A novel histone acetylation-associated gene signature with prognostic value in Ewing sarcoma by Anshun Wu, Fayin Liu, Lei Zhou, Runyi Jiang, Shangjiang Yu, Zihuan Zhou, Qi Zhang, Qian Zhang, Dongjie Jiang, Shaohui He, Haifeng Wei

“…Abstract Histone acetylation is an important epigenetic modification, modulating the development of many tumors. However, the functions of most histone acetylation-related genes (HARGs) and their prognostic values in Ewing sarcoma (EWS) remain unclear. …”
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Synthesis of CF₃-Indazoles via Rh(III)-Catalyzed C-H [4+1] Annulation of Azobenzenes with CF₃-Imidoyl Sulfoxonium Ylides by Yilong Shang, Chen Li, Guiqiu Wang, Guiwei Yao, Hongliang Wu, Xun Chen, Ruirui Zhai

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PET imaging of 52Mn labeled DOTATATE and DOTAJR11 by James M. Omweri, Hailey A. Houson, Shannon E. Lynch, Volkan Tekin, Anna G. Sorace, Suzanne E. Lapi

“…PET images of the radiotracers in AR42J tumor bearing mice demonstrated similar biodistribution in all organs except the tumor, with [52Mn]Mn-DOTATATE showing higher tumor uptake compared to [52Mn]Mn-DOTA-JR11. …”
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Simulation of Image-Guided Microwave Ablation Therapy Using a Digital Twin Computational Model by Frankangel Servin, Jarrod A. Collins, Jon S. Heiselman, Katherine C. Frederick-Dyer, Virginia B. Planz, Sunil K. Geevarghese, Daniel B. Brown, William R. Jarnagin, Michael I. Miga

“…This study establishes an MR imaging framework to construct three-dimensional biophysical digital twins to predict ablation delivery in livers with 5 levels of fat content in the presence of a tumor. Four microwave antenna placement strategies were considered, and simulated microwave ablations were then performed using 915 MHz and 2450 MHz antennae in <italic>Tumor Na&#x00EF;ve DTs</italic> (control), and <italic>Tumor Informed DTs</italic> at five grades of steatosis. …”
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Significance of Glutathione Peroxidase 1 and Caudal-Related Homeodomain Transcription Factor in Human Gastric Adenocarcinoma by Jing Jing Han, De Rong Xie, Li Li Wang, Ye Qing Liu, Gong Fa Wu, Qing Sun, Yan Xian Chen, Ying Wei, Zhi Quan Huang, Hai Gang Li

“…To investigate the expressions of glutathione peroxidase 1 (GPX1) and caudal-related homeodomain transcription factor (CDX2) in GAC and their correlation with clinicopathological features and tumor cell proliferation. Methods. The expressions of GPX1, CDX2, and Ki67 were immunohistochemically evaluated in 172 GAC specimens. …”
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Enhanced effect of radiofrequency ablation on HCC by siRNA-PD-L1-endostatin Co-expression plasmid delivered by Pengfei Chen, Kun Li, Jinwei Chen, He Hei, Jiaxin Geng, Nannan Huang, Mengyu Lei, Huijie Jia, Jianzhuang Ren, Chenwang Jin

“…The combination therapy significantly reduced tumor growth, angiogenesis, and PD-L1/VEGF expression in tumor tissues post-RFA. …”
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Construction of a prognostic model for gastric cancer based on immune infiltration and microenvironment, and exploration of MEF2C gene function by Si-yu Wang, Yu-xin Wang, Lu-shun Guan, Ao Shen, Run-jie Huang, Shu-qiang Yuan, Yu-long Xiao, Li-shuai Wang, Dan Lei, Yin Zhao, Chuan Lin, Chang-ping Wang, Zhi-ping Yuan

“…Finally, based on transcriptome sequencing data on 10 paired tumor tissues from Sun Yat-sen University Cancer Center, MEF2C expression was significantly lower in paracancerous tissues compared to tumor tissues and peritoneal metastases, and it was also lower in tumor tissues compared to peritoneal metastases, indicating a potential positive association between MEF2C expression and tumor invasiveness. …”
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Anaplastic Sarcoma of the Kidney by Apostolos P. Labanaris, Vahudin Zugor, Robert Smiszek, Reinhold Nützel, Reinhard Kühn

“…We present a case of an extremely rare and relatively new tumor entity of the kidney, the anaplastic sarcoma. …”
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A Case of Radical Resection of Esophageal Basaloid Cell Carcinoma After Hemostasis by Transarterial Embolization by Keita Sato, Koji Takahashi

