Naturally Occurring Canine Invasive Urinary Bladder Cancer: A Complementary Animal Model to Improve the Success Rate in Human Clinical Trials of New Cancer Drugs by Christopher M. Fulkerson, Deepika Dhawan, Timothy L. Ratliff, Noah M. Hahn, Deborah W. Knapp

“…Multiple canine clinical trials have been completed, and others are in progress with the aim of translating important findings into humans to increase the success rate of human trials, as well as helping pet dogs. …”
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Investigating the effectiveness of theory-based interventions for improving treatment adherence of patients with type 2 Diabetes Mellitus: A systematic review of Randomised Controlled Clinical Trials by Despoina Menti, Caroline Limbert, Georgios Lyrakos

“…Methods: An electronic search was conducted, including only Randomised Controlled Trials published in English and Greek from 2004 to 2016. …”

Couple-Based Intervention to Improve HIV Care Engagement for Women and their Partners in KwaZulu-Natal, South Africa: Outcomes of a Pilot Randomized Controlled Trial by Jennifer M. Belus PhD, Alastair van Heerden PhD, Abigail C. Hines MPH, Thembelihle P. Pita MCom, Yvonne Mdakane MSS, Jessica F. Magidson PhD, Heidi van Rooyen PhD, Ruanne V. Barnabas MBChB, PhD

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Increasing the uptake of long-acting reversible contraception in general practice: the Australian Contraceptive ChOice pRoject (ACCORd) cluster randomised controlled trial protocol by Danielle Mazza, Angela Taft, Kevin McGeechan, Kirsten Black, Heather McKay, Marion Haas, Jayne Lucke, Jeffery F Peipert

“…Any protocol modifications will be communicated to Ethics Committee and Trial Registration registry. The authors plan to disseminate trial outcomes through formal academic pathways comprising journal articles, nation and international conferences and reports, as well as using more ‘popular’ strategies including seminars, workshops and media engagements.Trial registration number ACTRN12615001346561.…”
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Comparison of Effect Sevoflurane-Based Anesthesia and Propofol-Based Anesthesia on the Early Postoperative Renal Function of Living Kidney Transplant Donors: A Randomized Controlled Trial by Cai J, Kang F, Han M, Huang X, Yan W, Wan F, Li J

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Vitrectomy combined with lens capsule flap transplantation in the treatment of high myopia macular hole retinal detachment: study protocol for a prospective randomised controlled trial by Xun Xu, Tianwei Qian, Hao Zhou, Weijun Wang, Ying Fan, Lin Xue, Xia Wu, Qiaoyun Gong, Luyao Ye

“…Intergroup comparisons of the proportions of patients with type I closure of MH will be performed with Fisher’s exact test.Ethics and dissemination Full ethics approval for this study was obtained from the Ethics Committee of Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China. The outcomes of the trial will be disseminated through peer-reviewed journals and at scientific conferences.Trial registration number ChiCTR2200057836.…”
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TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial by Wei Gao, Ping Hu, Aung Naing, Meredith McKean, Anthony Tolcher, Lillian L Siu, Keyvan Tadjalli-Mehr, Anja Victor, Emilia Richter, Marco A F Nogueira Filho, Thomas Kitzing, Stephan Gleicher, Daniel Holland

“…Further evaluation of M6223 is ongoing in combination with the PD-L1 inhibitor avelumab in patients with advanced urothelial carcinoma (JAVELIN Bladder Medley; NCT05327530).Trial registration number NCT04457778.…”
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Comparison of two skin protection regimes for the Prevention of Incontinence-associated Dermatitis in geriatric care (PID): a study protocol for an exploratory randomised controlled pragmatic trial by Jan Kottner, Monira El Genedy-Kalyoncu, Alexandra Fastner, Bettina Völzer, Kathrin Raeder, Konrad Neumann, Nils Axel Lahmann

“…Results will be disseminated through peer-reviewed open-access journals and international conferences.Trial registration number ClinicalTrials.gov (NCT05403762) and German Clinical Trials Register (Deutsches Register Klinischer Studien, or DRKS) (DRKS00028954).…”
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Efficacy of a guided internet-based intervention (iSOMA) for somatic symptoms and related distress in university students: study protocol of a randomised controlled trial by Harald Baumeister, Michael Witthöft, Eileen Bendig, Severin Hennemann, Katja Böhme, Maria Kleinstäuber, David Daniel Ebert

“…Results from this study will be published in peer-reviewed journals and presented at international conferences.Trial registration number DRKS00014375; Pre-results.…”
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Comparative effectiveness of physical activity interventions on cognitive functions in children and adolescents with Neurodevelopmental Disorders: a systematic review and network meta-analysis of randomized controlled trials by Ruiyuan Tao, Yijian Yang, Mark Wilson, Jeremy R. Chang, Chang Liu, Cindy H. P. Sit

“…Trial registration PROSPERO CRD42023409606.…”
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Efficacy and Safety of Murivenna Anal Infiltration Compared to Diltiazem Topical Application in Chronic Anal Fissure: Protocol for a Prospective, Randomized, Open-Label Clinical Trial by Pratap Shankar KM, Indu Puthan Purayil, Palengara Binitha, Amit Kumar Rai, Sophia Jameela, Azeem Ahmad, Chandra Sekhara Rao Bhogavalli, Narayanam Srikanth, Rabinarayan Acharya

“…MethodsThis is an open-labeled, randomized, controlled parallel group clinical trial with a sample size of 66 participants to be randomized and allocated in a 1:1 ratio to 2 groups. …”
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Role of adductor canal block and genicular nerve block on postoperative pain and enhanced recovery in patients undergoing total knee arthroplasty: A randomized clinical trial by Bassel Mohammed Elfokery, Mustafa Seet, Tareef Ashour, Hatem Alharbi, Mujeeb Ashraf, Hatim Alshareef, Mohammad Nyaz, Rayan Bakhreba, Atif Sait

