Levilactobacillus brevis CD2 as a multifaceted probiotic to preserve oral health: results of a double-blind, randomized, placebo-controlled trial in healthy adults by Serena Altamura, Francesca Lombardi, Francesca Rosaria Augello, Antonella Barone, Mario Giannoni, Benedetta Cinque, Davide Pietropaoli

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Clinical application of hempseed or flaxseed oil-based lyotropic liquid crystals: Evaluation of their impact on skin barrier function by Vitek Mercedes, Matjaž Mirjam Gosenca

“…Herein, eight novel lyotropic liquid crystals (LCCs) were investigated for the first time in a double-blind, interventional, before-after, single-group trial with healthy adult subjects and a twice-daily application regimen. …”
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Effect of Tai Chi combined with music therapy on the cognitive function in older adult individuals with mild cognitive impairment by Chunhui Zhou

“…This study investigates the effects of Tai Chi combined with music therapy on the cognitive function in older adult individuals with MCI.MethodsIn this randomized controlled trial, 66 older adult participants with MCI were randomly assigned to one of the following three groups: a Control Group (CG), a Tai Chi Group (TCG), and a Tai Chi Combined with Music Group (TCMG), with 22 participants in each group. …”
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Efficacy of the ECHOMANTRA online intervention to support recovery from anorexia nervosa in adult patients: study protocol of a randomized controlled multi-center trial by Yolanda Quiles, Álvaro Ruiz, Eva León-Zarceño, Javier Manchón, Marie-Carmen Neipp, Sofía Payá-López, Katina Kovacheva, Valentina Cardi

“…Methods In a multi − center pilot randomized controlled trial (RCT), 148 adult AN patients, and their carers, will be randomized to receive treatment as usual (TAU) or TAU plus ECHOMANTRA. …”
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Anaesthetic Efficacy of 4% Articaine in Comparison with 2% Lidocaine as Intraligamentary Injections after an Ineffective Inferior Alveolar Nerve Block in Mandibular Molars with Irr... by Nazanin Zargar, Elnaz Shooshtari, Leila Pourmusavi, Alireza Akbarzadeh Baghban, Hengameh Ashraf, Ardavan Parhizkar

“…The objective of the current study was to compare the anaesthetic efficacy of supplemental intraligamentary (IL) injection of 4% articaine with that of 2% lidocaine in the mandibular first and second molars with irreversible pulpitis after an ineffective inferior alveolar nerve block injection (IANB) using the same anaesthetic in a randomised triple-blind clinical trial. Seventy-six adult patients, who were diagnosed with irreversible pulpitis in the mandibular first or second molars, were divided into 2 groups and received IANB randomly. …”
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Achieving the Recommended Endotracheal Tube Cuff Pressure: A Randomized Control Study Comparing Loss of Resistance Syringe to Pilot Balloon Palpation by Fred Bulamba, Andrew Kintu, Nodreen Ayupo, Charles Kojjo, Lameck Ssemogerere, Agnes Wabule, Arthur Kwizera

“…This was a randomized clinical trial. We enrolled adult patients scheduled to undergo general anesthesia for elective surgery at Mulago Hospital, Uganda. …”
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Efficacy of Patellar Taping and Electromyographic Biofeedback Training at Various Knee Angles on Quadriceps Strength and Functional Performance in Young Adult Male Athletes with Pa... by Shahnaz Hasan, Asma Alonazi, Shahnawaz Anwer, Azfar Jamal, Suhel Parvez, Faiz Abdulaziz Saleh Alfaiz, Heng Li

“…., 30°, 60°, and 90° of knee flexion) on quadriceps strength and functional performance in people with PFPS were compared in this single-blind randomized controlled parallel trial. Methods. Sixty adult male athletes with PFPS (age: 26.9 ± 1.4 years) were randomly divided into two groups. …”
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ChatGPT-4 Performance on German Continuing Medical Education—Friend or Foe (Trick or Treat)? Protocol for a Randomized Controlled Trial by Christian Burisch, Abhav Bellary, Frank Breuckmann, Jan Ehlers, Serge C Thal, Timur Sellmann, Daniel Gödde

