The Effect of Oral Gabapentin and Pregabalin as a Prodrug in Pain Control after Orthopedic Surgery on the Upper Limb: A Double-Blind Parallel Randomized Clinical Trial Study by Lida Nouri, Rana Roshanfekr, Azam Biderafsh, Reza Pakzad, Hamed Azadi

“…In this double-blind randomized clinical trial study, 80 patients who were the candidates for elective orthopedic surgery on one of the parts of the upper limb were divided into two groups using balance-block randomization. …”
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First-in-human dose escalation trial to evaluate the clinical safety and efficacy of an anti-MAGEA1 autologous TCR-transgenic T cell therapy in relapsed and refractory solid tumors by Ignacio I Wistuba, Mamta Kalra, Linus Backert, Martin Wermke, Edwin R Parra, Jason John Luke, Apostolia M Tsimberidou, Sebastian Bunk, Mohammad B Hossain, Andrea Mayer-Mokler, Arun Satelli, Norbert Hilf, Steffen Walter, Cedrik M Britten, Van K Morris, Tobias A W Holderried, Winfried H Alsdorf, Katrin Wetzko, Borje S Andersson, Sandra Grund-Gröschke, Katrin Aslan, Anantha Marisetty, Swapna Satam, Jens Hukelmann, M Alper Kursunel, Karine Pozo, Andreas Acs, Melissa Baumeister, Claudia Wagner, Oliver Schoor, Ali S Mohamed, Delfi Krishna

“…We investigated the safety and tolerability of IMA202 in a first-in-human, dose escalation basket trial in human leucocyte antigen A*02:01 positive patients with melanoma-associated antigen A1 (MAGEA1)-positive advanced solid tumors.Trial design The 2+2 trial design was an algorithmic design based on a maximally acceptable dose-limiting toxicity (DLT) rate of 25% and the sample size was driven by the algorithmic design with a maximum of 16 patients. …”
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Clinical Efficacy of Curcumin and Vitamin E on Inflammatory-Oxidative Stress Biomarkers and Primary Symptoms of Menopause in Healthy Postmenopausal Women: A Triple-Blind Randomized Controlled Trial by Azizeh Farshbaf-Khalili, Alireza Ostadrahimi, Mojgan Mirghafourvand, Khatereh Ataei-Almanghadim, Sara Dousti, Amir Mehdi Iranshahi

“…The alleviation of anxiety in the vitamin E group was more than in the placebo group. Clinical Trial Registration. The trial was registered at the Iranian Registry of Clinical Trials (https://irct.ir/IRCT20131009014957N6).…”
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Study Protocol for the Hand OsteoArthritis Self-Management and Integrated Scheme (OASIS-H) to Improve Outcomes in Patients with Hand Osteoarthritis—an Open-Label Randomized Controlled Trial by Iris Yan Ki Tang, Lai Man Tang, Brian Ho, Joyce Wong, Amanda Lau, Suet Kei Kwok, Carmen Tze Kwan Ho

“…In this open-label, randomized controlled trial, symptomatic OA hand patients are included and randomized into early intervention and routine clinical care groups. …”
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Effectiveness of using implementation frameworks to facilitate the implementation of a stroke management guideline in the traditional Chinese medicine hospitals in China: protocol for a factorial randomised controlled trial by Zhuo Chen, Yefeng Cai, Wenjun He, Yiyuan Cai, Lingrui Liu, Qing Zhao, Sensen lv, Dong (Roman) Xu, Chun Hao, Lanping Zhang, Pengfei Guo, Yuning Shi

“…The results will be published in peer-reviewed academic journals and presented at national and international conferences to inform future practice and policy on the integration of TCM and Western medicine for stroke management.Trial registration details This study has been registered on the Open Science Framework with the DOI: 10.17605/OSF.IO/NJEVB.…”
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Exercise medicine as adjunct therapy during RADIation for CAncer of the prostaTE to improve treatment efficacy – protocol for the ERADICATE study: a phase II randomised controlled trial by Oliver Schumacher, Robert U. Newton, Colin Tang, Raphael Chee, Sjoerd B. Vos, Ronny S. Low, David Joseph, Dennis R. Taaffe, Daniel A. Galvão