“…Patients and Methods: This randomized trial was conducted on 50 subjects aged 40–75 years who underwent TKA under spinal anesthesia. …”
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Effect of nirmatrelvir/ritonavir (Paxlovid) on hospitalization among adults with COVID-19: An electronic health record-based target trial emulation from N3C. by Abhishek Bhatia, Alexander J Preiss, Xuya Xiao, M Daniel Brannock, G Caleb Alexander, Robert F Chew, Hannah Davis, Megan Fitzgerald, Elaine Hill, Elizabeth P Kelly, Hemalkumar B Mehta, Charisse Madlock-Brown, Kenneth J Wilkins, Christopher G Chute, Melissa Haendel, Richard Moffitt, Emily R Pfaff, N3C Consortium

“…<h4>Methods and findings</h4>This target trial emulation used a cohort of 703,647 patients with COVID-19 seen at 34 clinical sites across the United States between April 1, 2022 and August 28, 2023. …”
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Tissue Doppler echocardiography predicts long-term cardiovascular mortality: the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) legacy 20-year follow-up study by Simon Thom, Alice Stanton, Jamil Mayet, Amit Kaura, Darrel Francis, Anoop SV Shah, Andrew Sharp, Alun D Hughes, Neil R Poulter, Anenta Ratneswaren, Tong Wu, Somayeh Rostamian, Devan Wasan, PS Sever

“…Our aim was to evaluate whether this extends to predicting cardiovascular mortality after 20 years of follow-up.Methods Conventional (E) and tissue Doppler (e′) echocardiography was performed on hypertensive participants in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) with long-term follow-up ascertained via linkage to the Office of National Statistics. …”
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The Threshold of the Severity of Diabetic Retinopathy below Which Intensive Glycemic Control Is Beneficial in Diabetic Patients: Estimation Using Data from Large Randomized Clinical Trials by Yuqi Liu, Juan Li, Jinfang Ma, Nanwei Tong

“…We finally included DR-related studies involving intensive glucose control with large sample size and long follow-up time, including five large and high-quality randomized clinical trials (RCTs): DCCT, UKPDS, ACCORD, AdRem, and VADT. …”
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Evaluating the Impact of Pharmacotherapy in Augmenting Quit Rates Among Hispanic Adults in an App-Delivered Smoking Cessation Intervention: Secondary Analysis of a Randomized Controlled Trial by Margarita Santiago-Torres, Kristin E Mull, Brianna M Sullivan, Ana Paula Cupertino, Ramzi G Salloum, Matthew Triplette, Michael J Zvolensky, Jonathan B Bricker

“…However, this combined approach was not effective with the US clinical guideline–based app (QuitGuide). Trial RegistrationClinicalTrials.gov NCT02724462; https://clinicaltrials.gov/study/NCT02724462 International Registered Report Identifier (IRRID)RR2-10.1001/jamainternmed.2020.4055…”
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Dexamethasone added to induction and post-remission therapy in older patients with newly diagnosed acute myeloid leukemia: a multicenter, phase II trial (DEXAML-02) by Sarah Bertoli, Emilie Bérard, Pierre Peterlin, Romain Guieze, Yohan Desbrosses, Yosr Hicheri, Omar Benbrahim, Martin Carre, Corentin Orvain, Anne Banos, Marc Bernard, Emmanuel Gyan, Alain Saad, Safia Chebrek, Gabrielle Roth Guepin, Veronique Dorvaux, Laurence Sanhes, Maria Pilar Gallego-Hernanz, Carole Exbrayat, Laure Vincent, Chantal Himberlin, Célestine Simand, Norbert Vey, Cindy Fenoll, Ariane Mineur, Anne Huynh, Francois Vergez, Isabelle Luquet, Laetitia Largeaud, Eric Delabesse, Arnaud Pigneux, Christian Récher, French Innovative Leukemia Organization FILO

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Effectiveness of Repetitive Facilitative Exercise Combined with Electrical Stimulation Therapy to Improve Very Severe Paretic Upper Limbs in with Stroke Patients: A Randomized Controlled Trial by Hitoshi Ohnishi, Hiroyuki Miyasaka, Naoki Shindo, Kazuki Ito, Shiori Tsuji, Shigeru Sonoda

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Optimal dose of oxytocin to improve social impairments and repetitive behaviors in autism spectrum disorders: meta-analysis and dose–response meta-analysis of randomized controlled trials by Yingying Zhang, Xiaolu Zhang, Linghong Huang

“…However, there have been inconsistencies in the effects of OXT on social impairments and repetitive behaviors.MethodsA comprehensive search in PubMed, the Cochrane Library, Embase, and Web of Science was conducted to gather randomized controlled trials (RCTs) on the efficacy of OXT in patients diagnosed with ASD up to 11/06/2024. …”
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Can primary care research be conducted more efficiently using routinely reported practice-level data: a cluster randomised controlled trial conducted in England? by Jeremy Horwood, Alastair D Hay, Patricia Jane Lucas, Clare Clement, Peter S Blair, Jodi Taylor, Christie Cabral, Martin C Gulliford, Jenny Ingram, Padraig Dixon, Nick Francis, Athene Lane, Grace Young, Elizabeth Beech, Penny Seume, Scott Bevan, Sam T Creavin

“…Objectives Conducting randomised controlled trials (RCTs) in primary care is challenging; recruiting patients during time-limited or remote consultations can increase selection bias and physical access to patients’ notes is costly and time-consuming. …”
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