“…MethodsWe designed a randomized controlled trial, in which adult high school students attempt to solve CME tests across six medical specialties in three study arms in total with 18 CME training courses per study arm under different interventional conditions with varying amounts of permitted use of ChatGPT-4. …”
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Comparison of the effectiveness of the helmet interface using flow meters versus the mechanical ventilator for non-invasive ventilation in patients with coronavirus disease 2019. C... by Fernanda dos Reis Ferreira, João Carlos Ferrari Correa, Eduardo Storopoli, Diego Restivo Faria, Karina Cassaro, Natália Feitosa da Hora, Raphael Ritti, Rafael Akira Becker, Simone Dal Corso, Ivan Peres Costa, Luciana Maria Malosá Sampaio

“…Material and methods We conducted a single-center randomized clinical trial involving 100 adult SARS-CoV-2 patients in a specialized private hospital. …”
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Effects of a 12-Week Semi-Immersive Virtual Reality-Based Exercise Program on the Quality of Life of Older Adults Across Different Age Groups: A Randomized Controlled Trial by Li-Ting Wang, Yu-Wen Wang

“…This study was a randomized controlled trial involving older adults aged 65–85 years. Methods: Two age groups were each randomly assigned to experimental (EG) and control (CG) groups. …”
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The effect of physical activity on markers of oxidative and antioxidant stress in cancer patients: a systematic review and meta-analysis by Laerte Jônatas Leray Guedes, Victória Brioso Tavares, Saul Rassy Carneiro, Laura Maria Tomazi Neves

“…Methods We looked for randomized controlled trials that included adult with any type of cancer performing some physical activity and compared them to a control group of cancer patients with no physical activity. …”
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Patient experiences of an ankle fracture and the most important factors in their recovery: a qualitative interview study by Rebecca Samantha Kearney, Rebecca McKeown, David R Ellard, Zi Heng Liew

“…Participants recruited from the clinical trial sample were adults aged 18 years or over with a closed ankle fracture.Results Ten participants were interviewed, five of whom were female and six of whom needed an operation to fix their ankle fracture. …”
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Randomized controlled trials in central vascular access devices: A scoping review. by Mari Takashima, Gillian Ray-Barruel, Amanda Ullman, Samantha Keogh, Claire M Rickard

“…There were 119 trials (68%) involving adult participants only, with 18 (9%) pediatric and 20 (11%) neonatal trials. …”
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Experience of Acceptance and Commitment Therapy for those with mild traumatic brain injury (ACTion mTBI): A qualitative descriptive study. by Josh W Faulkner, Jason Chua, Amabelle Voice-Powell, Deborah L Snell, Maree Roche, John Moffat, Suzanne Barker-Collo, Alice Theadom

“…To establish the feasibility of this intervention, we wanted to understand participants' experiences of ACTion mTBI, determine acceptability and identify any refinements needed to inform a full-scale effectiveness trial. We recruited adults (≥16 years of age) diagnosed with mTBI who were engaged in community-based multidisciplinary rehabilitation. …”
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Heterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials by Myra Happe, Amelia R. Hofstetter, Jing Wang, Galina V. Yamshchikov, LaSonji A. Holman, Laura Novik, Larisa Strom, Francis Kiweewa, Salim Wakabi, Monica Millard, Colleen F. Kelley, Sarah Kabbani, Srilatha Edupuganti, Allison Beck, Florence Kaltovich, Tamar Murray, Susanna Tsukerman, Derick Carr, Carl Ashman, Daphne A. Stanley, Aurélie Ploquin, Robert T. Bailer, Richard Schwartz, Fatim Cham, Allan Tindikahwa, Zonghui Hu, Ingelise J. Gordon, Nadine Rouphael, Katherine V. Houser, Emily E. Coates, Barney S. Graham, Richard A. Koup, John R. Mascola, Nancy J. Sullivan, Merlin L. Robb, Julie A. Ake, Kirsten E. Lyke, Mark J. Mulligan, Julie E. Ledgerwood, Hannah Kibuuka, the VRC 208 and RV 422 study team

