Potential role of P4HB in the tumor microenvironment and its clinical prognostic value: a comprehensive pan-cancer analysis and experimental validation with a focus on KIRC by Linxue Zhang, Yu-wei Li, Tianyi Xie, Ke Sun, Xiang Huang, Wei Xiong, Rui-ji Liu

Subjects: Get full text

The expression of BHLHE22 in endometrial carcinoma: Associations with mismatch repair protein expression status, tumor-infiltrating immune cells, programmed death-ligand 1 and clinical outcomes by Lin-Yu Chen, Hsing-Yu Chen, Hung-Cheng Lai, Shiou-Fu Lin, Kuo-Chang Wen, Darmawi, Phui-Ly Liew

Subjects: Get full text

The Polymorphism −308G/A of Tumor Necrosis Factor-α Gene Modulates the Effect of Immunosuppressive Treatment in First Kidney Transplant Subjects Who Suffer an Acute Rejection by Ana Isabel Sánchez-Fructuoso, Isabel Pérez-Flores, Rosalia Valero, Maria Angeles Moreno, Miguel Fernandez-Arquero, Elena Urcelay, Cristina Fernández-Pérez, Jose Luis Santiago

“…The −308G/A SNP of tumor necrosis factor-alpha (TNF-α) gene affects TNF-α production. …”
Get full text

Three Cases of Previous Smokers with Rheumatoid Arthritis Who Did Not Respond to Tumor Necrosis Factor Inhibitors Were Treated Successfully with an Anti-Interleukin-6 Receptor Antibody by Yasuo Iwata

Get full text

Antitumor Activity of Whole-Plant Extracts from In Vitro Cultured and Wild-Growing <i>Clinopodium vulgare</i> Plants on a Panel of Human Tumor Cell Lines by Ani Georgieva, Inna Sulikovska, Tanya Toshkova-Yotova, Vera Djeliova, Sabrina Amiri, Nenad Tsonevski, Polina Petkova-Kirova, Krasimira Tasheva

“…The ability of <i>C. vulgare</i> to inhibit cancer cell migration and induce apoptosis in the tumor cells was examined by wound healing assay and fluorescence microscopic methods. …”
Get full text

The guided fire from within: intratumoral administration of mRNA-based vaccines to mobilize memory immunity and direct immune responses against pathogen to target solid tumors by Renhao Li, Jing-Chu Hu, Li Rong, Yige He, Xiaolei Wang, Xuansheng Lin, Wenjun Li, Yangfan Wu, Chaiyaporn Kuwentrai, Canhui Su, Thomas Yau, Ivan Fan-Ngai Hung, Xiang Gao, Jian-Dong Huang

“…Abstract We investigated a novel cancer immunotherapy strategy that effectively suppresses tumor growth in multiple solid tumor models and significantly extends the lifespan of tumor-bearing mice by introducing pathogen antigens into tumors via mRNA-lipid nanoparticles. …”
Get full text

Outcome of Limb-sparing Surgery with Custom Mega Endoprosthesis Reconstruction for Bone Tumors in a Tertiary Care Center—10-year Study: Where Do We Stand? by Subbiah Shanmugam, Pravenkumar R Ramaswami

Subjects: Get full text

Establishment and practice of the Traditional Chinese Medicine nursing clinic under the mode of Green treatment of tumor (肿瘤中医绿色护理门诊的建立与实践) by LIU Shuhong (刘书红), ZHAO Yanan (赵亚楠), YAN Kang (严康)

Subjects: “…tumor…”
Get full text

Head and neck squamous cell carcinoma epidemiology at diagnosis: A description of public and private health care systems in Brazil regarding tumor location, staging and risk factors by Heloisa Arantes, Diego Chaves Rezende Morais, Maria Aparecida do Carmo Rego, Paula de Mendonça Batista, Cicera Pimenta Marcelino, Milena Falcão Almeida, Marion Coting Braga, Paula Cristina Pungartnik, Angelica Carreira dos Santos, Juliana Ominelli, Tharcísio Machado Coelho, Fernanda Bohns Pruski Ramos, Marcelo Salgado, Marina Kelner, Cristiano Guedes Duque, Daniel Oliveira Brito, Carlos Gil Moreira Ferreira, Pedro Rafael Martins De Marchi

“…The main site of the primary tumor was the oropharynx in the private sector and oral cavity in the public sector. …”
Get full text

A novel gene signature for predicting outcome in colorectal cancer patients based on tumor cell-endothelial cell interaction via single-cell sequencing and machine learning by Lina Pang, Qingxia Sun, Wenyue Wang, Mingjie Song, Ying Wu, Xin Shi, Xiaonan Shi

