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The “Trojan Horse” Approach to Tumor Immunotherapy: Targeting the Tumor Microenvironment
Published 2014-01-01“…Most anticancer therapies including immunotherapies are given systemically; yet therapies given directly into tumors may be more effective, particularly those that overcome natural suppressive factors in the tumor microenvironment. The “Trojan Horse” approach of intratumoural delivery aims to promote immune-mediated destruction by inducing microenvironmental changes within the tumour at the same time as avoiding the systemic toxicity that is often associated with more “full frontal” treatments such as transfer of large numbers of laboratory-expanded tumor-specific cytotoxic T lymphocytes or large intravenous doses of cytokine. …”
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Human parietal epithelial cells as Trojan horses in albumin overload
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Endoscopic Vein Harvesting for Coronary Bypass Grafting: A Blessing or a Trojan Horse?
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Research on Clue Mining in Criminal Cases of Smart Phone Trojan Horse under the Background of Information Security
Published 2022-01-01“…At the same time, the basic principles and implementation methods of mobile phone Trojan horse hiding are also studied. Through the research of the broadcast receiver model of the Android platform, the background monitoring principle and implementation technology of the mobile phone Trojan horse are analyzed, and the theoretical foundation and technical support are provided for the implementation of the Trojan horse background monitoring program in this article. …”
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Trojan-horse silk fibroin nanocarriers loaded with a re-call antigen to redirect immunity against cancer
Published 2023-01-01“…Since tumor immune escape mechanisms do not impact pre-existing and consolidated immune responses, we tested the hypothesis of redirecting a pregenerated immunity to cancer: to recall a non-tumor antigen response against the tumor, silk fibroin nanoparticles (SFNs) have been selected as ‘Trojan-horse’ carriers, promoting the antigen uptake by the tumor cells.Methods SFNs have been loaded with either ovalbumin (OVA) or CpG oligonucleotide (CpG) as antigen or adjuvant, respectively. …”
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Persistence of Brucella abortus in the Bone Marrow of Infected Mice
Published 2018-01-01“…We propose that the BM is an essential niche for the bacterium to establish long-lasting infections and that infected PMNs may serve as vehicles for dispersion of Brucella organisms, following the Trojan horse hypothesis. Monocytes are solid candidates for Brucella reservoirs in the BM.…”
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Ethno-cultural particularity of English, French and Russian phrasiological units with components of names of domestic animals
Published 2018-12-01“…The conclusion is made that in these three languages universal meanings are set expressions with the components of «horse» (Trojan Horse, carthorse) and «cow» (milk cow), and that the comparative analysis of P.U. demonstrates difference in linguistic pictures of the world and sheds light on ethnic logic…”
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Synergistic effects of PS-NPs and Cd on ovarian toxicity in adolescent rats: Ferroptosis by induction of mitochondrial redox imbalance via the SIRT3-SOD2/Gpx4 pathway
Published 2025-01-01“…They can act as a“Trojan horse” to change the bioavailability and toxicity of heavy metals in the environment. …”
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Stochastic Stabilization of Malware Propagation in Wireless Sensor Network via Aperiodically Intermittent White Noise
Published 2020-01-01“…In this paper, we propose a novel heterogeneous model to describe the propagation dynamics of malware (viruses, worms, Trojan horses, etc.) in wireless sensor networks. Our model takes into consideration different battery-level sensor nodes contrary to existing models. …”
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Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics
Published 2013-01-01“…This review is focused on the current knowledge of receptor-mediated endocytosis/transcytosis and brain delivery using the Angiopep-2-conjugated system and the molecular Trojan horses. In addition, the role of neonatal Fc receptor (FcRn) in regulating the efflux of Immunoglobulin G (IgG) from brain to blood, and approaches to improve the pharmacokinetics of therapeutic biologics by generating Fc fusion proteins, and increasing the pH dependent binding affinity between Fc and FcRn, are discussed.…”
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Urinary bacteriophage cooperation with bacterial pathogens during human urinary tract infections supports lysogenic phage therapy
Published 2025-02-01“…These findings support the use of lysogenic phages as therapeutic Trojan Horses.…”
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