“…We investigated the safety and immunogenicity of a heterologous prime-boost regimen involving a chimpanzee adenovirus 3 vectored Ebola vaccine [either monovalent (cAd3-EBOZ) or bivalent (cAd3-EBO)] prime followed by a recombinant modified vaccinia virus Ankara EBOV vaccine (MVA-EbolaZ) boost in two phase 1/1b randomized open-label clinical trials in healthy adults in the United States (US) and Uganda (UG). …”
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Saffron therapy for the ongoing treatment of age-related macular degeneration by Peter J McCluskey, Thomas Hong, Andrew A Chang, John Grigg, Geoffrey K Broadhead, Timothy E Schlub, Eugenia Chu

“…Objective To assess the long-term efficacy and safety of oral saffron, a natural antioxidant, in treating mild/moderate age-related macular degeneration (AMD).Methods and analysis Open-label, extension trial of 93 adults (>50 years) with mild/moderate AMD and vision >20/70 Snellen equivalent in at least 1 eye. …”
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Effectiveness and Safety of Using Standardized Treatment Protocols for Hypertension Compared to Usual Care: A Meta‐Analysis of Randomized Clinical Trials by Gautam Satheesh, Rupasvi Dhurjati, Vivekanand Jha, Aletta E. Schutte, Bolanle Banigbe, Dorairaj Prabhakaran, Andrew E. Moran, Abdul Salam

“…We conducted a systematic review of randomized clinical trials (RCTs) among adults with hypertension, comparing hypertension STPs (intervention) with usual care (comparator) for effects on BP. …”
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A phase III, randomized, controlled noninferiority trial to study the efficacy and safety of imipenem/cilastatin/relebactam (IMI/REL) vs piperacillin/tazobactam (PIP/TAZ) in patien... by Junjie Li, Feng Wei, Peng Xiang, Zhengang Tang, Lianshu Ding, Luke Francis Chen, Maria Losada, Zlatka Iamboliyska, Fang Sun, Mingfen Zhu, Xiaodan Guo, Xiaoling Du, Chang Chen, Christopher Bruno, Sandra Koseoglu, Katherine Young, Min Zhou, Jieming Qu

“…Methods: In this phase III, double-blind, multinational, randomized trial (NCT03583333), adults with HABP/VABP were randomized 1:1 to receive intravenous IMI/REL (500 mg/250 mg) or piperacillin/tazobactam (PIP/TAZ; 4000 mg/500 mg) every 6 h for 7-14 days. …”
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Incidence of hyperkalemia RAASi and SGLT-2i treatment in individuals with diabetic kidney disease: a systematic review and network meta-analysis by Yahui Yuan, Yahui Yuan, Yahui Yuan, Chun Chen, Yuping Lin, Yehao Luo, Yehao Luo, Yehao Luo, Zhaojun Yang, Zhaojun Yang, Zhaojun Yang, Jingyi Guo, Jingyi Guo, Jingyi Guo, Qiaoyun Liu, Qiaoyun Liu, Qiaoyun Liu, Lu Sun, Guanjie Fan, Guanjie Fan, Guanjie Fan

“…Relevant randomized controlled trials (RCT) included adults with DKD who were treated with SGLT-2i and RAASi or their combination, with a minimum follow-up duration of 12 weeks. …”
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Safety and tolerability of intramuscular sotrovimab administered at different injection sites: results from the Phase 1 COSMIC study by Jennifer Moore, Alicia Aylott, Wen-Hung Chen, Jerzy Daniluk, Ian A. Hawes, Sergio Parra, Prosenjit Sarkar, Yasmin Sanchez-Pearson, Megan Turner, Amanda Peppercorn, Andrew Skingsley

“…This Phase 1, open-label trial randomized healthy adults to receive 62.5 mg/mL sotrovimab IM into each dorsogluteal muscle (2 × 4 mL injections), or 100 mg/mL sotrovimab IM into the dorsogluteal muscle (1 × 5 mL), the anterolateral thigh muscle (1 × 5 mL) or each deltoid muscle (2 × 2.5 mL). …”
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