“…Esophageal bleeding management typically involves endoscopy but becomes challenging with large or hemorrhagic tumors, especially in cases of rare basal cell carcinoma. …”
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Case report: Clonal evolution analysis of a rare case of meningioma lung metastases identifies actionable alterations in matched longitudinal tumour samples by Nicola Cosgrove, Orla M. Fitzpatrick, Orla M. Fitzpatrick, Liam Grogan, Liam Grogan, Bryan T. Hennessy, Bryan T. Hennessy, Simon J. Furney, Sinead Toomey

“…Following a discussion at a medical oncology multi-disciplinary team meeting, whole genome sequencing was requested in November 2021 and discussed at a neurosurgical molecular tumor board in June 2022. Sequencing was performed on matched longitudinal collected samples of the primary tumor resection, the re-excised recurrent tumor after adjuvant radiation therapy, the lung metastases before treatment with sunitinib, and one paired blood sample for tumor-normal analysis. …”
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Comparison of Inflammation-Based Prognostic Scores in a Cohort of Patients with Resectable Esophageal Cancer by G. Jomrich, M. Paireder, A. Gleiss, I. Kristo, L. Harpain, S. F. Schoppmann

“…The investigated prognostic scores should be used and interpreted carefully, and established factors like histology, including tumor size and differentiation, lymph node involvement, and status of resection margin remain the only reliable prognostic factors for patients suffering from resectable EC.…”
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Effect of diabetes mellitus on levels of insulin-like growth factors and their carrier proteins in Guerin’s carcinoma and it’s perifocal tissue in rats by E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, E. I. Surikova, I. V. Neskubina, Yu. A. Pogorelova, N. D. Cheryarina, P. S. Kachesova, L. A. Nemashkalova

“…DM in females upregulated levels of glucose both in the tumor and in perifocal tissues by 1.8 (p &lt; 0.05) and 8.1 times, respectively, but caused opposite changes in IGF-I - it's increase by 6.3 times in the tumor and decrease by 3.2 times in the perifocal area; as a result, such tumors with small primary nodes were more "aggressive" and actively metastasized. …”
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Insights Into the Role of Bmi‐1 Deregulation in Promoting Stemness and Therapy Resistance in Glioblastoma: A Narrative Review by Fatima Shaalan, Nissrine Ballout, Wafaa Takash Chamoun

“…ABSTRACT Background Glioblastoma (GBM) is the most common primary brain tumor in adults and has a median survival of less than 15 months. …”
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Epithelial cell diversity and immune remodeling in bladder cancer progression: insights from single-cell transcriptomics by Jianpeng Li, Yunzhong Jiang, Minghai Ma, Lu Wang, Minxuan Jing, Zezhong Yang, Mengzhao Zhang, Ke Chen, Jinhai Fan

“…Abstract Background The progression of bladder cancer (BC) from non-muscle-invasive bladder cancer (NMIBC) to muscle-invasive bladder cancer (MIBC) significantly increases disease severity. Although the tumor microenvironment (TME) plays a pivotal role in this process, the heterogeneity of tumor cells and TME components remains underexplored. …”
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Biometabolic Distribution of Tc-3PRGD2 and its Potential Value in Monitoring Chemotherapeutic Effects by Jian-Guo Wu, Shao-Li Song, Xiang Zhou, Fan Wang, Yin-Yan Zhu, Lei Xie, Fan Zhang, Gang Huang

“…Previous studies have reported that 99m Tc-3PRGD2 is an excellent tumor imaging agent that showed a good correlation with integrin α v β 3 , a main factor of tumor-induced angiogenesis. …”
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A Rare Clinical Presentation of Cholangiocarcinoma by Elisa Gravito-Soares, Marta Gravito-Soares, Pedro Figueiredo, Luis Tomé

“…Cholangiocarcinoma is an uncommon tumor, often diagnosed in the context of obstructive jaundice. …”
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PPARs Mediate Lipid Signaling in Inflammation and Cancer by Liliane Michalik, Walter Wahli

“…In addition, PPARs are tumor growth modifiers, via the regulation of cancer cell apoptosis, proliferation, and differentiation, and through their action on the tumor cell environment, namely, angiogenesis, inflammation, and immune cell functions. …”
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Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment by Jeffrey Koury, Li Zhong, Jijun Hao

“…However, dysfunctions of these pathways are evident in multiple tumor types and malignancies. Specifically, aberrant activation of these pathways is implicated in modulation of cancer stem cells (CSCs), a small subset of cancer cells capable of self-renewal and differentiation into heterogeneous tumor cells. …”
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Role of Cold atmospheric plasma in cancer management by Shrikant B. Mali

“…Cold atmospheric plasma (CAP) has shown potential in treating skin diseases and chronic wounds, reducing tumor-cell viability and stimulating stem-cell proliferation. …”
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PET Imaging of Steroid Hormone Receptor Expression by Louis Allott, Graham Smith, Eric O. Aboagye, Laurence Carroll

“…These receptors act to induce tumor proliferation. In the imaging context, total expression together with modulation of expression can yield predictive and prognostic information. …”
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