“…Improving treatment efficacy of EBRT with exercise may result in better patient outcomes clinically, while also addressing adverse effects of treatment and quality of life in prostate cancer patients. Trial registration The study was registered on the Australian New Zealand Clinical Trials Registry (ACTRN12624000786594) on 26/06/2024.…”
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Total Intravenous Anaesthesia with High-Dose Remifentanil Does Not Aggravate Postoperative Nausea and Vomiting and Pain, Compared with Low-Dose Remifentanil: A Double-Blind and Randomized Trial by Seong-Hyop Kim, Chung-Sik Oh, Tae-Gyoon Yoon, Min Jeng Cho, Jung-Hyun Yang, Hye Ran Yi

“…Furthermore, high-dose remifentanil showed more haemodynamic stability after endotracheal intubation. This trial is registered with KCT0000185.…”
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Metabolic and functional factors associated with a change in resting metabolic rate among older adults with type 2 diabetes– results from the CEV-65 randomized trial by Assaf Buch, Roy Eldor, Ofer Kis, Arie Ben-Yehuda, Gizell Green, Yona Greenman, Sharon Barak

“…Methods: 67 participants from CEV-65 trial (≥65 years, 61 % female) were randomly assigned to CRT, VegMedD, or empagliflozin for 10 weeks. …”
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Efficacy of Weekly Split versus Single Doses of Ergocalciferol on Serum 25-Hydroxyvitamin D among Patients on Continuous Ambulatory Peritoneal Dialysis: A Randomized Controlled Trial by Naowanit Nata, Jessada Kanchanasinitth, Pamila Tasanavipas, Ouppatham Supasyndh, Bancha Satirapoj

“…Weekly single and split doses of ergocalciferol 60,000 IU achieved similar effects on serum 25(OH)D levels among patients on CAPD with vitamin D insufficiency or deficiency, suggesting that weekly single dose would be prescribed for adequate vitamin D repletion. This trial is registered with TCTR20200821005.…”
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RETRACTED: The role of biofield energy treatment on psychological symptoms, mental health disorders, and stress‐related quality of life in adult subjects: A randomized controlled clinical trial by Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Sambhu Mondal, Snehasis Jana

“…Methods Seventy‐seven participants (39 male and 38 female) underwent clinical trial. This trial was simple randomized, placebo‐controlled, parallel‐group, open‐label, and single‐center with subjects, who have one or more psychological symptoms. …”
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Influence of a New “Call-Out Algorithm” for Management of Postoperative Pain and Its Side Effects on Length of Stay in Hospital: A Two-Centre Prospective Randomized Trial by Lisa Dybvik, Erlend Skraastad, Aigerim Yeltayeva, Aidos Konkayev, Tatiana Musaeva, Igor Zabolotskikh, Lars Bjertnaes, Vegard Dahl, Johan Raeder, Vladimir Kuklin

“…Postoperative ESS recording in combination with the possibility to call upon an anaesthesiologist when exceeding the threshold score might have contributed to the reductions of LOS in this two-centre study. This trial is registered with NCT02143128.…”
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A systematic review of Randomized Controlled Trials about some non-pharmacological interventions for treatment of hypertension: Physical exercise, sodium restriction, weight and alcohol use reduction by Amobi Akonobi, Jawad Khan

“…Original papers and randomized clinical trials, published in English between 1988 and 2010 and regarding hypertensive individuals as participants were included. …”
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Can electronic monitoring with a digital smart spacer support personalised medication adherence and inhaler technique education in patients with asthma?: Protocol of the randomised controlled OUTERSPACE trial by Job F. M. van Boven, Boudewijn H.J. Dierick, Maria Achterbosch, Sandra Been-Buck, Titia Klemmeier, Susanne J. van de Hei, Paul Hagedoorn, Huib A.M. Kerstjens, Janwillem W.H. Kocks

