Assessment of Tumor Burden Score as a Feasible and Reliable Tool for Prognosis Prediction for Hepatocellular Carcinoma Undergoing Hepatectomy: A Multicenter, Retrospective Study by Guan R, Zheng Z, Deng M, Mei J, Lin Y

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Loss of MTAP expression is strongly linked to homozygous 9p21 deletion, unfavorable tumor phenotype, and noninflamed microenvironment in urothelial bladder cancer by Natalia Gorbokon, Niklas Wößner, Viktoria Ahlburg, Henning Plage, Sebastian Hofbauer, Kira Furlano, Sarah Weinberger, Paul Giacomo Bruch, Simon Schallenberg, Florian Roßner, Sefer Elezkurtaj, Maximilian Lennartz, Niclas C Blessin, Andreas H Marx, Henrik Samtleben, Margit Fisch, Michael Rink, Marcin Slojewski, Krystian Kaczmarek, Thorsten Ecke, Tobias Klatte, Stefan Koch, Nico Adamini, Sarah Minner, Ronald Simon, Guido Sauter, Henrik Zecha, David Horst, Thorsten Schlomm, Lukas Bubendorf, Martina Kluth

“…MTAP IHC is a near perfect surrogate for MTAP deficiency in this tumor type.…”
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Dual inhibition of LAG-3 and PD-1 with IBI110 and sintilimab in advanced solid tumors: the first-in-human phase Ia/Ib study by Chenyu Mao, Anwen Xiong, Jiong Qian, Wenxiang Wang, Ying Liu, Tao Zhang, Zhihai Wu, Haiqing Ni, Jia Lu, Sixiang Long, Li Zhao, Yuling Chen, Caicun Zhou, Nong Xu

“…Herein, we evaluate the safety and efficacy of IBI110 (anti-LAG-3 antibody) with sintilimab (an anti-PD-1 antibody) in Chinese patients with advanced solid tumors. Methods In this open-label phase I study, phase Ia dose escalation of IBI110 monotherapy and phase Ib combination dose escalation of IBI110 plus sintilimab were conducted in patients with advanced solid tumors. …”
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Case report of a Sertoli cell tumor with unique presentation including fevers, weight loss, and leukocytosis in a 13-year-old male by Austin G. Kazarian, Caleb Q. Ashbrook, Charles F. Timmons, Craig A. Peters, Bruce J. Schlomer

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Advancing Radiobiology: Investigating the Effects of Photon, Proton, and Carbon-Ion Irradiation on PANC-1 Cells in 2D and 3D Tumor Models by Alexandra Charalampopoulou, Amelia Barcellini, Giuseppe Magro, Anna Bellini, Sara Sevan Borgna, Giorgia Fulgini, Giovanni Battista Ivaldi, Alessio Mereghetti, Ester Orlandi, Marco Giuseppe Pullia, Simone Savazzi, Paola Tabarelli De Fatis, Gaia Volpi, Angelica Facoetti

“…In vitro radiobiology has relied on two-dimensional (2D) cell culture models so far; however, these are not sufficient to replicate the complexity of the in vivo tumor architecture. Three-dimensional (3D) models become a paradigm shift, surpassing the constraints of traditional models by accurately re-creating morphological, histological, and genetic characteristics as well as the interaction of tumour cells with the microenvironment. …”
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S100A13-driven interaction between pancreatic adenocarcinoma cells and cancer-associated fibroblasts promotes tumor progression through calcium signaling by Liuyuan Xia, Xin Guo, Dong Lu, Yixin Jiang, Xiaohui Liang, Yiwen Shen, Jiayi Lin, Lijun Zhang, Hongzhuan Chen, Jinmei Jin, Xin Luan, Weidong Zhang

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Mature tertiary lymphoid structure associated CD103+ CD8+ Trm cells determined improved anti-tumor immune in breast cancer by Qin Fang, Shuru Chen, Xiaoyue Chen, Wei Zou, Di Chen, Yukang Huang, Chucheng Wu

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Peroxiredoxin 6 maintains mitochondrial homeostasis and promotes tumor progression through ROS/JNK/p38 MAPK signaling pathway in multiple myeloma by Dandan Gao, Yang Lv, Fei Hong, Dong Wu, Ting Wang, Gongzhizi Gao, Zujie Lin, Ruoyu Yang, Jinsong Hu, Aili He, Pengyu Zhang

“…Furthermore, PRDX6 deficiency combined with bortezomib induced a robust anti-tumor effect in MM cell lines. Finally, in vivo experiments also showed that the deficiency of PRDX6 inhibited tumor growth of tumor-bearing mice. …”
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Enhancing in Vitro anti-metastatic efficacy and deep penetration into tumor spheroid of docetaxel-loaded liposomes via size optimization for prostate cancer treatment by Saksorn Klibaim, Nutthanit Thumrongsiri, Natsorn Watcharadulyarat, Walailuk Chonniyom, Prattana Tanyapanyachon, Paweena Dana, Nattika Saengkrit

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Ionizing radiation and photodynamic therapy lead to multimodal tumor cell death, synergistic cytotoxicity and immune cell invasion in human bladder cancer organoids by Annabell Reinhold, Annegret Glasow, Sandra Nürnberger, Annett Weimann, Lucie Telemann, Jens-Uwe Stolzenburg, Jochen Neuhaus, Mandy Berndt-Paetz

