Interdisciplinary collaboration across secondary and primary care to improve medication safety in the elderly (IMMENSE study): study protocol for a randomised controlled trial by Liv Mathiesen, Jeanette Schultz Johansen, Kjerstin Havnes, Kjell H. Halvorsen, Stine Haustreis, Lillann Wilsgård Skaue, Elena Kamycheva, Kirsten K. Viktil, Anne Gerd Granås, Beate H. Garcia

“…Patient inclusion started in September 2016.Ethics and dissemination The trial was approved by the Norwegian Centre for Research Data and the Norwegian Data Protection Authority. …”
Get full text

How does individualised physiotherapy work for people with low back pain? A Bayesian Network analysis using randomised controlled trial data. by Bernard X W Liew, Jon J Ford, Marco Scutari, Andrew J Hahne

“…We sought to determine how this treatment works by using randomised controlled trial data to develop a Bayesian Network model.<h4>Methods</h4>300 randomised controlled trial participants (153 male, 147 female, mean age 44.1) with low back pain (of duration 6-26 weeks) received either individualised physiotherapy or advice. …”
Get full text

“The effect of intramuscular dexmedetomidine versus oral gabapentin premedication on the emergence agitation after rhinoplasty”. A prospective, randomized, double-blind controlled trial by Tamer Samir Abdelsalam Abdelaziz, Hatem Elsayed Mohammed Elsayed, Doaa Mohammed Kamal Eldin, Ismail Mohammed Ibrahim

“…Conclusions IM dexmedetomidine premedication was more efficient than gabapentin in the reduction of the emergence agitation incidence, severity, and postoperative pain scores after rhinoplasty in adults. Clinical trial registration number ID NCT05626998 on 25/11/2022.…”
Get full text

Effectiveness of Continuous Glucose Monitoring on Short-Term, In-Hospital Mortality Among Frail and Critically Ill Patients With COVID-19: Randomized Controlled Trial by Jiawei Shang, Ziming Yuan, Zuoyan Zhang, Quanhong Zhou, Yan Zou, Wei Wang

“…These findings support the use of CGM in the ICU and might help with the extension of application in various in-hospital settings. Trial RegistrationChinese Clinical Trial Registry ChiCTR2200059733; https://www.chictr.org.cn/showproj.html?…”
Get full text

The Effect of Intravenous Metoclopramide on Pain, Nausea, Discomfort, and Ease of Insertion of Nasogastric Tube in Emergency Department: A Double-blind Randomized Clinical Trial by Seyed Mohammad Hosseininejad, Farzad Bozorgi, Asieh Khodami, Hamed Aminiahidashti, Mohammad Hajizade Juybari

“…Methods: In this randomized, double-blind, placebo-controlled trial, 80 patients referred to Imam Khomeini Hospital, Mazandaran Province, Iran were enrolled. …”
Get full text

Bandage Contact Lens Application Reduces Fibrotic Wound Healing of Flap Margins after FS-LASIK: A Prospective Randomized Clinical Trial by Li-Quan Zhao, Liang-Mao Li, Jun Liu, Peng Li

“…In this prospective, randomized, interventional, observer-masked trial, 41 patients (82 eyes) with myopia and/or myopic astigmatism were scheduled to undergo FS-LASIK. …”
Get full text

Adverse events of hepatic anti-fibrotic agents in phase 3 and above clinical trials: a descriptive analysis of the WHO-VigiAccess database by Yuwei Liu, Yuwei Liu, Xu Zhao, Xu Zhao, Xinrui Wang, Xinrui Wang, Qiang Zhou, Qiang Zhou

“…This study assessed ADRs associated with anti-fibrotic agents as reported in the World Health Organization (WHO) VigiAccess database and compared the adverse reaction characteristics of these agents for optimizing therapeutic strategies.MethodsA detailed search was conducted on ClinicalTrial.gov to identify phase 3 or 4 clinical trials involving hepatic anti-fibrotic agents. …”
Get full text

Reduction effect of oral pravastatin on the acute phase response to intravenous zoledronic acid: protocol for a real-world prospective, placebo-controlled trial by Qi Liu, Min Zhang, Liyuan Tao, Chunli Song, Haiyan Li, Gengyu Han, Runting Li, Dongwei Fan, Guohong Du, Dongyang Liu

“…The results will be published in scientific peer-reviewed journals.Trial registration number NCT04719481.…”
Get full text

Clinical and cost-effectiveness of Knee Arthroplasty versus Joint Distraction for Osteoarthritis (KARDS): protocol for a multicentre, phase III, randomised control trial by Deborah D Stocken, Dennis G McGonagle, David Murray, Catherine Reynolds, Catherine Fernandez, David R Ellard, Andrew Metcalfe, Hemant Sharma, Paul Harwood, Hamish Simpson, Hemant Pandit, Susanne Arnold, Cerys Joyce Tassinari, Ruchi Higham, Isabelle Louise Smith, Ruben Mujica-Mota, Thomas William Hamilton, Julie Croft

“…Trial results will be disseminated at clinical conferences, through relevant patient groups and published in peer-reviewed journals.Trial registration number ISRCTN14879004; recruitment opened April 2021.…”
Get full text

