A Pleural Solitary Fibrous Tumor, Multiple Gastrointestinal Stromal Tumors, Moyamoya Disease, and Hyperparathyroidism in a Patient Associated with NF1 by Yoko Yamamoto, Ken Kodama, Shigekazu Yokoyama, Masashi Takeda, Shintaro Michishita

“…Loss of the gene function, due to a point mutation, leads to an increase in cell proliferation and the development of several tumors. We report a 60-year-old female patient manifesting hypercalcemia due to hyperparathyroidism, a solitary fibrous tumor (SFT) of the pleura, multiple gastrointestinal stromal tumors (GISTs), and moyamoya disease associated with NF1. …”
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Comparative analysis of EGFR mutations in circulating tumor DNA and primary tumor tissues from lung cancer patients using BEAMing PCR by Duhita Mirikar, Nandini Banerjee, Kumar Prabhash, Rajiv Kumar Kaushal, Vanita Naronha, C. S. Pramesh, George Karimundackal, Amit Joshi, Swapnil Rane, Ranjan Basak

“…Noninvasive mutation detection by assessing circulating tumor DNA (ctDNA) offers many advantages over tumor biopsy. …”
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Comprehensive single-cell atlas of colorectal neuroendocrine tumors with liver metastases: unraveling tumor microenvironment heterogeneity between primary lesions and metastases by Yiqiao Deng, Qichen Chen, Chengyao Guo, Jinghua Chen, Xin Li, Zhiyu Li, Yefan Zhang, Jianjun Zhao, Jianguo Zhou, Jianqiang Cai, Tao Yan, Xiaobing Wang, Xinyu Bi, Zhen Huang, Hong Zhao

“…Abstract Background Colorectal neuroendocrine tumors with liver metastases (CRNELM) are associated with a poorer prognosis compared to their nonmetastatic counterparts. …”
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CREB3L1 facilitates pancreatic tumor progression and reprograms intratumoral tumor-associated macrophages to shape an immunotherapy-resistance microenvironment by Yu Wang, Haiyan Xu, Li Cai, Yang Sun, Liwei Wang, Ming Yue, Xiaofei Zhang, Yanling Wang, Shumin Li, Shengbai Xue, Jingyu Ma, Tiebo Mao, Weiyu Ge, Daiyuan Shentu, Wenxin Lu, Yongchao Wang, Jiong Hu, Jiujie Cui

“…Clinically, CREB3L1 correlated with immune cell signatures as well as immune checkpoint blockade (ICB) treatment response and outcome that CREB3L1aberrant activation indicated poorer efficacy and worse prognosis than the low in PDAC which might empower clinical decision.Conclusions Collectively, this study revealed CREB3L1 facilitated PDAC progression, shaped an immune exclude tumor microenvironment and distinguished therapy response and outcome of ICB therapy indicating CREB3L1 could be a promising novel molecular target and biomarker for PDAC treatment.…”
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Calpain 2 regulates IL-1α secretion and inhibits tumor development via modulating calpain 1 expression in the tumor microenvironment by Zuhairah Binte Hanafi, Yu Mei, Huey Yee Teo, Ying Zhu, Chew Chin Yong Lionel, Jing Wen Chiu, Jinhua Lu, Haiyan Liu

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Alleviating Tumor Hypoxia and Immunosuppression via Sononeoperfusion: A New Ally for potentiating anti-PD-L1 blockade of solid Tumor by Guoliang Yang, Hui Li, Jiabei Yin, Lei Yao, Jun Yang, Jiawei Tang, You Wu, Meng Zhou, TingTing Luo, Yi Zhang, Jing Zhang, Xuezhi Yang, XiaoXiao Dong, Zheng Liu, Ningshan Li

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The role of cisplatin in modulating the tumor immune microenvironment and its combination therapy strategies: a new approach to enhance anti-tumor efficacy by Guandu Li, Xiangyu Che, Shijin Wang, Dequan Liu, Deqian Xie, Bowen Jiang, Zunwen Zheng, Xu Zheng, Guangzhen Wu

