Evaluating the efficacy of multi-incision and tube-dragging therapy combined with laser closure for high horseshoe-shaped anal fistula: Protocol of a prospective, randomized, controlled trial. by Min Yang, Zubing Mei, Qingming Wang, Ye Han, De Zheng

“…<h4>Methods and analysis</h4>This trial is a prospective, randomized, controlled and interventional study. …”
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Comparative Evaluation of the Safety and Efficacy of Long-Term Use of Imidafenacin and Solifenacin in Patients with Overactive Bladder: A Prospective, Open, Randomized, Parallel-Group Trial (the LIST Study) by Masayoshi Zaitsu, Koji Mikami, Noriko Ishida, Takumi Takeuchi

“…Overactive bladder (OAB) is a chronic disease, but comparative trials of anticholinergics, which are commonly used for treatment of OAB, have generally been performed for up to 12 weeks only. …”
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Comparative analysis of LMA Blockbuster® clinical performance: Blind versus Miller laryngoscope-guided insertion in paediatric general anaesthesia – A double-blinded, randomised controlled trial by Pooja Bihani, Shivanand, Rishabh Jaju, Naveen Paliwal, Sarita Janweja, Ankit Vyas

“…Methods: This randomised controlled trial study enroled 100 patients aged 1–4 years undergoing elective surgery. …”
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PROcalcitonin and NEWS2 evaluation for Timely identification of sepsis and Optimal use of antibiotics in the emergency department (PRONTO): protocol for a multicentre, open-label, randomised controlled trial by David Taylor-Robinson, Steve Goodacre, Neil French, Richard Body, Kerenza Hood, Emma Thomas-Jones, Jane Daniels, Sarah Walker, Ingeborg Welters, Mike Bradburn, Paul Schmidt, Enitan Carrol, Lucy Brookes-Howell, Sarah Milosevic, Andrew Tabner, Philip Pallmann, Stephen Aston, Gavin Barlow, Emma Richards, Emmanuel Nsutebu, Philip Howard, Matthew Inada-Kim, Stacy Todd, Fiona McGill, Martin Llewelyn, Louis Wihelmus Niessen, Joanne Euden, Julie Carman, Stephanie Gilbert, Sam Clarkstone, Jacqui Hughes, Lena Meister, Angela Brain, Matthew Scarborough, Sian O'Shea, Claire James

“…Findings will be disseminated through peer-reviewed journals and presented at scientific conferences.Trial registration number ISRCTN54006056.…”
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Feasibility of Cognitive Training in Combination With Transcranial Direct Current Stimulation in a Home-Based Context (TrainStim-Home): study protocol for a randomised controlled trial by Ulrike Grittner, Agnes Flöel, Rafal Nowak, Friederike Thams, Daria Antonenko, Merle Rocke, Robert Malinowski

“…Results will be available through publications in peer-reviewed journals and presentations at national and international conferences.Trial registration number NCT04817124.…”
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Effects of body weight-supported Tai Chi Yunshou training on upper limb motor function in stroke patients: A three-arm parallel randomized controlled trial. by Liying Zhang, Xiaoming Yu, Wangsheng Liao, Jiening Wang, Yan Lu, Naizhen Wang, Zhou Huanxia

“…<h4>Conclusions</h4>The 12-week BWS-TCY intervention has been shown to effectively improve upper limb motor function.<h4>Trial registration</h4>Retrospectively registered at chictr.org.cn on August 31, 2022 [ChiCTR2200063150] https://www.chictr.org.cn/showproj.html?…”
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Comparison of the two treatment methods in primary hyperparathyroidism due to solitary parathyroid adenoma, Ultrasound-guided percutaneous alcohol ablation vs. parathyroidectomy: a randomized controlled trial by Mohammad Eslamian, Babak Tavakoli, Alireza Firouzfar, Alireza Pouramini, Bijan Iraj, Mohsen Kolahdouzan, Marjan Mansourian