Armodafinil versus Modafinil in Patients of Excessive Sleepiness Associated with Shift Work Sleep Disorder: A Randomized Double Blind Multicentric Clinical Trial by D. V. Tembe, A. Dhavale, H. Desai, D. N. Mane, S. K. Raut, G. Dhingra, U. Sardesai, S. Saoji, M. Rohra, V. G. Shinde, M. Padsalge, A. Paliwal, K. Abbasi, P. Devnani, S. Papinwar, S. Phadke, H. Mehta, V. Bhailume

Get full text

Effectiveness of Leg Elevation to Prevent Spinal Anesthesia-Induced Hypotension during Cesarean Delivery in the Resource-Limited Area: Open Randomized Controlled Trial by Sofia Assen, Bedru Jemal, Adane Tesfaye

“…Performing leg elevation immediately after spinal anesthesia reduced the incidence of hypotension. The trial is registered with PACTR201908713181850.…”
Get full text

Comparative effects of Health Qigong and closed motor exercise on the physical and mental health of female drug rehabilitation participants: a randomized controlled trial by Guang Yang, Deyu Meng, Shichun He, Meiqi Wei, Man Li, Lu Zhang, Zhendong Pan, Ziheng Wang

“…These findings suggest that incorporating a combination of traditional martial arts and closed motor exercises could enhance rehabilitation programs for drug rehabilitation. Trial registration ClinicalTrials.gov NCT06454565. …”
Get full text

A pilot study of dimeticone oils versus sodium carbonate treatment for tungiasis: A randomized cohort trial in Homa Bay County, Kenya. by Kana Suzuki, Yasuhiko Kamiya, Chris Smith, Satoshi Kaneko, Gordon Okomo, Asiko Ongaya, Evans Amukoye

“…The findings suggest that NYDA should be made more available in tungiasis endemic area.<h4>Trial registration</h4>UMIN-CTR; UMIN 000044320.…”
Get full text

Comparison of Diaphragmatic Stretch Technique and Manual Diaphragm Release Technique on Diaphragmatic Excursion in Chronic Obstructive Pulmonary Disease: A Randomized Crossover Trial by Aishwarya Nair, Gopala Krishna Alaparthi, Shyam Krishnan, Santhosh Rai, R. Anand, Vishak Acharya, Preetam Acharya

“…This randomised crossover trial included 20 clinically stable patients with mild and moderate COPD classified according to the GOLD criteria. …”
Get full text

A pilot randomized controlled trial of the iPeer2Peer program in adolescents with sickle cell disease: A mixed method study by Lauren Kelenc, Brittany Wiles, Fareha Nishat, Chitra Lalloo, Anya Nair, Craig Eling, Melanie Kirby-Allen, Ewurabena Simpson, Roona Sinha, Richard Ward, William T. Zempsky, Sara Ahola Kohut, Jennifer N. Stinson

“…Method: A waitlist pilot randomized controlled trial was conducted. Adolescents randomized to the intervention group were matched with trained peer mentors (19–25 years; successfully managing their SCD), consisting of up to 10 sessions of approximately 30-min video calls over a 15-week period. …”
Get full text

The regular effects of concurrent aerobic and resistance exercise on global cognition in healthy elderly populations: A systematic review with meta-analysis of randomized trials by Liang Ding, Lijie Lou, Mingyang Zhang, Xing Zhang

“…Randomized controlled trials involving healthy older adults aged ≥65 years that assessed the cognitive effects of concurrent exercise were included. …”
Get full text

Different Approaches to requesting Consent for Routine data linkage in Neonatal follow-up (ACORN): protocol for a 2×2 factorial randomised trial by Jane E Harding, Barry Milne, Jenny Rogers, Greg Gamble, Jane Marie Alsweiler, Christopher McKinlay, Gavin Brown, Aakash Bajirao Rajay, Caroline Anne Crowther, Nike Franke, Trecia Wouldes

“…Dissemination will be via peer-reviewed publications, scientific meetings, educational sessions and public fora.Trial registration number ACTRN12621000571875 (Australian New Zealand Clinical Trials Registry).…”
Get full text

Effectiveness of a personal health coaching intervention (diabetescoach) in patients with type 2 diabetes: protocol for an open-label, pragmatic randomised controlled trial by Oliver Faude, Fiona Streckmann, Lukas Zahner, Markus Gerber, Vivien Hohberg, Jan-Niklas Kreppke, Jan Kohl, Eleonora Seelig, Daniel König

“…The results will be published in international peer-reviewed journals.Trial registration number ISRCTN79457541.…”
Get full text

Effects of 6 Months of Active Commuting and Leisure-Time Exercise on Fibrin Turnover in Sedentary Individuals with Overweight and Obesity: A Randomised Controlled Trial by Anne Sofie Gram, Martin Bæk Petersen, Jonas Salling Quist, Mads Rosenkilde, Bente Stallknecht, Else-Marie Bladbjerg

Get full text

Clinical Trial Assessing the Efficacy of Gabapentin Plus B Complex (B1/B12) versus Pregabalin for Treating Painful Diabetic Neuropathy by Alberto Mimenza Alvarado, Sara Aguilar Navarro

“…This trial is registered with ClinicalTrials.gov NCT01364298.…”
Get full text