A high number of tumor deposits (≥ 4) is an isolated predictor of local recurrence and distant metastasis in non-metastatic colorectal cancer: a single center study by Ahmed Bendari, Ebubekir Ucar, Alaa Bendari, Hamed Hammoud, FNU Kiran, Reham Al-Refai, Sunder Sham, Sanjay Kirshan Kumar, Ryan Des Jean, Manju Harshan

“…Multivariate analysis adjusted for age, lymph node status, and tumor deposits, identified that tumor deposits ≥ 4 was the only predictor of tumor recurrence following colorectal surgery and chemotherapy. …”
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Preoperative evaluation of red blood cell distribution width as a promising biomarker for discriminating between benign and malignant breast tumors and assessing breast cancer activity by Ajay Singh Thakur, Chandrashekhar Indoria, Ruby Sahu, Pratima Kujur, Renuka Gahine

“…Results: RDW demonstrated a statistically significant elevation in the cohort of patients with malignant breast tumors, those with metastatic breast tumors, a greater number of infiltrated axillary lymph nodes, larger tumor diameter, and a higher grade of the primary tumor mass. …”
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Herbal Extract SH003 Suppresses Tumor Growth and Metastasis of MDA-MB-231 Breast Cancer Cells by Inhibiting STAT3-IL-6 Signaling by Youn Kyung Choi, Sung-Gook Cho, Sang-Mi Woo, Yee Jin Yun, Sunju Park, Yong Cheol Shin, Seong-Gyu Ko

“…Here, we demonstrate that our new herbal extract, SH003, suppresses both tumor growth and metastasis of MDA-MB-231 breast cancer cells via inhibiting STAT3-IL-6 signaling path. …”
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The Beneficial Effect of IL-12 and IL-18 Transduced Dendritic Cells Stimulated with Tumor Antigens on Generation of an Antitumor Response in a Mouse Colon Carcinoma Model by Jagoda Mierzejewska, Katarzyna Węgierek-Ciura, Joanna Rossowska, Agnieszka Szczygieł, Natalia Anger-Góra, Bożena Szermer-Olearnik, Magdalena Geneja, Elżbieta Pajtasz-Piasecka

“…We examined the ability of DCs to migrate to the tumor-draining lymph nodes and infiltrate tumor tissue and to activate the local and systemic antitumor response. …”
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Tumor-Educated Platelets lncRNA-STARD4-AS1 and ELOA-AS1 as Potential Novel Biomarkers for the Early Diagnosis of Non-Small Cell Lung Cancer by Luo C, Lin Z, Huang F, Ning L, Yuan Y

Subjects: “…tumor-educated platelets…”
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TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial by Wei Gao, Ping Hu, Aung Naing, Meredith McKean, Anthony Tolcher, Lillian L Siu, Keyvan Tadjalli-Mehr, Anja Victor, Emilia Richter, Marco A F Nogueira Filho, Thomas Kitzing, Stephan Gleicher, Daniel Holland

“…Anti-TIGIT mode-of-action-related pharmacodynamic effects were observed in peripheral blood and in tumor tissue. RDEs were 1600 mg every 2 weeks or 2400 mg every 3 weeks for M6223 monotherapy and 1600+1200 mg every 2 weeks for M6223+BA.Conclusions M6223±BA had a manageable safety profile, with RDEs defined for both monotherapy and combination therapy. …”
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Quantitative Correlation at the Molecular Level of Tumor Response to Docetaxel by Multimodal Diffusion-Weighted Magnetic Resonance Imaging and [F]FDG/[F]FLT Positron Emission Tomography by Valerie S. Honndorf, Holger Schmidt, Hans F. Wehrl, Stefan Wiehr, Walter Ehrlichmann, Leticia Quintanilla-Martinez, Hervé Barjat, Sally-Ann Ricketts, Bernd J. Pichler

“…Compared to the extensive tumor growth observed in the vehicle-treated group (from 0.32 ± 0.21 cm 3 to 0.69 ± 0.40 cm 3 ), the administration of docetaxel led to tumor growth stasis (from 0.32 ± 0.20 cm 3 to 0.45 ± 0.23 cm 3 ). …”
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Ultrasound May Suppress Tumor Growth, Inhibit Inflammation, and Establish Tolerogenesis by Remodeling Innatome via Pathways of ROS, Immune Checkpoints, Cytokines, and Trained Immunity/Tolerance by Qian Yang, Ruijing Zhang, Peng Tang, Yu Sun, Candice Johnson, Jason Saredy, Susu Wu, Jiwei Wang, Yifan Lu, Fatma Saaoud, Ying Shao, Charles Drummer, Keman Xu, Daohai Yu, Rongshan Li, Shuping Ge, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

“…Our analysis suggests novel molecular mechanisms that are utilized by LIUS to induce tumor suppression and inflammation inhibition. Our findings may lead to development of new treatment protocols for cancers and chronic inflammation.…”
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Caracterización de la expresión de galectina-3 mediante inmunohistoquímica enlesiones intraepiteliales de glándula mamaria de perras sin evidencia de tumor by J. A. Caicedo, C. A. Iregui