“…Conclusion: Treatment with IR+PDT showed tumor-selective cytotoxicity with additive or synergistic effects in BCa organoids. …”
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Time-Dependent Prognostic Impact of Circulating Tumor Cells Detection in Non-Metastatic Breast Cancer: 70-Month Analysis of the REMAGUS02 Study by François-Clément Bidard, Lisa Belin, Suzette Delaloge, Florence Lerebours, Charlotte Ngo, Fabien Reyal, Séverine Alran, Sylvie Giacchetti, Michel Marty, Ronald Lebofsky, Jean-Yves Pierga

“…In non-metastatic breast cancer patients, the REMAGUS02 neoadjuvant study was the first to report a significant impact of circulating tumor cells (CTCs) detection by the CellSearch system on the distant metastasis-free survival (DMFS) and overall survival (OS) endpoints. …”
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Rapid Visualization of Human Tumor Xenografts through Optical Imaging with a Near-Infrared Fluorescent Anti–Epidermal Growth Factor Receptor Nanobody by Sabrina Oliveira, Guus A.M.S. van Dongen, Marijke Stigter-van Walsum, Rob C. Roovers, Jord C. Stam, Willem Mali, Paul J. van Diest, Paul M.P. van Bergen en Henegouwen

“…Quantification of the IR-conjugated proteins in the tumors revealed ≈ 17% of injected dose per gram 2 hours after injection of 7D12-IR, which was significantly higher than the tumor uptake obtained 24 hours after injection of cetuximab-IR. …”
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Over-the-Scope Clip-Associated Endoscopic Muscular Dissection for Seven Cases of Small Gastric Submucosal Tumor: A Video-Based Case Series by Xin Li, Rongfen Wei, Jianfu Qin, Fei Qin, Peng Peng, Mengbin Qin, Shiquan Liu, Jiean Huang

“…OTSC-associated endoscopic muscular dissection was based on the requirement of OTSC apparatus and ESD technique; after ligaturing the bottom of small GSMT by OTSC, ESD was performed to resect the tumors, and the wounds of ESD were closed by clips finally. …”
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Preparation and Characterization of Visible-Light-Activated Fe-N Co-Doped TiO2 and Its Photocatalytic Inactivation Effect on Leukemia Tumors by Kangqiang Huang, Li Chen, Jianwen Xiong, Meixiang Liao

“…Then the photocatalytic inactivation of Fe-N-doped TiO2 on leukemia tumors was investigated by using Cell Counting Kit-8 (CCK-8) assay. …”
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A Case of Cardiac Calcified Amorphous Tumor Presenting with Concomitant ST-Elevation Myocardial Infarction and Occipital Stroke and a Brief Review of the Literature by Kyaw Kyaw, Htun Latt, Sammy San Myint Aung, Chanwit Roongsritong

“…Cardiac calcified amorphous tumor (CAT) is an extremely rare benign intracavitary tumor of the heart. …”
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The Relationship between the Antitumor Effect of the IL-12 Gene Therapy and the Expression of Th1 Cytokines in an HPV16-Positive Murine Tumor Model by Flor García Paz, Vicente Madrid Marina, Ausencio Morales Ortega, Abimelec Santander González, Oscar Peralta Zaragoza, Ana Burguete García, Kirvis Torres Poveda, José Moreno, Juan Alcocer González, Eva Hernandez Marquez, Victor Bermúdez Morales

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Pengaruh Kombinasi Metformin dan Ekstrak Kunyit terhadap Kadar High Density Lipoprotein, Interleukin-6 dan Tumor Necrosis Factor-a by Fathia Kesuma Dinanti, Sri Priyantini Mulyani, Chodidjah - -

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Uncovering the role of tumor cGAS expression in predicting response to PD-1/L1 inhibitors in non-small cell lung cancer by Yuichi Ozawa, Yasuhiro Koh, Ryota Shibaki, Yuhei Harutani, Hiroaki Akamatsu, Atsushi Hayata, Takeya Sugimoto, Yuka Kitamura, Junya Fukuoka, Masanori Nakanishi, Nobuyuki Yamamoto

“…Abstract Objectives The impact of cGAS/STING tumor expression on PD-1/L1 inhibitor efficacy and the tumor microenvironment remain to be elucidated. …”
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New Classification of Benign Epithelial Tumors: Colorectal Polyps and Synchronous Neoplasms: An Update and Critical Assessment: An Analysis of 678 Consecutive Cases and 1137 Polyps by Ali KOYUNCUER, Tulay ZENGINKINET

“…All epithelial polyps were re-classified according to the World Health Organization classification of digestive system tumors-2019, 5th edition. Results: The cases of 60.5% were male and 39.5% were female. …”
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Unresectable Hepatic Metastasis of Uveal Melanoma: Hepatic Chemosaturation with High-Dose Melphalan—Long-Term Overall Survival Negatively Correlates with Tumor Burden by R. Brüning, M. Tiede, M. Schneider, P. Wohlmuth, H. Weilert, K. Oldhafer, A. Stang

“…PHP-M for nonresectable LMUV provides a safe and locally efficient liver-directed procedure that offers patients a chance for long-term OS, especially for patients with a low hepatic tumor burden.…”
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