Catheter ablation versus antiarrhythmic drugs with risk factor modification for treatment of atrial fibrillation: a protocol of a randomised controlled trial (PRAGUE-25 trial) by Stepan Havranek, Jiri Jarkovsky, Otakar Jiravský, Pavel Osmancik, Veronika Bulková, Jan Chovančík, Tomáš Roubíček, Dalibor Heřman, Zuzana Čarná, Vladimír Tuka, Martin Matoulek, Martin Fiala, Sylvie Stregl-Hruskova, Adam Latiňák, Jiřina Kotryová

“…So far, no study has compared the modern non-invasive (AADs combined with risk factor modification (RFM)) approach with modern invasive (CA) treatment. The aim of the trial is to compare the efficacy of modern invasive (CA) and non-invasive (AADs with risk factor management) treatment of AF.Methods and analysis The trial will be a prospective, multicentre, randomised non-inferiority trial. …”
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Prevention of Criminal Offenses as One of the Tasks of Criminal Proceedings by A. V. Ros, R. M. Balats

Subjects: “…preventive activities of pre-trial investigation agencies…”
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Efficacy and safety of PD-1/PD-L1 inhibitors in advanced or recurrent endometrial cancer: a meta-analysis with trial sequential analysis of randomized controlled trials by Ji Ren, Jinghe Wang, Yanan Wang, Dongying Yang, Jianming Sheng, Shili Zhu, Yunli Liu, Xiaoqi Li, Wei Liu, Binbin Zhang

“…This study sought to assess the efficacy and safety of this therapeutic combination in patients with advanced or recurrent EC.MethodsWe performed an exhaustive review of randomized controlled trials (RCTs) up to September 25, 2024, examining the efficacy and safety of combining PD-1/PD-L1 inhibitors with CT versus CT alone (or plus placebo) in advanced or recurrent EC. …”
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Response to Comment by Dr. Kuang on Our Manuscript “Immediate Oral Refeeding in Patients With Mild and Moderate Acute Pancreatitis: A Multicenter, Randomized Controlled Trial (PADI trial)” by Elena Ramírez-Maldonado, MD, PhD, Sandra López Gordo, MD, PhD, Robert Memba, MD, PhD, Rosa Jorba, MD, PhD, on behalf of the Catalan Pancreatitis Collaborative Group, Laia Blanco, Sandra M. Bacca, Joaquim Balsells, Carme Boqué, Pablo Collera Ormazabal, Daniel Coronado Llanos, Ignasi Elizalde, Laia Estalella, Maria Teresa Fernández Planas, Lidia Florit Serra, Inmaculada Fonoll, Nil Gómez Vallvé, Sergio González, Maria Alejandra Guerrero Ortíz, Jiazhen Li, Erik Llàcer-Millán, Rui Pedro Major Branco, David Nicolas, Elizabeth Pando, Mihai-Calin Pavel, Jing Quiao, Marta Rodrigo-Rodrigo, Ariadna Sánchez, Teresa Soriano, Guillem Soy, Eva Vaquero, Pengyu Wu, Heng Xi, Wen Zhong

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Impact of a pharmaceutical care service for patients with rheumatoid arthritis using a customised mobile device (the PROUD trial): study protocol for a randomised controlled trial by Jung-Yoon Choe, Hwajeong Lee, Yun-Kyoung Song, Seong-Kyu Kim, Ji-Won Kim, Ji-Eun Park, Ju-Eun Lee, Bo-Kyung Moon, Sung-Hoon Park

“…The study findings will be published in peer-reviewed journals.Trial registration number KCT0006508.…”
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The effect of an additional pre-extubational loading dose of caffeine citrate on mechanically ventilated preterm infants (NEOKOFF trial): Study protocol for a multicenter randomized clinical trial. by Kinga Kovács, Rita Nagy, Lilla Andréka, Brigitta Teutsch, Miklós Szabó, Péter Varga, Péter Hegyi, Péter Hársfalvi, Nándor Ács, Ágnes Harmath, Csaba Nádor, Ákos Gasparics

“…Since the Caffeine Therapy for Apnea of Prematurity (CAP) trial, caffeine has become one of the essential drugs at NICUs. …”
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Impact of the Clinical Trials Act 2018 on clinical trial activity in Japan from 2018 to 2020: a retrospective database study using new and conventional Japanese registries by Hiroyuki Taruno, Mari S Oba, Osamu Takizawa, Kayoko Kikuchi, Kazuaki Matsui, Mayumi Shikano