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Endoscopic endonasal approach for pituitary neuroendocrine tumor with septal mucosa incision tailored to tumor extension intending unilateral septal mucosa preservation by Hiroyoshi Kino, Hiroyoshi Akutsu, Shuho Tanaka, Takuma Hara, Yusuke Morinaga, Hidetaka Miyamoto, Rieko Ii, Koutarou Osawa, Eiichi Ishikawa

Subjects: “…Pituitary neuroendocrine tumor…”
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Tumor hypoxia evidences the differential regulation of Mdm2-p53 axis by PTEN in tumor derived vs. normal endothelial cells by Kinga Wilkus-Adamczyk, Klaudia Brodaczewska, Claudine Kieda

“…The tumor suppressor PTEN regulates angiogenesis, a process involving endothelial cells (ECs). …”
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Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interaction by Francesco Verona, Sebastiano Di Bella, Roberto Schirano, Camilla Manfredi, Francesca Angeloro, Giulia Bozzari, Matilde Todaro, Matilde Todaro, Giuseppe Giannini, Giuseppe Giannini, Giorgio Stassi, Veronica Veschi

“…Cancer stem cells (CSCs) are a small subset within the tumor mass significantly contributing to cancer progression through dysregulation of various oncogenic pathways, driving tumor growth, chemoresistance and metastasis formation. …”
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Retraction Note: Tspan8 and Tspan8/CD151 knockout mice unravel the contribution of tumor and host exosomes to tumor progression by Kun Zhao, Zhe Wang, Thilo Hackert, Claudia Pitzer, Margot Zöller

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Virus-like particle: a nano-platform that delivers cancer antigens to elicit an anti-tumor immune response by Weisen Ning, Sheng Yan, Yongyao Song, Hanning Xu, Jinling Zhang, Xiaomei Wang

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Primary epithelioid trophoblastic tumor of the lung: A case report by Qiongying Zhang, Wenwen Sun, Zhen Zhang, Jianmin Li

Subjects: “…epithelioid trophoblastic tumor (ett)…”
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PHYLLOID TUMORS OF MAMMARY GLANDS. CURRENT STATE OF THE PROBLEM by A. D. Zikiryakhodzhaev, I. M. Shirokikh, N. V. Kharchenko, G. M. Zapirov, E. K. Saribekyan, N. V. Ablitsova, A. V. Ermakov, M. A. Kunda, V. S. Sidorenko, H. S. Gevorgyan

Subjects: “…phylloid tumor…”
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Mature Cystic Teratoma with Neuroendocrine Tumor — Case Report by Tufail Ahmad Khan, Madiha Amin, Aneeta Singh, Anuja Sharma, K.C Goswami, Sujeet Bhat

Subjects: “…Presacral Tumor…”
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Tumor Suppressor Function of CYLD in Nonmelanoma Skin Cancer by K. C. Masoumi, Gina Shaw-Hallgren, Ramin Massoumi

“…In basal cell carcinoma, the tumor suppressor protein CYLD is repressed at the transcriptional levels through hedgehog signaling pathway. …”
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Advances and prospects of cell-penetrating peptides in tumor immunotherapy by Di Yang, Baorui Liu, Huizi Sha

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Breast Neuroendocrine Tumor. Case Report and Literature Review by Lidia Torres Aja

“…Primary neuroendocrine carcinomas of the breast are rare neoplasms, accounting for 2 to 5 % of breast tumors. For their diagnosis it is required that more than 50 % of the tumor present neuroendocrine features. …”
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Mechanisms of T-cell Depletion in Tumors and Advances in Clinical Research by Xiangfei Su, Mi Zhang, Hong Zhu, Jingwen Cai, Zhen Wang, Yuewei Xu, Li Wang, Chen Shen, Ming Cai

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Active Roles of Tumor Stroma in Breast Cancer Metastasis by Zahraa I. Khamis, Ziad J. Sahab, Qing-Xiang Amy Sang

“…Metastasis is the major cause of death for breast cancer patients. Tumors are heterogenous cellular entities composed of cancer cells and cells of the microenvironment in which they reside. …”
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