“…Results: Our analysis revealed two distinct cell subgroups, Malignant Cluster01 tumor cells, and Tip-like endothelial cells, showing significant interaction and closely associated with colorectal cancer prognosis. …”
Get full text

A Rare Case of Gastrointestinal Stromal Tumor with a Liver Metastasis Infiltrating the Inferior Vena Cava and Extending to the Right Atrium with an Early Recurrence after Surgical Extraction by Dimitrios Siamkouris, Marc Schloesser, Amr Yousef, Elmar Offers

“…Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the gastrointestinal tract. …”
Get full text

Response to Letter to the Editor on “Impact of the Surgical Approach for Neoadjuvantly Treated Gastroesophageal Junction Type II Tumors: A Multinational, High-Volume Center Retrospective Cohort Analysis” by Naita M. Wirsik, MD, Thomas Schmidt, MD, PhD, Christiane J. Bruns, MD

Get full text

Immune-related gene SOX10 affects ferroptosis in pancreatic cancer and facilitates tumor progression by targeting CMTM7-mediated Wnt/β-catenin signaling pathway by Guixing Jiang, Bicheng Wu, Kaikai Wang, Xiaofan Pu, Senhao Zhou, Xin Zhong, Xiaolong Liu, Suihan Wang, Tianyu Lin

“…After knocking down SOX10 using lentiviral transfection, SOX10 action on Wnt/β-catenin pathway and ferroptosis, as well as its anti-tumor activity in tumor-bearing mice were explored. …”
Get full text

In Vivo Biodistribution and Lifetime Analysis of Cy5.5-Conjugated Rituximab in Mice Bearing Lymphoid Tumor Xenograft Using Time-Domain Near-Infrared Optical Imaging by Stefania Biffi, Chiara Garrovo, Paolo Macor, Claudio Tripodo, Sonia Zorzet, Erika Secco, Francesco Tedesco, Vito Lorusso

“…In vitro, RI-Cy5.5 retained biologic activity and led to elevated cell-associated fluorescence on tumor cells. In vivo, TD optical imaging analysis of RI-Cy5.5 injected into lymphoma-bearing mice revealed a slow tumor uptake and a specific long-lasting persistence of the probe within the tumor. …”
Get full text

First-line combination therapy of immunotherapy plus anti-angiogenic drug for thoracic SMARCA4-deficient undifferentiated tumors in AIDS: a case report and review of the literature by Xiaoling Wei, Xiangju Xing, Wei Yao, Changzheng Wang, Yajie Xiao, Xianzhi Du

Subjects: “…thoracic SMARCA4-deficient undifferentiated tumor…”
Get full text

Use of thymidine kinase 1 autoantibody, thymidine kinase antigen, extracellular protein kinase A autoantibody, and C‐reactive protein for early detection of malignant tumors in dogs by Yoonhee Kim, Wonhee Lee, Byunggak Kim, Bonghwan Jang, Kyung‐Rok Yu, Hong Sook Kim, Minok Ryu, Yein Oh, Kyoungwon Seo, Chul Park, Ulsoo Choi, Dongha Bhang, Hwayoung Youn

Subjects: Get full text

Cancer Stem Cells from Tumor Cell Lines Activate the DNA Damage Response Pathway after Ionizing Radiation More Efficiently Than Noncancer Stem Cells by Heriberto Abraham Valencia-González, Graciela Ruíz, Elizabeth Ortiz-Sánchez, Alejandro García-Carrancá

“…Recently, a subpopulation of tumor cells, called cancer stem cells (CSC), has been characterized, and these have emerged as a major topic in cancer research. …”
Get full text

T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins by Stephanie Schlichtner, Inna M Yasinska, Gurprit S Lall, Steffen M Berger, Sabrina Ruggiero, Dietmar Cholewa, Nijas Aliu, Bernhard F Gibbs, Elizaveta Fasler-Kan, Vadim V Sumbayev

“…However, solid tumor cells at rest are known to secrete either very low amounts of galectin-9 or, in most of the cases, do not secrete it at all. …”
Get full text

Advances in the relationship between AP-1 and tumorigenesis, development and therapy resistance by Xinni Xue, Zhiwei Li, Jiahui Zhao, Ziyi Zhao, Zhihang Li, Yong Li, Yawen Liu, Huan He

Subjects: Get full text

Intra-oral approach for excision of an unusual cystic mass in a 12-year-Old girl: A case report by Nasem Jamal Yousef, Issa Saad, Marwan Al-Raeei, Chadi Azmeh, Maya Saad, Zeina Darwich

Subjects: “…Central giant cell tumors…”
Get full text