“…Objective To clarify the impact of Japan’s Clinical Trials Act (CTA), which was enacted in April 2018, on subsequent clinical trial activity through an analysis of Japanese registry data.Design Retrospective database study.Setting We extracted information on clinical intervention studies registered between 1 April 2018 and 30 September 2020 in the conventional University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) and the new Japan Registry of Clinical Trials (jRCT). …”
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A Randomized Trial Comparing Short versus Prolonged Hemostasis with Rescue Recanalization by Ipsilateral Ulnar Artery Compression: Impact on Radial Artery Occlusion—The RESCUE-RAO Trial by Dmitrii V. Ognerubov, Alexander Sedaghat, Sergey I. Provatorov, Andrey S. Tereshchenko, Olivier F. Bertrand, Ivo Bernat, Goar K. Arutyunyan, Olga A. Pogorelova, Maria I. Tripoten, Tatyana V Balakhonova., Anatoliy N. Samko, Evgeny V. Merkulov

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Prevention of Postoperative Events following Reversal with Sugammadex or Neostigmine (the P-PERSoN Trial): Pilot Data Following Early Termination of a Prospective, Blinded, Randomised Trial by Benjamin Olesnicky, Matthew Doane, Clare Farrell, Greg Knoblanche, Anthony Delaney

“…Conclusions. The P-PERSoN trial showed no difference in postoperative pulmonary complications between sugammadex and neostigmine based reversal of aminosteroid neuromuscular block, but was underpowered to show any difference due to early trial termination. …”
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Proposal and Strategy for Nursing-Led Research: Protocol for an Unfunded Clinical Trial by Leticia Carmen Simón-López, Ismael Ortuño-Soriano, Raquel Luengo-González, Paloma Posada-Moreno, Ignacio Zaragoza-García, Rubén Sánchez-Gómez

“… BackgroundClinical trials are known to provide cause-and-effect results and data with low levels of bias. …”
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Budesonide in treatment of alcohol-induced severe hepatitis: results of randomized trial by I. I. Komkova, M. V. Mayevskaya, V. T. Ivashkin

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The Canadian Optimal Therapy of COPD Trial: Design, Organization and Patient Recruitment by Shawn D Aaron, Katherine Vandemheen, Dean Fergusson, Mark FitzGerald, Francois Maltais, Jean Bourbeau, Roger Goldstein, Andrew McIvor, Meyer Balter, Denis O'Donnell

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Metformin increases mammographic breast density: a randomized controlled trial by Sadaf Alipour, Ladan Hosseini, Zohreh Forootan, Hadith Rastad, Leila Bayani, Mahboubeh Abedi, Bita Eslami

“…Conclusions This clinical trial showed that consumption of metformin 500 mg twice daily for 6 months is associated with a higher mammographic breast density as compared to the placebo group. …”
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Chapter 6. Statewide Red-Skinned Potato Variety Trials, 2006 by Chad M. Hutchinson, Doug Gergela

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Chapter 7. Statewide White-Skinned Potato Variety Trials, 2006 by Chad M. Hutchinson, Doug Gergela

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Effect of Pentoxifylline on Microalbuminuria in Diabetic Patients: A Randomized Controlled Trial by Shahrzad Shahidi, Marziyeh Hoseinbalam, Bijan Iraj, Mojtaba Akbari

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University of Florida Potato Variety Trial Program— ‘Elkton’ Commercial Evaluation by Lincoln Zotarelli, Douglas Gergela, Dana Fourman

“…The average yield of ‘Elkton’ in the commercial trials ranged between 295 and 324 cwt/ac, an average of 11 percent higher than that of the standard ‘Atlantic,’ and comparable to the yield range obtained in 19 trials conducted over a nine-year period by the University of Florida. …”
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Insight into the Advances in Clinical Trials of SARS-CoV-2 Vaccines by Syed Mohammed Basheeruddin Asdaq, Shahamah Jomah, Syed Imam Rabbani, Ali Musharraf Alamri, Salman Khalaf Salem Alshammari, Badr Sami Duwaidi, Majed Sadun Alshammari, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani, Nagaraja Sreeharsha, Mohd. Imran

“…All these vaccines in clinical trials have shown robust production of neutralizing antibodies sufficient to prevent infection. …”
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IUPHAR review: Drug repurposing in Schizophrenia – An updated review of clinical trials by Jihan K. Zaki, Jakub Tomasik, Sabine Bahn

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International REACH forgiveness intervention: a multisite randomised controlled trial by Tyler J Vanderweele, Nicole Rodriguez, Richard G Cowden, Man Yee Ho, Everett L Worthington, Andrea Ortega Bechara, Zhuo Job Chen, Elly Yuliandari Gunatirin, Shaun Joynt, Viacheslav V Khalanskyi, Hennadii Korzhov, Ni Made Taganing Kurniati, Anastasiya Anastasiya Salnykova, Liudmyla Shtanko, Sergiy Tymchenko, Vitaliy L Voytenko, Anita Zulkaida, Maya B Mathur

“…Objectives To determine whether a brief self-directed forgiveness workbook intervention could alter forgiveness, depression symptoms, and anxiety symptoms.Design A multisite randomised waitlist-controlled trial was conducted among 4598 participants. Recruitment occurred from 11 February 2020 to 30 September 2021. …”
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