. We analyzed tumor regression and lymph node response under different Mandard scores to assess the impact of Mandard score on prognosis. …”
Get full text

YAP Overexpression in Breast Cancer Cells Promotes Angiogenesis through Activating YAP Signaling in Vascular Endothelial Cells by Yu Yan, Qiang Song, Li Yao, Liang Zhao, Hui Cai

“…However, roles of YAP signaling that regulate the breast tumor angiogenesis have remained elusive. Tumor angiogenesis is coordinated by the activation of both cancer cells and vascular endothelial cells. …”
Get full text

Shaping oral and intestinal microbiota and the immune system during the first 1,000 days of life by Jie Zhu, Mingxin He, Simin Li, Yumeng Lei, Xiaochen Xiang, Zhi Guo, Qiang Wang

Get full text