“…Method A single-centered randomized, not-blinded parallel clinical trial in consecutive patients with pHPT treated with percutaneous alcohol ablation (PEA) between January 2020 and November 2021. …”
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Neuromuscular and structural tendon adaptations after 6 weeks of either concentric or eccentric exercise in individuals with non-insertional Achilles tendinopathy: protocol for a randomised controlled trial by Deborah Falla, Eduardo Martinez-Valdes, Ignacio Contreras-Hernandez

“…The results of the study will be published in peer-review journals.Trial registration number ISRCTN46462385.…”
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Injection of Lidocaine Alone versus Lidocaine plus Dexmedetomidine in Impacted Third Molar Extraction Surgery, a Double-Blind Randomized Control Trial for Postoperative Pain Evaluation by Javad Alizargar, Milad Etemadi Sh, Nasser Kaviani, Shu-Fang Vivienne Wu, Keyvan Jafarzadeh, Parisa Ranjbarian, Nan-Chen Hsieh

“…This double-blind randomized control trial study evaluated postoperative pain and associated factors following impacted third molar extraction surgery. …”
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Effect of cryotherapy, laser therapy and intraligamentary dexamethasone injection on post-treatment pain after single visit RCT–A double-blinded, randomized placebo-controlled trial by Dr Sana Fatima, Dr Sonali Taneja, Dr Vivek Aggarwal, Dr Akriti Dheer, Dr Punya Taneja

“…Aim: This study designed to evaluate the effect of adjuvant therapies on the intensity of post-treatment pain after single-visit RCT in molars with symptomatic apical periodontitis. Method: ology: This trial was reported according PRIRATE 2020 guidelines and registered with CTRI/2019/03/018,153.100 patients diagnosed with symptomatic apical periodontitis with a preoperative pain allocated to 4 groups,Group-1: placebo,Group-2:Intraligamentary injection of dexamethasone, Group-3:cryotherapy, Group-4: laser therapy. …”
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The anti-PD-L1/CTLA-4 bispecific antibody KN046 plus lenvatinib in advanced unresectable or metastatic hepatocellular carcinoma: a phase II trial by Da Xu, Hongwei Wang, Quan Bao, Kemin Jin, Ming Liu, Wei Liu, Xiaoluan Yan, Lijun Wang, Yanqiao Zhang, Guangyu Wang, Yue Ma, Zhigang Ma, Chunhui Zhang, Jiebing Tang, Sha Wang, Jiaohui Pang, Ting Xu, Kun Wang, Baocai Xing

“…Abstract This open-label phase II trial (NCT04542837) aimed to evaluate the efficacy and safety of KN046 combined with lenvatinib in patients with advanced hepatocellular carcinoma (HCC), and explore the potential response biomarkers. …”
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Treatment Options for Advanced Non-Small Cell Lung Cancer After Failure of Previous Immune Checkpoint Inhibitors and Chemotherapy: Meta-Analysis of Five Randomized Controlled Trials by Andrea Messori, Andrea Ossato, Lorenzo Gasperoni, Luna Del Bono, Alessandro Inno, Vera Damuzzo

“…Only randomized controlled trials (RCTs) were included (endpoint, overall survival [OS]). …”
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Association of ERCC2/XPD polymorphisms and the risk of head and neck carcinoma: a systematic review, meta-analysis, trial sequential analysis, network analysis, and functional effects by Mohammad Moslem Imani, Ali Ashabi, Farzad Rezaei, Atefe Saffar Shahroudi, Sadegh Kashkouli, Edris Sadeghi, Masoud Sadeghi