“…The aim of this study is to assess the feasibility of undertaking a definitive randomised controlled trial of personalised, smart spacer data-driven education and explore clinical benefits.Methods and analysis We present the design of the multicentre, randomised controlled OUtcomes following Tailored Education and Retraining: Studying Performance and AdherenCE feasibility trial of 2 months. …”
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The effect of two different tidal volume on ventilation distribution in living donor laparoscopic nephrectomy using electrical impedance tomography: A single-blind randomized clinical trial by Dita Aditianingsih, Ratna Farida Soenarto, Cynthia Afriany

“…Materials and Methods: A single-blind, randomized clinical trial was conducted on 30 patients who were assigned to the group receiving an intraoperative TV of 6 mL/kg (VT-6) or 10 mL/kg (VT-10) during laparoscopic nephrectomy surgery. …”
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Efficacy of non-invasive ventilation and oxygen therapy on immunocompromised patients with acute hypoxaemic respiratory failure: protocol for a systematic review and meta-analysis of randomised controlled trials by Juhong Shi, Gang Liu, Meng Wang, Tao Wang, Yi Li, Yi Yang, Xuezhong Yu, Huadong Zhu, Yong Ma, Zongru Li, Lixi Zhang, Kun He, Jianqiang He

“…The use of non-invasive ventilation (NIV) or oxygen therapy among these patients remains controversial, according to the inconsistent results of several randomised clinical trials (RCTs). This meta-analysis aims to evaluate whether NIV or oxygen therapy is the more appropriate initial oxygenation strategy for the immunocompromised patients with acute respiratory failure.Method We will search all the RCTs that compared the efficacy of NIV and oxygen therapy on immunocompromised adult patients with acute hypoxaemic respiratory failure on the major databases (Cochrane Library, MEDLINE, EMBASE, Web of Science and others), conference proceedings and grey literature. …”
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Mamá Empoderada: study protocol for a pilot trial of a novel parenting and mental health prevention intervention for migrant mothers with young children at the Mexico-US border by Gudelia Rangel, Shira M Goldenberg, Eileen Pitpitan, Kaylee Ramage, Ietza Bojorquez-Chapela, Cecilia Martinez-Torteya, Katherine Rosenblum, Chelsie Hernandez, Monica Alvarez

“…We have recently adapted this intervention for MMC in Mexico and will conduct a pilot randomised controlled trial (RCT) of the intervention with MMC (n=100; Ntreatment=50; Ncontrol=50). …”
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Author Correction: Effectiveness of physical activity interventions on reducing perceived fatigue among adults with chronic conditions: a systematic review and meta-analysis of randomised controlled trials by Ioulia Barakou, Kandianos Emmanouil Sakalidis, Ulric Sena Abonie, Tracy Finch, Katie L. Hackett, Florentina Johanna Hettinga

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Comparative Evaluation of Functional Outcomes in High Condylar Fractures Treated with Closed Methods with and without Temporomandibular Joint Arthrocentesis: A Research Protocol for a Randomised Controlled Trial by Sachindra Dubey, Nitin Bhola, Anchal Agarwal

“…Materials and Methods: A randomised controlled trial will be conducted at Siddharth Gupta Memorial Cancer Hospital, Sawangi, Wardha, Maharashtra, India, from September 2024 to May 2026, involving 10 patients. …”
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Engagement With an Internet-Administered, Guided, Low-Intensity Cognitive Behavioral Therapy Intervention for Parents of Children Treated for Cancer: Analysis of Log-Data From the ENGAGE Feasibility Trial by Christina Reuther, Louise von Essen, Mudassir Imran Mustafa, Markus Saarijärvi, Joanne Woodford

“…Subsequently, we conducted the ENGAGE feasibility trial and EJDeR was found to be acceptable and feasible. …”
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Effect of Low Dose Aspirin in Low Risk Pregnant Ladies with Abnormal Uterine Artery Doppler Results, and the Evaluation of Maternal and Fetal outcomes: A Randomized Clinical Trial by Parzhin Jalal Ali, Chro Najmaddin Fattah

“…Patients and Methods: A randomized clinical trial was performed on 50 pregnant ladies (?16 weeks of gestation) in Sulaymaniyah Maternity Teaching Hospital during January 2017 to January 2018. …”
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