Platelet membrane biomimetic nanomedicine induces dual glutathione consumption for enhancing cancer radioimmunotherapy by Xiaopeng Li, Yang Zhong, Pengyuan Qi, Daoming Zhu, Chenglong Sun, Nan Wei, Yang Zhang, Zhanggui Wang

“…Thanks to the tumor-targeting ability of the platelet membranes, PMD can target and aggregate to the tumor site, which is internalized by tumor cells. …”
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Repurposing of phosphodiesterase-5 inhibitor sildenafil as a therapeutic agent to prevent gastric cancer growth through suppressing c-MYC stability for IL-6 transcription by Zhenzhan Zhang, Wuqing Huang, Donghua Huang, Zhou Xu, Qingfeng Xie, Xin Tan, Wenjun He, Weihao Yang, Guoxin Li, Jianguang Ji, Hao Liu

“…By combing a couple of nationwide Swedish registers, GC patients who received PDE5 inhibitors were compared to matched controls while adjusting for confounding factors. The anti-tumor effect and mechanism of the PDE5 inhibitor sildenafil were evaluated via using tumor cells, patient-derived tumor organoids and xenograft animal models in GC. …”
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Helicobacter pylori SlyD stabilizes TPT1 via hnRNPK and enhances OCT1-mediated CDX2 transcriptional activation to drive gastric intestinal metaplasia by Shuwen Zheng, Yingying Wang, Chuxuan Ni, Rui Guo, Xunan Qiu, Jijun Chen, Lu Wang, Xiaohu Sun, Moye Chen, Yunen Liu, Yuan Yuan, Yuehua Gong

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NIR‐II AIEgens nanosystem for fluorescence and chemiluminescence synergistic imaging‐guided precise resection in osteosarcoma surgery by Ruotong Li, Kaiyuan Liu, Qian Hu, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Xingjun Zhu, Wei Sun

“…Targeted tumor imaging‐guided surgery (IGS) is facilitated by FL and CL nanoprobes (FLNP and CLNP) constructed based on BBTD14. …”
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Carnitine palmitoyltransferase 1C promotes EMT-associated cisplatin resistance in non-small cell lung cancer cells by Renjie Chen, Jiahui Wang, Shuoyu Huang, Xuefeng Hu, Xinran He, Tiange Zhang, Yunhan Hu, Huijun Wei, Sihui Nian, Yushu Huang, Zhihao Wu

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Stroma-derived Dickkopf-1 contributes to the suppression of NK cell cytotoxicity in breast cancer by Seunghyun Lee, Biancamaria Ricci, Jennifer Tran, Emily Eul, Jiayu Ye, Qihao Ren, David Clever, Julia Wang, Pamela Wong, Michael S. Haas, Sheila A. Stewart, Cynthia X. Ma, Todd A. Fehniger, Roberta Faccio

“…Abstract Mechanisms related to tumor evasion from NK cell-mediated immune surveillance remain enigmatic. …”
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Mechanical HIFU and immune checkpoint inhibition: toward clinical implementation by Vera Mekers, Mirjam de Visser, Karijn Suijkerbuijk, Clemens Bos, Chrit Moonen, Roel Deckers, Gosse Adema

“…Mechanical High-Intensity Focused Ultrasound (M-HIFU) represents a promising tumor ablative therapy, inducing cavitation within the tumor, resulting in tumor cell destruction and the release of danger signals and tumor antigens, two key factors contributing to anti-tumor immune responses.Methods/Results: Preclinical studies on the impact of M-HIFU on the anti-tumor immune response are guiding the translational application of this technique in the clinical setting. …”
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Giant Adrenal Myelolipoma in a Patient without Endocrine Disorder: A Case Report and a Review of the Literature by Yoshifumi Nakayama, Nobutaka Matayoshi, Masaki Akiyama, Yusuke Sawatsubashi, Jun Nagata, Masanori Hisaoka, Keiji Hirata

“…A 62-year-old woman presented to our surgical outpatient clinic with a retroperitoneal tumor. A clinical examination revealed an elastic soft, smooth-surfaced, painless, child-head-sized tumor with poor mobility, which was located in the left upper abdomen. …”
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DNA-mediated self-assembly oxidative damage amplifier combined with copper and MTH1 inhibitor for cancer therapy by Cui Ren, Zhiyong Shi, Xiaowen Zhang, Xueer Yu, Yang Gao, Zhi Qi, Yu Chen, Yong Wang