“…The findings reported that the ethnicity and the cancer subtype for rs13181, the ethnicity, the sample size, and the control source for rs1799793, and the ethnicity and the control source for rs238406 polymorphisms were effective factors in the pooled results. Trial sequential analysis suggested that the studies included an insufficient number of individuals. …”
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Impact of Weight Loss on Physical Function with Changes in Strength, Muscle Mass, and Muscle Fat Infiltration in Overweight to Moderately Obese Older Adults: A Randomized Clinical Trial by Adam J. Santanasto, Nancy W. Glynn, Mark A. Newman, Christopher A. Taylor, Maria Mori Brooks, Bret H. Goodpaster, Anne B. Newman

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Strength training for osteoporosis prevention during early menopause (STOP-EM): a pilot study protocol for a single centre randomised waitlisted control trial in Canada by Leigh Gabel, Lauren A Burt, Christina J Alexander, Leah Kaluta, Patrick W Whitman, Emma O Billington

“…Feasibility outcomes will be used to inform a larger, future trial aimed at identifying the efficacy of the exercise intervention for improving various health outcomes, including bone density and muscle mass. …”
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Evaluating Meaningful Changes in Patient‐Reported Outcome Measurement Information System–Fatigue Scores from Three Phase 3 Clinical Trials of Sarilumab for Patients With Rheumatoid Arthritis by Clifton O. Bingham, Emily Molina, Amy Praestgaard, Stefano Fiore, David Cella

“…Methods Data from three phase 3 randomized controlled trials of patients with RA who received sarilumab—MOBILITY, TARGET, and MONARCH—were evaluated. …”
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Tadalafil treatment for fetuses with early-onset growth restriction: a protocol for a multicentre, randomised, placebo-controlled, double-blind phase II trial (TADAFER IIb) by Hiroaki Tanaka, Yasuhiro Tanaka, Yoichi Aoki, Masayuki Endo, Tomoaki Ikeda, Shintaro Maki, Masafumi Nii, Kayo Tanaka, Satoshi Tamaru, Toru Ogura, Yuki Nishimura, Tomomi Kotani, Akihiko Sekizawa, Masahiko Nakata, Koji Nakamura, Kenji Nagao, Ichiro Yasuhi, Hiroshi Kawamura, Sho Takakura, Mayumi Kotera, Takafumi Ushida, Norihiko Kikuchi, Tadatsugu Kinjo, Mayumi Takano, Sachie Suga, Michi Kasai, Osamu Yasui, Yuka Maegawa, Shigeru Aoki, Yoshio Yoshida

“…Our findings will be widely disseminated through peer-reviewed publications.Trial registration jRCTs041190065.…”
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Factors influencing role preferences in decision-making of healthy women with BRCA1/2 pathogenic variants: subanalysis from a randomised controlled decision coaching trial by Sibylle Kautz-Freimuth, Arim Shukri, Claudia Stracke, Anna Isselhard, Birte Berger-Höger, Anke Steckelberg, Frank Vitinius, Nicola Dikow, Marion Kiechle, Cornelia Meisel, Achim Wöckel, Marion Tina von Mackelenbergh, Rita Schmutzler, Kerstin Rhiem, Stephanie Stock

“…With this profile, the DC programme expands the existing counselling and care concept to include a measure that can also specifically cover the support needs of younger women and those with a lower education level. Trial registration DRKS-ID: DRKS00015527. Registered 30/10/2019.…”
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Effects of the Proactive Interdisciplinary Self-Management (PRISMA) Program on Online Care Platform Usage in Patients with Type 2 Diabetes in Primary Care: A Randomized Controlled Trial by Esther du Pon, Nanne Kleefstra, Frits Cleveringa, Ad van Dooren, Eibert R. Heerdink, Sandra van Dulmen

“…In a randomized controlled trial, patients with T2DM received either PRISMA with usual care or usual care only. …”
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Evaluate Short-Term Outcomes of abciximab in ST-Segment Elevation Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis of Randomized Clinical Trials by Nan Bai, Ying Niu, Ying Ma, Yao-Sheng Shang, Peng-Yu Zhong, Zhi-Lu Wang

“…Ten randomized controlled trials with 5008 patients met inclusion criteria. …”
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