“…El objetivo de este trabajo fue caracterizar la expresión de la galectina-3 por medio de inmunohistoquímica en 19 glándulas mamarias (GM) de seis perras sin evidencia de tumor que contenían 50 tipos de LIEs y 7 carcinomas invasivos, teniendo en cuenta el porcentaje de células positivas y la intensidad del color de la inmunoreacción. …”
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Near-Infrared Fluorescence Imaging of EGFR-Overexpressing Tumors in the Mouse Xenograft Model Using scFv-IRDye800CW and Cetuximab-IRDye800CW by Abolfazl Amini, Yaghoub Safdari, Fatemeh Tash Shamsabadi

“…In the current study, we produced a scFv-based near-infrared probe (called cet.Hum.scFv-IRDye-800CW) and evaluated its ability in recognizing and imaging of EGFR-overexpressing tumors in a mouse model. Like the molecular probe consisting of its parental antibody (cetuximab, an FDA-approved monoclonal antibody) and IRD800CW, cet.Hum.scFv-IRDye-800CW was able to recognize EGFR-overexpressing tumors in mice. cet.Hum.scFv-IRDye-800CW was found to be superior to the cetuximab-based probe in imaging of mouse tumors. …”
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The combination of CDX2 expression status and tumor-infiltrating lymphocyte density as a prognostic factor in adjuvant FOLFOX-treated patients with stage III colorectal cancers by Ji-Ae Lee, Hye Eun Park, Hye-Yeong Jin, Lingyan Jin, Seung Yeon Yoo, Nam-Yun Cho, Jeong Mo Bae, Jung Ho Kim, Gyeong Hoon Kang

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Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian Population by Lynnette R. Ferguson, Dug Yeo Han, Claudia Huebner, Ivonne Petermann, Murray L. Barclay, Richard B. Gearry, Alan McCulloch, Pieter S. Demmers

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Did You Know? An Easy Trick for Measuring Tumor Size, Clearance Margins, and Breslow Thickness Under the Microscope If You Do Not Have an Inbuilt Scale in the Eyepiece by Sasi Kiran Attili

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Acute Pericarditis Occurring Three Days after Intravesical Instillation of Mitomycin C after Transurethral Bladder Tumor Resection in a 64-Year-Old Woman by Vineet Meghrajani, Arsalan Hashmi, Shuo Cheng Lin, Zvi Plawes, Shelly Brejt

“…We present a 64-year-old woman who developed symptoms of acute pericarditis three days after undergoing intravesical instillation of mitomycin C following transurethral bladder tumor resection. Mitomycin C is a chemotherapeutic agent which acts by alkylation of DNA and is known to be cardiotoxic when systemically administered. …”
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Impact of sleep deprivation on colon cancer: Unraveling the KynA-P4HA2-HIF-1α axis in tumor lipid metabolism and metastasis by Zuojie Peng, Jia Song, Wenzhong Zhu, Haijun Bao, Yuan Hu, Yongping Shi, Xukai Cheng, Mi Jiang, Feifei Fang, Jinhuang Chen, Xiaogang Shu

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2-Deoxy-D-Glucose: A Novel Pharmacological Agent for Killing Hypoxic Tumor Cells, Oxygen Dependence-Lowering in Covid-19, and Other Pharmacological Activities by Raman Singh, Vidushi Gupta, Antresh Kumar, Kuldeep Singh

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Multimodal Imaging of Patients With Gliomas Confirms C-MET PET as a Complementary Marker to MRI for Noninvasive Tumor Grading and Intraindividual Follow-Up After Therapy by Kai R. Laukamp MD, Florian Lindemann PhD, Matthias Weckesser MD, Volker Hesselmann MD, Sandra Ligges PhD, Johannes Wölfer MD, Astrid Jeibmann MD, Bastian Zinnhardt PhD, Thomas Viel PhD, Michael Schäfers MD, Werner Paulus MD, Walter Stummer MD, Otmar Schober PhD, MD, Andreas H. Jacobs MD

“…The value of combined L-( methyl -[ 11 C]) methionine positron-emitting tomography (MET-PET) and magnetic resonance imaging (MRI) with regard to tumor extent, entity prediction, and therapy effects in clinical routine in patients with suspicion of a brain tumor was investigated. …”
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Response to Comment on: “Prognostic Relevance of Primary Tumor Sidedness in Early-Stage Colorectal Cancer: An Integrated Analysis of 4 Randomized Controlled Trials (JCOG2003A)” by Akira Ouchi, MD, PhD, Shunsuke Tsukamoto, MD, PhD, Atsuo Takashima, MD, PhD, Yasuhiro Shimada, MD, Tetsuya Hamaguchi, MD, PhD, Masafumi Inomata, MD, PhD, Yasumasa Takii, MD, Ryo Sadachi, PhD, Yukihide Kanemitsu, MD

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Microwave Ablation Combined with Flt3L Provokes Tumor‐Specific Memory CD8+ T Cells‐Mediated Antitumor Immunity in Response to PD‐1 Blockade by Meixiang Wang, Jing Sang, Fengkuo Xu, Shulong Wang, Peng Liu, Ji Ma, Zhengtao Chen, Qi Xie, Zhigang Wei, Xin Ye

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Characterizing tumor biology and immune microenvironment in high-grade serous ovarian cancer via single-cell RNA sequencing: insights for targeted and personalized immunotherapy strategies by Fu Zhao, Fu Zhao, Xiaojing Jiang, Yumeng Li, Tianjiao Huang, Zhikai Xiahou, Wenyang Nie, Qian Li

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