“…Chemo-dynamic therapy (CDT) has a great potential in tumor extirpation. It entails producing hypertoxic reactive oxygen species (ROS) that damage the DNA of tumor cells and other biomacromolecules. …”
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Preliminary Diagnosis and Characterization of a Spontaneous Immature Testicular Teratoma in an Interferon Receptor-Deficient Mouse Model by ZHAO He, ZHANG Fan, XIAO Yuzhou, AN Xuefang, ZHANG Tao, LI Li

“…Upon dissection, the tumor tissue was encapsulated in a smooth capsule. …”
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Mixoid Liposarcoma by Azamris Azamris, Peri Handayani, Muhammad Rifki

“…If the early detected the cure rate can be better. Wide Excision Tumor is the modality for treatment of Liposarcoma. …”
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Glucose Metabolism of Human Prostate Cancer Mouse Xenografts by Hossein Jadvar, Xiankui Li, Antranik Shahinian, Ryan Park, Michel Tohme, Jacek Pinski, Peter S. Conti

“…The growth pattern of the CWR-22 tumor was best approximated by an exponential function (tumor size in mm 3 = 14.913 e 0.108 × days , R 2 = .96, n = 5). …”
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Pan-Cancer Analysis of B4GALNT1 as a Potential Prognostic and Immunological Biomarker by Hang Yi, Yiwen Lin, Yutong Li, Yeqi Guo, Ligong Yuan, Yousheng Mao

“…Gangliosides act as important roles in tumor progression. B4GALNT1 is a key enzyme in ganglioside biosynthesis. …”
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Prognostic Implication of Preoperative Behavior Changes in Patients with Primary High-Grade Meningiomas by Andrej Vranic, Frederic Gilbert

“…High-grade meningiomas are rare extra-axial tumors, frequently causing brain invasion and prominent brain edema. …”
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Colonic Adenocarcinoma with Plasmacytoid Feature: Histopathology and Molecular Characteristics of a Rare Neoplasm with an Unusual Presentation by Noor Marji, Jasrerman Dhillon, Gregory Y. Lauwers, Sebastian Feuerlein, Reza Nikfar, Monica Chatwal, Aram Vosoughi

“…Colorectal carcinoma with noncohesive tumor cells has been described in tumors with signet ring cells (mucinous adenocarcinoma and signet ring cell adenocarcinoma) and rhabdoid feature (carcinoma with sarcomatoid component). …”
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Oncocytoma of the Parotid Gland with Facial Nerve Paralysis by Seijiro Hamada, Keishi Fujiwara, Hiromitsu Hatakeyama, Akihiro Homma

“…Parotid gland tumor with facial nerve paralysis is strongly suggestive of a malignant tumor. …”
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A Case of GATA3 Positive Pleomorphic Liposarcoma, Epithelioid Variant: A Diagnostic Pitfall by Makoto Abe, Nobuo Hoshi, Sayuri Hoshi, Kaoru Hirabayashi, Kazutaka Kikuta, Toru Hirozane, Rumi Nakagawa, Tsukasa Mizuno, Hiroshi Nakamura, Koichi Inoue, Takehiko Yamaguchi

“…Histological examination revealed a tumor with epithelioid morphology. The tumor consists of solid sheets of epithelioid tumor cells with focal aggregates of pleomorphic lipoblasts. …”
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Multi-modality Imaging Identifies Key Times for Annexin V Imaging as an Early Predictor of Therapeutic Outcome by Stefanie J. Mandl, Carina Mari, Matthias Edinger, Robert S. Negrin, Jonathan F. Tait, Christopher H. Contag, Francis G. Blankenberg

“…Biodistribution analyses revealed a biphasic increase of annexin V uptake within the tumor-bearing tissues of mice. An early peak occurring before actual tumor cells loss was observed between 1 and 5 hr after treatment, and a second longer sustained rise from 9 to 24 hr after therapy, which heralds the onset of tumor cell loss as confirmed by BLI. …”
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Progress in immune microenvironment, immunotherapy and prognostic biomarkers in pediatric osteosarcoma by Lin Zhang, Haoming Jiang, Haichao Ma

“…Pediatric osteosarcoma, the most prevalent primary malignant bone tumor in children, is marked by aggressive progression and a generally poor prognosis. …”
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Effector, Memory, and Dysfunctional CD8+ T Cell Fates in the Antitumor Immune Response by John Reiser, Arnob Banerjee

“…The adaptive immune system plays a pivotal role in the host’s ability to mount an effective, antigen-specific immune response against tumors. CD8+ tumor-infiltrating lymphocytes (TILs) mediate tumor rejection through recognition of tumor antigens and direct killing of transformed cells. …”
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